ライフサイエンスコーパス: gamma-tubulin

1 x (gamma-TuC), consisting of GCP1-6 (GCP1 is gamma-tubulin).

2 rmed either spontaneously or by oligomers of gamma-tubulin.

3 GIT1 and gamma-tubulin complex proteins with gamma-tubulin.

4 CPAP) and the pericentriolar localization of gamma-tubulin.

5 tly as a polymerase or acts dependently with gamma-tubulin.

6 d dendrites, we examined the distribution of gamma-tubulin.

7 in-1 (BAP1) as a deubiquitination enzyme for gamma-tubulin.

8 play altered fractionation of beta-actin and gamma-tubulin.

9 tive complex and likely equimolar amounts of gamma-tubulin.

10 organizing centers with Aurora kinase A and gamma-tubulin.

11 taining gain- or loss-of-function alleles of gamma-tubulin.

12 the widespread microtubule nucleation factor gamma-Tubulin.

13 levels of the microtubule nucleation protein gamma-tubulin.

14 by promoting the centrosomal accumulation of gamma-tubulin.

15 to the centrosome independently of BARD1 and gamma-tubulin.

16 d that both arrestins directly interact with gamma-tubulin.

17 mains mediate longitudinal interactions with gamma-tubulin.

18 sequence" present in all alpha-, beta-, and gamma-tubulins.

19 y originate in the C-terminal regions of the gamma-tubulins.

20 ata indicate that in the face of predominant gamma-tubulin-1 expression, the accumulation of gamma-tu

21 Localization of gamma-tubulin-1 in mature neurons was confirmed by immun

22 ve RT-PCR and 2-dimensional-PAGE showed that gamma-tubulin-1 is the dominant isotype in fetal neurons

23 ma-tubulin-2 accumulates in the adult brain, gamma-tubulin-1 remains the major isotype in various bra

24 It is thought that gamma-tubulin-1 represents a ubiquitous isotype, whereas

25 f gamma-tubulin-2, whereas the expression of gamma-tubulin-1 was unchanged.

26 Although gamma-tubulin-2 accumulates in the adult brain, gamma-tu

27 ma-tubulin-1 expression, the accumulation of gamma-tubulin-2 in mature neurons and neuroblastoma cell

28 tive stress may denote a prosurvival role of gamma-tubulin-2 in neurons.

29 n-1 represents a ubiquitous isotype, whereas gamma-tubulin-2 is found predominantly in the brain, whe

30 l development and oxidative stress points to gamma-tubulin-2 prosurvival function.

31 rial inhibitors, resulted in upregulation of gamma-tubulin-2, whereas the expression of gamma-tubulin

32 MIN subunit3 (AUG3), a homolog of animal dim gamma-tubulin 3, plays a critical role in gamma-tubulin-

33 AUG3), which encodes a homolog of animal dim gamma-tubulin 3/human augmin-like complex, subunit 3, wa

34 nistically, NDRG1 physically associates with gamma-tubulin, a key component of the centrosome, with r

35 We report discrimination of human gamma-tubulins according to their electrophoretic and im

36 ntially decreases microtubule nucleation and gamma-tubulin accumulation at the centrosome.

37 n and Src promote microtubule nucleation and gamma-tubulin accumulation at the centrosome.

38 respective epitope showing immunolabeling of gamma-tubulin, actin, Golgi protein, and the transcripti

39 complex subunit in this tissue revealed that gamma-tubulin acts with NOCA-1 in parallel to Patronin/P

40 urgery altered the trafficking of alpha- and gamma-tubulin after fertilization.

41 A cold-sensitive gamma-tubulin allele of Aspergillus nidulans, mipAD159,

42 Nuclear gamma-tubulin also regulates S-phase progression by mode

43 Reduction of gamma-tubulin also rescued dendrite regeneration in back

44 eated from multiprotein complexes containing gamma-tubulin and associated gamma-tubulin complex prote

45 nd spindle formation rely on the activity of gamma-tubulin and associated proteins throughout the cel

46 Branching microtubule nucleation requires gamma-tubulin and augmin and is stimulated by factors pr

47 comets initiated at boutons, indicating that gamma-tubulin and augmin are required for activity-depen

48 that microtubule-nucleating proteins such as gamma-tubulin and CeGrip-1 that are centrosome component

49 s apically and have aberrant localization of gamma-tubulin and CeGrip-1.

50 We showed that MPK6 interacted with gamma-tubulin and co-sedimented with plant microtubules

51 This acentrosomal nucleation requires gamma-tubulin and CP309, the Drosophila homolog of AKAP4

52 ediated a novel interaction between p115 and gamma-tubulin and functioned in its centrosomal targetin

53 is mediated by complexes that are formed by gamma-tubulin and gamma-tubulin complex proteins.

54 Pk3 activity, cilia growth was inhibited and gamma-tubulin and Nedd1 no longer associated with the ba

55 We show that the microtubule regulators gamma-tubulin and NOCA-1 are recruited to hemidesmosomes

56 (gamma-TuSC), consisting of two molecules of gamma-tubulin and one copy each of the accessory protein

57 ex (gamma-TuSC) consists of two molecules of gamma-tubulin and one molecule each of Spc97 and Spc98.

58 ent processes in nucleation, one promoted by gamma-tubulin and one promoted by XMAP215.

59 ulin ring complex (gamma-TuRC) together with gamma-tubulin and other GCPs to regulate the assembly of

60 NEDD1 specifically co-localizes with gamma-tubulin and pericentrin at microtubule-organizing

61 iated with the MT-organizing center proteins gamma-tubulin and pericentrin, are major sites of muscle

62 on allele impairs centrosomal recruitment of gamma-tubulin and pericentrin, interferes with microtubu

63 tic mutant of BAP1 reduced ubiquitination of gamma-tubulin and prevented mitotic defects.

64 correlation between the expression levels of gamma-tubulin and RB1 and that in tumor cell lines with

65 so defective in spindle pole localization of gamma-tubulin and showed spindle assembly checkpoint (SA

66 crotubules are stabilized by the presence of gamma-tubulin and Spc72, a protein that tethers the gamm

67 gulation of Ran GTPase, serotransferrin, and gamma-tubulin and suppression of light-evoked electrophy

68 eral known molecules, including the template gamma-tubulin and the polymerase XMAP215.

69 inases regulate the cellular localization of gamma-tubulin and thereby control S-phase progression.

70 -tubulin complex in T. brucei is composed of gamma-tubulin and three GCP proteins, GCP2-GCP4, and is

71 ose gradients and that XCTK2 associated with gamma-tubulin and Xgrip109 by immunoprecipitation.

72 been made in understanding the functions of gamma-tubulin and, in particular, its role in microtubul

73 n of mature centrioles capable of recruiting gamma-Tubulin, and a nonphosphorylatable Cetn2 mutant ca

74 ry centrosomes had less centrosome-localized gamma-tubulin, and Plk1 blockade prevented MT growth, wh

75 First, gamma-tubulin appears to redistribute directly from the

76 Alpha-, beta-, and gamma-tubulin are conserved in all eukaryotes.

77 gamma-Tubulins are highly conserved members of the tubul

78 We discovered that Arpc1b colocalizes with gamma-tubulin at centrosomes and stimulates Aurora A act

79 ndle stability was associated with decreased gamma-tubulin at MTOCs in NEDD1-depleted oocytes, as wel

80 lexes (gammaTuSCs) comprise two molecules of gamma-tubulin bound to the C-terminal domains of GCP2 an

81 xpression of a non-phosphorylatable Ala(385)-gamma-tubulin but were enhanced by expression of SadB, w

82 the BRCA1/BARD1-dependent ubiquitination of gamma-tubulin causes centrosome amplification.

83 Here we report that GRK5 co-localizes with gamma-tubulin, centrin, and pericentrin in centrosomes.

84 In the germline, NOCA-1 and gamma-tubulin co-localize at the cell surface, and inhib

85 hich forms a complex with GCP2-GCP6 (GCP for gamma -Tubulin Complex Protein).

86 The multisubunit gamma-tubulin complex (gamma-TuC) is critical for microt

87 nctions as a multiprotein complex called the gamma-tubulin complex (gamma-TuC), consisting of GCP1-6

88 Microtubule (MT) nucleation depends on the gamma-tubulin complex (gamma-TuC), in which multiple cop

89 to1/2 complex, which binds and activates the gamma-tubulin complex and also recruits the gamma-tubuli

90 o1/2 complex stability, interaction with the gamma-tubulin complex and microtubule nucleation activit

91 suggest that Spc110 facilitates higher-order gamma-tubulin complex assembly.

92 gamma-Tubulin complex constitutes a key component of the

93 Here we report that the gamma-tubulin complex in T. brucei is composed of gamma-

94 ogether, these results identified an unusual gamma-tubulin complex in T. brucei, uncovered an essenti

95 ytokinesis defects, suggesting a role of the gamma-tubulin complex in the regulation of cytokinesis.

96 To date, it has been enigmatic how the gamma-tubulin complex is recruited to the sidewall of co

97 show that during mitosis GIPs play a role in gamma-tubulin complex localization, spindle stability an

98 To date, the molecular mechanisms modulating gamma-tubulin complex location remain largely unknown.

99 Microtubule nucleation by the gamma-tubulin complex occurs primarily at centrosomes, b

100 The conserved gamma-tubulin complex organizes spindle and astral micro

101 mplex (gammaTuSC) composed of gamma-tubulin, gamma-tubulin complex protein (GCP)2 and GCP3, whereas a

102 c.997C>T [p.Arg333Cys]) in TUBGCP2, encoding gamma-tubulin complex protein 2 (GCP2), in two individua

103 plex with Alp6, a fission yeast homologue of gamma-tubulin complex protein 3 (GCP3).

104 investigate the role of the highly conserved gamma-tubulin complex protein 3-interacting proteins (GI

105 TUBGCP4 encodes gamma-tubulin complex protein 4, a component belonging t

106 ocations marked by green fluorescent protein-gamma-tubulin complex protein2-tagged gamma-nucleation c

107 distribution pattern, similar to that of the gamma-tubulin complex protein2.

108 abidopsis thaliana proteins interacting with gamma-tubulin complex protein3 (GCP3), GCP3-interacting

109 le from those of the AUG1-7 subunits and the gamma-tubulin complex proteins (GCPs) that exhibit biase

110 exes containing gamma-tubulin and associated gamma-tubulin complex proteins (GCPs).

111 s and stimulates the association of GIT1 and gamma-tubulin complex proteins with gamma-tubulin.

112 mplexes that are formed by gamma-tubulin and gamma-tubulin complex proteins.

113 Budding yeast Spc110, a member of gamma-tubulin complex receptor family (gamma-TuCR), recr

114 s of spindle MTOCs distribution, that is the gamma-tubulin complex receptor Spc72 and the protein Kar

115 amma-tubulin small complex (gamma-TuSC), and gamma-tubulin complex receptors (gamma-TuCRs) Spc72 and

116 TOC sites has been proposed as a key step in gamma-tubulin complex recruitment and MTOC formation, bu

117 n Trypanosoma brucei, the composition of the gamma-tubulin complex remains elusive, and it is not kno

118 Controlled degradation of a gamma-tubulin complex subunit in this tissue revealed th

119 ns of MOZART1/Mzt1 through interactions with gamma-tubulin complex subunits and gamma-TuCRs.

120 ) as an additional member of the BRCA1/BARD1/gamma-tubulin complex that is critically involved in cen

121 gamma-tubulin complex and also recruits the gamma-tubulin complex to both centrosomal (spindle pole

122 e augmin complex functions in recruiting the gamma-tubulin complex to cortical MTs and initiating MT

123 T)-dependent MT nucleation by recruiting the gamma-tubulin complex to MT walls to generate new MTs [1

124 The Spc110 C terminus links the gamma-tubulin complex to the central plaque of the SPB b

125 ubulin and Spc72, a protein that tethers the gamma-tubulin complex to the spindle pole body.

126 icentrin, Spc110, binds to and activates the gamma-tubulin complex via its N terminus, allowing nucle

127 complex overwhelmingly colocalized with the gamma-tubulin complex.

128 ch localizes to MTOCs and interacts with the gamma-tubulin complex.

129 confirmed this finding for Spc72 and for the gamma-tubulin complex.

130 gamma-Tubulin complexes are essential for microtubule (M

131 In contrast, Nedd1-gamma-tubulin complexes did not promote nucleation but w

132 n has been determined, and the components of gamma-tubulin complexes have been identified.

133 Although gamma-tubulin complexes have primarily been implicated i

134 The probability of nucleation from gamma-tubulin complexes localized at the cell cortex was

135 ively, our studies demonstrate that distinct gamma-tubulin complexes regulate different microtubule b

136 ulin on Ser(385) formed chromatin-associated gamma-tubulin complexes that moderate gene expression.

137 mplex receptor family (gamma-TuCR), recruits gamma-tubulin complexes to microtubule (MT) organizing c

138 RT1/Mzt1 is required for the localization of gamma-tubulin complexes to microtubule (MT)-organizing c

139 Nucleation-competent CDK5RAP2-gamma-tubulin complexes were maintained at centrosomes u

140 le exit specifically triggered loss of Nedd1-gamma-tubulin complexes, providing a mechanistic link co

141 Microtubules are nucleated in vivo by gamma-tubulin complexes.

142 The bulk of CMTs are initiated from gamma-tubulin-containing nucleation complexes localized

143 by the composition, position and dynamics of gamma-tubulin-containing nucleation complexes, which rep

144 ogue of the APC/C activator protein Cdh1, in gamma-tubulin-dependent inactivation of the APC/C.

145 im gamma-tubulin 3, plays a critical role in gamma-tubulin-dependent MT nucleation and amplification

146 tion of neuronal activity, and we found that gamma-tubulin-dependent presynaptic MT nucleation contro

147 l proteins, including Pericentrin, Pcm1, and gamma-tubulin, depends on Nesprin-1, an outer nuclear me

148 -body components, provokes misrecruitment of gamma-tubulin, disorganization of this microtubule frame

149 l polo-like kinase 1 signaling underlies the gamma-tubulin distribution defects observed with Gravin

150 red for normal spindle pole organization and gamma-tubulin distribution.

151 ins co-localized with the centrosomal marker gamma-tubulin during interphase and mitosis and were fou

152 accumulation and asymmetric distribution of gamma-tubulin during mitosis.

153 Reducing levels of gamma-tubulin exacerbated long-term degeneration induced

154 at gamma-tubulin mutations or alterations of gamma-tubulin expression play an important role in certa

155 Silencing of gamma-tubulin expression reduced presynaptic MT nucleati

156 Second, gamma-tubulin fails to accumulate apically in wild-type

157 Moreover, in activated BMMCs, gamma-tubulin formed complexes with tyrosine-phosphoryla

158 c siRNA injection caused the dissociation of gamma-tubulin from the spindle poles, resulting in sever

159 gamma-Tubulin functions as a multiprotein complex called

160 Thus, gamma-tubulin functions to regulate this key mitotic and

161 ubulin small complex (gammaTuSC) composed of gamma-tubulin, gamma-tubulin complex protein (GCP)2 and

162 fusions have shown that GIPs colocalize with gamma-tubulin, GCP3, and/or GCP4 and reorganize from the

163 Humans possess 2 gamma-tubulin genes.

164 enters (MTOCs) and coimmunoprecipitates with gamma-tubulin Gtb1 from cell extracts.

165 The structure of gamma-tubulin has been determined, and the components of

166 At the same time, data have accumulated that gamma-tubulin has important but less well understood fun

167 ubules and interacts with alpha-, beta-, and gamma-tubulin, heat shock proteins 70 and 90 (HSP-70; HS

168 sDAPs alter the distal border of centrosomal gamma-tubulins, illustrating a new role of sDAPs.

169 indispensable component for the function of gamma -tubulin in MT nucleation and organization in plan

170 We found that GCP4 was associated with gamma -tubulin in vivo in Arabidopsis thaliana.

171 In our efforts to understand the role of gamma-tubulin in cell cycle regulation, we have created

172 We found that Arl4D colocalized with gamma-tubulin in centrosomes and the depletion of Arl4D

173 The aug7-1 mutation caused delocalization of gamma-tubulin in the mitotic spindle and phragmoplast.

174 etion spread its localization beyond that of gamma-tubulin, indicating an MT-dependent regulation of

175 , in bone marrow-derived mast cells (BMMCs), gamma-tubulin interacts with p21-activated kinase intera

176 metric architecture, the gamma-TuRC arranges gamma-tubulins into a helical geometry poised to nucleat

177 gamma-Tubulin is an important cell division regulator th

178 evolutionarily conserved Cdk1 site (S360) in gamma-tubulin is correlated with the number and organiza

179 The mechanism that regulates localization of gamma-tubulin is currently unknown.

180 Moreover, we show that binding to gamma-tubulin is not essential for integrating into the

181 Microtubule (MT)-dependent MT nucleation by gamma-tubulin is required for interphase plant cells to

182 the purported functional differences between gamma-tubulins is unknown.

183 Differential expression of human gamma-tubulin isotypes during neuronal development and o

184 tibodies that can discriminate between human gamma-tubulin isotypes.

185 se each gamma-TuSC contains two molecules of gamma-tubulin, it was assumed that the gamma-TuRC-specif

186 h, whereas overexpression rescued centrosome gamma-tubulin levels and centrosome dynamics.

187 We show that gamma-tubulin localises asymmetrically to the somatic Go

188 we show that loss of B1 enhanced centrosomal gamma-tubulin localization and microtubule nucleation.

189 We examined gamma-tubulin localization and microtubule regrowth afte

190 To explore whether microtubule nucleation by gamma-tubulin might contribute to polarity, we analyzed

191 , gamma-TuSCs oligomerize into spirals of 13 gamma-tubulin molecules per turn.

192 anchoring of MTs required the same number of gamma-tubulin molecules.

193 ma-TuSCs with approximately three additional gamma-tubulin molecules.

194 icrotubules and followed similar dynamics to gamma-tubulin, moving from poles to midzone during the a

195 gamma-tubulin, or a phosphomimetic Asp(385)-gamma-tubulin mutant.

196 A gamma-tubulin mutation in Aspergillus nidulans, mipA-D15

197 Finally, the gamma-tubulin mutation mipAD159 causes a nuclear-specifi

198 Finally, evidence is emerging that gamma-tubulin mutations or alterations of gamma-tubulin

199 These centrioles can neither recruit gamma-tubulin nor nucleate microtubules when eggs are in

200 Cytosolic gamma-tubulin nucleates alpha- and beta-tubulin in a gro

201 r that polymerizes to form microtubules, and gamma-tubulin nucleates microtubules as a component of t

202 f seven gamma-TuSCs with a slight surplus of gamma-tubulin nucleates MTs in vivo.

203 We show that the gamma-tubulin nucleation complex (gammaTC) favors the ol

204 ated Spc72, the cytoplasmic receptor for the gamma-tubulin nucleation complex, as the most upstream d

205 found that SadB-mediated phosphorylation of gamma-tubulin on Ser(385) formed chromatin-associated ga

206 the active form of MAP kinase interacts with gamma-tubulin on specific subsets of mitotic microtubule

207 , compromises the localization of augmin and gamma-tubulin on the spindle and phragmoplast MT arrays

208 Depletion of either gamma-tubulin or XMAP215 was partially rescued by adding

209 re enhanced by expression of SadB, wild-type gamma-tubulin, or a phosphomimetic Asp(385)-gamma-tubuli

210 ic reconstruction of the filament reveals 13 gamma-tubulins per turn, matching microtubule symmetry,

211 ion led to loss of PCM components, including gamma-tubulin, pericentrin, and Cdk5Rap2, with centrosom

212 pericentriolar proteins to MTNCs, including gamma-tubulin, pericentrin, Cep68, Cep170, and Cdk5RAP2.

213 gamma-Tubulin plays a universal role in microtubule nucl

214 on to the spindle pole body, and, thus, that gamma-tubulin plays an important role in inactivating AP

215 dies specific for cilia (acetylated tubulin, gamma-tubulin, polycystin [PC] 1, PC2, and KIF3A), fibro

216 Finally, we show that XMAP215 and gamma-tubulin promote alphabeta-tubulin assembly in an a

217 anced level of free cytosolic Ca(2+) affects gamma-tubulin properties and stimulates the association

218 ines with a nonfunctioning RB1, reduction of gamma-tubulin protein levels leads to induction of apopt

219 Simultaneous reduction of RB1 and gamma-tubulin protein levels results in an E2F1-dependen

220 Here, we describe that RB1 and gamma-tubulin proteins moderate each other's expression

221 Binding of the gamma-tubulin receptor Spc110 to the central plaque from

222 1 binds to the scaffold-protein Nud1 and the gamma-tubulin receptor Spc72.

223 covers a new role for Gravin in coordinating gamma-tubulin recruitment during mitosis and illuminates

224 aphase and anaphase, leading to disorganized gamma-tubulin recruitment in centrosomes.

225 impaired both the Augmin-MT interaction and gamma-tubulin recruitment to the spindles, thus resultin

226 ts in mislocalized Plk1 and poor centrosomal gamma-tubulin recruitment, potentially contributing to m

227 Complexes of Mto2 and Mto1 with gamma-tubulin regulate microtubule assembly.

228 In this way, the C-terminal region of gamma-tubulin regulates S-phase progression.

229 out of dendrites with an activated kinesin, gamma-tubulin remained in dendrites.

230 plex protein 4, a component belonging to the gamma-tubulin ring complex (gamma-TuRC) and known to reg

231 ein-dependent manner and interacted with the gamma-tubulin ring complex (gamma-TuRC) and the centriol

232 iates interactions with proteins of both the gamma-tubulin ring complex (gamma-TuRC) and the gamma-tu

233 While the MT nucleator, gamma-tubulin ring complex (gamma-TuRC) has been identif

234 The gamma-tubulin ring complex (gamma-TuRC) is an essential

235 ing MT nucleation pathway envisages that the gamma-tubulin ring complex (gamma-TuRC) is recruited to

236 fission yeast, the kinesin-14 Pkl1 binds the gamma-tubulin ring complex (gamma-TuRC) microtubule-orga

237 ted that Cdc2-dependent phosphorylation on a gamma-tubulin ring complex (gamma-TuRC) recruitment prot

238 GCP2 forms the multiprotein gamma-tubulin ring complex (gamma-TuRC) together with ga

239 chondrial surface, recruits the MT nucleator gamma-tubulin ring complex (gamma-TuRC), and is sufficie

240 requires many identified components, such as gamma-tubulin ring complex (gamma-TuRC), components of t

241 found that besides the microtubule nucleator gamma-tubulin ring complex (gamma-TuRC), the branching e

242 ly by correctly localising the MT nucleator, gamma-Tubulin Ring Complex (gamma-TuRC), within the cell

243 crotubules (MTs), which are nucleated by the gamma-tubulin ring complex (gamma-TuRC).

244 (GCP)2 and GCP3, whereas animals contain the gamma-tubulin ring complex (gammaTuRC) composed of gamma

245 The gamma-tubulin ring complex (gammaTuRC) is a microtubule

246 The gamma-tubulin ring complex (gammaTuRC) is the major micr

247 In vivo, MT nucleation is controlled by the gamma-tubulin ring complex (gammaTuRC), a 2.1-MDa comple

248 5, and 6) to form the core of the so-called gamma-tubulin ring complex (gammaTuRC).

249 letion in human cells destabilizes the large gamma-tubulin ring complex and abolishes CEP215(CM1)-ind

250 ogress in understanding the structure of the gamma-tubulin ring complex and its components has led to

251 ues to generate the attachment sites for the gamma-tubulin ring complex and, possibly, other pericent

252 me and functions in the stabilization of the gamma-tubulin ring complex assembly.

253 unterpart, MAP20 does not cooperate with the gamma-tubulin ring complex in microtubule nucleation.

254 , phragmoplast, and cortical arrays when the gamma-tubulin ring complex is anchored and activated by

255 FAM190A was localized to the gamma-tubulin ring complex of early mitosis and to the m

256 process that is templated in the cell by the gamma-tubulin ring complex or by preexisting microtubule

257 protein2-tagged gamma-nucleation complexes (gamma-tubulin ring complex), therefore indicating that a

258 Microtubule nucleation requires the gamma-tubulin ring complex, and during the M-phase (mito

259 nucleates microtubules as a component of the gamma-tubulin ring complex.

260 otic spindle formation as a component of the gamma-tubulin ring complex.

261 ed by a noncanonical mechanism not involving gamma-tubulin ring complex.

262 to form a ring-like structure (in metazoans, gamma-tubulin ring complex; gamma-TuRC) [1-7].

263 tion of microtubules arises from distributed gamma-tubulin ring complexes (gamma-TuRCs) at the cell c

264 Microtubules are nucleated and anchored by gamma-tubulin ring complexes (gamma-TuRCs) embedded with

265 Mukherjee and Conduit introduce gamma-tubulin ring complexes (gamma-TuRCs), multi-protei

266 amma-TuSCs assemble with other proteins into gamma-tubulin ring complexes (gamma-TuRCs).

267 bule nucleation within cells is catalyzed by gamma-tubulin ring complexes localized at specific micro

268 ET and Xenopus XCTK2 cofractionated with the gamma-tubulin ring complexes on sucrose gradients and th

269 In mitotic cells, it was observed that the gamma -tubulin signal associated with the mitotic spindl

270 Thus, the RB1/gamma-tubulin signal network can be considered as a new

271 hich multiple copies of the heterotetrameric gamma-tubulin small complex (gamma-TuSC) associate to fo

272 The gamma-tubulin small complex (gamma-TuSC) consists of two

273 , we reconstituted the interactions of Mzt1, gamma-tubulin small complex (gamma-TuSC), and gamma-tubu

274 The 300-kDa gamma-tubulin small complex (gamma-TuSC), consisting of

275 TUB4) encoding the evolutionarily conserved gamma-tubulin small complex (gamma-TuSC), which nucleate

276 ma-tubulin ring complex (gamma-TuRC) and the gamma-tubulin small complex (gamma-TuSC).

277 ere that budding yeast CK1delta, Hrr25, is a gamma-tubulin small complex (gammaTuSC) binding factor.

278 nt organisms: the budding yeast contains the gamma-tubulin small complex (gammaTuSC) composed of gamm

279 x (gammaTuRC), a 2.1-MDa complex composed of gamma-tubulin small complex (gammaTuSC) subunits.

280 ltimers act to multimerize the fission yeast gamma-tubulin small complex and that multimerization of

281 ab11 increases astral microtubules, restores gamma-tubulin spindle pole localization, and generates r

282 Shot/Patronin foci do not co-localize with gamma-tubulin, suggesting that they do not nucleate new

283 gamma-tubulin targets independently of NOCA-1, but NOCA-

284 ty in the epidermis to identify two pools of gamma-tubulin that are biochemically and functionally di

285 Both increased and decreased activity of gamma-tubulin, the core microtubule nucleation protein,

286 s but was rescued by concurrent reduction of gamma-tubulin, the core microtubule nucleation protein.

287 The posttranslational modification of gamma-tubulin through ubiquitination is vital for regula

288 lusory Clb3-Cdk1-specific phosphorylation of gamma-tubulin, thus establishing the timing of this even

289 These results show that NOCA-1 acts with gamma-tubulin to assemble non-centrosomal arrays in mult

290 A1-BARD1 heterodimer binds and ubiquitinates gamma-tubulin to inhibit centrosome amplification and pr

291 iolar material, specifically pericentrin and gamma-tubulin, to the centrosome.

292 y, mutation of one conserved Cdk site within gamma-tubulin (Tub4-S360D) caused mitotic delay and aber

293 Genes encoding alpha-, beta, and gamma-tubulins (TUBAs, TUBBs, and TUBGs), but not delta-

294 recovery after photobleaching analysis that gamma-tubulin was stably integrated into MT nucleation s

295 In addition, chromatin levels of gamma-tubulin were decreased by the reduction of SadB le

296 with local nucleation, tagged and endogenous gamma-tubulins were found in specific positions in dendr

297 tly of NOCA-1, but NOCA-1 targeting requires gamma-tubulin when a non-essential putatively palmitoyla

298 pend on the evolutionarily conserved protein gamma -tubulin, which forms a complex with GCP2-GCP6 (GC

299 ism for BAP1 involved in deubiquitination of gamma-tubulin, which is required to prevent abnormal mit

300 ectron microscopy revealed an association of gamma-tubulins with mitochondrial membranes.