ライフサイエンスコーパス: gamma-synuclein

1 d increased expression of beta-synuclein and gamma synuclein.

2 shares high sequence identity with beta- and gamma-synuclein.

3 ducted with antibodies to alpha-, beta-, and gamma-synuclein.

4 ng the MTZ, which contain protease resistant gamma-synuclein.

5 closely related members, alpha-, beta-, and gamma-synuclein.

6 disease, and the highly homologous beta and gamma-synuclein.

7 hibition of the 20 S proteasome by monomeric gamma-synuclein.

8 close homologues, termed beta-synuclein and gamma-synuclein.

9 e protofibrils comprising alpha-synuclein or gamma-synuclein.

10 ne-activated apoptosis pathway is blocked by gamma-synuclein.

11 bodies, but these do not stain for beta- or gamma-synuclein.

12 described in the homologous genes beta- and gamma-synuclein.

13 as observed at 4:1 molar excess of beta- and gamma-synucleins.

14 s, we investigated the effect of ziram on ZF gamma-synuclein 1 (gamma1).

15 most abundant message (75-80%), followed by gamma-synuclein (10-15%) and alpha-synuclein (8-10%).

16 We demonstrate here that beta- and gamma-synuclein (a third homologue that is expressed pri

17 alpha-, beta-, and gamma-Synuclein, a novel family of neuronal proteins, ha

18 s, none of which contained beta-synuclein or gamma-synuclein abnormalities.

19 opathological changes include aggregation of gamma-synuclein, accumulation of various inclusions in n

20 stent with alphaS and its homologs beta- and gamma-synuclein all forming tetramers while sharing only

21 Two aSyn paralogs, beta- and gamma-synuclein, also interact with DNA differently than

22 No genetic link between beta and gamma-synuclein, and any neurodegenerative disease has b

23 -1, microtubule associated protein-2 (MAP2), gamma-synuclein, and NeuN, whereas Brn3 transcription fa

24 s were detected with alpha- but not beta- or gamma-synuclein antibodies in 22% of FAD brains, and alp

25 alpha-, beta-, and gamma-Synuclein are intrinsically disordered proteins im

26 These results indicate that beta- and gamma-synuclein are intrinsically less fibrillogenic tha

27 alpha-Synuclein and family members beta- and gamma-synuclein are presynaptic proteins that sense and

28 In addition, beta and gamma-synuclein are reported to aggregate less readily t

29 p53 and gamma-synuclein are two major regulators of cancer patho

30 curring synuclein isoforms (alpha, beta, and gamma-synuclein) are similarly effective inhibitors of P

31 Two homologous proteins, beta- and gamma-synucleins, are also abundant in the brain.

32 Our data reveal gamma-synuclein as a regulator of lipid handling in adip

33 cytes during glaucoma likely depends on this gamma-synuclein, as mice lacking gamma-synuclein fail to

34 beta- and gamma-synucleins, as well as the Parkinson's disease-ass

35 These findings demonstrate that gamma-synuclein can be involved in neuropathophysiologic

36 ons that drastically accelerate aggregation, gamma-synuclein can form fibrils with a lag phase roughl

37 Importantly, oxidized gamma-synuclein can initiate alpha-synuclein aggregation

38 e we show that another member of the family, gamma-synuclein, can be easily oxidized and form annular

39 We find that gamma-synuclein closely resembles alpha-synuclein in its

40 r data indicate that oncogenic activation of gamma-synuclein contributes to the development of breast

41 In breast cancer, increased expression of gamma-synuclein correlates with disease progression.

42 Most importantly, beta- and gamma-synuclein could not be cross-seeded with alpha-syn

43 gamma-Synuclein-deficient adipocytes also contain fewer

44 ains, using antibodies to alpha-, beta-, and gamma-synuclein, demonstrated many alpha-synuclein-posit

45 Consequently, overexpression of gamma-synuclein did not have any noticeable effect on th

46 We have found that gamma-synuclein-expressing cells are significantly more

47 nblastine is significantly down-regulated in gamma-synuclein-expressing cells, indicating that the pa

48 reason, we characterized alpha-, beta-, and gamma-synuclein expression in primary hippocampal neuron

49 nds on this gamma-synuclein, as mice lacking gamma-synuclein fail to up-regulate Mac-2 at the MTZ aft

50 The IC(50) of monomeric gamma-synuclein for the 20 S proteolysis was 400 nm.

51 er's disease, but beta-synuclein (betaS) and gamma-synuclein (gammaS) have not yet been implicated in

52 Further, beta-synuclein (betaS) and gamma-synuclein (gammaS) immunoreactivity was detected i

53 S)], as well as in various types of cancers [gamma-synuclein (gammaS)].

54 Although gamma-synuclein (gammaSyn) is 55% identical in sequence

55 Co-incubating beta-synuclein with gamma-synuclein had no effect on the inhibition of the 2

56 arkably, another member of this gene family, gamma-synuclein, has been shown to be overexpressed in b

57 Knockdown of gamma-synuclein in adipocytes causes redistribution of t

58 ata suggest that the functions of alpha- and gamma-synucleins in presynaptic terminals are not fully

59 d detected alpha-synuclein, but not beta- or gamma-synuclein, in glial cytoplasmic inclusions (GCIs)

60 of the synuclein family, beta-synuclein and gamma-synuclein, in the development and progression of n

61 ividually expressing mouse alpha-, beta-, or gamma-synuclein, indicating they are functionally redund

62 cal properties to alpha-synuclein, beta- And gamma-synucleins inhibit alpha-synuclein fibril formatio

63 In the current study, we have found that gamma-synuclein is associated with two major mitogen-act

64 Recently we and others have found that gamma-synuclein is dramatically up-regulated in the vast

65 gamma-Synuclein is highly expressed in human white adipo

66 Here we show that gamma-synuclein is nutritionally regulated in white adip

67 ted brain mitochondria of alpha-, beta-, and gamma-synuclein knock-out mice and monomeric alpha-synuc

68 hat brain mitochondria of alpha-, beta-, and gamma-synuclein knock-out mice are uncoupled, as charact

69 NK1), and have shown that over-expression of gamma-synuclein leads to constitutive activation of ERK1

70 a these independent but complementary roles, gamma-synuclein may coordinately modulate lipid storage

71 We hypothesize that gamma-synuclein may deliver SNAP-23 to the SNARE complex

72 Two amino acid residues in gamma-synuclein, methionine and tyrosine located in neig

73 determine if levels of alpha-, beta- and/or gamma-synuclein mRNAs are differentially affected in bra

74 e NMNAT2 mutant driven by RGC-specific mouse gamma-synuclein (mSncg) promoter restores decreased NAD(

75 , we present an RGC-specific promoter, mouse gamma-synuclein (mSncg) promoter, and perform extensive

76 d female mouse eyes and identified the mouse gamma-synuclein (mSncg) promoter, which specifically and

77 Compared with HFD-fed WT mice, HFD-fed gamma-synuclein-null mutant mice display increased lipol

78 We also tested the effects of gamma-synuclein on apoptosis and activation of JNK and E

79 xcess expression of the third family member, gamma-synuclein, on the nervous system we generated tran

80 be independent of the presence of beta- and gamma-synucleins or effects on presynaptic calcium and a

81 te-stage breast and ovarian cancers and that gamma-synuclein over-expression can enhance tumorigenici

82 astine, etoposide does not activate JNK, and gamma-synuclein over-expression has no apparent effect o

83 a suggest that post-translationally modified gamma-synuclein possesses prion-like properties and may

84 ein for nigral dopaminergic neurons, whereas gamma-synuclein proved to be nontoxic and had very low a

85 ese data, we hypothesize that the alpha- and gamma-synucleins regulate proteasomal function and that

86 rative effects induced by alpha-, beta-, and gamma-synuclein revealed that beta-synuclein was eventua

87 gamma-Synuclein secreted from neuronal cells into condit

88 Here, we assessed whether gamma-synuclein shares the ability of alpha-synuclein to

89 w that fresh solutions of alpha-, beta-, and gamma- synuclein show the same natively unfolded structu

90 Both beta and gamma-synuclein show less extensive transient long-range

91 However, gamma Synuclein (SNCG) is also highly associated with br

92 gamma synuclein (SNCG), previously identified as a breas

93 Taking advantage of the fact that gamma-synuclein (Sncg) mRNA is expressed specifically an

94 ms, Brn3b (Pou4f2), Brn3c (Pou4f3), Thy1 and gamma-synuclein (Sncg), and some other markers of neuron

95 asomal activities only weakly, but monomeric gamma-synuclein strongly inhibited ubiquitin-independent

96 rolase L1, rat ortholog of human DJ-1/Park7, gamma-synuclein, superoxide dismutase 1), anti-oxidant p

97 gamma-Synuclein (Syn G) is highly expressed in retinal g

98 oxidation plays a key role in the ability of gamma-synuclein to aggregate and seed the aggregation of

99 synuclein family members beta-synuclein and gamma-synuclein to DAT trafficking is not known.

100 -casein, recombinant human alpha-, beta- and gamma-synuclein, together with the A30P and A53T mutants

101 nsgenic mice expressing high levels of mouse gamma-synuclein under control of Thy-1 promoter.

102 , no fibrils could be detected for beta- and gamma-synuclein under the same conditions.

103 gamma-Synuclein, unlike its homologs, formed a soluble o

104 in the presynaptic terminal, whereas little gamma-synuclein was expressed at all.

105 n was of intermediate toxicity to yeast, and gamma-synuclein was non-toxic.

106 synaptic vesicles, the C-terminal domain of gamma-synuclein was not able to interact with synaptobre

107 ng brains of mice lacking alpha-, beta-, and gamma-synuclein, we report that extracellular monomeric

108 tion-related proteins, including Abeta42 and gamma-synuclein, we sought to determine whether latrepir

109 aggregation properties of alpha-, beta-, and gamma-synuclein were comparatively elucidated in the rat

110 were decreased in AD and DLBD, and levels of gamma-synuclein were increased in AD cases.

111 perties of a random coil, whereas alpha- and gamma-synucleins were slightly more compact and structur