ライフサイエンスコーパス: gallstone

1 utput compared to WT mice, they still formed gallstones.

2 abdominal ultrasound examinations to detect gallstones.

3 It is also a core protein of cholesterol gallstones.

4 pic retrograde cholangiopancreatography, and gallstones.

5 a neoplasm in the group of patients without gallstones.

6 bile cholesterol and, thus, the formation of gallstones.

7 al inhibitor of initial biofilm formation on gallstones.

8 These cancers are associated with gallstones.

9 believed to be intermediates in formation of gallstones.

10 associated with the presence of cholesterol gallstones.

11 s frequently associated with the presence of gallstones.

12 iliary cholesterol secretion and cholesterol gallstones.

13 mmune system for the formation and growth of gallstones.

14 assembly into larger aggregates and finally gallstones.

15 sms that lead to the formation and growth of gallstones.

16 racellular traps (NETs) and the formation of gallstones.

17 use women are twice as likely as men to form gallstones.

18 risk factor, such as reflux esophagitis and gallstones.

19 risks of hepatitis (21 [0.5%] vs 18 [0.4%]), gallstones (106 [2.3%] vs 106 [2.3%]), or cancer (438 [9

20 These results suggest that MI and gallstones, 2 seemingly unrelated diseases, are intrinsi

21 Thirty isoattenuating gallstones (4.3-24.7 mm in diameter) were evaluated.

22 story of liver dysfunction (62 [27.4%]), and gallstones (53 [23.5%]) were commonly reported.

23 mia, fibrates may lead to the development of gallstones, a risk factor for pancreatitis.

24 isease, cirrhosis, hepatocellular carcinoma, gallstones, acute pancreatitis, and pancreatic cancer.

25 tals, for acute pancreatitis overall and for gallstone aetiology but not for alcoholic acute pancreat

26 month for acute pancreatitis overall or for gallstone aetiology, but for alcoholic acute pancreatiti

27 itals for acute pancreatitis overall and for gallstone aetiology, the study factors had limited impac

28 cholic acid (UDCA) prevents the formation of gallstones after bariatric surgery.

29 rticipants (591 of 5928); of these, 6.8% had gallstones and 3.2% had cholecystectomy at baseline.

30 ants, including 207 participants (6.5%) with gallstones and 986 (30.9%) with metabolic syndrome.

31 Adult patients with gallstones and abdominal pain were included.

32 Gallstones and alcohol misuse are long-established risk

33 e long-term occurrence of clinical events of gallstones and associations between ultrasound observati

34 ncreatitis is associated with alcohol abuse, gallstones and bacterial infection.

35 Hence, gallstones and cholecystectomy are associated with the r

36 Colorectal cancer risk associated with gallstones and cholecystectomy decreased with increasing

37 Gallstones and cholecystectomy may be related to digesti

38 Gallstones and cholecystectomy were associated with incr

39 ship was found for both ultrasound-diagnosed gallstones and cholecystectomy.

40 ated that salmonellae form biofilms on human gallstones and cholesterol-coated surfaces in vitro and

41 onellae form bile-mediated biofilms on human gallstones and cholesterol-coated surfaces in vitro.

42 atients might have higher risk in developing gallstones and conducted a population-based study to exa

43 for the presence of NETs in human and murine gallstones and describe an immune-mediated process requi

44 mon bile duct exploration (LCBDE) deals with gallstones and ductal stones in one session, the limited

45 mization will be stratified for pre-existing gallstones and for type of surgery.

46 hat there are noncausal associations between gallstones and intestinal cancer.

47 y alleviate biofilm formation on cholesterol gallstones and the chronic carrier state.

48 myocardial infarction, urinary obstruction, gallstone, and sepsis.

49 Larger, multiple, and older gallstones are associated with events.

50 Cholesterol gallstones are associated with slow intestinal transit i

51 Gallstones are common and contribute to morbidity and he

52 Although gallstones are recognized causes of gallbladder cancer,

53 Gallstones are the most common cause of acute pancreatit

54 rol persons subjected to cholecystectomy for gallstones as controls.

55 We show that gallstone assembly essentially requires neutrophil extra

56 sporter, Abcg5/g8, is Lith9 in mice, and two gallstone-associated variants in ABCG5/G8 have been iden

57 Five of the gallstone associations are protein-altering variants, an

58 ncluded 401 patients with abdominal pain and gallstones (assumed eligible for cholecystectomy), mean

59 fR mutant formed extensive biofilms on mouse gallstones at 7 and 21 days postinfection; DeltafimAICDH

60 tant for attachment to and/or persistence on gallstones at later points of chronic infection, whereas

61 Ten percent had awareness of their gallstones; awareness was associated with uncomplicated

62 These findings offer direct evidence that gallstone biofilms occur in humans and mice, which facil

63 ABCG5/8 and NPC1L1 expression was similar in gallstone carriers and controls regardless of p.D19H pre

64 cholesterol absorption but not synthesis in gallstone carriers was diminished by about 21% based on

65 ls 28%, P = 0.0347 and wild type controls to gallstone carriers with 19H allele 37%, P = 0.0030).

66 No one knows exactly what proportion of gallstones cause clinical events among subjects unaware

67 Symptomatic gallstones cause high financial and disease burden for p

68 ithogenesis, we investigated the biliary and gallstone characteristics in male wild-type (WT), ABCG5(

69 s, American Society of Anesthesiology score, gallstone characteristics, local inflammation, blood los

70 e was initially suspected to have concurrent gallstone cholangitis and a newly diagnosed hepatocellul

71 His past medical history included recurrent gallstone cholangitis and a previous cholecystectomy.

72 The presence of gallstones (cholelithiasis) is a highly prevalent and se

73 revalence 1%) had a 5-fold increased risk of gallstones compared to those with a score <1.0 (11%).

74 ficients improve detection of isoattenuating gallstones compared with previously reported dual-energy

75 ous adverse event in the intervention group (gallstones) could be attributable to rapid and excessive

76 Fewer than 20% of subjects with gallstones develop clinical events.

77 Rapid weight loss is a major risk factor for gallstone development.

78 sk of coronary artery disease, hypertension, gallstones, diabetes, cancer, metabolic syndrome, and vi

79 astrointestinal cancers were associated with gallstone disease (11.2% of patients with gallstone dise

80 of study participants with (34) and without gallstone disease (134).

81 t-side colon cancer was also associated with gallstone disease (2.57% of patients with gallstone dise

82 Cholesterol gallstone disease (CGD) results from a biochemical imbal

83 ssion, open cholecystectomy, and complicated gallstone disease (each P < 0.05).

84 Gallstone disease (GD) is one of the most common present

85 cally different populations of patients with gallstone disease (GSD) and stone-free controls to ident

86 Gallstone disease (GSD) is a common gastrointestinal dis

87 Gallstone disease (GSD) is related to several diabetes r

88 atitis (OR 8.66; 1.05-71.48; P = 0.045), and gallstone disease (OR 3.29; 2.02-5.36; P < 0.0001).

89 The primary endpoint is symptomatic gallstone disease after 24 months, defined as admission

90 er UDCA reduces the incidence of symptomatic gallstone disease after Roux-en-Y gastric bypass or slee

91 se also modifies the severity of symptomatic gallstone disease and its treatment.

92 Both gallstone disease and p.D19H of ABCG8 are associated wit

93 y lipid secretion plays an important role in gallstone disease and reverse cholesterol transport (RCT

94 emporal associations between screen-detected gallstone disease and specific cancers is limited.

95 her a genetic risk score was associated with gallstone disease and whether individual gallstone loci

96 cipants biennially reported their history of gallstone disease and whether they had undergone cholecy

97 The cumulative incidences of MI and gallstone disease as a function of age and increasing ge

98 andomized controlled trials with symptomatic gallstone disease as primary endpoint have not been cond

99 is an important risk factor for cholesterol gallstone disease because women are twice as likely as m

100 Gallstone disease can lead to severe complications and o

101 Breast cancer had a weak association with gallstone disease depending on other factors (10.6% of p

102 Of these, 4,106 developed symptomatic gallstone disease during up to 34 years of follow-up.

103 ence interval: 2.39 to 3.39) for symptomatic gallstone disease for individuals with a genotype score

104 We extracted genetic associations with gallstone disease from the Global Biobank Engine (GBE),

105 Participants with gallstone disease had higher all-cause mortality in age-

106 In the US population, persons with gallstone disease have increased mortality overall and m

107 BCG8) confers susceptibility for cholesterol gallstone disease in humans.

108 hence risk of myocardial infarction (MI) and gallstone disease in opposite directions.

109 We identified 19 loci to be associated with gallstone disease in the GBE.

110 Screen-detected gallstone disease in the general population is associate

111 in STSL have been linked to lipid levels and gallstone disease in whites.

112 Gallstone disease is a common complex disease that confe

113 Gallstone disease is associated with p.D19H of ABCG8 as

114 The risk of gallstone disease may be increased in patients with CN s

115 290Ser) conferred per-allele odds ratios for gallstone disease of 1.30-1.36.

116 y), fibrosis/cirrhosis (HR 5.11; 3.29-7.96), gallstone disease or cholangitis (HR 2.72; 2.55-2.91, an

117 The genetic underpinnings of gallstone disease remain incompletely understood.

118 nd rs4245791 were associated positively with gallstone disease risk, whereas the association for the

119 ery and ERCP, serving as a base for audit of gallstone disease treatment.

120 aimed to identify genetic associations with gallstone disease using publicly available data from the

121 th gallstone disease (2.57% of patients with gallstone disease vs 0.96% without; hazard ratio, 2.04;

122 th gallstone disease (11.2% of patients with gallstone disease vs 6.64% without; hazard ratio, 1.50;

123 ing on other factors (10.6% of patients with gallstone disease vs 7.41% without; hazard ratio, 1.44;

124 the HLS, the multivariable HR of symptomatic gallstone disease was 0.26 (95% CI: 0.15, 0.45) for wome

125 y adjusted hazard ratio (HR) for symptomatic gallstone disease was 2.84 (95% confidence interval [CI]

126 We examined whether gallstone disease was associated with overall and cause-

127 Gallstone disease was defined as ultrasound-documented g

128 Gallstone disease was identified in 10% of participants

129 between the HLS and the risk of symptomatic gallstone disease was investigated using Cox proportiona

130 Symptomatic gallstone disease was self-reported and validated by rev

131 Corresponding HRs for symptomatic gallstone disease were 1.43 (95% CI: 0.99-2.05) overall,

132 1,140 consecutive patients with symptomatic gallstone disease were recruited during 2008-2010 at Kuo

133 ctiveness of three diagnostic strategies for gallstone disease with possible choledocholithiasis: non

134 well as protection against atherosclerosis, gallstone disease, and obesity.

135 d normal weight) and the risk of symptomatic gallstone disease, and to estimate the proportion of cas

136 er ABCG8 as a locus associated with risk for gallstone disease, but findings have not been reported f

137 smooth muscle (GBSM) function that occurs in gallstone disease, but their mechanism of action is unkn

138 t abdominal ultrasound examination to detect gallstone disease, but were not informed of their gallst

139 mated causal odds ratio (OR) for symptomatic gallstone disease, by instrumental variable analysis for

140 y index, race, admission acuity, complicated gallstone disease, hospital teaching status, and open ve

141 otential therapeutic targets for cholesterol gallstone disease, particularly in women and patients ex

142 his locus to a more diverse ethnic group for gallstone disease, susceptibility to biliary cancer, and

143 pplications in cholestatic liver disease and gallstone disease, two serious health concerns for human

144 yperhomocysteinemia can occur in cholesterol gallstone disease, we hypothesized that this may result

145 In this large-scale GWAS of gallstone disease, we identified 4 loci in genes that ha

146 evated BMI and increased risk of symptomatic gallstone disease, which is most pronounced in women.

147 and rectal cancers were not associated with gallstone disease.

148 isms that were associated independently with gallstone disease.

149 identify additional genetic risk factors for gallstone disease.

150 erol metabolism may be involved in pediatric gallstone disease.

151 ing 5,647 with MI and 3,174 with symptomatic gallstone disease.

152 st MI, but increases the risk of symptomatic gallstone disease.

153 BMI) is associated with an increased risk of gallstone disease.

154 6946 women and 2513 men reported symptomatic gallstone disease.

155 cipients with asymptomatic and uncomplicated gallstone disease.

156 undergo open cholecystectomy for complicated gallstone disease.

157 contributing factor in the manifestation of gallstone disease.

158 n: We identified six susceptibility loci for gallstone disease.

159 Roux-en-Y gastric bypass develop symptomatic gallstone disease.

160 nd prostate cancers were not associated with gallstone disease.

161 admission or hospital visit for symptomatic gallstone disease.

162 sition, such as that observed in cholesterol gallstone disease.Due to the challenges in directly stud

163 CG8 has been identified as a risk factor for gallstone disease; this variant has been associated with

164 tive benefits of frequent nut consumption on gallstone diseases are observed in both sexes.

165 ent a considerable proportion of symptomatic gallstone diseases.

166 l absorption and pathogenesis of cholesterol gallstone, dyslipidemia, and diabetes.

167 ications, including iron overload, bilirubin gallstones, extramedullary hematopoiesis, pulmonary hype

168 e evidence that Helicobacter species promote gallstone formation and hepatobiliary tumors in laborato

169 This metabolic trait precedes gallstone formation and is a feature of ethnic groups at

170 ed impact of these different risk factors on gallstone formation has not yet been examined.

171 erlying the lithogenic effect of estrogen on gallstone formation have become more complicated with th

172 Gallstone formation in adults is a common, yet incomplet

173 ently of ERalpha, to increase susceptible to gallstone formation in female mice; both GPR30 and ERalp

174 e severity of and shortened the interval for gallstone formation in PKCbeta(-/-) mice and was associa

175 Gallstone formation in the mutant mice was accompanied b

176 utrophils by metoprolol, effectively inhibit gallstone formation in vivo.

177 ersecretion as the mechanism for cholesterol gallstone formation, thereby drawing a link between "pos

178 derived cholesterol from plasma to bile, and gallstone formation, which works independently of the AB

179 ry cholesterol secretion, and the absence of gallstone formation.

180 s high levels of biliary cholesterol promote gallstone formation.

181 ment of biliary sludge in the early stage of gallstone formation.

182 , including hypersensitivity to diet-induced gallstone formation.

183 tion, all of which enhance susceptibility to gallstone formation.

184 nalysis was performed to evaluate the 5-year gallstone-free survival rates for the 2 cohorts.

185 CT method for differentiating isoattenuating gallstones from bile and compare it with previously repo

186 as significant biofilms were not detected on gallstones from Escherichia coli infected gallbladders.

187 nd bacterial biofilms could be visualized on gallstones from these carriers whereas significant biofi

188 Cancer, Prostate Cancer, Testicular Cancer, Gallstones, Glaucoma, Gout, Atrial Fibrillation, High Ch

189 ur group was significantly lower than in the gallstone group (p < 0.05).

190 PP7 and was higher in the tumour than in the gallstone group.

191 Pathogenesis of gallstones (GS) is multifactorial and multiple genetic a

192 Patients with gallstones had a high frequency of preneoplastic lesions

193 Individuals with gallstones had a similar increase in risk of death as th

194 Biofilm formation on gallstones has been demonstrated to be a mechanism of pe

195 energy CT methods for detecting noncalcified gallstones have reduced accuracy for gallstones smaller

196 Dominant etiologies include gallstones, hepatic sequestration, viral hepatitis, and

197 etabolic syndrome are known risk factors for gallstones; however, the combined impact of these differ

198 t Sample from 2004 to 2009 was performed for gallstone ileus cases treated surgically by enterotomy w

199 Gallstone ileus is a mechanical bowel obstruction caused

200 Gallstone ileus is a rare surgical disease affecting mai

201 from 2004 to 2009, 3268 (0.095%) were due to gallstone ileus-an incidence lower than previously repor

202 ased study to examine the risk of developing gallstone in osteoporotic patients in Taiwan.

203 respectively; P = .02) and the presence of a gallstone in the gallbladder infundibulum (78% and 22% f

204 s acute cholecystitis) and the presence of a gallstone in the gallbladder infundibulum are associated

205 , the Cox regression analysis of the risk of gallstone in the osteoporosis and comparison cohorts yie

206 ers evaluated the presence of isoattenuating gallstones in each image.

207 al role in the formation of estrogen-induced gallstones in female mice.

208 phenotype was an independent risk factor for gallstones in participants < 50 years old (odds ratio (O

209 Spillage of gallstones in the abdominal cavity may rarely occur duri

210 te is highly associated with the presence of gallstones in the gallbladder of infected carriers upon

211 form biofilms on the surfaces of cholesterol gallstones in the gallbladders of mice and human carrier

212 unger participants also had a higher risk of gallstones in the MAO (OR = 5.41, 95% CI = 2.31-12.66),

213 Dropped gallstones in the peritoneal and extra-peritoneal cavity

214 describe an unusual case of infected spilled gallstones in the right sub-phrenic space, prospectively

215 mechanism causing an increased incidence of gallstones in these patients have as yet not been identi

216 increased biliary cholesterol secretion and gallstones in WT, but not ABCG5(-/-)/G8(-/-) or ABCG8 (-

217 ults demonstrate an increased association of gallstones in younger people (< 50 years old) with metab

218 The incidence of gallstones increased from 9% in control mice to 95% in P

219 For gallstones larger than 9 mm, no significant difference w

220 n mice identified a susceptibility locus for gallstones (Lith6) spanning the Apobec-1 locus, the stru

221 ith gallstone disease and whether individual gallstone loci were associated with plasma levels of lip

222 For gallstones measuring 9 mm or smaller, the segmented imag

223 There was an association between gallstones more than 5 years old and acute cholecystitis

224 and sex-matched children (n = 82) and adult gallstones (n = 187) served as controls.

225 liver function values in serum (n = 28) and gallstones (n = 46) of consecutively cholecystectomized

226 -year follow-up period, 114 and 311 cases of gallstone occurred in the osteoporosis and comparison co

227 as found to be significantly associated with gallstones (odds ratio [OR] = 2.9, P = 0.0220, 95% confi

228 osing the mice to development of cholesterol gallstones on a lithogenic diet.

229 dary endpoints consist of the development of gallstones on ultrasound at 24 months, number of cholecy

230 /S and CT imaging for pancreatitis ruled out gallstones or anatomical etiologies.

231 is study was to determine if screen-detected gallstones or cholecystectomy are associated with occurr

232 disease was defined as ultrasound-documented gallstones or evidence of cholecystectomy.

233 iopancreatography (ERCP) in 59 patients with gallstone, other benign disease, tumour, and primary scl

234 itis (26.6%), choledocholithiasis (5.7%), or gallstone pancreatitis (2.4%).

235 ecystectomy shortly after admission for mild gallstone pancreatitis has been proposed based on observ

236 entification of patients with predicted mild gallstone pancreatitis in whom early cholecystectomy is

237 end that patients with an initial episode of gallstone pancreatitis receive cholecystectomy.

238 consensus among surgeons that patients with gallstone pancreatitis should undergo cholecystectomy to

239 dmission versus after clinical resolution of gallstone pancreatitis that is predicted to be mild resu

240 Adults with predicted mild gallstone pancreatitis were randomized to cholecystectom

241 ents in the treatment of patients with acute gallstone pancreatitis with regards to the timing of ERC

242 In patients with predicted mild gallstone pancreatitis, cholecystectomy within 24 hours

243 In mild gallstone pancreatitis, laparoscopic cholecystectomy per

244 formed within 48 hours of admission for mild gallstone pancreatitis, regardless of resolution of abdo

245 ble for the onset of clinical biliary (i.e., gallstone) pancreatitis and creates highly reproducible

246 l absorption as well as de novo synthesis in gallstone patients stratified according to 19H risk alle

247 Of the 350 gallbladder specimens from gallstone patients, hyperplasia was found in 32%, metapl

248 arcinoma patients, being only 19% of that in gallstone patients.

249 We investigated the biliary and gallstone phenotypes in ovariectomized female GPR30(-/-)

250 G8 (-/-) mice displayed the same biliary and gallstone phenotypes.

251 tumour plus PSC group was also lower than in gallstone plus other benign disease group (p < 0.05).

252 These patients are prone to gallstones, portal hypertension and possible surgical co

253 formation of undesirable assemblies such as gallstone precursors, and how they can stabilize free-fl

254 layed biliary lipid secretion rates and high gallstone prevalence rates similar to WT mice without an

255 ve provided insight into the pathogenesis of gallstones, primary biliary cirrhosis, and primary scler

256 ile-induced biofilm formation on cholesterol gallstones promotes gallbladder colonization and mainten

257 In most cholesterol gallstone-prone humans, lithogenic bile carries large qu

258 ection strategy for surgery in patients with gallstones reduces cholecystectomies, but the impact on

259 Factors associated with gallstone-related acute hospitalization included male se

260 imilarly shaped association with risk of non-gallstone-related acute pancreatitis as that observed fo

261 naire at baseline, and cases of incident non-gallstone-related acute pancreatitis were identified by

262 men and 111 cases in women) of incident non-gallstone-related acute pancreatitis were identified.

263 may be associated with decreased risk of non-gallstone-related acute pancreatitis.

264 h and lean fish separately, with risk of non-gallstone-related acute pancreatitis.

265 atients with their 2-year risk of developing gallstone-related complications, allowing patients and p

266 ity Hospital, Geneva, Switzerland, for acute gallstone-related conditions with an intermediate risk o

267 s of care and modeled their risk of emergent gallstone-related hospitalization or cholecystectomy at

268 The 2-year emergent gallstone-related hospitalization rate was 11.1%, with a

269 Beyond gallstone-related morbidity we found a strong positive a

270 e C57L, C57BL/6, and SWR mice but not in the gallstone-resistant AKR mice.

271 (e.g., between plasma campesterol levels and gallstones risk; and between immunoglobulin A and juveni

272 Results For all gallstones, segmented images provided the highest mean i

273 experiments using Nramp1(+/+) mice harboring gallstones showed that only the DeltaycfR mutant formed

274 d pairwise comparisons, and the agreement of gallstone sizes measured at pathologic examination with

275 lcified gallstones have reduced accuracy for gallstones smaller than 9 mm.

276 lstones; subjects were not informed of their gallstone status.

277 nical events among subjects unaware of their gallstone status.

278 tone disease, but were not informed of their gallstone status.

279 Gallstone subclasses shared enhanced cholesterol synthes

280 study population comprised 664 subjects with gallstones; subjects were not informed of their gallston

281 nfection; DeltafimAICDHF was not observed on gallstone surfaces after the 7-day-postinfection time po

282 analyzed data from the Swedish Registry for Gallstone Surgery and Endoscopic Retrograde Cholangiopan

283 also registered in the Swedish registry for gallstone surgery and ERCP (GallRiks) and correlations b

284 Thirty-day follow-up of both gallstone surgery and ERCP is mandatory, as is an additi

285 is a validated national quality registry for gallstone surgery and ERCP, serving as a base for audit

286 s observation prompted us to compare dietary gallstone susceptibility in Apobec-1(-/-) mice and conge

287 became elevated during cholelithogenesis in gallstone-susceptible C57L, C57BL/6, and SWR mice but no

288 s in Taiwan have a higher risk of developing gallstone than the general population.

289 The MAO and MANO phenotypes had more gallstones than the MHO and MHNO phenotypes, regardless

290 fed a lithogenic diet developed cholesterol gallstones that supported biofilm formation during persi

291 However, we hypothesize that in addition to gallstones, the gallbladder epithelium aids in the estab

292 All consecutive patients with gallstones undergoing cholecystectomy from 2007-2011 wer

293 The prevalence of gallstones was 7.1% and of cholecystectomy was 5.3%.

294 ty markers in circulation, a 58% increase in gallstone weight, a 40% increase in hepatic cholesterol

295 The prevalence rates of gallstones were 80% in wild-type and ERalpha(-/-) mice t

296 rials and Methods From May 2017 to May 2018, gallstones were collected from 105 patients (34 men; mea

297 However, no gallstones were formed in GPR30(-/-) mice treated with G

298 Patients >=18 years with abdominal pain and gallstones were included at five surgical outpatient cli

299 suggesting a possible causal association of gallstones with GBC.

300 were also significantly high in people with gallstones without cholecystectomy.