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1 lated, synthesized, and screened against the galanin receptor.
2 and in vivo for its affinity and efficacy at galanin receptors.
3 and in vivo for its affinity and efficacy at galanin receptors.
4 nin acts as an endogenous anticonvulsant via galanin receptors.
5 we identified the sites of expression of the galanin receptor 1 (GAL-R1) subtype in the rat stomach a
6 d showed marked regional variations, GAL and galanin receptor 1 (GALR1) being most abundant.
7                              Variants in the galanin receptor 1 (GALR1) gene have been associated wit
8                                              Galanin receptor 1 (GALR1) maps to a common region of 18
9              The G-protein-coupled receptor, galanin receptor 1 (GALR1), maps to this region of chrom
10  mutant showed antagonistic activity against galanin receptor 1 (GalR1)-mediated response, and decrea
11 nfluence on the brain, primarily through the galanin receptor 1 a (galr1a).
12 ve effects of galanin were via activation of galanin receptor 1 expressed specifically on cholangiocy
13  different models of chronic pain requires a galanin receptor 1-triggered depression of excitatory sy
14                                              Galanin receptor affinity, serum stability, lipophilicit
15 riment indicated that galnon, a nonselective galanin receptor agonist, did not affect cocaine-induced
16  Direct activation of galanin receptors by a galanin receptor agonist, galnon, was found to produce a
17                  We found that activation of galanin receptors alone is not sufficient to mediate the
18  spectra of galanin action mediated by these galanin receptors and regulate the diverse physiological
19 ) neurons, inhibited OX neurons, whereas the galanin receptor antagonist M40 (galanin-(1-12)-Pro3-(Al
20 ricular (i.c.v.) infusions of 4 doses of the galanin receptor antagonist M40 or galanin and were allo
21 cid following either an injection of M-40 (a galanin receptor antagonist) or saline.
22                               Furthermore, a galanin receptor antagonist, M40, attenuated the antidep
23             These effects were attenuated by galanin receptor antagonists (M35 > M40 >/= M15).
24 reover, use of intracerebroventricular (ICV) galanin receptor antagonists in prior studies precluded
25                                    All three galanin receptors are found in the VTA, SN, NA, and LC;
26                                     Multiple galanin receptors are predicted to mediate its effects,
27                                     Multiple galanin receptors are predicted to underlie its physiolo
28 ew nonpeptide ligands, capable of activating galanin receptors, are available today.
29 data further implicate brain and spinal cord galanin receptors as drug targets and provide an example
30      The pharmacological exploitation of the galanin receptors as drug targets for treatment of epile
31                         Direct activation of galanin receptors by a galanin receptor agonist, galnon,
32               Accordingly, drugs that target galanin receptors can alter behavioral responses to drug
33 the isolation by expression cloning of a rat galanin receptor cDNA distinct from GALR1.
34 alanin and its receptors and the fate of the galanin/receptor complex after the binding event are not
35         We now report the cloning of a third galanin receptor distinct from GALR1 and GALR2.
36                Similarly, mRNAs encoding the galanin receptors GAL1 (GALR1), GAL2 (GALR2) and GAL3 GA
37        The galanin action is mediated by the galanin receptors (GAL1/2/3R).
38                        There are three known galanin receptor (GALR) subtypes (GALR1, GALR2, and GALR
39 howed robust inhibition by G(i)/G(o)-coupled galanin receptors (GalR1), but not by Gq-coupled galanin
40 tivity for the three identified neuropeptide galanin receptors, GalR1, GalR2, and GalR3, was determin
41 cation of cDNA ends of a cDNA encoding a new galanin receptor (GalR2) from rat hypothalamus.
42 nin receptors (GalR1), but not by Gq-coupled galanin receptors (GalR2).
43 ng and expression of a cDNA encoding a novel galanin receptor (GalR3).
44 eceptor subtypes but only the type I (GalR1) galanin receptor has been cloned.
45                   Consistent with this idea, galanin receptors have been demonstrated throughout the
46 found to be markedly more effective than the galanin receptor in activating G-proteins.
47 For example, GalR3 seems to be the important galanin receptor in both the human LC and DRN versus Gal
48  enhance the understanding of specificity of galanin-receptor interactions.
49 -NH(2) motif and exhibited high affinity for galanin receptors (K(i) = 3.5 nM and 51.5 nM for GalR1 a
50                           M40, a peptidergic galanin receptor ligand, blocks galanin-induced impairme
51 Pro2-(Ala-Leu)2-Ala-NH2 (M40), a peptidergic galanin receptor ligand, has been shown to block galanin
52              To generate systemically active galanin receptor ligands that discriminate between GalR1
53 he interaction between galanin and rat GalR1 galanin receptor (rGalR1) and rGalR1-mediated ligand int
54 discrepancies exist, suggesting that another galanin receptor(s) may be present in some brain areas.
55 g was only detected for NPY, suggesting that galanin receptor signaling may be impaired.
56 detail a new mechanism for the regulation of galanin receptor signaling which may link altered functi
57 ese MORs form functional heteromers with the galanin receptor subtype Gal1 (Gal1R), which modulate th
58 or selective heteromerization of MOR and the galanin receptor subtype Gal1 (Gal1R).
59  between galanin and one of the three cloned galanin receptor subtypes (GalR2) expressed in Chinese h
60                                        Three galanin receptor subtypes (GalRs) have been recently clo
61                                 To date, two galanin receptor subtypes have been cloned.
62  modulates seizures in the brain through two galanin receptor subtypes, GalR1 and GalR2.
63  pharmacophores within galanin for the three galanin receptor subtypes.
64 re occurrence, potentially through different galanin receptor subtypes.
65 at is known about the ability of galanin and galanin receptors to alter neuronal activity, and we dis
66                                              Galanin receptors type 1 (GalR1) and/or type 2 (GalR2) r
67 inding revealed the presence of both NPY and galanin receptors, while functional receptor binding was