ライフサイエンスコーパス: gamma-herpesvirus

1 d NK cell-mediated immune control of a human gamma-herpesvirus.

2 e from dealing effectively with a pathogenic gamma-herpesvirus.

3 aintain long-term control of this persistent gamma-herpesvirus.

4 Epstein-Barr virus (EBV), a common oncogenic gamma-herpesvirus.

5 oma-associated herpesvirus (KSHV) is a human gamma-herpesvirus.

6 re conserved in the EBNA1 orthologs of other gamma herpesviruses.

7 sequences were distributed more uniformly in gamma-herpesviruses.

8 esviruses but not in members of the beta- or gamma-herpesviruses.

9 coma-associated herpesvirus (KSHV) and other gamma-herpesviruses.

10 activated differently in alpha- compared to gamma-herpesviruses.

11 ay contribute to immune control of oncogenic gamma-herpesviruses.

12 DNA features differed in alpha- compared to gamma-herpesviruses.

13 ved circRNAs have recently been described in gamma-herpesviruses.

14 the beta-subfamily and absent in alpha- and gamma-herpesviruses.

15 monstrate a novel mechanism where the murine gamma herpesvirus 68 (gammaHV68) latency-associated, ant

16 oma-associated herpesvirus (KSHV) and murine gamma herpesvirus 68 (MHV-68), plays a critical role in

17 pe III ER membrane protein encoded by murine gamma herpesvirus 68.

18 llowing intragastric inoculation with murine gamma-herpesvirus 68 (gamma HV-68), expression of substa

19 after respiratory challenge with the murine gamma-herpesvirus 68 (gammaHV-68), then develop symptoms

20 model of gamma-herpesvirus infection, murine gamma-herpesvirus 68 (gammaHV-68), we were surprised to

21 Infection of medial smooth muscle cells with gamma-herpesvirus 68 (gammaHV68) causes severe chronic v

22 Murine gamma-herpesvirus 68 (gammaHV68) infection is a new mode

23 s are generated and maintained during murine gamma-herpesvirus 68 (gammaHV68) persistent infection de

24 e we demonstrate that infection of mice with gamma-herpesvirus 68 (gammaHV68) provides a novel model

25 of complement factor C3 (C3) and the murine gamma-herpesvirus 68 (gammaHV68) RCA protein in viral pa

26 ins of mice with a murine gamma-herpesvirus, gamma-herpesvirus 68 (gammaHV68), is providing insights

27 ths after respiratory exposure to the murine gamma-herpesvirus 68 (gammaHV68), then succumb with symp

28 ct effector mechanisms of CD4 T cells during gamma-herpesvirus 68 (gammaHV68)-persistent infection ar

29 Murine gamma-herpesvirus 68 (MHV-68) infection of mice represen

30 cial for maintenance of latency during mouse gamma-herpesvirus 68 (MHV-68) infection.

31 Murine gamma-herpesvirus 68 (MHV-68) provides an important expe

32 d the differentiation and function of murine gamma-herpesvirus 68 (MHV-68)-specific CD4(+) T cells us

33 /- and wt mice were infected with the murine gamma-herpesvirus 68 (MHV-68).

34 we report that the miRNAs encoded by murine gamma-herpesvirus 68 (MHV68) are also generated via atyp

35 T-I CTL function and the clearance of murine gamma-herpesvirus 68 and lymphocytic choriomeningitis cl

36 However, murine gamma-herpesvirus 68 causes a chronic lytic infection in

37 of a full-length oncogenic viral cyclin from gamma-herpesvirus 68 complexed with cdk2.

38 istinct from host protein synthesis shutoff, gamma-herpesvirus 68 down-regulates surface MHC class I

39 The murine gamma-herpesvirus 68 has many similarities to EBV, and i

40 mmune surveillance, exemplified by the mouse gamma-herpesvirus 68 M3 decoy receptor.

41 The murine gamma-herpesvirus 68 replicates in epithelial sites afte

42 for the generation and maintenance of murine gamma-herpesvirus 68-specific CD8(+) set now have been a

43 ical factors in limiting the level of murine gamma-herpesvirus-68 (gammaHV-68) infection.

44 The murine gamma-herpesvirus-68 (gammaHV68) establishes viral laten

45 Murine gamma-herpesvirus-68 (gammaHV68), a rodent pathogen rela

46 ) T cell population during persistent murine gamma-herpesvirus-68 (MHV-68) infection.

47 The murine gamma-herpesvirus-68 (MHV-68) K3 protein, like that of t

48 k-old apoE-/- mice were infected with murine gamma-herpesvirus-68 (MHV-68).

49 f memory CD8(+) T cells reactive to a murine gamma-herpesvirus-68 Ag.

50 cobacterium tuberculosis), and viral (murine gamma-herpesvirus-68 and Sendai) infections.

51 a murine MHC class II-restricted epitope in gamma-herpesvirus-68 gp150 (gp150(67-83)I-A(b)) that eli

52 The murine gamma-herpesvirus-68 has biological and structural simil

53 role of Abs in control of persistent murine gamma-herpesvirus-68 infection.

54 ma-herpesvirus experimental infection model, gamma-herpesvirus-68.

55 The gamma-herpesviruses additionally evade T cells during th

56 Two other T-lymphotropic gamma-herpesviruses, AlHV-1 and OvHV-2, do not produce a

57 mune evasion strategy shared by at least two gamma-herpesviruses allows continued lytic infection in

58 Gamma herpesviruses also encode homologs of the Bcl-2 fa

59 We examined alpha- and gamma-herpesvirus alterations to a type of alternative s

60 of infection and protective immunity for the gamma-herpesviruses and demonstrate the utility of repli

61 cal and structural similarities to the human gamma-herpesviruses, and provides an important in vivo e

62 The gamma-herpesviruses are characterized by their ability t

63 Gamma-herpesviruses are efficacious pathogens which are

64 Because the gamma-herpesviruses are highly species-specific and mice

65 The gamma-herpesviruses are oncogenic B cell lymphotrophic v

66 r pathology induced by gammaHV68 and suggest gamma-herpesviruses as candidate etiologic agents for hu

67 oma-associated herpesvirus (KSHV) is a human gamma-herpesvirus associated with several human malignan

68 ted herpesvirus (KSHV) is an oncogenic human gamma-herpesvirus associated with the endothelial malign

69 ic vaccination strategies must target latent gamma-herpesvirus at the site of infection.

70 P receptors in mice results in an increased gamma-herpesvirus burden and an altered host response.

71 These data demonstrate that a gamma-herpesvirus can accelerate atherosclerosis in the

72 Rhesus lymphocryptovirus (rhLCV) is a gamma-herpesvirus closely related to EBV, which establis

73 ng latent infection with gammaHV68, a murine gamma-herpesvirus closely related to human gamma-herpesv

74 HHV-8 is a B-lymphotropic gamma-herpesvirus closely related to the Epstein-Barr vi

75 we report the X-ray structures of beta- and gamma-herpesvirus core NECs obtained through an innovati

76 We have identified a major gamma-herpesvirus-divergent locus (DL-B) in HHV-8 DNA en

77 The gL proteins of alpha herpesviruses and gamma herpesviruses do not have a significant percentage

78 with B cell lines transformed by the related gamma-herpesvirus EBV.

79 The oncogenic gamma-herpesviruses EBV and Kaposi sarcoma-associated he

80 The human gamma-herpesviruses EBV and Kaposi's sarcoma-associated

81 The gamma-herpesvirus, EBV, is reliably found in a latent st

82 The human gamma-herpesviruses, EBV and Kaposi's sarcoma-associated

83 The human gamma-herpesviruses, EBV and Kaposi's sarcoma-associated

84 The human gamma-herpesviruses, EBV and Kaposi's sarcoma-associated

85 Gamma-herpesviruses encode a cytoplasmic mRNA-targeting

86 Many gamma-herpesviruses encode candidate oncogenes including

87 Several gamma-herpesviruses encode homologs of host regulators o

88 Several gamma-herpesviruses encode proteins related to the mamma

89 alpha-, beta-, and gamma-Herpesviruses encode putative viral protein kinase

90 ble tegument components included the EBV and gamma-herpesvirus-encoded BLRF2, BRRF2, BDLF2 and BKRF4

91 Here, we discuss gamma-herpesvirus-encoded miRNAs and focus on recent fin

92 This gamma-herpesvirus encodes for several unique proteins th

93 us nuclear antigen 1 (EBNA-1) of the related gamma-herpesvirus Epstein-Barr virus, specific DNA recog

94 The gamma-herpesviruses Epstein-Barr virus and Kaposi's sarc

95 are homology with two lymphotropic oncogenic gamma-herpesviruses, Epstein-Barr virus and Herpesvirus

96 ssociated herpesvirus (KSHV) is an oncogenic gamma-herpesviruses etiologically associated with severa

97 d herpesvirus, we have used a natural rodent gamma-herpesvirus experimental infection model, gamma-he

98 Together, these observations suggested that gamma-herpesviruses exploit the B cell life cycle in the

99 gamma-Herpesviruses express proteins that modulate B lym

100 A new member of the gamma-herpesvirus family, HHV-8 (also known as Kaposi's

101 mediate early transcription activator of the gamma-herpesvirus family.

102 tion of inbred strains of mice with a murine gamma-herpesvirus, gamma-herpesvirus 68 (gammaHV68), is

103 By using a gamma-herpesvirus (gammaHV) infection model, we demonstr

104 The M3 gene of the gamma-herpesvirus gammaHV68 encodes an abundant secreted

105 effective, long-term control of a persistent gamma-herpesvirus (gammaHV68) in Ig(-/-) microMT mice, s

106 The experimental mouse gamma-herpesvirus, gammaHV68 (or MHV-68), has provided a

107 gamma-herpesviruses (gammaHVs) are common human pathogen

108 Gamma-herpesviruses (gammaHVs) are widespread oncogenic

109 Gamma herpesviruses (GHVs) are responsible for a substan

110 ck of relevant small animal models for human gamma-herpesviruses has impeded progress in understandin

111 Investigations into a murine gamma-herpesvirus have now provided evidence that vaccin

112 against gamma-herpesvirus infection and that gamma-herpesviruses have evolved an immune evasion strat

113 Thus, oncogenic gamma-herpesviruses have evolved diverse strategies to c

114 Tumor-causing gamma-herpesviruses have evolved elaborate mechanisms to

115 ion of three prototypical alpha-, beta-, and gamma herpesviruses, i.e., VZV, human cytomegalovirus (H

116 us recrudescence can be modeled using murine gamma-herpesvirus in CD4 T cell-depleted mice.

117 ided valuable new information on the role of gamma-herpesviruses in the pathogenesis of AIDS-associat

118 The gamma-herpesviruses, in contrast to the alpha- and beta-

119 gammaHV68 shares latency programs with human gamma-herpesviruses - including the loci for gene 73, v-

120 learly distinct from those seen in beta- and gamma-herpesviruses, including a salt bridge formed betw

121 ection with either influenza virus or murine gamma-herpesvirus induced the expected expression of GrB

122 us, we could characterize the nature of this gamma-herpesvirus-induced PTCL-like disease and identify

123 as been unclear whether lytic infection with gamma herpesviruses induces a similar effect.

124 ically alcelaphine herpesvirus 1 (AlHV-1), a gamma-herpesvirus inducing malignant catarrhal fever (MC

125 Disease associated with persistent gamma-herpesvirus infection (EBV, HHV-8) is a significan

126 Disease associated with persistent gamma-herpesvirus infection (EBV, human herpesvirus 8) i

127 hat complement is a key host defense against gamma-herpesvirus infection and that gamma-herpesviruses

128 important roles during latent and persistent gamma-herpesvirus infection and that herpesviruses encod

129 ation of immune surveillance against chronic gamma-herpesvirus infection in immunosuppressed individu

130 ockade of IFNgamma reactivated latent murine gamma-herpesvirus infection in vivo, suggesting a "two-s

131 anscription factor Stat6, reactivated murine gamma-herpesvirus infection in vivo.

132 l for understanding how immunity and chronic gamma-herpesvirus infection inter-relate.

133 prominent during the replicative phase of a gamma-herpesvirus infection protects against subsequent

134 in the generation of protective memory to a gamma-herpesvirus infection remains unknown.

135 Using the murine model of gamma-herpesvirus infection, murine gamma-herpesvirus 68

136 r expression makes toward immunity against a gamma-herpesvirus infection.

137 in the establishment and control of chronic gamma-herpesvirus infection.

138 erstanding of the CD4 T cell response during gamma-herpesvirus infection.

139 s are critical for the control of persistent gamma-herpesvirus infection.

140 nce of CD8 T cell memory during a persistent gamma-herpesvirus infection.

141 important for immune control of EBV-related gamma-herpesvirus infection.

142 y that the defective control of intercurrent gamma-herpesvirus infections in patients with AIDS not o

143 ic persistent viral infections, particularly gamma-herpesvirus infections.

144 butor to alterations in gene expression, and gamma-herpesviruses interface with the host RNA targetin

145 establishment and maintenance of latency in gamma-herpesviruses is crucial because latency plays a p

146 a model where the genomic integrity of human gamma-herpesviruses is maintained by active neutralizati

147 Kaposi's sarcoma (KS) herpesvirus (KSHV), a gamma herpesvirus, is tightly linked with KS, primary ef

148 ated members of the rhadinovirus subgroup of gamma herpesviruses, K1 and STP exhibit no similarity in

149 The tumorigenic human gamma-herpesvirus Kaposi's sarcoma-associated herpesviru

150 The human gamma herpesviruses, Kaposi sarcoma-associated virus (KS

151 A newly recognized gamma herpesvirus known as Kaposi sarcoma-associated her

152 ssecting mechanisms of CD4 immune control of gamma-herpesvirus latency and the development of therape

153 largely protect against subsequent wild-type gamma-herpesvirus latency establishment.

154 ice represents a unique system for analyzing gamma-herpesvirus latency in splenic B cells at differen

155 c viral replication is not a requirement for gamma-herpesvirus latency in vivo and suggest that viral

156 ntribution of humoral immunity to control of gamma-herpesvirus latency, and have significant implicat

157 step in containing virus reactivation during gamma-herpesvirus latency.

158 T cells are essential for immune control of gamma-herpesvirus latency.

159 ls are critical effectors for the control of gamma-herpesvirus latent infection, and they mediate thi

160 n important experimental model for analyzing gamma-herpesvirus latent infection.

161 stein-Barr virus (EBV) is a highly prevalent gamma-herpesvirus, latently infecting B cells for the hu

162 n excellent animal model system to study the gamma herpesvirus life cycle both in vitro and in vivo.

163 Unique to gamma-herpesviruses, like Kaposi's sarcoma-associated he

164 Recently, the DNA sequences of a novel human gamma-herpesvirus-like (HHV-8) agent have been detected

165 MP1 signaling.IMPORTANCE EBV is a ubiquitous gamma herpesvirus linked to malignancies such as nasopha

166 It has been proposed that the gamma-herpesviruses maintain lifelong latency in B cells

167 Intranasal infection of mice with the murine gamma-herpesvirus MHV-68 results in an acute lytic infec

168 us recrudescence can be modeled using murine gamma-herpesvirus (MHV)-68 in mice lacking CD4(+) T cell

169 We infected mice with a murine gamma-herpesvirus (MHV-68).

170 w chimera mice after infection with a murine gamma-herpesvirus, MHV-68.

171 matically in mice infected with a persistent gamma-herpesvirus, MHV-68.

172 FN responses is a conserved function for NHP gamma-herpesvirus miRNAs and provide important mechanist

173 In this study, using a murine gamma-herpesvirus model, we demonstrate an early dominan

174 (pneumonia virus of mice, PVM) or persistent gamma-herpesvirus (Murid herpesvirus 4, MuHV-4) infectio

175 faces differ considerably in these beta- and gamma-herpesvirus NECs, the binding free energy contribu

176 e pre-eminent animal model for understanding gamma-herpesvirus pathogenesis and immunity.

177 ctions for studies of this valuable model of gamma-herpesvirus pathogenesis.

178 CD8 T cell memory that is maintained during gamma-herpesvirus persistence has the capacity to surviv

179 As gamma-herpesviruses primarily cause human disease during

180 olving infection with influenza A virus or a gamma-herpesvirus promoted conversion of effector cells

181 The mouse gamma-herpesvirus protein mK3 is a viral RING-CH-type E3

182 response, Tarakanova et al. characterized a gamma-herpesvirus protein, which phosphorylates histone

183 Immune surveillance failure followed by gamma-herpesvirus recrudescence can be modeled using mur

184 Immune surveillance failure followed by gamma-herpesvirus recrudescence can be modeled using mur

185 RNAs expressed by multiple non-human primate gamma-herpesviruses regulate anti-viral responses by dir

186 ine lymphotropic herpesvirus-1 (PLHV-1) is a gamma-herpesvirus related to Epstein-Barr virus (EBV) an

187 ously developed recombinant (r) forms of the gamma-herpesvirus rhesus monkey rhadinovirus (rRRV) expr

188 to determine whether non-human primate (NHP) gamma-herpesviruses (rhesus lymphocryptovirus [rLCV], rh

189 First, we find that human gamma-herpesvirus RNRs engage A3B via largely distinct s

190 rpesvirus in B cells, suggesting a conserved gamma-herpesvirus role.

191 svirus (KSHV) is a recently discovered human gamma herpesvirus strongly implicated in AIDS-related ne

192 e gamma-herpesvirus closely related to human gamma-herpesviruses such as EBV and Kaposi's sarcoma-ass

193 uired for malignant transformation caused by gamma-herpesviruses, such as Kaposi's sarcoma virus.

194 are encoded by Herpesvirus saimiri (HVS), a gamma Herpesvirus that causes aggressive T cell leukemia

195 Murine herpesvirus-68 (MHV-68) is a type 2 gamma herpesvirus that productively infects alveolar epi

196 HHV-8 is an oncogenic gamma-herpesvirus that causes Kaposi's sarcoma, Castlema

197 Herpesvirus saimiri, a gamma-herpesvirus that establishes latency in the T cell

198 stein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus that establishes life-long infection a

199 Herpesvirus saimiri (HVS) is a gamma-herpesvirus that expresses Sm class U RNAs (HSURs)

200 Epstein-Barr virus (EBV) is a lymphotropic gamma-herpesvirus that has co-evolved with human species

201 The Epstein-Barr virus (EBV) is a gamma-herpesvirus that infects B cells and epithelial ce

202 (KSHV), or human herpervirus 8 (HHV-8), is a gamma-herpesvirus that infects human lymphocytes and is

203 EBV is a B lymphotrophic gamma-herpesvirus that is associated with multiple human

204 Herpesvirus saimiri (HVS) is an oncogenic gamma-herpesvirus that produces microRNAs (miRNAs) by co

205 saimiri (HVS) is an oncogenic, lymphotropic, gamma-herpesvirus that transforms human and simian T cel

206 svirus (also named human herpesvirus 8) is a gamma-herpesvirus that undergoes both lytic and latent i

207 al RNRs to antagonize A3B is conserved among gamma-herpesviruses that infect humans and Old World mon

208 Unlike other gamma-herpesviruses, that encode transmembrane proteins

209 The DNA sequences of a novel human gamma-herpesvirus type 8 (HHV-8) have recently been dete

210 NA decay rates impact transcription and that gamma-herpesviruses use this feedback mechanism to facil

211 A gamma-herpesvirus v-bcl-2 was essential for efficient ex

212 A previously undescribed gamma-herpesvirus was cultured from acute JME white matt

213 repeats predominated in alpha-herpesviruses, gamma-herpesviruses were enriched in short, GC-rich init

214 KSHV is a gamma herpesvirus with homology to herpesvirus Saimiri a

215 driving force in selecting for an ancestral gamma-herpesvirus with an expanded RNR functionality thr

216 uman and primate lymphotropic herpesviruses (gamma-herpesviruses) with the development of lymphomas,