ライフサイエンスコーパス: gap junction

1 h chemical synapses and electrical synapses (gap junctions).

2 abolish the CO(2) -dependent closing of the gap junction.

3 he DG, such as PARK7, RACK1, and connexin 31/gap junction.

4 electrotonic neuronal coupling by actions on gap junctions.

5 the central canal (CC) that are coupled via gap junctions.

6 synapses containing silent but ready-to-use gap junctions.

7 or the combination of chemical synapses and gap junctions.

8 spikelets and dendro-dendritic or axo-axonal gap junctions.

9 pled to surrounding oligodendrocytes through gap junctions.

10 ng is amplified in neighboring cells through gap junctions.

11 ted neurons reveal that they are coupled via gap junctions.

12 gesting that the dye-coupling is mediated by gap junctions.

13 ommunication of cardiac muscle cells through gap junctions.

14 dock further between adjacent cells to form gap junctions.

15 rically coupled at the intercalated discs by gap junctions.

16 zed that VLDL can modulate and reduce atrial gap junctions.

17 t uninfected cells through contact dependent gap junctions.

18 erate increase in PCO2 (55 mmHg) closes Cx26 gap junctions.

19 connexin43, suggesting a role for connexin43 gap junctions.

20 xternal receptors or intracellularly through GAP junctions.

21 duced Ca(2+) release and propagation through gap junctions.

22 0%) but had no effect on Cx26(K125R) or Cx31 gap junctions.

23 ue (NBDG) between HeLa cells coupled by Cx26 gap junctions.

24 (25-35) causes rapid internalization of Cx43 gap junctions.

25 ular processes by which Abeta can alter Cx43 gap junctions.

26 e we investigate the action of CO(2) on Cx26 gap junctions.

27 The cellular basis of these synapses is the gap junction, a group of intercellular channels that med

28 p junction loci, which suggests targeting of gap junction activity as a preventive strategy for obesi

29 Gap junctions also propagate innate and adaptive antivir

30 This corrected both gap junction and hemichannel activity.

31 rom cortex and thalamus, as well their local gap junction and inhibitory synaptic connections reveals

32 cal synapses are the functional correlate of gap junctions and allow transmission of small molecules

33 ears, deciphering the links among connexins, gap junctions and cancer, researchers are now beginning

34 solution connectomics strategies to identify gap junctions and cellular partnerships.

35 Gap junctions and connexin hemichannels are key regulato

36 In conclusion, MetS-VLDL modulates gap junctions and delays both atrial and ventricular con

37 The opposing actions of CO(2) on Cx26 gap junctions and hemichannels thus depend on the same r

38 Learning experience weakens the gap junctions and induces a repulsive sensory response t

39 a JNK antagonist was sufficient to maintain gap junctions and prevent asynchronous contraction of ca

40 rus into mice leads to the redistribution of gap junctions and promotes ventricular tachycardia, show

41 and tracer permeability rule out coupling by gap junctions and purinoceptors.

42 of the AWC(ON) subtype is established using gap junctions and SLO BK potassium channels to repress a

43 hows that purified CALHM2 channels form both gap junctions and undecameric hemichannels.

44 ission, persisted during partial blockade of gap junctions and were mediated, in part, by AMPAergic t

45 e connexin, innexin and pannexin, which form gap junctions and/or bona fide cell surface channels.

46 IP(3) receptor, gap junction, and mechanosensitive calcium channel TRPC1

47 distinct functional channels: hemichannels, gap junctions, and endoplasmic reticulum (ER) Ca(2+) cha

48 region adjacent to but not overlapping with gap junctions, and forms puncta before the clusters of g

49 and the signal can be mediated by ATP and/or gap junctions, and is species dependent.

50 beta-cells propagates to the delta-cells via gap junctions, and the consequential stimulation of soma

51 le function, reduced total Cx43, and reduced gap junctions, and they died suddenly at 2 to 4 weeks of

52 ependent and CO(2) -dependent closure of the gap junction are thus mechanistically independent.

53 Gap junctions are arrays of intercellular channels forme

54 CE STATEMENT Electrical synapses mediated by gap junctions are fundamental components of neural netwo

55 Gap junctions are intercellular channels that allow dire

56 Gap junctions are intercellular conduits that permit the

57 Gap junctions are present in most tissues and play essen

58 erens junctions; neither tight junctions nor gap junctions are present.

59 Gap junctions are prominent synaptic components of ON CB

60 Gap junctions are ubiquitous in metazoans and play criti

61 Gap junctions are ubiquitous throughout the nervous syst

62 We investigated connexin-assembled gap junctions as an alternative route for discharging la

63 gnals (1) does not require the rod-cone Cx36 gap junctions as has been proposed in the past; and (2)

64 signals do not require the rod-to-cone Cx36 gap junctions as proposed in the past, but rather, can b

65 connexin 32 (Cx32), the predominant hepatic gap junction, as a critical regulator of spreading cGAS-

66 lar pool of Cx43 with a parallel decrease in gap junction assembly at the surface.

67 1)-mediated phosphorylation of Cx43 promotes gap junction assembly.

68 onnexin 30 (Cx30) promoted formation of Cx30 gap junctions at points of contacts between adjacent non

69 rin and connexin-43 in adherens junction and gap junction between pericytes and ECs are downregulated

70 Thus, in a sparsely connected network, gap junctions between a small subset of cells can, throu

71 odulation of electrical coupling through the gap junctions between inferior olive neurons by inhibito

72 and the formation of connexin 43-containing gap junctions between monocytes and DCs.

73 ductance, largely reduced sensitivity to the gap junction blocker meclofenamic acid and loss of dye c

74 ifferent coupling conditions: carbenoxolone (gap junctions blocker), control, and picrotoxin (GABA-A

75 extracellular ATP and were inhibited by the gap junction blockers 1-octanol and carbenoxolone.

76 is bound is the closed configuration for the gap junction but the open state for the hemichannel.

77 te without chemical synaptic transmission or gap junctions, but can generate electric fields which in

78 We identify how gap junctions can amplify spatial variations in cell vol

79 exin 43 (Cx43), one of the major proteins of gap junctions, can adversely impact myocardial cell beha

80 ng cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophages have a negative resti

81 kin-Huxley equations and a 36-state model of gap junction channel gating to simulate electrical signa

82 We isolated gap junction channel mutants that reduce coupling betwee

83 evel of connexin43 (Cx43), a protein forming gap junction channels and hemichannels associated with d

84 ons, and forms puncta before the clusters of gap junction channels appear on the membrane.

85 KEY POINTS: Gap junction channels are essential for the formation an

86 only a few defined molecules passing through gap junction channels have been linked to specific funct

87 Gap junction channels made of different connexins have d

88 It forms gap junction channels that act as electrical synapses.

89 43-A44V and Cx43-E227D all formed functional gap junction channels with the same efficiency as wild-t

90 electrical synapses, composed of plaques of gap junction channels, continuously transmit signals tha

91 results suggest that in addition to forming gap junction channels, Cx50 acts as an adhesive molecule

92 endently inhibit Cx26-Asp50Asn expression in gap junction channels, reverting the dominant negative e

93 r to connexins, but do not form cell-to-cell gap junction channels.

94 hes plays a critical role in the assembly of gap junction channels.

95 ness in humans, which are knock-outs for the gap-junction channels connexin 26 and connexin 30 genes,

96 vide a tool for similar exploration of other gap junction circuits.

97 n M151L, also abolished the CO(2) -dependent gap junction closure.

98 This cell line displayed impaired gap junction communication and hyperactive hemichannels,

99 ectural stability, structure and function of gap junction communication channels.

100 genic differentiation and connexin 43 (CX43) gap junction communication in cultured pluripotent cells

101 dings reveal that soluble Si stimulates Cx43 gap junction communication in hDFC and induces gene expr

102 cantly increased CX43 protein expression and gap junction communication in hDFC.

103 pontaneous activity, cadherin expression and gap junction communication.

104 ns (TJ), adherens junctions, desmosomes, and gap junction complexes.

105 in astrocyte-like glia and in changes in the gap-junction component innexin2 in cortex glia.

106 d how metabolites mobilize through astrocyte gap junctions composed of connexin 43 (Cx43).

107 Gap junctions composed of connexin36 (Cx36) electrically

108 Gap junctions comprise arrays of intercellular channels

109 strated that elevated CO(2) reduced the Cx26 gap junction conductance (median reduction 66.7%, 95% CI

110 In HF-AS, enhancing gap junction conductance (with rotigaptide) increased co

111 nge in PCO2 caused a median reduction in the gap junction conductance of 41.7% (95% CI, 26.6-53.7%).

112 tifying potassium current (IK1) density, and gap junction conductance.

113 osphorylation events consistent with altered gap junction conductance.

114 tis elegans The molecular composition of the gap junctions connecting RMG hub neurons with sensory sp

115 ially provide cell-to-cell coupling when the gap junction connection is absent.

116 also demonstrated lowered expression of the gap junction connexin 43.

117 hannel functions, which differs from another gap junction, connexin 43 (Cx43), during skin wound heal

118 In contrast to gap junctions, connexin hemichannels become particularly

119 Gap junctions contain intercellular channels that enable

120 tive high-frequency hearing, suggesting that gap junctions contribute to passive cochlear mechanics a

121 Gap junctions control the intercellular exchange of crit

122 By doing so, gap junctions control virtually all aspects of the hepat

123 ub-and-spoke circuit of neurons connected by gap junctions controls aggregation behavior and related

124 ell-autonomous intrinsic light responses and gap junction coupling among ipRGCs contribute to the pro

125 Ca(2+) and Na(+) signalling, K(+) buffering, gap junction coupling and metabolism.

126 ne proteins, restored Abeta-induced impaired gap junction coupling between astrocytes.

127 suggesting that NMDA receptor modulation of gap junction coupling between these cells involves the G

128 ells identified a novel mechanism to improve gap junction coupling by pharmaceutically targeting Cx43

129 2-PAA stimulated cAMP synthesis and enhanced gap junction coupling in a concentration-dependent manne

130 cal link between adenosine receptors and the gap junction coupling in endothelial cells of the blood-

131 The increase in gap junction coupling in the adult CC was paralleled by

132 adenosine receptor subtype A2B increases the gap junction coupling in the human blood-brain barrier e

133 Although the increased gap junction coupling is cAMP-dependent, neither the pro

134 tions in Cx43 localization and reductions in gap junction coupling occur in failing hearts, contribut

135 y of energy substrates by reducing astrocyte gap junction coupling with dominant negative connexin 43

136 We show that Abeta(25-35) impairs functional gap junction coupling yet increases hemichannel activity

137 ne in the coordination of [Ca(2+)] dynamics, gap junction coupling, and insulin secretion dynamics wi

138 It is shown how reduced IK1 density and gap junction coupling, as observed in heart failure, inc

139 mixing of cell types is mediated in part by gap junction coupling.

140 as an alternative or supporting mechanism to gap junction coupling.

141 a(2+) influx, which leads to the increase in gap junction coupling.

142 suppressed the 2-PAA-related enhancement of gap junction coupling.

143 not affect the 2-PAA-related enhancement of gap junction coupling.

144 red a suppression of alpha-cell activity via gap junction-dependent activation of delta-cells.

145 We conclude that gap junction-dependent NDRG1 regulation might explain so

146 TraA clusters, which resemble eukaryotic gap junctions, direct the robust exchange of cellular go

147 beled putative MC dendrites further revealed gap junctions distributed uniformly along the apical den

148 cogen, interstitial fibrosis, and myocardial gap junction distribution.

149 ctivity ([Ca(2+)]) and insulin secretion via gap-junction electrical coupling.

150 In each case, we modulated gap-junction electrical coupling.

151 Gap junctions establish direct pathways for cells to tra

152 ns are disrupted by manipulating cadherin or gap junction expression.

153 es of intercellular communication, involving gap junctions, extracellular vesicles, and tunneling nan

154 ap junctions, we show that modulation of the gap junctions facilitates olfactory learning.

155 Vertebrates have 2 gap junction families: pannexins (Panxs) and connexins (

156 -out, indicated that lactate anions permeate gap junctions faster than highly-buffered H(+) ions.

157 t integrates native cellular behavior (e.g., gap junction formation and biosignal processing) with no

158 connexin family of membrane proteins enable gap junction formation and homeostasis, supporting commu

159 These interactions regulate Cx43 and gap junction formation and stability.

160 ing protein nlr-1/CASPR in the regulation of gap junction formation in multiple tissues across differ

161 to actin to recruit F-actin networks at the gap junction formation plaque, and the formation of F-ac

162 lr-1/CASPR acts as an early stage signal for gap junction formation through anchoring of F-actin netw

163 le about the molecular mechanisms underlying gap junction formation.

164 ring mechanistic predictions for synapse and gap junction formation.

165 netic identity of neurons guides synapse and gap-junction formation and show that such genetically dr

166 tion of selective glial networks mediated by gap junctions formed by members of the connexin family.

167 However, the majority of gap junctions formed by ON CBCs unexpectedly occur betwe

168 apses in zebrafish, Danio rerio, require two gap-junction-forming Connexins for formation and functio

169 We identify gap-junction-forming innexin proteins as critical.

170 causes only hearing loss, exhibited impaired gap junction function and showed no transdominant intera

171 These findings reveal specific targeting of gap junction function by Ad5 leading to loss of intercel

172 Loss of gap junction function occurs prior to reduced Cx43 prote

173 Gap junction (GJ) channels permit molecules, such as ion

174 is coordinated by soluble factors, exosomes, gap junction (GJ) channels, and the recently described t

175 Gap junction (GJ) channels, formed of connexin (Cx) prot

176 role of zonula occludens-1 protein (ZO-1) in gap junction (GJ) function, we generated and analyzed a

177 impulses, a function mainly accomplished by gap junctions (GJ) composed of Cx43 (connexin 43).

178 tion of adherens junctions, tight junctions, gap junctions (GJ), and desmosomes.

179 In the retina, diverse functions of neuronal gap junctions (GJs) have been established.

180 ells, and presents as hemichannels (HCs) and gap junctions (GJs) on the cell membrane.

181 ion, specifically via connexin (Cx)-mediated gap junctions (GJs), play a key role in the long-term su

182 Gap junctions (GJs), which are proteinaceous channels, c

183 gap junctional protein innexin shaking-B to gap junctions (GJs).

184 synchronization of myometrial cells through gap junctions (GJs).

185 ntermembrane spacing at ID sites adjacent to gap junctions (GJs; 64 +/- 9 nm versus 17 +/- 1 nm in co

186 nclear, altered distribution and function of gap junctions have been associated with acute myocardial

187 This is particularly relevant given that gap junctions have been implicated in tumor suppression.

188 bility and intercellular channel activity of gap junctions; however, the molecular basis for these ef

189 These results reveal roles of gap junctions in a complex behavior at cellular resoluti

190 fferent proteins to connexin36/35-containing gap junctions in an activity-dependent manner.

191 del may provide new insight into the role of gap junctions in breast cancer progression.

192 in interactions that govern the formation of gap junctions in Caenorhabditis elegans, five of which a

193 t understanding of the role of connexins and gap junctions in cancer, with particular focus on the re

194 Notably, it is abolished by a mutation in gap junctions in projection neurons and is found to be m

195 nt preservation of conventional synapses and gap junctions in the inner plexiform layer is also obser

196 propagate as intercellular Ca(2+) waves via gap junctions in the intact liver.

197 pillary diameter by pericytes and a role for gap junctions in vascular network interactions.

198 Connexins, the proteins that form gap junctions in vertebrates, are highly regulated and t

199 hibited features consistent with the loss of gap junctions including reduced membrane conductance, la

200 death; endothelial denudation or inhibiting gap junctions increased SMC death; delocalization of cyt

201 t the cell surface in the form of functional gap junctions indicating that Abeta(25-35) causes rapid

202 Conversely, in CTL hearts, gap junction inhibition (carbenoxolone) decreased coupli

203 Whereas endothelial denudation or gap junction inhibition (carbenoxolone; 100 um) increase

204 Carbenoxolone, a gap junction inhibitor, antagonized modafinil, but not m

205 tocytes and the neighboring parenchyma via a gap junction intercellular communication pathway.

206 sine phosphorylation of the Cx32CT increased gap junction intercellular communication.

207 expressed by astrocytes in the CNS and forms gap junction intercellular communications between astroc

208 cologic reversal of DNA methylation enhanced gap-junction intercellular communication and cell-cell i

209 ired the internalization of Cx43, preserving gap junction-intercellular coupling in cardiomyocytes.

210 tractile signal apparently spreading through gap junctions into neighboring muscle cells.

211 ated in the granulosa cells diffuses through gap junctions into the oocyte, maintaining meiotic proph

212 the effect of CO(2) on Cx26 hemichannels and gap junctions is mediated through changes in the lowest

213 calcium signalling by increasing connexin36 gap junction levels on the plasma membrane.

214 We identified a gap-junction-like structure using a glycosylation-defici

215 haracterize EpAT infiltration, fibrosis, and gap junction localization.

216 hogenesis influence epigenetic repression of gap junction loci, which suggests targeting of gap junct

217 en multiple cellular constituents, including gap junctions, mechanosensitive ion channels, energy-con

218 In retinal degenerations, these same gap junctions mediate oscillatory activity that contribu

219 gs demonstrate the existence of an efficient gap junction-mediated Ag transfer pathway between monocy

220 pply metabolic substrates to neurons through gap junction-mediated astroglial networks.

221 ma occurs secondary to RGC death through the gap junction-mediated bystander effect.

222 Modulation of gap junction-mediated electrical synapses is a common fo

223 of glial fibrillary acidic protein, stronger gap junction-mediated SGC-SGC and neuron-SGC coupling, i

224 ent potassium currents that are amplified by gap junction-mediated tumour interconnections, forming a

225 results suggest that lateral excitation via gap junctions modulates odor tuning in the antennal lobe

226 hus, our findings identify the function of a gap junction modulation in an in vivo model of learning

227 ts from downregulation of the abundance of a gap junction molecule, which is regulated by cell-autono

228 nt of their role as structural precursors of gap junctions, namely between the cytosol of an individu

229 dwork for exploration of mechanisms by which gap junction nexus stability modulates intercellular com

230 velocity and decreases the time delays over gap junctions of reduced coupling in the EMI model simul

231 taneous conductance-voltage rectification of gap junctions on an asymmetry of cell-to-cell signaling.

232 The facilitating effect of intraglomerular gap junctions on interglomerular synchrony is through tr

233 We observe that with weak gap junction or excitatory synaptic coupling, network he

234 Moreover, we find that blockade of gap junctions or ablation of Cx36 significantly reduces

235 ia electrical or chemical connections (i.e., gap junctions or excitatory/inhibitory synapses).

236 Pharmacological blockade of gap junctions or genetic ablation of connexin 36 (Cx36)

237 nect to cone photoreceptor pathways via Cx36 gap junctions or via chemical synapses.

238 ent stem cells (hiPSCs) contained functional gap junctions partially contributed by Connexin 45 (CX45

239 hosphorylation-based mechanism that impaired gap junctions (particularly, loss of connexin-43 express

240 es, which were predominantly enriched in the gap junction pathway.

241 PD) upregulated kynurenine, plasminogen, and gap-junction pathways.

242 ticipating in the pathological remodeling of gap junctions, paving the way to innovative therapeutic

243 NLR-1 is located in the gap junction perinexus, a region adjacent to but not ove

244 and perifusion insulin secretion assays, and gap junction permeability measurements.

245 arkedly increases endogenous myocardial Cx43 gap junction plaque size at the intercalated discs.

246 tations (Y151C, V181M, R183C and L239I) form gap junction plaques and produce levels of junctional co

247 164Q and C168Y) either form no morphological gap junction plaques or, if they do, produce little or n

248 n potential firing in MCs through changes in gap junction properties.

249 anslated small C terminus isoform, GJA1-20k (Gap Junction Protein Alpha 1- 20 kDa), which is required

250 The gap junction protein Connexin 43 (Cx43) contributes to c

251 ltered expression and function of astroglial gap junction protein connexin 43 (Cx43) has increasingly

252 mined whether dysregulated expression of the gap junction protein connexin 43, which has been observe

253 It is known that the gap junction protein connexin-36 is widely expressed in

254 Aberrant expression of the cardiac gap junction protein connexin-43 (Cx43) has been suggest

255 ely invading breast cancer cells express the gap junction protein connexin-43 (Cx43), yet whether Cx4

256 ne mutations causing loss of function of the gap junction protein connexin32 (Cx32).

257 The gap junction protein connexin43 (Cx43, gene name GJA1) f

258 c.148G>A, p.D50N) in the GJB2 gene, encoding gap junction protein Cx26, which alters gating propertie

259 scriptional repression of GJA1 (encoding the gap junction protein Cx43) and other genes related to in

260 y mutations in GJB1, which codes for Cx32, a gap junction protein expressed by Schwann cells and olig

261 concomitant with increased expression of the gap junction protein Gja1.

262 Connexin32 (Cx32) is a major gap junction protein in the liver and brain.

263 riate AV node conduction through maintaining gap junction protein localization.

264 Pannexin-3 (Panx3) is a gap junction protein that is required for regulating cel

265 of connexin-43 (Cx43), the major ventricular gap junction protein, in DMD cardiomyopathy.

266 ealed the presence of Cx43, the main cardiac gap junction protein, localized to cell-cell borders.

267 l (A88V) mutation in the gene coding for the gap-junction protein connexin30 (Cx30) protects the coch

268 Instead, sharing requires gap junction proteins (normally associated with transpor

269 3 and Cx43 are the most abundantly expressed gap junction proteins from each family.

270 he complete description of the expression of gap junction proteins in the nervous system of the worm

271 x (ECM) protein deposition and disruption of gap junction proteins, connexins.

272 Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensu

273 Here we describe a RGC that relies on gap junctions, rather than chemical synapses, to convey

274 tional examples throughout the literature of gap junction regulation by kinases, indicate that one ca

275 teraction with ZO-1 plays a critical role in gap junction regulation.

276 es in Cx43, Himelman et al. observed reduced gap junction remodeling and lateralization of Cx43 immun

277 stem cell derived-cardiomyocytes reveal Cx43 gap junction remodeling by reduced ZO-1 complexing.

278 Cx36 gap junctions represent multimolecular complexes and con

279 The weakening of the gap junctions results from downregulation of the abundan

280 synapses containing silent but ready-to-use gap junctions.SIGNIFICANCE STATEMENT In this work, we pr

281 Indeed, selective block of gap junctions significantly reduced propagation but not

282 We propose that, in addition to altering gap junction stability, Cx43 phosphorylation directly an

283 ound that it was the ACs coupled to RGCs via gap junctions that were lost in glaucoma, whereas uncoup

284 The use of antidromic-rectifying gap junctions to amplify chemical transmission is potent

285 For gap junctions to properly control electrical synchroniza

286 es from a network of electrical synapses via gap junctions to RGCs of a different type, the F-mini-OF

287 s produced in the soma and delivered through gap junctions to the germline; there it is used in fatty

288 independently of Cx43, is critical for Cx43 gap junction trafficking, maintenance of Cx43 protein, a

289 tes slower mechanisms of regulation, such as gap junction turnover.

290 imilar to chemical synapses, Cx36-containing gap junctions undergo activity-dependent plasticity and

291 ower expression of connexin43, a major known gap junction unit in vascular cells.

292 Here, we map the network contribution of gap junctions using a high-resolution connectomics datas

293 The potent role of gap junctions was confirmed in patch-clamp recordings in

294 ircuit of interneurons that are connected by gap junctions, we show that modulation of the gap juncti

295 olar epithelial cells (AECs) lacked Sting or gap junctions were blocked, PS-GAMP-mediated adjuvantici

296 he neighboring microvascular network through gap junctions, where it regulates contractile pericytes

297 we developed methods to inhibit unc-9-based gap junctions with dominant-negative unc-1 transgenes.

298 oocyte, and that they often branch and make gap junctions with each other.

299 In mammalian retina, gap junctions within the Aii amacrine cell-ON cone bipol

300 nological role of Cx43, we hypothesized that gap junctions would be targeted during adenovirus type 5