ライフサイエンスコーパス: gamma-c

1 meric receptor complex (IL-2Ralpha/IL-2Rbeta/gamma(c)).

2 ubunit IL-2Rbeta and the common gamma-chain (gamma(c)).

3 sing IL-15/IL-2Rbeta and common gamma chain (gamma(c)).

4 nd the common cytokine receptor gamma chain (gamma(c)).

5 m spinach chloroplasts (alpha(R)(3)beta(R)(3)gamma(C)).

6 to the common cytokine receptor gamma chain, gamma(c).

7 es the common cytokine receptor gamma chain, gamma(c).

8 ceptor subunits IL-2R alpha, IL-2R beta, and gamma(c).

9 ha/IL-2R beta to IL-2/IL-2R alpha/IL-2R beta/gamma(c).

10 to the common cytokine receptor gamma chain, gamma(c).

11 action between IL-2 and the shared receptor, gamma(c).

12 he common gamma chain of cytokine receptors, gamma(c).

13 [Ta6Br12(H2O)6](2+), and gamma-cyclodextrin (gamma-CD).

14 graphene oxide with gamma-cyclodextrin (rGO/gamma-CD).

15 inclusion complexes with gamma-cyclodextrin (gamma-CD).

16 native cyclodextrins (alpha-CD, beta-CD, and gamma-CD).

17 d in the order FA/alpha-CD < FA/beta-CD < FA/gamma-CD.

18 ation of a tight complex between TNP-Ado and gamma-CD.

19 antial interaction of the TNP hydrogens with gamma-CD.

20 ing an octahedral-type metallic cluster with gamma-CD.

21 the transverse channels formed from linking (gamma-CD)6 body-centered cuboids in three dimensions.

22 y, form body-centered cubic arrangements of (gamma-CD)(6) cubes linked by eight-coordinate alkali met

23 in is mediated by specialized populations of gamma-c aA receptors (GABAARs) that are selectively enri

24 Such compounds formed gamma-C-(alkyl)-nucleoside triphosphate analogues with h

25 carbonate in an alcohol solvent proceeds via gamma-C-alkylation rather than alpha-C-alkylation result

26 ith transcriptional activation of germline C(gamma), C(alpha), and C(epsilon) genes and triggers the

27 CSR from C( micro ) to multiple downstream C(gamma), C(alpha), and C(epsilon) genes through latent me

28 emonstrate a functional requirement for both gamma c and the gamma c-associated Janus family tyrosine

29 y studying the specific interactions between gamma-CD and both types of inorganic units.

30 nd HP-gamma-CD; the complexes formed with HP-gamma-CD and HP-beta-CD had the greatest stability const

31 which supports specific interactions between gamma-CD and POM units.

32 Novel structures of gamma(c) and beta(c) complexes show us new twists, such

33 ork material composed of gamma-cyclodextrin (gamma-CD) and alkali metal salts--namely, CD-MOF.

34 o receptors, IL-4R alpha/common gamma-chain (gamma(c)) and IL-4R alpha/IL-13R alpha1, and only the la

35 l shared cytokine signaling receptors-gp130, gamma(c), and beta(c).

36 R alpha makes no contacts with IL-2R beta or gamma(c), and only minor changes are observed in the IL-

37 and (2-hydroxypropyl)-gamma-cyclodextrin (HP-gamma-CD), and the effects of the complexation on the st

38 The fact that the -OCCO- moieties of gamma-CD are not prearranged in a manner conducive to en

39 ctional requirement for both gamma c and the gamma c-associated Janus family tyrosine kinase 3 (JAK3)

40 itude compared to free curcumin and curcumin:gamma-CD at pH 11.5.

41 rexpression of Jak3 enhanced accumulation of gamma(c) at the plasma membrane.

42 cular chemical complementarities between the gamma-CD-based ditopic cation and POM open a wide scope

43 IL-15-mediated RANTES production by Rag2(-/-)gamma(c)(-/-) bone marrow cells occurred independently o

44 IL-15 induced RANTES production by Rag2(-/-)gamma(c)(-/-) bone marrow cells, but the presence of gam

45 the P2, but not P1, sequence for binding of gamma C by the alpha(M)I-domain and suggest that the adh

46 T)) and HTLV-1(p12KO) We found that NOD/SCID/gamma(C) (-/-) c-kit(+) mice engrafted with human tissue

47 A general regio- and stereoselective gamma-C-C bond formation is achieved using alpha-halocar

48 Immunodeficient Rag2(-/-)gamma(c)(-/-)CD47(-/-) C57BL/6 mice were humanized by th

49 (+)T cell loss was inversely correlated with gamma(c)(+) CD8(+) T cells in individual tissues.

50 pha) gene to express a codon-optimized human gamma(c) cDNA.

51 also identify an indirect role that another gamma (c) chain cytokine plays in schistosome developmen

52 Because the common gamma ( gamma (c)) chain cytokine interleukin (IL)-7 is also imp

53 ates signaling by the beta and common gamma (gamma(c)) chain heterodimer of the IL-2 receptor through

54 d a phosphotyrosine signal attributed to the gamma(c)-chain, which occurred at much lower levels in t

55 es in the ER and interacts with the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R), t

56 ors: the alpha, beta and the "common gamma" (gamma(c)) chains.

57 terotrimeric receptors share their beta- and gamma(c)-chains, but have distinct alpha-chains.

58 vidence of positive selection on full length gamma-c clade genes.

59 ages, most genes belong to an avian-specific gamma-c clade, within which sequences cluster by species

60 The structure of the TNP-Ado:gamma-CD complex was determined by 2D nuclear magnetic r

61 e from that of the IL-2-IL-2Ralpha-IL-2Rbeta-gamma(c) complex, despite their different receptor-bindi

62 expressing the mouse IL-15Ralpha-IL-15Rbeta-gamma(c) complex, suggesting that this effect is specifi

63 Single-crystal XRD analysis reveals that POM:gamma-CD constitutes a highly versatile system which giv

64 This enthalpic mechanism utilized by gamma(c) contrasts with the favorable entropic mechanism

65 th anti-CD3/CD28, cytokine secretion by both gamma c cytokine and anti-CD3/CD28 pretreated T cells wa

66 Exposure of gamma c cytokine pretreated T cells to PD-1 ligand-IgG h

67 These data suggest that gamma c cytokine-induced PD-1 does not interfere with cy

68 IL-15 belongs to the gamma(c) cytokine family and possesses similar propertie

69 statically expand in vivo in response to the gamma(c) cytokine IL-7, despite intact proximal signalin

70 Tofacitinib therapy strongly inhibits gamma(c) cytokine-induced JAK/STAT5 activation, whereas

71 ures of complexes of the common gamma-chain (gamma(c)) cytokine receptors and their cytokines have be

72 T cell proliferation, or survival driven by gamma c cytokines.

73 The common gamma-chain (gamma c) cytokines IL-2, IL-7, IL-15, and IL-21, which p

74 Finally, we show that other gamma(c) cytokines act similarly to IL-2 in up-regulatin

75 amma(c) subunit molecule is shared among all gamma(c) cytokines and clearly involved in T-cell functi

76 After whole-blood activation with the gamma(c) cytokines IL-2, IL-7, and IL-15, STAT5 phosphor

77 en by a degenerate multicomponent network of gamma(c) cytokines; this explains why deficiencies of si

78 The common gamma-chain (gamma(c)) cytokines signal through the Janus kinase (JAK

79 The gamma(c)-cytokines are critical regulators of immunity a

80 These results support the use of gamma(c)-cytokines in cancer immunotherapy, and establis

81 amma(c)'s ability to recognize six different gamma(c)-cytokines.

82 eat tumor in lymphopenic common gamma chain (gamma(c))-deficient hosts.

83 normal mice and induces these genes in RAG2/gamma(c)-deficient mice.

84 gs) of all nonprotonated aromatic carbons (C(gamma), C(delta 2) and C(epsilon 2).

85 he C(alpha)-C(beta), C(beta)-C(gamma), and C(gamma)-C(delta) bond axes as indicated by (2)H line-shap

86 ither methyl group reorientation about the C(gamma)-C(delta) bond axis or by additional librational m

87 lic attack by acetoacetate to form the new C(gamma)-C(delta) bond in 3 and complete the gamma-substit

88 )-C(gamma)) and chi(2,1) (C(alpha)-C(beta)-C(gamma)-C(delta1)), we propose a detailed molecular model

89 Interleukin (IL)-21 is a gamma(c)-dependent cytokine produced by activated T cell

90 mically unique fashions for each ligand, the gamma(c)-dependent cytokines appear to seek out some sem

91 rejection of liver metastases, whereas other gamma c-dependent non-T non-B cells, possibly lymphoid d

92 peptide duplicating the 365-383 sequence in gamma C, designated P3, efficiently inhibited clot retra

93 (-/-) bone marrow cells, but the presence of gamma(c) did not increase bone marrow cell sensitivity t

94 Consistent with their identical IL-2Rbeta-gamma(c) dimer geometries, IL-2 and IL-15 showed similar

95 Surface gamma(c) distribution was differentially expressed on CD

96 Thus, unlike other cytokine receptors, gamma(c) does not require Jak3 for receptor membrane exp

97 a 377-395 and gamma 190-202 sequences in the gamma C domain of fibrinogen, respectively, blocked the

98 pha IIb beta 3 with the AGDV sequence in the gamma C-domain of fibrinogen and/or RGD sites in the A a

99 ese data suggest that the P3 sequence in the gamma C-domain of fibrinogen defines a previously unknow

100 in binding, recombinant wild-type and mutant gamma C domains were prepared, and their interactions wi

101 peptides spanning P3 and mutant recombinant gamma C-domains demonstrated that the P3 activity is con

102 ased numbers of NK cells; and absent in Rag2/gamma(c)-double-deficient mice, which lack T, B, and NK

103 Down-regulation of gamma(c) during early HIV/SIV infection may inhibit T-ce

104 In response to IFN-gamma, C/EBP-beta undergoes phosphorylation at a critica

105 eas addition of 10 mM alpha-CD, beta-CD, and gamma-CD enhances fluorescence by factors of 2, 7, and 1

106 ownstream IgH constant region exons (e.g., C gamma, C epsilon, or C alpha), which affects switching f

107 h lymphocytes, for which IL-15/IL-2Rbeta and gamma(c) expression are essential.

108 ther in vitro experiments found that surface gamma(c) expression could be down-regulated following hi

109 However, surface gamma(c) expression was rapidly and significantly down-r

110 We found that gamma(c) expression was required to signal the different

111 ere combined immunodeficiency in humans, and gamma(c) family cytokines collectively regulate developm

112 ptor (IL-7Ralpha) and comparisons with other gamma(c) family members.

113 role of cytokines of the common gamma-chain (gamma(c)) family in the determination of the effector he

114 eceptor structure in the common gamma-chain (gamma(c)) family of receptors and cytokines.

115 nfirmed the CD levels, being predominant the gamma-CD followed by alpha-CD, whereas very low beta-CD

116 affinity of the inner and outer faces of the gamma-CD for the polyoxometalate surfaces.

117 g 20 mM hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) for a number of important neuromessengers incl

118 gular lattices with a critical ratio gamma = gamma c = [Formula: see text], supporting previous theor

119 face, moving the C termini of IL-7Ralpha and gamma(c) from a distance of 110 A to less than 30 A at t

120 P2 did not decrease the binding function of gamma C further.

121 receptors interleukin (IL)-2R beta , common gamma (C gamma ) chain, IL-7R alpha , IL-15R alpha; and

122 notypic differences), i.e., Rag2 (-) (/) (-) gamma(c) (-) (/) (-), gamma(c) (-) (/) (-), Rag2 (-) (/)

123 mmon cytokine receptor gamma-chain (Rag2(-/-)gamma(c)(-/-)) genes indicated that uNK cells originate

124 pha or common cytokine receptor gamma chain (gamma(c)) genes were deleted in thymocytes just before p

125 ontains the entire human common gamma chain (gamma(c)) genomic sequence driven by the gamma(c) promot

126 en photoexcited D-/L-Trp enantiomers and rGO/gamma-CD giving rise to an enantioselective photolumines

127 On the basis of our calculations, remote gamma'-C-H arylation is preferred for unsubstituted carb

128 e first example of enantioselective benzylic gamma-C-H arylations of alkyl amines, and proceeds with

129 ve beta-C-H bonds and benzylamine derivative gamma-C-H bonds has been developed.

130 With leucine, HAT from the alpha- and gamma-C-H bonds was observed.

131 [3.3.1]nonane enabled by two key, sequential gamma-C-H lactonizations, with the latter that fixes the

132 Monoselective gamma-C-H olefination and carbonylation of aliphatic aci

133 25 has been achieved by preventing access to gamma-C-H positions for intramolecular insertion.

134 K(+) and Li(+) ions with gamma-cyclodextrin (gamma-CD) has been shown to substitute the K(+) ion site

135 (+) ratio was varied with respect to that of gamma-CD, have been conducted in order to achieve the hi

136 inactive IL-7Ralpha homodimer and IL-7Ralpha-gamma(c) heterodimer to the active IL-7-IL-7Ralpha-gamma

137 r antibodies that bind a specific IL-4Ralpha/gamma(c) heterodimeric complex in its native signaling c

138 own to "trans-present" IL-15 to an IL-2Rbeta/gamma(c) heterodimeric receptor on responding cells to i

139 aft in immunodeficient Rag1(-/-) or Rag1(-/-)gamma(c)(-/-) hosts.

140 We report that in humanized Rag2(-)/(-) gamma(c)(-)/(-) (hu-Rag2(-)/(-) gamma(c)(-)/(-)) mice, a

141 The formation of THY/gamma-CD-IC (1:1 and 2:1) was proved by experimental (X-

142 her preservation rate and stability than THY/gamma-CD-IC (1:1).

143 THY/gamma-CD-IC (2:1) exhibited higher preservation rate and

144 THY as observed in TGA and stability of THY/gamma-CD-IC (2:1) was higher, as shown by a modelling st

145 CD-IC-NF (2:1) than zein-THY-NF and zein-THY/gamma-CD-IC-NF (1:1).

146 :1) was higher than zein-THY-NF and zein-THY/gamma-CD-IC-NF (1:1).

147 It is worth mentioning that zein-THY/gamma-CD-IC-NF (2:1) preserved much more THY as observed

148 re, much more THY was released from zein-THY/gamma-CD-IC-NF (2:1) than zein-THY-NF and zein-THY/gamma

149 imilarly, antibacterial activity of zein-THY/gamma-CD-IC-NF (2:1) was higher than zein-THY-NF and zei

150 It was demonstrated that zein-THY/gamma-CD-IC-NF (2:1) was most effective in inhibiting th

151 electrospun zein nanofibrous webs (zein-THY/gamma-CD-IC-NF) were fabricated as a food packaging mate

152 s of the complete set of type I (IL-4R alpha/gamma(c)/IL-4) and type II (IL-4R alpha/IL-13R alpha1/IL

153 ECDs but a stronger association between the gamma(c)/IL-7Ralpha ECDs, similar to previous studies of

154 ly restored splenic architecture in Rag2(-/-)gamma(c)(-/-)-immunodeficient mice.

155 of chiral enantiomers to form complexes with gamma-CD in different molecular orientations as demonstr

156 ernary complex, IL-15 binds to IL-2Rbeta and gamma(c) in a heterodimer nearly indistinguishable from

157 resence of the receptor, it colocalized with gamma(c) in endosomes and at the plasma membrane.

158 es shape recognition code in order to engage gamma(c) in related fashions.

159 ng a catalytic amount of gamma-cyclodextrin (gamma-CD) in water has been developed to give substitute

160 Thymol (THY)/gamma-Cyclodextrin(gamma-CD) inclusion complex (IC) encapsulated electrospu

161 sed to explain recently discovered IL-7- and gamma(c)-independent gain-of-function mutations in IL-7R

162 The IL-2/gamma(c) interface itself exhibits the smallest buried s

163 complex teaches that interfaces between the gamma(c) interleukins and their receptors can vary in si

164 The large enhancement by gamma-CD is attributed to its larger hydrophobic cavity,

165 escribed by R(-gamma(c)), where the exponent gamma(c) is approximately 5/3 independent of the dimensi

166 termed CD-MOFs, wherein gamma-cyclodextrin (gamma-CD) is linked by coordination to Group IA and IIA

167 The common cytokine receptor gamma chain, gamma(c), is a component of the receptors for interleuki

168 The gamma(c) isoform is highly conserved in mammals, but it

169 lly, we identify a small 16-kDa subunit (the gamma(c) isoform) derived by an intron retention mechani

170 Both alpha and gamma(c) isoforms are predominantly expressed in many ra

171 onal antibody not only detects the alpha and gamma(c) isoforms but also several other isoforms in pan

172 ase activity assays using purified alpha and gamma(c) isoforms indicate that the latter negatively mo

173 Without gamma(c), Jak3 localized in the cytosol, whereas in the

174 h the process was most efficient in Rag2(-/-)gamma(c)(-/-)Kit(W/Wv) hosts, gamma(c)-mediated signals

175 Compound Rag2(-/-)gamma(c)(-/-)Kit(W/Wv) mutants lack competitive hematopo

176 some of the residual lymphoid development in gamma(c) KO mice and presumably in patients with X-linke

177 Injection of TSLP into gamma(c) KO mice induced the expansion of T and B cells.

178 e KO mice had a greater lymphoid defect than gamma(c) KO mice.

179 In contrast to interleukin-2Ralpha, gamma(c) localized poorly to the plasma membrane and acc

180 nt in Rag2(-/-)gamma(c)(-/-)Kit(W/Wv) hosts, gamma(c)-mediated signals alone played a key role in the

181 ing, the requirement for full-length Jak3 in gamma(c) membrane trafficking was remarkably stringent;

182 ng CD4(+) T cell reservoir of hu-Rag2(-)/(-) gamma(c)(-)/(-) mice.

183 Rag2(-)/(-) gamma(c)(-)/(-) (hu-Rag2(-)/(-) gamma(c)(-)/(-)) mice, as in humans, resting CD4(+) T ce

184 e prophylactic delivery of IL-15 to Rag2(-/-)gamma(c)(-/-) mice (mature T, B, and NK cell negative) a

185 al therapy (ART) in humanized (hu-) Rag2(-/-)gamma(c)(-/-) mice allows suppression of viremia below t

186 scid/gamma(c)(-/-) (NSG) and BALB/c Rag2(-/-)gamma(c)(-/-) mice are the most commonly used mouse stra

187 We generated RAG2(-/-)gamma(c)(-/-) mice in which we replaced the gene encodin

188 gatively regulates phagocytosis, in Rag2(-/-)gamma(c)(-/-) mice on a mixed 129/BALB/c background, whi

189 We conclude that humanized BALB/c-Rag2(-/-)gamma(c)(-/-) mice represent a unique and valuable resou

190 In summary, hSIRPa-transgenic Rag2(-/-)gamma(c)(-/-) mice represent a unique mouse strain suppo

191 for the secretion of human IL-15 to Rag2(-/-)gamma(c)(-/-) mice resulted in significant increases in

192 bone marrow transplantation of the Rag2(-/-)gamma(c)(-/-) mice that restored the uNK cell population

193 Rag2(-/-) gamma(C)(-/-) mice transplanted with human hematopoietic

194 ly deleted in Rag2(-/-), but not in Rag2(-/-)gamma(c)(-/-) mice.

195 anted them into irradiated newborn Rag2(-/-) gamma(c)(-/-) mice.

196 hematopoietic stem cells in BALB/c-Rag2(-/-)gamma(c)(-/-) mice.

197 gements exhibit a common feature wherein the gamma-CD moiety interacts with the Dawson-type POMs thro

198 The hu-Rag2(-/-)gamma(c)(-/-) mouse may therefore facilitate testing of

199 ma 383-411 (P2-C) and gamma 377-411 produced gamma C mutants which were defective in binding to the a

200 IL-15-mediated RANTES production by Rag2(-/-)gamma(c)(-/-) myeloid bone marrow cells.

201 pe of the host, i.e., IL-7ralpha(-/-) versus gamma(c) (-/-) Nonetheless, the difference in cellularit

202 NOD/scid/gamma(c)(-/-) (NSG) and BALB/c Rag2(-/-)gamma(c)(-/-) mi

203 ared to control hu-HSC-transplanted NOD/SCID/gamma(c)(null) mice inoculated with equivalent high-tite

204 The plasma of the irradiated NOD/SCID/gamma(c)(null) mice transplanted with hu-HSC transduced

205 c/severe combined immunodeficient (NOD/SCID)/gamma(c)(null) mice with markedly different efficacies a

206 IV infection, we used the humanized NOD/SCID/gamma(c)(null) mouse model, which becomes populated with

207 Here, we examined expression and function of gamma(c) on T cells during SIV infection in Rhesus macaq

208 n fits with structural data showing that its gamma-C peptide and eptifibatide exhibit comparable elec

209 es through remote protonation of the pyrrole gamma-C pi-bonds.

210 in (gamma(c)) genomic sequence driven by the gamma(c) promoter.

211 release from 1(K) is triggered by peripheral gamma-C protonation at the nacnac subunits, which DFT ca

212 structure of the IL-15-IL-15Ralpha-IL-2Rbeta-gamma(c) quaternary complex, IL-15 binds to IL-2Rbeta an

213 i.e., Rag2 (-) (/) (-) gamma(c) (-) (/) (-), gamma(c) (-) (/) (-), Rag2 (-) (/) (-) IL-7ralpha (-) (/

214 K(+)-ion sites and accounting for the cation/gamma-CD ratio in CD-MOF-1.

215 -13, tumor necrosis factor-alpha, interferon-gamma, C-reactive protein, and procalcitonin were measur

216 IL-2 and IL-15, despite usage of common beta gamma c receptor chains.

217 eir receptors to bind the shared, activating gamma(c) receptor.

218 rkable progress in the structural biology of gamma(c) receptors and their cytokines or interleukins,

219 t IL-15 in trans to low-affinity IL-15R beta gamma(c) receptors on memory CD8(+) T cells.

220 eta receptors, as well as IL-2 with beta and gamma(c) receptors proceeds through enthalpy-entropy com

221 he mechanism may also be applicable to other gamma(c) receptors that form inactive homodimers and het

222 ned whether Jak3 and the common gamma chain (gamma(c)) reciprocally regulate their plasma membrane ex

223 into a composite binding site for the final gamma(c) recruitment.

224 in the common cytokine-receptor gamma chain (gamma(c)), resulting in disruption of development of T l

225 Mutation of the gene encoding gamma(c) results in X-linked severe combined immunodefic

226 ype I complex reveals a structural basis for gamma(c)'s ability to recognize six different gamma(c)-c

227 eceptor, IL-15Ralpha and IL-2/IL-15Rbeta and gamma(c) shared with IL-2.

228 for IL-2 and IL-15 in assembling quaternary gamma(c) signaling complexes and an antiparallel interlo

229 gamma(c) signaling in the tumor-bearing host was importa

230 cells expressing Runx3d could arise without gamma(c) signaling, but these cells were developmentally

231 s disease and suggesting that blocking IL-21/gamma(c)-signaling pathways may provide a means for cont

232 ulatory Foxp3(+)CD4(+) T cells which require gamma(c) signals for survival.

233 manner reminiscent of the structures of some gamma-CD solvates, but with added crystal stability impa

234 promote the palladium-catalyzed amination of gamma C(sp(3) )H and C(sp(2) )H bonds of secondary amide

235 und to be highly valuable for both the (beta/gamma)-C(sp(3))-H functionalization catalytic cycles.

236 le light photoredox catalysis enables direct gamma- C(sp(3))-H alkylation of saturated aliphatic carb

237 of Pd(II)-catalyzed, picolinamide-assisted, gamma-C(sp(2))-H activation and Z-selective arylation of

238 (3))-H bonds afforded moderate yields of the gamma-C(sp(2))-H and gamma-C(sp(3))-H bisarylated cinnam

239 d arylation of an allylamine containing both gamma-C(sp(2))-H and gamma-C(sp(3))-H bonds afforded mod

240 a six-membered palladacycle is favored over gamma-C(sp(2))-H bond functionalization when both positi

241 (2))-H bonds of benzoic acid derivatives and gamma-C(sp(2))-H bonds of benzylamine derivatives has be

242 ere effectively translated to a Pd-catalyzed gamma-C(sp(3) )-H arylation process for secondary alkyla

243 elling experiments, which indicated that the gamma-C(sp(3) )-H bond cleavage is the rate-limiting ste

244 Pd(II) -catalyzed arylation of gamma-C(sp(3) )-H bonds of aliphatic acid-derived amides

245 rogen-atom transfer (HAT) processes to guide gamma-C(sp(3) )-H chlorination.

246 we disclose a general strategy for aliphatic gamma-C(sp(3) )-H functionalization guided by a masked a

247 The first example of Pd(II) -catalyzed gamma-C(sp(3) )-H functionalization of aliphatic and ben

248 e scale reactions and diversification of the gamma-C(sp(3) )-H olefinated products.

249 In addition, MPAAs enabled the gamma-C(sp(3) )-H olefination of free carboxylic acids t

250 Reported herein is the distal gamma-C(sp(3) )-H olefination of ketone derivatives and

251 n-deficient 2-pyridone were critical for the gamma-C(sp(3) )-H olefination of ketone substrates.

252 methylation or gamma-CH arylation step, the gamma-C(sp(3) )H amination provided access to complex py

253 The gamma-C(sp(3))-H arylation arose from the Pd(II)-catalyz

254 via transient directing-group-enabled direct gamma-C(sp(3))-H arylation of 3-methylheteroarene-2-carb

255 Pd(II)-catalyzed gamma-C(sp(3))-H arylation of primary amines is realized

256 reaction period to 48-70 h led to successive gamma-C(sp(3))-H arylation/intramolecular amidation and

257 moderate yields of the gamma-C(sp(2))-H and gamma-C(sp(3))-H bisarylated cinnamylamines.

258 the subsequent evaluation of the Pd-mediated gamma-C(sp(3))-H bond activation is described.

259 es the preferential activation of the distal gamma-C(sp(3))-H bond over the proximate beta-C(sp(3))-H

260 ylamine containing both gamma-C(sp(2))-H and gamma-C(sp(3))-H bonds afforded moderate yields of the g

261 nd that enables Pd(II)-catalysed coupling of gamma-C(sp(3))-H bonds in triflyl-protected amines with

262 rt an efficient method for the alkylation of gamma-C(sp(3))-H bonds of picolinamide-protected aliphat

263 Pd(II)-catalyzed olefination of gamma-C(sp(3))-H bonds of triflyl (Tf) and 4-nitrobenzen

264 essive arylation/intramolecular amidation of gamma-C(sp(3))-H bonds.

265 th the BDG-directed functionalization of the gamma-C(sp(3))-H bonds.

266 ve arylation/intramolecular amidation of the gamma-C(sp(3))-H bonds.

267 The first example of free amine gamma-C(sp(3))-H fluorination is realized using 2-hydrox

268 bled cooperative catalysis for the beta- and gamma-C(sp(3))-H functionalizations of ketones are inves

269 The common gamma(c) subunit molecule is shared among all gamma(c) c

270 span the entire length of the IL-2R beta and gamma(c) subunits.

271 IL-4 signaling through IL-4R alpha/gamma(c) suppresses Ca2T6 and SPRR gene expression in no

272 gamma(c)(+) T cells were mainly functional as evidenced

273 ) from this strain contained one molecule of gamma-C(tag) per Pol III* assembly, indicating that the

274 a containing a C-terminal biotinylation tag (gamma-C(tag)) was provided in trans at physiological lev

275 A pronounced destabilization of the gamma C-terminal helix during hydrolysis-driven rotation

276 epitope exposure, AGDV, like the fibrinogen gamma C-terminal peptide and RGD, caused integrin extens

277 Channels with a truncated alpha, beta,or gamma C terminus were not inhibited by arachidonic acid

278 c) heterodimer to the active IL-7-IL-7Ralpha-gamma(c) ternary complex whereby the two receptors under

279 Here we have identified a sequence within gamma C that mediates binding of fibrinogen to platelets

280 th the common cytokine receptor gamma chain (gamma(c)), the protein whose expression is defective in

281 with HP-alpha-CD, beta-CD, HP-beta-CD and HP-gamma-CD; the complexes formed with HP-gamma-CD and HP-b

282 f IL-2 wedges tightly between IL-2R beta and gamma(c) to form a three-way junction that coalesces int

283 D-MOF-4 displays a channel structure wherein gamma-CD tori are perfectly stacked in one dimension in

284 Therefore, RAG2(-/-)gamma(c)(-/-) TPO-humanized mice represent a useful mode

285 Thus, gamma(c)-transduced cytokine signals are required for cy

286 gh these mice had normal lymphocyte numbers, gamma(c)/TSLPR double KO mice had a greater lymphoid def

287 2O)6](2+) ion is closely embedded within two gamma-CD units to give a supramolecular ditopic cation,

288 eric livers in immunodeficient BALB-DeltaRAG/gamma(c) -uPA (urokinase-type plasminogen activator) mic

289 itored for integration and expression of the gamma(c) vector and for functional immunological recover

290 gamma-CD was found to be highly efficacious in carrying

291 However, gamma(c) was expressed at comparable levels on the surfa

292 acking Jak3, and plasma membrane turnover of gamma(c) was independent of Jak3.

293 Two possible structures of FA/gamma-CD were suggested, the first one being analogous t

294 desalted by ultrafiltration in the presence gamma-CD, were concentrated on-capillary by large-volume

295 conditions is quantitatively described by R(-gamma(c)), where the exponent gamma(c) is approximately

296 re the common cytokine receptor gamma chain (gamma(c)), which is mutated in humans with X-linked seve

297 es the common cytokine receptor gamma chain, gamma(c), which is mutated in humans with X-linked sever

298 arithm of the folding rates also scale as R(-gamma(c)), with deviations only being seen for very smal

299 es the common cytokine receptor gamma-chain, gamma(c), with IL-2, IL-4, IL-7, IL-9, and IL-15.

300 SDS micelles and neutral gamma-cyclodextrin (gamma-CD) zones, where the analytes bound inside micelle