ライフサイエンスコーパス: gamma-catenin

1 but decreased nuclear levels of plakoglobin (gamma-catenin).

2 ripheral adaptors (e.g., ZO-1 and alpha- and gamma-catenins).

3 due to altered regulation of both beta- and gamma-catenin.

4 containing E-cadherin and alpha-, beta-, and gamma-catenin.

5 molecules E-cadherin and alpha-, beta-, and gamma-catenin.

6 immunoprecipitate well with alpha-catenin or gamma-catenin.

7 increased the association of E-cadherin with gamma-catenin.

8 n Ser-139) by up-regulating N/E-cadherin and gamma-catenin.

9 lasma membrane requires beta-catenin but not gamma-catenin.

10 l adhesion kinase, paxillin, E-cadherin, and gamma-catenin.

11 vl3, Fbxw-1, Cul1, CK1epsilon, CK1delta, and gamma-catenin.

12 SLUG, and down-regulation of E-cadherin and gamma-catenin.

13 elative to those lines that highly expressed gamma-catenin.

14 tenin gene family including beta-catenin and gamma-catenin.

15 nodal metastasis and expression of E-cad and gamma-catenin.

16 pan-cadherin, VE-cadherin, beta-catenin, and gamma-catenin.

17 of cytoplasmic proteins: alpha-and beta- or gamma- catenin.

18 association of ZO-1 with alpha-, beta-, and gamma-catenins.

19 signal levels for plakoglobin (also known as gamma-catenin), a protein that links adhesion molecules

20 DPAGT1 TCF/LEF sequence also interacted with gamma-catenin, a close homologue of beta-catenin, althou

21 fragments of VE-cadherin, beta-catenin, and gamma -catenin after post-CPB perfusion, indicating part

22 he first biochemical evidence that, in vivo, gamma-catenin also mediates interactions between classic

23 tion and Western blotting, the expression of gamma-catenin, an adherens junction protein, was decreas

24 rect interaction of Kindlin-2 with beta- and gamma-catenin and actin was demonstrated in co-immunopre

25 adherin-based complexes, including beta- and gamma-catenin and actin, components of adherens junction

26 acellular transducers of cadherin signaling, gamma-catenin and alpha-catenin predominate in the later

27 In contrast, gamma-catenin and CDH2 are expressed predominantly in th

28 ng directly and simultaneously with beta- or gamma-catenin and cortical actin filaments, Kindlin-2 st

29 n protein content, whereas modest changes in gamma-catenin and E-cadherin expression were recorded.

30 eport here that APC regulates both beta- and gamma-catenin and gamma-catenin functions as an oncogene

31 gamma-catenin and its DNA-binding partner LEF-1 indirect

32 the slit diaphragm ZO-1, alpha-, beta-, and gamma-catenin and P-cadherin.

33 severe learning impairments, upregulation of gamma-catenin and reductions in synaptic adhesion and sc

34 We found 1) significantly more gamma-catenin and SHP-2 bound to the truncated than to t

35 sitive displaying increased interaction with gamma-catenin and vinculin compared with the endogenous

36 tyrosine phosphorylation levels of beta- and gamma-catenins and p120-Cas, and structural and function

37 Components of cell-cell (beta- and gamma-catenin) and cell-matrix (focal adhesion kinase an

38 the three major catenins (alpha-, beta-, and gamma-catenin) and enhanced Ca2+-dependent cellular cohe

39 e caspase-mediated cleavage of beta-catenin, gamma-catenin, and APC protein might contribute to pacli

40 ntration-dependent cleavage of beta-catenin, gamma-catenin, and APC protein, but not alpha-catenin or

41 endothelial (VE)-cadherin, beta-catenin and gamma-catenin, and associated mitogen-activated protein

42 l and vimentin; up-regulation of E-cadherin, gamma-catenin, and estrogen receptor alpha; and decrease

43 reduced expression for E-cad, beta-catenin, gamma-catenin, and p120 in squamous cell carcinomas but

44 ous expression for E-cad, alpha-, beta-, and gamma-catenin, and p120 were observed in 10%, 17%, 8%, 3

45 phosphorylation of beta-catenin, plakoglobin/gamma-catenin, and p120(cas) on tyrosine residues.

46 on proteins focal adhesion kinase, paxillin, gamma-catenin, and p120(Cas).

47 on of zonula adherens proteins, VE-cadherin, gamma-catenin, and p120(ctn).

48 fragment was unable to bind to beta-catenin, gamma-catenin, and p120, suggesting that this cleavage e

49 tion of VE-cadherin-associated beta-catenin, gamma-catenin, and p120-catenin by modulating the quanti

50 he tyrosine phosphorylation of beta-catenin, gamma-catenin, and p120-catenin complexed with VE-cadher

51 rin complex (VE-cadherin, alpha-, beta-, and gamma-catenin, and p120/p100) localizes to adherens junc

52 of tyrosine phosphorylation of beta-catenin, gamma-catenin, and p120ctn, as well as the dissociation

53 ain (occludin, ZO-1, cadherin, beta-catenin, gamma-catenin, and platelet-endothelial cell adhesion mo

54 e conditionally removed from MuSCs beta- and gamma-catenin, and, separately, alphaE- and alphaT-caten

55 dherin family of proteins, alpha-, beta- and gamma-catenins, and cytoskeletons.

56 that proteolysis and altered localization of gamma-catenin are early markers for the response of cell

57 Both beta- and gamma-catenins are reported to link classical cadherins

58 lopment, cadherin-2 and its binding partner, gamma-catenin, are preferentially expressed by OSN axons

59 Taken together, we identify gamma-catenin as a novel regulator of HAI-1, which is a

60 -dependent gene transcription and highlights gamma-catenin as a potentially novel tumor suppressor pr

61 he parental cells resulted in proteolysis of gamma-catenin as evaluated in membrane pellet preparatio

62 ne phosphorylation inversely correlates with gamma-catenin association; 4) PECAM-1 recruits gamma-cat

63 hanism involving the interaction of Tcf with gamma-catenin at the DPAGT1 promoter.

64 ent reduction in OB-cadherin, alpha-catenin, gamma-catenin, beta-catenin, vimentin and galectin-3 pro

65 e cytosolic domain upstream of the beta- and gamma-catenin binding motifs of E-cadherin.

66 The beta- and gamma-catenin binding site resides within the F1 and F3

67 adherins to the actin cytoskeleton, but only gamma-catenin binds to the desmosomal cadherins, which l

68 Similar findings have been obtained for gamma-catenin but not alpha-catenin.

69 red expression of E-cad or alpha-, beta-, or gamma-catenins but coincided with the up-regulation of a

70 n of E-cadherin by 42%, beta-catenin by 37%, gamma-catenin by 136%, and desmoglein 3 by 300%, whereas

71 This study shows that gamma-catenin can function as an inhibitor of beta-caten

72 This effect on E-cadherin/gamma-catenin complexes was shared with the nonisoform s

73 y cisplatin treatment, including cleavage of gamma-catenin, could affect the ability of cells to inte

74 No mutations of the gamma-catenin (CTNNG1), GSK-3alpha (GSK3A), or GSK-3beta

75 Our results show that gamma-catenin-dependent cadherin function is required fo

76 of the beta-catenin/TCF7L2 complex, whereas gamma-catenin down-regulates it.

77 patterns of alpha-catenin, beta-catenin, and gamma-catenin, during definition of the cardiac cell pop

78 However, knocking-down gamma-catenin expression had no effect.

79 Moreover, transfection of these cells with a gamma-catenin expression plasmid reduced the elevated TC

80 stic variables, E-cad and alpha-, beta-, and gamma-catenin expression were of positive prognostic val

81 enin protein content in NSCLC cells with low gamma-catenin expression.

82 confocal microscopy, which showed a loss of gamma-catenin from adherens plaques after cisplatin trea

83 the first time, the separation of N-cadherin/gamma-catenin from N-cadherin/beta-catenin complexes and

84 ell as the dissociation of alpha-catenin and gamma-catenin from VE-cadherin.

85 C regulates both beta- and gamma-catenin and gamma-catenin functions as an oncogene.

86 Cells transfected with the gamma-catenin gene are sensitive to cisplatin compared w

87 In addition, gamma-catenin had a distinctive localization to the vert

88 and several amino-terminal mutated forms of gamma-catenin had similar transforming activity.

89 tions and like binding to APC, evidence that gamma-catenin has an important role in cancer has been l

90 Though beta- and gamma-catenin have analogous structures and functions an

91 state levels of alpha- and beta-catenins and gamma-catenin in K5-expressing ECs were drastically redu

92 ant cells may indicate an important role for gamma-catenin in mediating or modulating the toxicity of

93 Expression of gamma-catenin in NSCLC cells resulted in reduced cell mi

94 2 expression closely parallels that seen for gamma-catenin in OSN axons.

95 of cells to cisplatin, and reduced levels of gamma-catenin in resistant cells may indicate an importa

96 Uncleaved cytoplasmic gamma-catenin increased under the same conditions.

97 at selective disruption of the CBP/beta- and gamma-catenin interactions using ICG-001 leads to differ

98 We show that gamma-catenin interacts with several beta-catenin bindin

99 how that: 1) not only beta-catenin, but also gamma-catenin is associated with PECAM-1 in vitro and in

100 elieve this novel vimentin-linked N-cadherin/gamma-catenin junction provides the tensile strength nec

101 n was associated exclusively with N-cadherin/gamma-catenin junctions.

102 VE-cadherin, beta-catenin, and gamma-catenin levels were significantly greater in the a

103 Furthermore, the data imply beta- and gamma-catenin may have distinct roles in Wnt signaling a

104 junctions in transfected SW480 cells; and 5) gamma-catenin may recruit PECAM-1 into an insoluble cyto

105 We conclude that gamma-catenin-mediated CDH2 adhesion may influence OSN t

106 Therefore, targeting gamma-catenin-mediated HAI-1 expression might be a usefu

107 ecifically, the epithelial genes E-cadherin, gamma-catenin, MTA3, and estrogen receptor alpha (ERalph

108 Moreover, the affects of gamma-catenin on cell migration were observed to be p53-

109 e identified a novel role for the affects of gamma-catenin on non-small cell lung cancer (NSCLC) cell

110 c) interacts, in cytoplasm and nucleus, with gamma-catenin, one of its desmosomal partners, and with

111 tion of RK3E cells by mutant beta-catenin or gamma-catenin or after ligand-induced activation of a be

112 on N-cadherin was linked to vimentin through gamma-catenin or beta-catenin we developed an innovative

113 ation of catenins (beta-catenin, plakoglobin/gamma-catenin, or p120(cas)) with E-cadherin.

114 In common with beta-catenin and plakoglobin (gamma-catenin), p120(ctn) contains a central Armadillo r

115 in (cadherin-5), desmoglein, alpha, beta and gamma catenin, p120(ctn) and alpha-actinin.

116 in, alpha (alpha)-, beta (beta)-, and gamma (gamma)-catenin, p120, p27, and adenomatous polyposis col

117 1, GTPase-activating protein, beta-catenin, gamma-catenin, p120cas, SHP-1, and SHP-2.

118 mutations alter regulation of both beta- and gamma-catenin, perhaps explaining why the frequency of A

119 We show that E-cadherin, beta-catenin, and gamma-catenin (plakoglobin) are all concentrated in cave

120 t beta-catenin loss leads to upregulation of gamma-catenin (plakoglobin), a partial functional homolo

121 gamma-Catenin (Plakoglobin), a well-described structural

122 beta-Catenin and gamma-catenin (plakoglobin), vertebrate homologs of Dros

123 with intracellular catenins (alpha-, beta-, gamma-catenin/plakoglobin and p120CAs).

124 We show here that beta-catenin, gamma-catenin/plakoglobin, and p120-Cas are all signific

125 1 stimulates E-cadherin binding to beta- and gamma-catenin, promotes cytoskeletal association of the

126 , a histone deacetylase inhibitor, increased gamma-catenin protein content in NSCLC cells with low ga

127 Treatment of NSCLC cells expressing reduced gamma-catenin protein with 5-aza-2'-deoxycytidine (5aza2

128 in the NSCLC cell lines that underexpressed gamma-catenin relative to those lines that highly expres

129 The Kindlin-2 binding sites for beta- and gamma-catenin reside within its F1 and F3 subdomains.

130 junctions by inducing cleavage of beta- and gamma-catenin, resulting in cell detachment.

131 ZO-1) and adherens complex (alpha, beta, and gamma catenins) revealed diminished intensity and redist

132 gamma-Catenin's transforming activity, like beta-catenin

133 We find that joint inactivation of beta- and gamma-catenin scrambles motor neuron settling position i

134 Furthermore, the re-expression of gamma-catenin sensitized NSCLC cells to c-MET inhibitor-

135 ary NSCLC tumors revealed negligible to weak gamma-catenin staining in approximately 30% of the speci

136 However, in contrast to beta-catenin, gamma-catenin strongly activated c-Myc expression and c-

137 e closely related family member plakoglobin (gamma-catenin) that maintained both adherens junctions a

138 the intercalated disc with alpha-actinin and gamma-catenin, the latter being a known disease gene for

139 mma-catenin association; 4) PECAM-1 recruits gamma-catenin to cell-cell junctions in transfected SW48

140 xpression and c-Myc function was crucial for gamma-catenin transformation.

141 Cleavage of gamma-catenin was specific to cisplatin treatment in tha

142 By contrast, gamma-catenin was weakly expressed or absent in several

143 These cleavages of beta-catenin and gamma-catenin were apoptosis-dependent, not mitosis-depe

144 tically, the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyt

145 ugh changes in E-cadherin, beta-catenin, and gamma-catenin were identified in individual cell lines.

146 d apoptosis and cleavage of beta-catenin and gamma-catenin were inhibited by the pan-caspase inhibito

147 However, the tumor suppressive affects of gamma-catenin were not fully understood.

148 dherin recruits alpha- and beta-catenins and gamma-catenin, which interact with the actin cytoskeleto