ライフサイエンスコーパス: futile cycle

1 if not regulated tightly, could result in a futile cycle.

2 t bifunctional activities without creating a futile cycle.

3 back to cysteine sulfinic acid and AMP in a futile cycle.

4 sterol actively effluxed by ABC1, creating a futile cycle.

5 tes, allow metabolic plasticity, and prevent futile cycles.

6 coli, these functions are separated to avoid futile cycling.

7 d neutral invertase, associated with minimal futile cycling.

8 ariant stabilized cob(II)alamin and promoted futile cycling.

9 omote uncoupling of the Serca pump and cause futile cycling.

10 turnover from strand passage, manifesting in futile cycling.

11 t they are coordinately regulated to prevent futile cycling.

12 gulate an activated FBPase in order to avoid futile cycling?

13 -AT target genes, as NF-ATs are subject to a futile cycling across the nuclear envelope owing to enga

14 This apparent futile cycle allows eggs to maintain elevated cytoplasmi

15 k(HR) estimates glucose/glucose-6-phosphate futile cycling, along with glucose recycling through the

16 embrane domains MalF and MalG that generated futile cycling; although interaction with MBP stimulated

17 TP costs of phloem loading, nutrient uptake, futile cycles and/or protein/membrane turnover.

18 yeast glycolysis and the coupled pathways of futile cycling and glycogen and trehalose synthesis (whi

19 birth-death process, an example of enzymatic futile cycle, and a stochastic switch model.

20 eschedule metabolic activities, (3) suppress futile cycles, and (4) make ion transport more efficient

21 host metabolism, leading to flux imbalances, futile cycles, and undesired phenotypes.

22 With the assumption that futile cycles are tightly regulated in reality, the FBA

23 e production, resting myosin consumes ATP in futile cycles at two rates, the slower one being associa

24 Recent discoveries of other BAT futile cycles based on creatine and succinate have provi

25 xperimental conditions and identified a high futile cycle between oxaloacetate and pyruvate, indicati

26 diated lipolysis creates an energy-consuming futile cycle between TG hydrolysis and resynthesis, lead

27 d requires tight regulatory control to avoid futile cycles between carboxylation and decarboxylation.

28 duction of beta-lapachone by NQO1 leads to a futile cycling between the quinone and hydroquinone form

29 tose-binding site of MalF likely generated a futile cycle by preventing maltose from binding to MalFG

30 Calcineurin suppresses this futile cycling by a non-catalytic mechanism involving th

31 Further experiments confirmed this futile cycle; cells without FepB transported FeEnt acros

32 Cellular levels of 5fTHF are regulated by a futile cycle comprising the enzymes SHMT and 5,10-methen

33 he model simulations indicate that the 5fTHF futile cycle dampens the stochastic noise in FOCM that r

34 Solutions with minimal futile cycling diverted surplus energy and electrons tow

35 To avoid infinite futile cycles, folded LRP6 molecules undergo palmitoylat

36 Our studies reveal that the zebrafish gene futile cycle (fue) is required in the zygote for male pr

37 This protein is related to zebrafish futile cycle (Fue), a nuclear envelope (NE) constituent

38 The zebrafish futile cycle gene is shown to encode a maternally expres

39 ed ultrasensitivity in a kinase/phosphatase "futile cycle" has been a paradigmatic example of collect

40 osphate-1-kinase coupled with the absence of futile cycling implies an undetermined mechanism of coor

41 on of alternative electron flow pathways and futile cycles in energy rebalancing.

42 urthermore, the ED pathway does not generate futile cycles in organisms that fix CO2 via the Calvin-B

43 and histochemical measurements, we show that futile cycling in roots of barley (Hordeum vulgare) seed

44 t increases fatty acid oxidation and calcium futile cycling in the skeletal muscle of mice.

45 emingly opposed functions and explains how a futile cycle is avoided-cytoplasmic p300/CBP E4 activiti

46 evious reported noise-induced bistability in futile cycles is found to have originated from the kinas

47 g thermogenic brown and beige adipose tissue futile cycling may be an important strategy to increase

48 ional functional modalities on the enzymatic futile cycle mechanism that include stochastic amplifica

49 Here, we propose a futile cycle model of enhancer-mediated regulation that

50 ell maintenance costs, in agreement with the futile cycling model of ammonium toxicity.

51 Our study fundamentally revises the futile-cycling model by demonstrating that NH3 is the ma

52 this phenomenon is not exclusively due to a futile cycle of abortive TLS followed by exonucleolytic

53 involvement of the proofreading subunit in a futile cycle of base insertion/excision with the UmuC st

54 presence of free fatty acids and leads to a futile cycle of Ca(2+) accumulation and release when exo

55 ir target biosynthetic machinery involving a futile cycle of cell wall synthesis and degradation, the

56 es, lack of central core protein POC5, and a futile cycle of centriole formation and disintegration.

57 persist to the next cell cycle, leading to a futile cycle of centriole formation and disintegration.

58 NAP hydrolyses phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphory

59 These findings link a futile cycle of creatine metabolism to adipose tissue en

60 e metabolic signature of WAT by activating a futile cycle of de novo fatty acid synthesis and beta-ox

61 iglycerides to the liver, which results in a futile cycle of enhanced VLDL production and increased k

62 e, we demonstrated that PAP2 can stimulate a futile cycle of fatty acid (FA) synthesis and degradatio

63 cs and RNA-seq data suggested TCDD induced a futile cycle of fatty acid activation and acyl-CoA hydro

64 AC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, whic

65 rom the gluconeogenic process and prevents a futile cycle of glucose phosphorylation.

66 gulatory role of GltC may be prevention of a futile cycle of glutamate synthesis and degradation in t

67 phorylation of p31(comet) by Plk1 prevents a futile cycle of MCC assembly and disassembly during the

68 adopts two major conformations to prevent a futile cycle of methionine production and consumption.

69 s the mitochondrial inner membrane, create a futile cycle of nutrient oxidation without generating AT

70 sequence are not cleaved, thereby avoiding a futile cycle of removal and readdition of these essentia

71 erted to PC and TAG, and appeared to be in a futile cycle of synthesis and degradation.

72 f enduring lipid droplets that prevented the futile cycle of TAG biosynthesis/lipolysis and instead c

73 Collectively, the data reveal a futile cycle of unregulated transcription, siRNA product

74 flux systems, protects cells from continuous futile cycles of Ca(2+) across the inner mitochondrial m

75 Subsequent futile cycles of DNA mismatch repair can lead to a p53-a

76 Viomycin inhibition also promotes futile cycles of GTP hydrolysis by EF-G.

77 We suggest that these result from futile cycles of recombinational elongation and truncati

78 s then cycled back to methionine, leading to futile cycles of SAM synthesis and recycling and explain

79 d therefore to drug resistance by preventing futile cycles of translesion synthesis and mismatch corr

80 It is hypothesized that futile cycles of translesion synthesis past cisplatin-DN

81 e that adipocytes lack GyK and thereby avoid futile cycles of triglyceride breakdown and resynthesis

82 iggering transcription-coupled repair (TCR), futile cycles of which may lead to repeat expansion or c

83 e turnover and suggesting that CD36 promotes futile cycling of fatty acids into triglyceride.

84 In conclusion, high futile cycling of fatty acids is important for maintaini

85 Elevated futile cycling of hepatic lipids was also observed.

86 sphate from catabolism to anabolism avoiding futile cycling of key nutrients.

87 By this mechanism, SLN promotes the futile cycling of SERCA, contributing to muscle heat pro

88 A second mechanism is through futile cycling of SR calcium whereby SERCA-mediated SR c

89 2014) report that memory T cells activate a "futile cycle" of de novo fatty-acid synthesis and concur

90 MMR-mediated damage tolerance and futile cycle repair processes are discussed, as well as

91 3R calcium channel leads to an ATP-depleting futile cycle, resulting in activation of the energy sens

92 te in the protocol but was timed to minimize futile cycling, since phosphorylase a became inhibited b

93 embrane without generating ATP, leading to a futile cycle that consumes glucose metabolites and gluta

94 rate, can decompose to produce H(2)O(2) in a futile cycle that consumes NADPH.

95 ith the ferrous heme-NO species is part of a futile cycle that does not directly contribute to NO syn

96 which inhibit modularity, through enzymatic futile cycles that consume energy, typically in the form

97 This led to futile cycling the LLO pathway, exacerbated by GDP-manno

98 ely back to the original quinone, creating a futile cycle, the byproducts of which are deleterious re

99 (bio)chemical-reaction mechanisms, enzymatic futile cycles, the external noise may induce a bistable

100 chastic model of FOCM by including the 5fTHF futile-cycle to explore its effect on the FOCM network.

101 w that a single-player system may escape the futile cycle trap by limiting transfer of reducing equiv

102 malate into oil is low and that flux through futile cycles (wasting ATP) is low, which contrasts with

103 c regulatory properties for the formation of futile cycles were further considered in the model, resu

104 nesis is achieved through increased rates of futile cycling, which are observed in several systems, m

105 egulated to allow fine-tuning and to prevent futile cycles while carbon is being fixed.

106 rylation of X-5-P by Pho13p might generate a futile cycle with xylulokinase overexpression.

107 which has implications for the coherence of futile cycles within an integrated tissue.