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2 yme glucosyltransferase UDP galactose:beta-D-galactosyl-1, 4-N-acetyl-D-glucosaminide alpha(1-3)galac
3 rase uridine 5'-diphosphate galactose:beta-D-galactosyl-1, 4-N-acetyl-D-glucosaminide alpha(1-3)galac
4 L5), and (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyl
5 ase, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha2,6-sialylt
6 cribe the cloning of a UDP-galactose: beta-d-galactosyl-1,4-glucosylceramide alpha-1, 3-galactosyltra
7 nthesized by the enzyme UDP galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha(1-3)galact
8 d to be an AGP by precipitation with (beta-D-galactosyl)3 Yariv phenylglycoside and by amino acid com
11 ARSA) activity toward the natural substrate, galactosyl-3-sulfate ceramide (or sulfatide), is perform
15 tibodies are primarily directed to alpha-1,3-galactosyl (alpha Gal) residues on endothelial cell surf
16 nating tumor cell membranes to express alpha-galactosyl (alpha-gal) epitopes (i.e., Galalpha1,3Galbet
19 ferase (alpha3GT) catalyzes the synthesis of galactosyl-alpha-1,3-beta-galactosyl structures in mamma
20 ediated through preformed antibodies against galactosyl-alpha-1,3-galactose (Galalpha-1,3-Gal) epitop
21 which were produced by cell lines expressing galactosyl(alpha1-3)galactosyl (alphaGal) sugars, were f
22 rom alphaGal-negative cells, indicating that galactosyl(alpha1-3)galactosylation sensitizes these vir
25 ve prepared in baboons high titer anti-alpha-Galactosyl (alphaGal) and anti-porcine aortic endothelia
26 ted by the interaction of natural anti-alpha-galactosyl (alphaGal) antibodies with alphaGal epitopes
27 ntibodies (NAbs) against a terminal alpha1-3 galactosyl (alphaGal) epitope have been identified as th
28 by cell lines expressing galactosyl(alpha1-3)galactosyl (alphaGal) sugars, were found to be less stab
30 s (Arabidopsis thaliana) XyG, which contains galactosyl and fucosyl substituents, tomato (Solanum lyc
31 erts a strong alpha-directing effect in both galactosyl and glucosyl donors, irrespective of the conf
34 entropy change of binding of the two groups (galactosyl and glucosyl) of oligosaccharides to the two
35 -exposed N-acetylneuraminyl, alpha- and beta-galactosyl, and N-acetylhexosaminyl sugars from human an
38 ion of these rice genes, including fucosyl-, galactosyl-, and acetyltransferases, in the correspondin
40 of renal fibroblasts with baboon anti-alpha-Galactosyl antibodies resulted in increased synthesis of
41 etic factors that shape the human anti-alpha-galactosyl antibody response, and provide a framework fo
45 3), (G(M3), N-acetylneuraminosyl-alpha(2, 3)-galactosyl-beta(1,4)-glucosylceramide), were inactive in
46 oteins generated glycoproteins with terminal galactosyl-beta-1, 4-GlcNAc and thus permitted their iso
48 harness endogenous anti-galactose-alpha-1,3-galactosyl-beta-1,4-N-acetyl-glucosamine (anti-alphaGal)
49 sy), glucosyl-beta1'1-sphingosine (Glu-Sph), galactosyl-beta1'1-ceramide (Gal-Cer), or lactosyl-beta1
50 ation of the major xenogeneic antigen, alpha-galactosyl, by injecting donor animals with monoreactive
51 ta 1,4GlcNAc beta 1, 4GlcNAc) and an alpha 3-galactosyl-capped trisaccharide (Gal alpha 1,3Gal beta 1
53 y high affinity) site binds both the alpha 3-galactosyl-capped trisaccharide and the two fucosylated
60 her species can present the glycolipid alpha-galactosyl ceramide (alpha-GalCer) to mouse natural kill
61 ll responses to the glycolipid antigen alpha-galactosyl ceramide (alpha-GalCer) were dampened by prio
62 ogs of the well known NKT cell agonist alpha-galactosyl ceramide (alpha-GalCer), bacterial glycolipid
63 ion with the NKT cell-specific agonist alpha-galactosyl ceramide (alphaGC), Sh2d1a-/- splenocytes did
66 using the previously cloned cDNA encoding a galactosyl ceramide 3-O-sulfotransferase, which we term
67 the CD1d molecule to bind and present alpha-galactosyl ceramide after lysosomal processing of a prec
68 in response to the model iNKT cell Ag alpha-galactosyl ceramide and expressed lower amounts of the T
70 simple strategy for the synthesis of beta-C-galactosyl ceramide and its new aza-variant analogue is
71 le for assembly or the ability to bind alpha-galactosyl ceramide and to present it to human NKT cells
72 Cell surface expression was detected for galactosyl ceramide but not for CC-chemokine receptor 5,
74 The preparation of the glycosphingolipid galactosyl ceramide from an orthogonally protected five-
78 1) and recognize lipid antigens (e.g., alpha-galactosyl ceramide) presented by nonpolymorphic CD1 mol
80 ugh both Gal3ST-2 and Gal3ST-3 do not act on galactosyl ceramide, Gal3ST-3 is only moderately more ho
81 er T (NKT) cells mobilizing glycolipid alpha-galactosyl ceramide, used to mature splenic DCs, served
82 ion factor 21 and GATA3 expression and alpha-galactosyl ceramide-induced cytokine production in vivo.
83 levels of IL-4 following TCR ligation, alpha-galactosyl ceramide-stimulated NKT cells from the livers
89 aded with a synthetic NKT cell ligand, alpha-galactosyl-ceramide (alpha-GalCer; KRN-7000) in five pat
91 In vivo stimulation of iNKT cells by alpha-galactosyl-ceramide was effective in both preventing and
92 nistration of concanavalin A (ConA) or alpha-galactosyl-ceramide, which induce liver inflammation and
93 Additionally, the synthesis of the 2-azido-galactosyl chloride donor was optimized into a three-ste
94 ployed a silver oxide for coupling a 2-azido-galactosyl chloride donor with two acceptors, Fmoc-Ser/T
96 digestion indicated that the majority of the galactosyl component was in the furanoic conformation (b
97 l other genes in the biosynthetic pathway of galactosyl-containing complex oligosaccharides were more
98 exo-galactanase levels and the highest wall galactosyl content during the early stages of ripening,
100 This strategy has allowed us to identify the galactosyl derivative 14a, as an interesting hit exhibit
103 rthermore, in the Borrelia burgdorferi alpha-galactosyl diacylglycerol-CD1d complex, TCR binding caus
104 3,6-anhydro-bridge or a suitable 3,6-anhydro-galactosyl donor to form the unfavored 1,2-cis-equatoria
105 elds of the glycosylations using fluorinated galactosyl donors indicated that the fluorine modificati
108 di-O-benzoyl, and 4,6-di-O-benzoyl protected galactosyl donors, with the highly electron-withdrawing
110 of anionic nucleophiles toward the covalent galactosyl-enzyme intermediate of the reactions catalyze
111 trophenyl beta-D-galactopyranoside through a galactosyl-enzyme intermediate that shows a high reactiv
113 f the beta-D-galactopyranosyl group from the galactosyl-enzyme intermediates of the galactosyl transf
115 d GlcSph from the far more abundant isobaric galactosyl epimers naturally occurring in white matter.
118 saged through these cells acquired the alpha-galactosyl epitope in association with the envelope glyc
119 se data suggest that expression of the alpha-galactosyl epitope on the surface of viruses may have im
120 -78 cells expressed high levels of the alpha-galactosyl epitope on their membrane surface, rendering
122 t, like other retroviruses bearing the alpha-galactosyl epitope, HIV modified to express this epitope
123 nthetic disaccharide that contains the alpha-galactosyl epitope, indicating that virolysis is mediate
128 ng natural antibodies recognizing alpha(1,3)-galactosyl epitopes (alphaGal) not present on human cell
129 e found to express very low amounts of alpha-galactosyl epitopes (Gal alpha1-3Gal beta1-4GlcNAc-R).
130 esulted in synthesis and expression of alpha-galactosyl epitopes (Gal(alpha)1-3Gal(beta)1-4GlcNAc-R)
131 nti-Gal antibody, which interacts with alpha-galactosyl epitopes (i.e., Gal alpha1-3Gal beta1-4GlcNAc
132 e carbohydrates, such as appearance of alpha-galactosyl epitopes as a result of up-regulation of the
133 d, as measured in ELISA with synthetic alpha-galactosyl epitopes linked to bovine serum albumin or wi
134 It is suggested that synthesis of alpha-galactosyl epitopes on freshly isolated human tumor cell
135 e immune system responds vigorously to alpha-galactosyl epitopes on xenografts by activating many B l
139 selective, but more beta-selective using the galactosyl fluoride and depending on the acceptor used.
140 e evidences towards the higher resistance of galactosyl-fructose linkages during its intestinal degra
141 rate that different heterologously expressed galactosyl-, fucosyl-, and xylosyltransferases can trans
143 yl galactosyl globoside (SGG) and disialosyl galactosyl globoside (DSGG), which specifically bound ur
145 ress two extended globoseries GSLs, sialosyl galactosyl globoside (SGG) and disialosyl galactosyl glo
146 od group-related glycosphingolipid, sialosyl galactosyl globoside (SGG), has recently been implicated
147 lysaccharide components with a wide range of galactosyl, glucosyl and mannosyl linkages that do not d
148 ular protein that catalyzes the formation of galactosyl-glucosyl-diacylglycerol, a glycolipid importa
149 glycosyltransferases in other families with galactosyl-, glucosyl-, and xylosyltransferase activitie
150 hermophilus T-1 can also utilize lactose and galactosyl-glycerol via the cellobiose-PTS system togeth
151 esence of cellobiose, with either lactose or galactosyl-glycerol, revealed initially logarithmic grow
153 es of alpha-galactosidase A, and these alpha-galactosyl glycoconjugates were found in corneal keratoc
154 that VVH displays a preference for terminal galactosyl groups including N-acetyl-d-galactosamine and
155 ing of 3 with the peracetylated glucosyl and galactosyl halides 12a,b and 26 afforded, after saponifi
156 e 99m Tc diethylenetriamine pentaacetic acid-galactosyl-human serum albumin for evaluation of functio
159 the first-generation protocol, per-O-benzyl galactosyl iodide was efficiently coupled with activated
161 ting that the recognition of the nonreducing galactosyl is essentially conserved, whereas the adjacen
163 actose [Gal-beta(1 --> 6)-Glc] and 6'-O-beta-galactosyl-lactose [Gal-beta(1 --> 6)-Gal-beta(1 --> 4)-
164 thetic fluorescent acceptors with a terminal galactosyl, lactosyl or N-acetyl-lactosaminyl moiety.
169 an enzyme that hydrolyzes internal endo-beta-galactosyl linkages in keratan sulfate, and glycoconjuga
170 actomannan, BoMan26B generated a mixture of (galactosyl) manno-oligosaccharides shorter than mannohex
171 repeating phosphodisaccharide (consisting of galactosyl-mannose)) and LPG coincubated with LPG-neutra
173 The findings indicate that plants tailor galactosyl modification on glucomannans for constructing
175 ccumulation of glycosphingolipids with alpha-galactosyl moieties consisting predominantly of globotri
176 ycosphingolipids that have terminal a-linked galactosyl moieties in vascular endothelial cells causes
179 ities, and in particular a compound having a galactosyl moiety at C-4 of the nonreducing GlcNAc moiet
180 tion coordinate involves the movement of the galactosyl moiety deep into the active site pocket.
182 lts provide strong confirmation that the non-galactosyl moiety of permease substrates abuts Ala(122)
183 ative LT, LT(G33D) was unable to bind to the galactosyl moiety of Sepharose 4B or GM1 but did retain
187 bound to its putative ganglioside receptor, galactosyl-N-acetylgalactosaminyl (N-acetyl-neuraminyl)
193 C-4 GlcNAc hydroxyl group versus that of the galactosyl OH-3 in the selective glycosylation of a tris
194 of extrusion on bioactive compounds (sucrose-galactosyl oligosaccharides, insoluble dietary fibre, re
196 lpha2-->1 Sph, other lyso-phospholipids, and galactosyl- or lactosyl-Sph did not block such adhesion,
199 d FUT2, a pair of GDP-L-fucose:beta(1-->4)-D-galactosyl-R 2-alpha-L-fucosyltransferase enzymes (EC 2.
201 it preferentially to the 2-O-position of the galactosyl residue closest to the reducing end of the re
202 rbing the hydrophobic alpha face of the beta-galactosyl residue leads to complete loss of binding to
204 p of glycerol and to the 6-hydroxyl group of galactosyl residue of beta-galactosyl 1-->1 sphingosine
206 (r) Fucosylation by alpha 1,2-L-FT of the galactosyl residue which occurs on the antennary structu
207 of which lacks the Kdo linked to O-6 of the galactosyl residue, another that lacks the galacturonic
209 of neutral sphingolipids with terminal alpha-galactosyl residues and subsequent accumulation in sever
211 suggest that N-linked glycans with terminal galactosyl residues facilitate cell surface binding and
213 ty was confirmed via a quantified release of galactosyl residues from cell wall fractions containing
215 ses associated with these membranes transfer galactosyl residues from UDP-Gal to diacylglycerol.
218 oes not indiscriminately fucosylate terminal galactosyl residues in complex-type N-glycans, but it fa
219 lation of material containing terminal alpha-galactosyl residues in cultured embryonic fibroblasts de
220 iae that bind to two receptors: beta1-linked galactosyl residues in glycosphingolipids and the phosph
221 -deutero-methylation analysis indicated that galactosyl residues in the polysaccharide backbone are 3
222 lpha face that is uniquely displayed by beta-galactosyl residues is essential to the recognition of t
224 de A and Amide I in blood serum, and alpha-D-galactosyl residues of glycosphingolipids in urine.
225 fers beta1,6-linked GlcNAc preferentially to galactosyl residues of N-acetyllactosamine close to nonr
227 orescent-labeled lectin specific for alpha-D-galactosyl residues showed accumulation of substrate in
228 ntly more radiolabel from [2-(3)H]Man into L-galactosyl residues suggesting that the mutation increas
229 ulate glycosphingolipids with terminal alpha-galactosyl residues that come from intracellular synthes
231 esent multivalent sialylated and/or sulfated galactosyl residues under the conditions of the binding
232 de chains vary in length from one to over 20 galactosyl residues, and they are partly substituted wit
238 ate, 4-p-coumaroylquinic acid, quercetin-3-O-galactosyl-rhamnosyl-glucoside, kaempferol-3-O-glucosyl-
240 g: Cys148 hydrophobically interacts with the galactosyl ring, while Glu126 and Arg144 are charge pair
242 of replicating promastigotes is mediated by galactosyl side chain (scGal) modifications of phosphogl
243 f a conserved alpha-L-fucosyl-(1-->2)-beta-D-galactosyl side chain and excessive galactosylation at a
245 compounds such as lyso-phosphatidylcholine, galactosyl-Sph (psychosine), and lactosyl-Sph at 0.5-10
247 hesized that the accumulation of psychosine (galactosyl-sphingosine) in the TWI CNS may result in the
248 s the synthesis of galactosyl-alpha-1,3-beta-galactosyl structures in mammalian glycoconjugates.
249 nes and Staphylococcus aureus) or containing galactosyl substituents (those of Listeria spp. and Lact
251 ivity on galactomannan with a high degree of galactosyl substitution and was shown to be endo-acting
252 26 epitope has been identified as a beta-1,6-galactosyl substitution of beta-1,4-galactan requiring m
253 ctosyltransferase, MUR3, but is required for galactosyl-substitution of xyloglucan at a different pos
254 annan backbones acquire variable patterns of galactosyl substitutions, depending on plant development
257 e laminin binding to collagen IV, to bind to galactosyl sulfatide, and to selectively convert alpha-s
259 ination of affinity chromatography on beta-D-galactosyl-Synsorb and ion-exchange chromatography on DE
260 icity of galectin-1 for eight different beta-galactosyl terminal disaccharides was studied using mole
261 ciency leads to impaired catabolism of alpha-galactosyl-terminal lipids such as globotriaosylceramide
262 ; EC ) leads to impaired catabolism of alpha-galactosyl-terminal lipids such as globotriaosylceramide
266 the full chemical affinity of azide ion for galactosyl transfer from the mutant enzyme which lacks t
267 presents the requirement for the coupling of galactosyl transfer from the native enzyme to the thermo
268 m the galactosyl-enzyme intermediates of the galactosyl transfer reactions catalyzed by E461G and E46
269 ignificant prolongation of heterotopic alpha Galactosyl transferase "knock-out" and human CD46 transg
270 e biosynthetic enzyme UDP-galactose:ceramide galactosyl transferase (CGT) are incapable of synthesizi
271 Mycobacterium tuberculosis being a putative galactosyl transferase (GalTr) implicated in galactan sy
273 nces of a rat sialyl transferase and a human galactosyl transferase along with the Arabidopsis homolo
274 s were transduced with an exogenous alpha1-3-galactosyl transferase gene, which codes for the termina
277 sing human serum on wild-type (WT) and alpha-galactosyl transferase knockout (GalTKO)/hCD46-transgeni
279 osphorylcholine (ChoP), and lic2, a putative galactosyl transferase that adds the terminal galactose
280 osyl transferase A (pgtA), which encodes the galactosyl transferase that catalyzes the synthesis of t
281 mutants, we found that lgtE, which encodes a galactosyl transferase that is required for elongating t
282 -like protein 2, alpha-lactalbumin, beta-1,4-galactosyl transferase, and poly-Ig (immunoglobulin) rec
285 intermediate is extended by two bifunctional galactosyl transferases, GlfT1 and GlfT2, and then it is