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1 LT gene encoding Gb3/CD77 synthase (alpha1,4-galactosyltransferase).
2 conversion of UDP-Gal to UDP, using 1-4-beta-galactosyltransferase.
3 the lgt2 gene of D4, which encodes beta(1-4)-galactosyltransferase.
4 the product of one of these genes encodes a galactosyltransferase.
5 transferase and the lgt2 encodes a beta(1-4) galactosyltransferase.
6 It is the first pH-sensitive method for galactosyltransferase.
7 port here a new pH-indicator-based assay for galactosyltransferase.
8 ity of another Mn-dependent enzyme, beta-1,4-galactosyltransferase.
9 ly distinguished from the trans-Golgi marker galactosyltransferase.
10 ans bre-5, which encodes a putative beta-1,3-galactosyltransferase.
11 m for the substrate binding of the alpha1, 3-galactosyltransferase.
12 em containing equal amounts of epimerase and galactosyltransferase.
13 nd a UDP-galactose dependent (1-->6)-alpha-D-galactosyltransferase.
14 antigen is not synthesized in the absence of galactosyltransferase.
15 tively, using domains from mannosidase-1 and galactosyltransferase.
16 B gene encoding the terminal oligosaccharide galactosyltransferase.
17 matically galactosylated by bovine beta(1,4)-galactosyltransferase.
18 ctive toward T-synthase but not another beta-galactosyltransferase.
19 ucosaminyltransferase 2 (B3GNT2) and beta1,4-galactosyltransferases.
20 ntaining conserved domains of core-1 beta1,3-galactosyltransferases.
23 this phenotype using Mutant [core 1 beta1,3-galactosyltransferase 1 (C1galt1)(FF):zona pellucida gly
25 evated levels of the long isoform of beta1,4-galactosyltransferase 1 (GalT), a proportion of which is
26 rystallographic structures of bovine beta1,4-galactosyltransferase 1 and human glucuronyltransferase
28 es are due largely to the vertebrate beta1,4-galactosyltransferase-1 (beta4Gal-T1), which is found as
30 Moreover, because of the promiscuity of the galactosyltransferase, 18 unique O-glucosylated peptides
31 osaminyltansferase-7 (beta3GnT7) and beta1,4-galactosyltransferase-4 (beta4GalT4), in the production
32 n by knockdown of the gene encoding beta-1,3-galactosyltransferase 5 (beta3GalT5) in the globo-series
33 essed human fucosyltransferase 3 and beta1,3-galactosyltransferase 5 in mice, reconstituting the glyc
34 aining 11A [CLEC11A]) normalized by beta-1,3-galactosyltransferase 6 (B3GALT6) level yielded a best-f
35 sylceramide (LacCer) synthesized by beta-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the
37 GAG) biosynthetic enzymes, the human beta1,4-galactosyltransferase 7 (hbeta4GalT7) is characterized b
39 ese-dependent enzymes, most notably beta-1,4-galactosyltransferase, a Golgi enzyme essential for bios
40 because of mutation of the gene for ceramide galactosyltransferase, a key enzyme for galactosphingoli
41 omologue of cj1136, which encodes a putative galactosyltransferase according to the annotation of the
42 nephropathy indicated a decrease in beta1,3-galactosyltransferase activity and an increase in N-acet
44 ydrolase but has recently been shown to have galactosyltransferase activity in Arabidopsis thaliana.
45 jection of zebrafish beta4GalT1 mRNA returns galactosyltransferase activity to control levels and res
46 -terminal region of FT85 abolishes Skp1 beta-galactosyltransferase activity with minimal effects on t
47 lumen with a K(m) of 2.7 microm;(c) detected galactosyltransferase activity(ies) in the lumen of the
51 nal WbbY domain is a UDP-Galp-dependent GT-A galactosyltransferase adding beta-(1->3)-linked d-Galp,
54 why family GT6 members, like bovine alpha1,3-galactosyltransferase (alpha1,3-GalT), have a nucleophil
57 Disruption of the gene encoding pig alpha1,3-galactosyltransferase (alpha1,3GT) by homologous recombi
58 ells have a natural mutation in the alpha1,3 galactosyltransferase (alpha1,3GT) gene and lack alpha-G
59 because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species
60 the UDP-galactose:beta-galactoside-alpha1-3-galactosyltransferase (alpha1,3GT) gene, which ablated t
62 hich requires the enzyme product of alpha1,3-galactosyltransferase (alpha1,3GT), are sugar chains on
64 the function of PgtA, a dual function beta3-galactosyltransferase/alpha2-fucosyltransferase that con
68 The retaining glycosyltransferase, alpha-1,3-galactosyltransferase (alpha3GT), is mutationally inacti
70 Notably, two domains harbored by beta-1,3 galactosyltransferase, an essential enzyme in forming pl
71 demonstrated an increase in overall beta(1,3)galactosyltransferase and alpha(2,3)sialyltransferase ac
72 ian beta1,4-galactosyltransferase or beta1,4-galactosyltransferase and alpha2,6-sialyltransferase gen
73 ectors designed to express mammalian beta1,4-galactosyltransferase and alpha2,6-sialyltransferase gen
74 the porcine submaxillary gland core 1 beta 3-galactosyltransferase and alpha2-fucosyltransferase exhi
75 ntiviral vector expressing porcine alpha 1,3 galactosyltransferase and transplanted into lethally irr
76 l chemoenzymatic method based on a wild-type galactosyltransferase and uridine diphosphate galactose
77 eins that are lipooligo/polysaccharide alpha-galactosyltransferases and alpha-glucosyltransferases.
79 from the pIgR, asialoglycoprotein receptor, galactosyltransferase, and CD89 is constitutively expres
81 ids predominant in photosynthetic membranes, galactosyltransferases associated with these membranes t
82 n-dependent kinases related to the mammalian galactosyltransferase-associated protein kinase p58, and
83 long with marked down-regulation of beta-1,3-galactosyltransferase (B3GALT5) upon conversion to naive
84 transgenic animals with a heterozygous alpha-galactosyltransferase background (Tg Gal-/+), and from n
85 and/or resialylated TNFR-IgG using beta-1,4-galactosyltransferase (beta1,4GT) and/or alpha-2,3-sialy
88 then demonstrate that among various beta1, 4-galactosyltransferases (beta4Gal-Ts), beta4Gal-TI is mos
90 method to assay UDP-Gal:beta-d-GlcNAcbeta1,4-galactosyltransferase (beta4GalT-I) enzymatic activity.
92 form of the N-terminal region exhibits beta-galactosyltransferase but not fucosyltransferase activit
93 strongly inhibited modification by the PgtA galactosyltransferase but not the fucosyltransferase.
94 ion catalyzed by lipopolysaccharyl-alpha-1,4-galactosyltransferase C (LgtC) from Neisseria meningitid
96 ate directly via decreased expression of the galactosyltransferase C1GalT1 and, indirectly, via incre
97 e Golgi-targeting mechanisms of core 1 beta3 galactosyltransferase (C1GalT1) and core 2 beta1,6-N-ace
99 that there are three different sets of lipid galactosyltransferases capable of galactoglycerolipid bi
100 ponse to proton release that accompanies the galactosyltransferase-catalyzed galactose transfer.
103 zyme to generate GCs, UDP-galactose:ceramide galactosyltransferase (CGT(-/-)), exhibit severe postnat
104 he axonal protein NCP1 or the glial ceramide galactosyltransferase (CGT) display disruptions in AGJs
105 at encodes the enzyme UDP-galactose:ceramide galactosyltransferase (Cgt), which is responsible for ca
108 g galactose alpha 1,3 galactose in alpha 1,3 galactosyltransferase deficient (gal knockout) mice usin
109 were used as heart graft donors to alpha1,3-galactosyltransferase deficient (GalT KO; B6, H-2) recip
110 ow cells (BMC) were transplanted to alpha1,3-galactosyltransferase deficient (GalT-/-) mice condition
112 s for an anti-Gal IgM antibody into an alpha-galactosyltransferase-deficient (Gal-/-) background.
115 a similar splenic subpopulation of alpha1, 3-galactosyltransferase-deficient and wild-type mice.
116 from animals with the transgene in an alpha-galactosyltransferase-deficient background (Tg Gal-/-),
117 s study, we take advantage of the ability of galactosyltransferase-deficient knockout (GT-Ko) mice to
118 nd (Tg Gal-/+), and from nontransgenic alpha-galactosyltransferase-deficient littermates (Gal-/-) dem
119 unity, we here used MyD88-, TRIF-, and alpha-galactosyltransferase-deficient mice to study B cell phe
123 DP-galactose 4-epimerase, EC ) and alpha1, 3-galactosyltransferase (EC ) with an N-terminal His(6) ta
124 osyl-1, 4-N-acetyl-D-glucosaminide alpha(1-3)galactosyltransferase (EC 2.4.1.151) or simply alphaGT.
128 ing effect on Drosophila melanogaster core 1 galactosyltransferase enzyme activity and a predominant
129 uorescent or biotin tags using an engineered galactosyltransferase enzyme and [3 + 2] azide-alkyne cy
130 zymatic approach that exploits an engineered galactosyltransferase enzyme to selectively label O-GlcN
136 formatics, but its identification as a beta4-galactosyltransferase family member was experimentally c
137 p is predicted to be a member of the beta1,3-galactosyltransferase family, and Pvg3p-green fluorescen
138 ains exists among other members of the beta3-galactosyltransferase family, recombinant enzyme did not
140 gene family that includes: murine alpha1, 3-galactosyltransferase, Forssman (Gb(5)) synthase, and th
141 in both organisms, and a bifunctional alpha-galactosyltransferase from CAZy family GT77 mediates the
143 By using the promiscuous NmLgtB-B beta1-4 galactosyltransferase from Neisseria meningitidis we dem
144 e changed the donor requirement of alpha1, 3-galactosyltransferase from UDP-galactose to UDP-glucose
147 re of the catalytic domain of bovine beta1,4-galactosyltransferase (Gal-T1) co-crystallized with UDP-
149 mammals, humans lack a functional alpha-1,3-galactosyltransferase (GalT) gene and produce abundant a
150 s-mediated gene transfer of porcine alpha1,3 galactosyltransferase (GalT) is able to induce tolerance
151 the characterization of a zebrafish beta1,4-galactosyltransferase (GalT), which has substantial homo
154 ucosylceramide synthase and LacCer synthase (galactosyltransferase, GalT-2) inhibitor, inhibited LPS/
156 otype were linked to variation of a putative galactosyltransferase gene (beta-(1,3)galT); mutagenesis
158 as a result of up-regulation of the alpha1,3-galactosyltransferase gene and concomitant reduction in
159 homozygous for the knockout of the alpha1-3 galactosyltransferase gene appear to express low but det
161 -accelerating factor transgenic or alpha-1,3-galactosyltransferase gene knockout miniature swine.
162 urvival of cardiac xenografts from alpha 1-3 galactosyltransferase gene knockout pigs, which express
165 availability of pigs homozygous for alpha1,3-galactosyltransferase gene knockout, and improved immuno
167 nerated by homologous disruption of alpha1,3-galactosyltransferase gene, is capable of producing natu
169 l antibodies (Abs) in baboons after alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pig heart
171 ic cardiac xenotransplantation from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) swine to b
172 radiated human or wild type (WT) or alpha1,3-galactosyltransferase gene-knockout (GT-KO) pig PBMC in
173 rombotic microangiopathy (TM) after alpha1,3-galactosyltransferase gene-knockout (GTKO) pig organ tra
174 in response to wild-type (WT) and alpha-1,3-galactosyltransferase gene-knockout (GTKO) porcine aorti
175 ent cytotoxicity to wild-type (WT), alpha1,3-galactosyltransferase gene-knockout (GTKO), and TKO pig
176 d cells (RBCs) from wild-type (WT), alpha1,3-galactosyltransferase gene-knockout (GTKO), and TKO pigs
177 in baboons after Tx of livers from alpha1,3-galactosyltransferase gene-knockout (GTKO, n=1) or GTKO
178 s from genetically engineered pigs (alpha1,3-galactosyltransferase gene-knockout [GTKO] pigs and pigs
180 peracute rejection did not occur in alpha1,3-galactosyltransferase gene-knockout kidney xenografts.
183 We examined pathologic changes in alpha1,3-galactosyltransferase gene-knockout pig kidneys transpla
184 ononuclear cells from wild-type and alpha1,3-galactosyltransferase gene-knockout pigs) and anti-Gal I
185 s that do not express Gal epitopes (alpha1,3-galactosyltransferase gene-knockout pigs) might remove t
189 from SLA identical wild type (WT), alpha1, 3-galactosyltransferase (GGTA1) KO, GGTA1/ cytidine monoph
190 RISPR/Cas9 system to inactivate the collagen galactosyltransferase GLT25D1 and GLT25D2 genes in osteo
192 odifying enzyme possessing LH, hydroxylysine galactosyltransferase (GT), and galactosylhydroxylysine-
193 tosaminyltransferase (GTA) and alpha-(1-->3)-galactosyltransferase (GTB) catalyze the final step in A
196 ain SS1 or SS1::0826kan, in which a beta-1,4-galactosyltransferase (HP0826), an LPS biosynthetic enzy
197 se 2, Drosophila melanogaster core 1 beta1,3-galactosyltransferase, human alpha2,3-sialyltransferase,
200 ona pellucida glycoprotein, ZP3, via beta1,4-galactosyltransferase I (GalT I), a lectin-like receptor
201 of sperm lacking the long isoform of beta1,4-galactosyltransferase I (GalT I), a sperm surface protei
203 d forms of five of the biosynthetic enzymes: galactosyltransferase I and glucuronosyltransferase I, r
205 zymes of the pathway (xylosyltransferase and galactosyltransferase I) show that the assembly of the p
206 5B2, which encode glucuronosyltransferase I, galactosyltransferase I, and the 3'-phosphoadenosine 5'-
207 the zebrafish ortholog of mammalian beta1,4-galactosyltransferase I, beta4GalT1, and its requirement
213 g in late pachytene spermatocytes, the beta4-galactosyltransferase-I (beta4GalT-I) gene is transcribe
214 evidence suggests that ZP3 binds to beta-1,4-galactosyltransferase-I (GalTase) on the sperm surface.
216 d-galactosyl-1,4-glucosylceramide alpha-1, 3-galactosyltransferase (iGb(3) synthase) from a rat place
219 indicating that beta3GalT6 is the so-called galactosyltransferase II involved in glycosaminoglycan b
223 ave cloned Gb(3) synthase, the key alpha1, 4-galactosyltransferase in globo-series glycosphingolipid
224 ent or by knocking down the relevant enzyme, galactosyltransferase in Sb(R)LD (KD Sb(R)LD), compromis
225 indicate a gatekeeper function for the beta3-galactosyltransferase in the PgtA dual reaction, and ide
227 , suggesting that the disrupted genes encode galactosyltransferases in plant cell wall synthesis.
229 conclude that the R2866 lgtC gene encodes a galactosyltransferase involved in synthesis of the 4C4 e
232 DP-galactose:glycoprotein-alpha-GalNAc beta3-galactosyltransferase) is most sensitive to the presence
233 s specific client T-synthase (Core 1 beta1-3-galactosyltransferase) is required for folding of the en
235 the absence of alphaGAL epitopes, humans and galactosyltransferase knock-out (GALT/ KO) mice express
237 e report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a to
239 demonstrated that skin grafts from alpha-1,3 galactosyltransferase knockout (GalT-KO) miniature swine
240 previously reported life-supporting alpha1,3-galactosyltransferase knockout (GalTKO) thymokidney xeno
242 this treatment was demonstrated in alpha1,3-galactosyltransferase knockout mice producing anti-Gal a
243 This hypothesis was tested in alpha-1,3-galactosyltransferase knockout mice, which produce anti-
247 llagen type IV alpha-1 (COL4A1) and Beta-1,3-galactosyltransferase-like (B3GALTL) have been reported
249 re swine with a null allele of the alpha-1,3-galactosyltransferase locus (GGTA1) by nuclear transfer
252 binds to the acceptor site of human beta1-4-galactosyltransferase much like the acceptor trisacchari
253 with the previously characterized xyloglucan galactosyltransferase, MUR3, but is required for galacto
254 d its serum-sensitive phenotype and that the galactosyltransferase mutant retained its serum-resistan
256 nsertionally inactivated the gene encoding a galactosyltransferase necessary for serotype O1 O-antige
258 the addition of either galactose by beta1,3-galactosyltransferase or a terminal sialic acid by a N-a
260 nsect cell lines that have mammalian beta1,4-galactosyltransferase or beta1,4-galactosyltransferase a
261 tter, no obvious homologues of known beta1-4-galactosyltransferase or beta1-2- or beta1-6-N-acetylglu
262 bohydrate-active enzyme database family GT4 (galactosyltransferases) or to family GT64 (C-terminal do
263 ongly influenced UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 5 (B4GALT5) expressio
265 the asialoglycoprotein receptor or beta-1, 4-galactosyltransferase, previously described on HT-29 cel
267 identification on gels of a putative 51 kDa galactosyltransferase protein, and the isolation, clonin
268 ccharides have relied on the use of beta-1,3-galactosyltransferases recently cloned and characterized
269 o knockdown c1galt1 (T-synthase), a critical galactosyltransferase required for the synthesis of core
270 iously yielded iGb(3) synthase, the alpha1,3-galactosyltransferase required in isoglobo-series GSL.
271 f culmination, cells lacking AgtA, an alpha3-galactosyltransferase required to extend the trisacchari
272 was demonstrated unambiguously as a beta-1,3 galactosyltransferase responsible for converting GM2-lik
273 nt of a group of putative bacterial beta-1,3-galactosyltransferases revealed the presence of two cons
274 P-P-LU-galactan, catalyzed by a bifunctional galactosyltransferase (Rv3808c) capable of adding altern
275 he X-linked gene that encodes core 1 beta1,3-galactosyltransferase-specific chaperone 1 (C1GALT1C1, a
276 equences found in previously described beta3-galactosyltransferases, suggesting this enzyme is only d
277 rior studies suggested that the core 1 beta3-galactosyltransferase (T-synthase) is a specific client
279 lNAc-transferases (GALNT), the core 1 beta-3-galactosyltransferase (T-synthase), three alpha2-6-sialy
281 the primary follicle stage of core 1 beta1,3-galactosyltransferase (T-synthase; generates core 1-deri
282 ions 310-322) which is also found in beta1,4-galactosyltransferases (termed the Gal/GalNAc-T motif).
283 ositionally and shown to encode a xyloglucan galactosyltransferase that acts specifically on the thir
284 smic reticulum for T-synthase, a Golgi beta3-galactosyltransferase that generates the core 1 O-glycan
285 cated that Rv3789 interacts in vivo with the galactosyltransferase that initiates the elongation of t
286 GalT5 is a previously unidentified zebrafish galactosyltransferase that is essential for proper patte
287 e inactivation of the gene encoding alpha1-3 galactosyltransferase, the enzyme that synthesizes the g
288 ing protein, or subsequently modified with a galactosyltransferase to build more complex carbohydrate
289 f beta-galactosides using a bacterial beta-4-galactosyltransferase/-UDP-4'-gal-epimerase fusion prote
291 les of these GSLs and the key enzyme beta1,3-galactosyltransferase V (beta3GalT5) that converts Gb4 t
295 d lysosomal trafficking of the Golgi protein galactosyltransferase was sortilin independent and occur
296 hemically characterized a bacterial beta-1,3-galactosyltransferase (WbiP) from Escherichia coli O127,
297 pes 6A/6B have wciNalpha, encoding alpha-1,3-galactosyltransferase, whereas serotypes 6C/6D have wciN
298 sferases that includes vertebrate beta(1, 4)-galactosyltransferases, which create galactose-beta(1, 4
299 rized grafts in the combination of alpha 1,3-galactosyltransferase wild-type (GalT(+/+)) and deficien
300 he detergent solubilisation of the fenugreek galactosyltransferase with retention of activity, the id