ライフサイエンスコーパス: funnel

1 oteins is observed, the so-called "hydration funnel".

2 (CE)] and ion transfer efficiency (e.g., ion funnels).

3 ss transfer capillary followed by a dual ion funnel.

4 ning of a hydrophobic gate at the end of the funnel.

5 er of biological unfoldases represented as a funnel.

6 st point of a negatively charged cytoplasmic funnel.

7 ye1 binds with its TLD to the Pol II jaw and funnel.

8 l conversion through a nested intermolecular funnel.

9 facing funnel and a smaller periplasm-facing funnel.

10 ol II protrusion and RPB10 to the polymerase funnel.

11 interaction with PSMA's amphipathic entrance funnel.

12 s, as well as the characterization of energy funnels.

13 dynamics and unidirectional efficient energy funneling.

14 strong evidence for multidirectional energy funneling.

15 zed resonance in metallic nanoslits by light funneling.

16 The Mia40 role is to funnel a rough folding landscape, skipping the accumulat

17 lycocalyx facilitates integrin clustering by funnelling active integrins into adhesions and altering

18 ented, light-harvesting donor molecules that funnel all excitation quanta by ultrafast energy transfe

19 n two domains, with a large cytoplasm-facing funnel and a smaller periplasm-facing funnel.

20 The closed channel has an empty cytoplasmic funnel and an extracellular funnel that is filled with a

21 led with transport media (TM) (sealed at its funnel and back entrance with a stopper) and the tissue

22 scale brain network topology is organized to funnel and concentrate information flow in the hippocamp

23 pH sensor at the entrance of the cytoplasmic funnel and opening of a hydrophobic gate at the end of t

24 co-translational translocation, the ribosome funnel and the channel of the protein translocation comp

25 adjustment for heterogeneities, we used both funnel and trim-and-fill analyses to identify a negligib

26 unbiased simulation results reveal a weakly funneled and rugged free energy landscape of SH4UD, whic

27 d drift tube bracketed by electrodynamic ion funnels and coupled to a high resolution quadrupole time

28 A nanopore biosensor actively funnels and threads analytes through a molecular-scale a

29 ure, the model presents a closed cytoplasmic funnel, and a periplasmic funnel of greater volume.

30 e extracellular cavity, open the cytoplasmic funnel, and result in a approximately 5 A vertical reloc

31 he shallow network or data-abundant limit is funneled, and thus easy to optimize.

32 ons (m/z 124-1131), the ambient pressure ion funnel (APIF) is demonstrated to improve ion abundances,

33 by 2D polarization imaging using the single funnel approximation.

34 lations confirmed the existence of a binding funnel as the main bottleneck.

35 aging, the exchange was performed in the ion funnel at 10 Torr pressure.

36 a well-known mechanism in which enzymes are funneled between enzyme active sites through a physical

37 mally frustrated binding pocket leading to a funneled binding landscape.

38 The sensor combines a traditional funnel bubble trap with an Arduino logger, a pressure se

39 ia and HSP90 pathways are interconnected and funneled by PRKD2 into the NF-kappaB/VEGF-A signaling ax

40 robe size ( approximately 25 mum), the Micro-funnel can be implanted into live multicellular tumor sp

41 Craterellus tubaeformis (Funnel Chanterelle) is among the most abundant wild mush

42 s adaptor PPFIA1, which we propose acts as a funnel combining FN secretion and recycling of active al

43 mobilization of a copper calix[6]azacryptand funnel complex on gold-modified electrodes is reported.

44 A conserved electronegative funnel connects this region to the intramembranous high-

45 aper with aspect ratios (funnel tip width to funnel depth) of 0.1 to 1.0.

46 a focused ion beam (FIB) instrument, and the funnel design had a constant 5 degrees taper with aspect

47 An "off-axis" ion funnel design has been developed to reduce the source co

48 is work, we developed and investigated a new funnel design that aims to seamlessly couple to SLIM at

49 Metabolites collected in the Micro-funnel device were then extracted by a microscale sampli

50 Direct binding via the binding funnel dominates the binding kinetics, and only approxim

51 effects in the affected nerves which likely funnel down to common clinical features.

52 est conceptual and methodological issues and funnels down to matters arising from specific empirical

53 apacity and operating the electrodynamic ion funnel (EDIF) at approximately 4 Torr, a single pumping

54 expected from a perfect antenna, LH2s showed funneling efficiencies close to unity.

55 In contrast, CPs showed lower average funneling efficiencies, greatly varying from molecule to

56 ates, using a single parameter called energy funneling efficiency (epsilon).

57 hree ideal QD monolayers can provide exciton funneling efficiency above 80% from the most distant lay

58 It funnels electrons coming from NADH and ubiquinol to cyto

59 as a three-dimensional geometric diode that funnels electrons preferentially in one direction throug

60 The ion funnel enables a much higher proportion of ions to exit

61 and photocatalysis, where it is necessary to funnel energy or charge to specific regions within the s

62 kbone can be used to quickly and efficiently funnel energy to chromophores with localized energy mini

63 This funneled energy landscape is the result of foldable prot

64 This view does not match the funneled energy landscape paradigm of a very large numbe

65 The funneled energy landscape theory implies that protein st

66 d that protein folding can be described by a funneled energy landscape.

67 fold into three-dimensional structures in a funneled energy landscape.

68 t proteins fold through parallel pathways on funneled energy landscapes, although experimental detect

69 citons with a type II alignment, but it will funnel excitons into one layer with a type I alignment.

70 In the base-to-tip direction, the funnel exhibits a lower ion conductance and a higher ele

71 hat aims to seamlessly couple to SLIM at the funnel exit.

72 ed a microscale collection device, the Micro-funnel, fabricated from biocompatible fused silica capil

73 The electrodynamic ion funnel facilitates efficient focusing and transfer of ch

74 In this work a new SLIM "flat funnel" (FF) module has been developed and demonstrated

75 tractor networks, we have uncovered that the funneled flux landscape is crucial for the emergence and

76 Post-drift, an ion funnel focuses the radially spread pulses of ions into t

77 ng different dimensionality, allowing energy funneling from lower-dimensional nanosheets (high-bandga

78 rability network represents an endophenotype funneling genetic risks for various psychiatric illnesse

79 , whereas, in the tip-to-base direction, the funnel has a higher ion conductance and a lower electroo

80 ent approach that leads to a molecular-scale funnel, having an effective chromophore concentration of

81 electrode was used to direct ions to an ion funnel HPIF at a pressure of 9-10 Torr.

82 rthogonal higher pressure electrodynamic ion funnel (HPIF) and an ion funnel trap combined with a tri

83 preciated "Central Asian Flyway", which must funnel hundreds of thousands of migrants from central As

84 simulations further showed that a hydration funnel (i.e., a gradient in retardation of hydrogen bond

85 switch from exciton dissociation to exciton funneling in a MoSe(2)/WS(2) heterostructure, which mani

86 veness, stability, fidelity, and attentional funnelling in social learning.

87 pHDock produces successful local docking funnels in approximately half (79/161) the protein compl

88 ransmembrane segments, cytosolic and luminal funnels in TMCO1 and TMEM147, respectively, suggest rout

89 The asymmetric geometry of the nanofluidic funnel induces not only ion current rectification but al

90 The two V. cholerae autoinducers funnel information into a shared signal relay pathway.

91 he excitatory cell class that preferentially funnels information to lateral frontal cortices in mice

92 In this study, a dual ion funnel interface consisting of an orthogonal higher pres

93 I-generated ions into an electrodynamic dual-funnel interface results in increased sensitivity charac

94 led to a QTOF mass spectrometer using an ion funnel interface to evaluate the m/z range transmitted a

95 ial S-lens interface and an in-line dual-ion funnel interface.

96 ly expected for aggregation, PrP dimers were funneled into a thermodynamically stable misfolded state

97 source of intracellular metabolites that are funneled into polyketide biosynthesis has proven elusive

98 -loaded macrophages revealed that glucose is funneled into the pentose phosphate pathway (PPP), which

99 ion and at a counting fence where smolts are funnelled into high densities].

100 be the metabolic breakdown of triuret, which funnels into biuret metabolism.

101 perimental characterization of a DC-only ion funnel is described herein.

102 The cytoplasmic funnel is empty, while the extracellular funnel is fille

103 mic funnel is empty, while the extracellular funnel is filled with a plug domain.

104 oiety, which harvests the optical energy and funnel it to the luminescent metal center.

105 In the funneled landscape, proteins fold to their native states

106 onsistent with multiple stochastic routes on funnel landscapes, and it gives good agreement with the

107 onics leverages engineered nanostructures to funnel light into small volumes and intensify nonlinear

108 2 and i+3 monomers, forming a sophisticated, funnel-like architecture.

109 potential energy landscapes have a distinct funnel-like bias toward the folded hairpin state, consis

110 destabilized by our optimization, making the funnel-like binding energy landscape more biased toward

111 trap, which is consistent with the idea of a funnel-like landscape.

112 ostrils have a rectangular medial wall and a funnel-like lateral opening, nasal channels run obliquel

113 orted structure of lipovitellin, which has a funnel-like lipid-binding cavity, the lipid-binding site

114 of homodimeric Na(+)-PPase forms an unusual funnel-like structure with a catalytic site in the cytop

115 tril sulcus representing the lateral wall is funnel-like.

116 ribution to the full free energy, it appears funnel-like.

117 The PPAD active site is a funnel located on one of the cylinder bases.

118 We also show that the presence of the funnel makes the tension along the backbone of the subst

119 lysine ring that defines the wide end of the funnel may selectively allow cation diffusion into the c

120 ved at an affordable computational cost make funnel metadynamics a valuable method for drug discovery

121 This stereoselection analysis is extended by funnel metadynamics to a range of WTIgP variants whose p

122 ional theory-based (DFT-b) tight binding and funnel metadynamics to advance our earlier QM/MM maturat

123 Furthermore, funnel metadynamics unveils important information about

124 veloped a metadynamics-based approach, named funnel metadynamics, that allows the ligand to enhance t

125 sing an innovative free-energy method called funnel-metadynamics (FM), which we have recently develop

126 ng absolute binding free-energy estimated by funnel-metadynamics simulations and solution NMR experim

127 therefore, have evolved collectively to give funneled minimally frustrated landscapes but some strate

128 In the Foldon Funnel Model, proteins fold in units of secondary struct

129 In addition, we found a set of ultrafast funneling molecules that harvest three times more energy

130 n, dissolution and partition in a separating funnel; moreover, it gives higher recoveries, comparable

131 present a new approach, Multi-Stemmed Nested Funnel (MSNF), to develop pedo-transfer functions (PTFs)

132 closed cytoplasmic funnel, and a periplasmic funnel of greater volume.

133 mbrane surface proximal to the calcium entry funnel of SERCA.

134 ion of F5Hs are consistent with preferential funneling of 4CL5 products toward G-lignin biosynthesis

135 ry production in streptomycetes involves the funneling of environmental and physiological signals to

136 this architecture would favor the efficient funneling of pectinases at convergent points within the

137 hich are also responsible for the subsequent funneling of the excitation energy to the reaction cente

138 unctional hypothesis is that this convergent funneling of the full blend of pectinases constitutes a

139 short-chain fatty acids, which included the funneling of the lignocellulosic carbohydrates to lactat

140 RNA helicase activity promotes unwinding and funneling of the single-stranded piRNA precursor transcr

141 he landscape, quantifying the degrees of the funneling of the underlying potential and flux landscape

142 Here we show how funnelling of cellular resources, after global transcrip

143 ly modify the band-gap, leading to efficient funnelling of excitons towards isolated strain-tuned qua

144 cesses have been proposed to account for the funnelling of gas towards the galactic centre to feed th

145 nd analysis; in practical terms, a broadband funnelling of infrared radiation with fractional bandwid

146 of broadband light absorption and efficient funnelling of photogenerated excitons to points of maxim

147 These results illuminate how the folding funnels of natural proteins arise and provide the founda

148 hamber is linked to the fourth channel by a 'funnel' of charged residues.

149 Three RNA-binding domains form an open funnel on one face of the catalytic domain that allows R

150 folding landscapes of membrane proteins are funneled once the proteins' topology within the membrane

151 ion introduction through ring electrode ion funnels or more conventional ion optics to SLIM can invo

152 e new device, termed a periodic focusing ion funnel (PF IF), provides an efficient alternative to the

153 riction, large proteins are released through funnel plasmodesmata in discrete pulses, a phenomenon we

154 ted to the protophloem by a unique class of 'funnel plasmodesmata'.

155 ng the modified Newcastle-Ottawa scale and a funnel plot (effect size measured using Hedges' g follow

156 Funnel plot analysis suggested substantial publication b

157 ication bias risks were assessed by means of funnel plot analysis.

158 ication bias risks were assessed by means of funnel plot analysis.

159 Funnel plot and Egger test did not reveal significant pu

160 A funnel plot and Egger's test did not suggest significant

161 Publication bias was evaluated via funnel plot and Egger's test.

162 Funnel plot and heterogeneity analyses were also perform

163 The funnel plot and the Egger's test (p=0.44) showed no evid

164 Funnel plot asymmetry among SLC6A3 studies was identifie

165 cation, subgroup, meta-regression and Deeks' funnel plot asymmetry analyses were employed.

166 Funnel plot asymmetry and trim-and-fill revealed a clear

167 hes, sample size and intervention effects on funnel plot asymmetry, using empirical datasets and illu

168 Examination of the funnel plot did not provide evidence of publication bias

169 lization tool that is the counterpart of the funnel plot in the multivariate setting.

170 as assessed via Begg's and Egger's tests and funnel plot inspection.Findings from 12 RCTs (n = 609 pa

171 es (I2 = 28.9%; Q = 18.27, P = .16), and the funnel plot provided no evidence for publication bias.

172 Visual inspection of a funnel plot revealed no publication bias, which was conf

173 Funnel plot was not performed due to the limited number

174 nterval (CI) 0%-41%, and chi = 0.26] and the funnel plot was symmetrical both according to visual and

175 Funnel plot, Q statistics, and I(2) were used to test th

176 sted and corrected for publication bias by 3 funnel plot-based methods.

177 pital trust level, and contrasted these in a funnel plot.

178 est for both omega-3 and folic acid studies; funnel plots also revealed asymmetry (reflecting potenti

179 Publication bias was evaluated by using funnel plots and Egger's and Begg's tests.

180 We used funnel plots and Egger's linear regression to test for p

181 ore, and publication bias was assessed using funnel plots and Egger's statistic.

182 We assessed reporting bias with funnel plots and heterogeneity with the I statistic.

183 tatistics, publication bias was assessed via funnel plots and the Begg and Egger tests, and methodolo

184 Publication bias was evaluated by funnel plots and the Egger test.

185 Funnel plots demonstrated positive publication bias in P

186 all of the information presented by separate funnel plots for each outcome while elucidating more com

187 on visual or statistical examination of the funnel plots for either disease management or health beh

188 Funnel plots have been widely used to detect small-study

189 We used funnel plots of the hazard ratio to assess bias.

190 We found that funnel plots of the Standardized Mean Difference (SMD) p

191 Funnel plots revealed a symmetrical distribution with no

192 Funnel plots showed no evidence of publication bias (P =

193 Comparison-adjusted funnel plots suggest the presence of small-study effects

194 Funnel plots suggested reporting bias, and sensitivity a

195 We conclude that funnel plots using the SMD in combination with the SE ar

196 n was performed to analyze heterogeneity and funnel plots were applied to evaluate publication bias.

197 Funnel plots were asymmetric with a bias toward lower od

198 l for publication bias was explored by using funnel plots, Begg's and Egger's tests, and Duval and Tw

199 and meta-regression, and publication bias by funnel plots, Egger's test, and fill/trim methods.

200 the potential bias of small studies, we used funnel plots, the Begg rank correlation test, and the Eg

201 Publication bias was corrected for using funnel plots, the Egger regression test, and a trim and

202 Publication bias was evaluated by funnel plots, the Egger test, and the Begg test.

203 We excluded relevant sources of bias by funnel plots.

204 sual or analytical detection of asymmetry in funnel plots.

205 atistic and evaluated publication bias using funnel plots.

206 Publication bias was modeled using funnel plots.

207 Publication bias was assessed using funnel plots.

208 bias) was determined by Egger regression and Funnel-plotting.

209 ilibrium fitness "seascapes" can dynamically funnel populations to genotypes unobtainable in static e

210 While the funneled potential landscape is often crucial for the st

211 -in-cell simulations show how the structures funnel protons to the tight focus.

212 vides an efficient alternative to the rf ion funnel providing high ion transmission with fewer electr

213 P1' glutarate occupies the spacious entrance funnel rather than the conserved glutamate-binding S1' p

214 of ozone into the high-pressure trapping ion funnel region preceding the IMS cell.

215 B-scan revealed a closed funnel retinal detachment.

216 first time the use of a radio frequency ion-funnel (RFIF) in the reaction region (drift tube) of a p

217 This rectangular ion funnel (RIF) was initially evaluated by ion simulations,

218 A very small funnel right below the TLC tip collected the solvent and

219 , each decay mechanism contains factors that funnel RNA substrates to abundant exo- and/or endonuclea

220 These submarine channels funnel sediment, nutrients, pollutants and organic carbo

221 e ring that constricts the narrow end of the funnel serves as a broad cation selectivity filter, wher

222 The orthogonal ion injection into a funnel shaped separation region can greatly reduce space

223 the authors show that DNA injected through a funnel-shaped entrance more efficiently enters the nanoc

224 Such funnel-shaped potential energy landscapes may be typical

225 e that molecular crystallization can involve funnel-shaped potential energy landscapes through a deta

226 d key residues in the positively charged and funnel-shaped substrate access tunnel that gated substra

227 The funnel-shaped tail lower collar attaches the expanded na

228 ew device operation motifs including quantum-funnel solar cells, non-contact chromophore pumping from

229 tif may provide specificity in inhibition to funnel specific olfactory information, such as food and

230 The basic idea is to funnel spins from a large area of spin Hall material int

231 , an intramembrane protease, using perfectly funneled structure-based models that implicitly account

232 on of 91% at 400-2,500 nm and the microscale funnel structures lead to average reflection of 7% at 2.

233 oscale gaps (0-200 nm) as well as microscale funnel structures.

234 g, may line the channel's cytoplasmic-facing funnel surface, stabilize the channel's overall structur

235 (ESI) interface, a tandem electrodynamic ion funnel system, a collisional flatapole, a quadrupole mas

236 Here, we report an ion funnel that can be used to effectively focus ions at amb

237 that the microtubule forms an electrostatic funnel that guides the dynein's microtubule binding doma

238 mpty cytoplasmic funnel and an extracellular funnel that is filled with a small helical domain, calle

239 icro-traps that confine bacteria using micro-funnels that open into trapping chambers.

240 , whereby the electrostatic field acts as a 'funnel' that sweeps the GABA molecules towards the bindi

241 pe has a volcano shape, rather than a simple funnel, that folding is two-state (single-exponential) w

242 n challenge of infrared photodetectors is to funnel the light into a small nanoscale active area and

243 tion extracts suppresses these fluctuations, funneling the complex into a single conformation on the

244 nce of the position of the Schnauzenorgan in funneling the fish's self-generated electric field.

245 s on the conformational space, progressively funneling the molecule to the native state.

246 that this type of motor should be capable of funneling the photon energy into specific rotary modes,

247 us creating additional plus (+) subsites and funneling the polymeric substrate through the tunnel-sha

248 create an attractive electrostatic potential funneling the zinc cations toward the binding sites.

249 used by the detailed-balance-breaking, which funnels the downhill migration of excitons.

250 Interaction with PX funnels the free-state equilibrium of NT by stabilizing

251 sible; the interaction with pre-existing gas funnels the gas into nuclear regions (<1 kpc) to form ne

252 rylates and activates the enzyme Nth1, which funnels the storage carbohydrate trehalose into central

253 rationalized by the principle of an "energy funnel", the carotenoids still pose many open questions.

254 yptophans form light-harvesting networks and funnel their excitation energy to the pyramid centers to

255 est diffusive sun photons on large areas and funnel them onto much smaller areas of highly efficient

256 ion mechanisms with geographic features that funnel them toward Mexican overwintering sites, a remark

257 sms to usurp the host's metabolic resources, funneling them towards the production of virion componen

258 sector we find the landscape is indeed very funneled: Thermodynamic landscape analysis indicates tha

259 othesized that AQP3 transports glycerol and "funnels" this primary alcohol to PLD2 to form a pro-diff

260 pon a fraction of the population, birth is a funnel through which all individuals must pass.

261 unknown whether these changes are ultimately funneled through a stable corticospinal output channel o

262 K transcriptional response in human cells is funneled through Integrator, an RNA polymerase II-associ

263 constant 5 degrees taper with aspect ratios (funnel tip width to funnel depth) of 0.1 to 1.0.

264 We propose ATG9A acts as a membrane-embedded funnel to facilitate lipid flipping and to redistribute

265 se that PelC functions as an electronegative funnel to guide the positively charged Pel polysaccharid

266 convergence, in which sensory information is funneled to a small set of output neurons that guide beh

267 the parasite for pyrimidine nucleotides are funneled to uracil and then phosphoribosylated to UMP in

268 ates of pigments can result in robust energy funneling to the initial excitation conditions and tempe

269 polyol region lining a channel interior that funnels to its narrowest region at the C3-hydroxyl group

270 via upper pathways that act as a "biological funnel" to convert heterogeneous substrates to central i

271 nfolding events and the landscape is locally funneled toward "ideal" chromosome structures that repre

272 es of natural foldable proteins are strongly funneled toward the native state.

273 nnectivity actively shapes information flow, funneling traffic towards some nodes and away from other

274 ess ion manipulations (SLIM) employed an ion funnel trap (IFT) to accumulate ions from a continuous e

275 electrodynamic ion funnel (HPIF) and an ion funnel trap combined with a triple quadrupole mass spect

276 ignificantly improved performance for an ion funnel trap upon adding helium; the signal intensities f

277 on ejection into the drift tube from the ion funnel trap.

278 reviously reported charge capacity of an ion funnel trap.

279 s: (a) Panel traps were superior to multiple-funnel traps, (b) bark beetles and woodborers were captu

280 Ion packets introduced from gates, ion funnel traps, and other conventional ion injection mecha

281 ty and orientation were examined using Emlen funnel trials.

282 ns (IOL) cartridge and pulled further in the funnel using 25 G end-grasping forceps.

283 morphae (i.e., trapdoor spiders, tarantulas, funnel web spiders, etc.) is one of three main lineages

284 Funnel-web envenomations are mostly inflicted by male sp

285 y profiling venom-gland transcriptomes of 10 funnel-web species, we report 22 delta-HXTXs.

286 -HXTX-Ar1a, the lethal toxin from the Sydney funnel-web spider Atrax robustus, induces pain in mice b

287 ch to demonstrate that the lethal Australian funnel-web spider produces 33 superfamilies of venom pep

288 proteins, Hadronyche versuta (Blue Mountains funnel-web spider) neurotoxin (Hvt) and onion leaf lecti

289 Australian funnel-web spiders are infamous for causing human fatali

290 Although 35 species of Australian funnel-web spiders have been described, only nine delta-

291 espite their deep evolutionary origin within funnel-web spiders, consistent with a defensive role.

292 icient pumping of fluids through nanofluidic funnels when a symmetric AC waveform is applied.

293 rns which regions of the protein (un)folding funnel, which can be explored by activation of protein i

294 Here, a binding funnel, which increasingly confines the translational as

295 inds to arginine residues located in the UCP funnel, which leads to a decrease in UCP's proton transp

296 veals an overall downhill but rugged binding funnel with multiple pathways.

297 hat the landscape of the protein is a triple funnel with two folded structures and one misfolded stru

298 that the folding energy landscapes are more funneled with binding, indicating that binding helps fol

299 sfolded domains are part of the same folding funnel, with commitment to one structure or the other oc

300 energy surface is canyon-like, with a smooth funnel within a two dimensional subspace capturing over