ライフサイエンスコーパス: gamma-butyrolactone

1 increase than five-membered alpha-methylene-gamma-butyrolactone.

2 to install the alpha-alkylidene-beta-hydroxy-gamma-butyrolactone.

3 mmetric intermediate ultimately derived from gamma-butyrolactone.

4 its counterparts, gamma-hydroxybutyrate and gamma-butyrolactone.

5 Many streptomycetes produce extracellular gamma-butyrolactones.

6 erted to a variety of biologically important gamma-butyrolactones.

7 h a high proportion of (E)-alpha-benzylidene-gamma-butyrolactones.

8 gamma-trifluoromethylated cis-fused bicyclic gamma-butyrolactones.

9 ee-step synthesis of two naturally occurring gamma-butyrolactones.

10 ,2-acyl migrations delivering bridged, spiro-gamma-butyrolactones.

11 rig cyclization reactions to provide hydroxy-gamma-butyrolactones.

12 s were screened in the context of generating gamma-butyrolactones.

13 nolides, gamma-hydroxycyclohexenones, and/or gamma-butyrolactones.

14 mfetamine, ephedrine, gamma-hydroxybutyrate; gamma-butyrolactone, 1,4-butanediol, flunitrazepam, keta

15 MA), 221 (10%) used gamma-hydroxybutyrate or gamma-butyrolactone, 175 (8%) used methamphetamine, and

16 lactone, diketene (4-methyleneoxetan-2-one), gamma-butyrolactone, 2(5H)-furanone, and delta-valerolac

17 lactone, diketene (4-methyleneoxetan-2-one), gamma-butyrolactone, 2(5H)-furanone, and delta-valerolac

18 e method includes access to tetrahydrofuran, gamma-butyrolactone, 2-isooxazoline, pyrrolidine, and th

19 tes, S. coelicolor A3(2) and S. griseus: (1) gamma -butyrolactones; (2) a complex cascade of mostly u

20 y enriched 5-substituted alpha-exo-methylene gamma-butyrolactones 3a-i.

21 1b, 1f, 1j, and 1l forms alpha-exo-methylene-gamma-butyrolactones 5b, 5f, 5j, and 5l in moderate to g

22 ovides the disubstituted alpha-exo-methylene gamma-butyrolactones 6a and 6b with good to excellent le

23 e transformed to the trans-4,5-disubstituted gamma-butyrolactones 7a, 7l, and 7p.

24 sA is required for A-factor synthesis of the gamma-butyrolactone A-factor and consequently for strept

25 clopropyl carbinols to form alpha-alkylidene-gamma-butyrolactones (ABLs) is reported.

26 ns contrasts with other reports that loss of gamma-butyrolactones abolishes antibiotic production.

27 d with (TGM/DBA) or without (TGM) a dimethyl-gamma-butyrolactone acrylate (DBA)-containing lactone ri

28 ation results in predominantly 5-substituted gamma-butyrolactones along with a small amount of buteno

29 mic acid, hydroxymethylfurfural, lipids, and gamma-butyrolactone also contributed to score and sensor

30 A variety of gamma-butyrolactone analogues also modulate GABA-induced

31 synthesis, and evaluation of alpha-methylene-gamma-butyrolactone analogues and their evaluation as an

32 alpha-Methylene-gamma-butyrolactone and alpha-methylene-delta-valerolact

33 ama hydration-translactonization to form the gamma-butyrolactone and an intramolecular aldol cyclizat

34 ry involved in the ring-opening reactions of gamma-butyrolactone and delta-valerolactone, the conform

35 Novel 5-(1'-hydroxy)-gamma-butyrolactone and gamma-butyrolactam subunits were

36 degradable plastics, based on copolymers of gamma-butyrolactone and its ring-fused derivative, with

37 ntargeted metabolomic approaches, two major (gamma-butyrolactone and methyl heptenone) and four minor

38 logous aldol addition of alpha,beta-dichloro gamma-butyrolactones and gamma-butyrolactams with aldehy

39 s with activated ketones and imines provides gamma-butyrolactones and lactams, respectively.

40 deletion mutant of scbR also failed to make gamma-butyrolactones and showed delayed Red production.

41 g epsilon-caprolactone, delta-butyrolactone, gamma-butyrolactone, and D, L, meso, and racemic lactide

42 tors that negatively regulates metabolism of gamma-butyrolactone, and its repressing function is reli

43 gmentation reactions to provide butenolides, gamma-butyrolactone, and/or beta,gamma-epoxycyclohexanon

44 y the federal government, 1,4-butanediol and gamma-butyrolactone, another precursor of gamma-hydroxyb

45 ting enantioenriched, densely functionalized gamma-butyrolactones are of high synthetic utility, as h

46 alpha-Alkylidene-gamma-butyrolactones are readily prepared by the palladi

47 olactone) (PVL), poly(lactic acid), and poly(gamma-butyrolactone), are elucidated.

48 taH degrees of ring-opening with methanol of gamma-butyrolactone-based monomers provided a model to p

49 ts are versatile latent carbonyls from which gamma-butyrolactones, beta-hydroxy methyl ketones, and b

50 ntly transcribed gene, scbR, which encodes a gamma-butyrolactone binding protein.

51 latory genes, which are related to genes for gamma-butyrolactone-binding proteins.

52 Polyketide, non-ribosomal peptide, and gamma-butyrolactone biosynthetic enzymes are primarily s

53 er, cyclic poly(gamma-methyl-alpha-methylene-gamma-butyrolactone) (c-PMMBL), from the bio-based monom

54 A method of preparing enantiopure hydroxy-gamma-butyrolactones containing multiple contiguous ster

55 Butenolides and gamma-butyrolactones control the production of pharmaceu

56 and solvolysis, the poly(oxanorbornene-fused gamma-butyrolactone) could be cleanly chemically recycle

57 2.8 +/- 2.4 kcal/mol for beta-propiolactone, gamma-butyrolactone, delta-valerolactone, and epsilon-ca

58 loaddition with alkene to afford diverse new gamma-butyrolactone derivatives in very good yields.

59 d carbamates, as well as tetrahydrofuran and gamma-butyrolactone derivatives, without erosion of enan

60 enantioselective allylic alkylation using a gamma-butyrolactone-derived silyl ketene acetal.

61 ed lactonization to afford the corresponding gamma-butyrolactones, each as a single isomer.

62 riately functionalized spiro alpha-methylene-gamma-butyrolactones, efficiently prepared from (R)-4-am

63 highly selective NHC-catalyzed synthesis of gamma-butyrolactones from the fusion of enals and alpha-

64 nitriles has been explored for the access of gamma-butyrolactone-fused 1-pyrrolines.

65 The [3+2] annulation of gamma-butyrolactone-fused donor-acceptor cyclopropanes w

66 g opening/cyclization to give the respective gamma-butyrolactone-fused gamma-butyrolactams in good yi

67 However, the bioderived five-membered gamma-butyrolactone (gamma-BL) is commonly referred as '

68 tion of the biorenewable "non-polymerizable" gamma-butyrolactone (gamma-BL) to a high-molecular-weigh

69 nown low-ceiling-temperature (LCT) monomers, gamma-butyrolactone (gamma-BL) toward ring-opening polym

70 gamma-butyrolactone (GBL) (750 mg/kg i.p.) increased DOP

71 um lead triiodide (FAPbI(3)) in a mixture of gamma-butyrolactone (GBL) and 2-methoxyethanol (2ME), a

72 ces these processes are under the control of gamma-butyrolactone (GBL) autoregulatory systems.

73 use of diffusible signaling molecules of the gamma-butyrolactone (GBL) family.

74 of neuronal impulse flow and DA release with gamma-butyrolactone (GBL) increased DA concentrations in

75 the dorsal striatum of rats submitted to the gamma-butyrolactone (GBL) model of absence epilepsy, amy

76 In the gamma-butyrolactone (GBL) model of DA autoreceptor funct

77 wever, abolition of DA neuronal activity [by gamma-butyrolactone (GBL) treatment or transection of th

78 om the forebrain, absence seizures evoked by gamma-butyrolactone (GBL), and audiogenic seizures in ge

79 lformamide (DMF), dimethyl sulfoxide (DMSO), gamma-butyrolactone (GBL), and water.

80 reated with the nerve impulse flow inhibitor gamma-butyrolactone (GBL).

81 3-Hydroxy-gamma-butyrolactone has been identified as one such chem

82 g cyclopropyl ring to access fused tricyclic gamma-butyrolactones has been described.

83 The stereochemistry of these hydroxy-gamma-butyrolactones has been established using NOE spec

84 equence gave access to a naturally occurring gamma-butyrolactone in good yield, with excellent diaste

85 acted from culture fluids, but differed from gamma-butyrolactones in being alkali resistant.

86 n isatin-derived spirocyclic alpha-methylene-gamma-butyrolactone is a suitable core for optimization

87 e Heck cyclization of nonracemic benzylidene gamma-butyrolactone is studied toward the asymmetric syn

88 ould limit the synthesis of ethyl esters and gamma-butyrolactone, keeping the accumulation of off-fla

89 t part of the cluster directs synthesis of a gamma-butyrolactone-like autoregulator.

90 That putative gamma-butyrolactone material was not produced when orf18

91 alpha-Methylene-gamma-butyrolactone (MBL), a naturally occurring and bio

92 ese results indicate a complex mechanism for gamma-butyrolactone-mediated regulation of antibiotic bi

93 rived renewable gamma-methyl-alpha-methylene-gamma-butyrolactone (MMBL).

94 ltimate intermediate with an alpha-methylene gamma-butyrolactone moiety was identified as a promising

95 fully biobased tricyclic oxanorbornene-fused gamma-butyrolactone monomer (M1).

96 from a solution of CH(3)NH(3)I and PbI(2) in gamma-butyrolactone on a 400 nm thick film of TiO(2) (an

97 The chemical synthesis of poly(gamma-butyrolactone) (PgammaBL) through the ROP process

98 Additionally, they show that the gamma-butyrolactones probably interact at two different

99 oregulator in addition to being required for gamma-butyrolactone production.

100 ethyl monosuccionate, diethyl succinate and gamma-butyrolactone production.

101 convergent desaturation of 4,5-disubstituted gamma-butyrolactones (Quercus-like lactones), funneling

102 ation of three further bld genes and several gamma-butyrolactone receptor genes have led to new ideas

103 ces lividans, we showed that TylP, a deduced gamma-butyrolactone receptor, downregulated reporter gen

104 uences, similar to the targets for authentic gamma-butyrolactone receptors, in the promoters of tylP,

105 Peripherally, C75, an alpha-methylene-gamma-butyrolactone, reduces adipose tissue and fatty li

106 Gamma-butyrolactones regulate secondary metabolism and,

107 ized Streptomyces homologue CprB, which is a gamma-butyrolactone regulator.

108 with analogous functions to the better known gamma-butyrolactone regulatory molecules.

109 ne, 3-phenylbutyraldehyde, and alpha-hydroxy-gamma-butyrolactone, relying on cyanoborohydride for cou

110 rate and 3,4-dihydroxybutyric acid+3-hydroxy-gamma-butyrolactone, respectively, molecules with potent

111 am as a nitrogen analogue of alpha-methylene-gamma-butyrolactone resulted in a total loss of the reac

112 well as the stereoselective attachment of a gamma-butyrolactone ring to a tetracycle core structure

113 lineC bond and a highly stable five-membered gamma-butyrolactone ring.

114 Addition of the gamma-butyrolactone SCB1 of S. coelicolor resulted in lo

115 mpounds and in the synthesis of a diffusible gamma-butyrolactone, SCB1, that can elicit precocious Ac

116 ethylene-gamma-butyrolactone to alpha-methyl-gamma-butyrolactone, Sharpless kinetic resolution, Sharp

117 ndicate that the lack of polymerizability of gamma-butyrolactone should be attributed to the low stra

118 CF sigma factors, antibiotic biosynthesis, a gamma-butyrolactone signalling system, members of the ac

119 cally relevant polycyclic products bearing a gamma-butyrolactone structural motif, thus broadening th

120 These led to a revised gamma-butyrolactone structure for the metabolite.

121 ompound (N55) with a new N-linoleoyl-2-amino-gamma-butyrolactone structure was purified from fenugree

122 ng roles for the respective gene products in gamma-butyrolactone synthesis.

123 nolactone (template I) and 4,4-disubstituted gamma-butyrolactone (template II), with the latter produ

124 t for the synthesis of biologically relevant gamma-butyrolactones through dual activation under ambie

125 ereoselective hydrogenation of exo-methylene-gamma-butyrolactone to alpha-methyl-gamma-butyrolactone,

126 hat AttK, AttL, and AttM collectively covert gamma-butyrolactone to succinate.

127 as been developed that allows functionalized gamma-butyrolactones to be prepared in one step from sim

128 n a formal total synthesis of a known marine gamma-butyrolactone-type metabolite.

129 These gamma-butyrolactones underwent intramolecular radical cy

130 gamma-Butyrolactone, unlike delta-valerolactone, does no

131 r describes an enantioselective synthesis of gamma-butyrolactones, using the N-tolyl-substituted oxaz

132 ral synthetic strategy to cis-fused bicyclic gamma-butyrolactones via the retro-Diels-Alder reaction/

133 ompared for the stereoselective synthesis of gamma-butyrolactones via the sequence of N-acylation, C(

134 after the diethyl phosphonate derivative of gamma-butyrolactone was treated with potassium hexamethy

135 kenyl- or homoalkynyl-alpha,beta-unsaturated gamma-butyrolactones was found to accelerate the rate of

136 oxyoxol-2-ene (C(5)-1), the enol tautomer of gamma-butyrolactone, was generated in the gas phase as t

137 alpha-Heteroaromatic-gamma-butyrolactones were engaged in a highly regio-, di

138 Mono- and multi-functionalised gamma-butyrolactones were synthesised through exo-cyclis

139 n to give the corresponding tetracyclic cage gamma-butyrolactones, which were employed as precursors

140 by the reaction of optically pure 3-hydroxy-gamma-butyrolactone with a primary amine to give an amid

141 -enals to racemic alpha-keto esters, forming gamma-butyrolactones with three contiguous stereocenters

142 A scbA mutant produced no gamma-butyrolactones, yet overproduced two antibiotics,