ライフサイエンスコーパス: gate

1 for cell-cell communication (bicellular AND gate).

2 ids, the phenylalanines act as the channel's gate.

3 ent cations intracellular to the hydrophobic gate.

4 2P) channels studied so far all lack a lower gate.

5 tween the ATP-binding pocket and the helical gate.

6 uation, incorrect start codons, and a failed gate.

7 as an effective latch for the phenylalanine gate.

8 e-input OR, AND, and disjunctive normal form gates.

9 rst ever documented Thermal AND and OR logic gates.

10 e operations are realized by unitary quantum gates.

11 assembled, such as logic AND gates and IMPLY gates.

12 d studies of the structural basis of channel gating.

13 ture-sensitive structure is coupled to TRPM8 gating.

14 ltiple residues, including those involved in gating.

15 at determines both cation selectivity and pH gating.

16 present a strong response under electrolytic gating.

17 ontrolled proton evolution with ionic liquid gating.

18 olog of ANKRD26, to orchestrate proper cilia gating.

19 mutant (H25R/E118A) that exhibits an open pH gate across a broad range of pH values.

20 vivo without the use of any complicated time-gating algorithms or systems, which existing tools are u

21 a gate locally, and also opens the opposite gate allosterically.

22 ing site of leiomodin can act as a "swinging gate" allowing limited actin polymerization, thus making

23 ger protein, thrombin, selectively opens the gate and enables a 330-fold increase inw the transport r

24 utant also has flexibility in the activation gate and is subject to transmembrane allostery.

25 Mutations within the X-gate and the surrounding regions markedly affect both th

26 utionary dynamic networks revealing enhanced gated and cascaded functions.

27 o the allosteric gating and regulation of CN-gated and nucleotide-modulated channels and CNG channel-

28 Finally, various functional logic gates and circuits are demonstrated.

29 complexity are assembled, such as logic AND gates and IMPLY gates.

30 s to delineate the molecular determinants of gating and ion permeation.

31 l nanopockets are known to affect mechanical gating and may be linked to large variability in tension

32 se results appear incompatible with standard gating and rebound models.

33 des mechanistic insights into the allosteric gating and regulation of CN-gated and nucleotide-modulat

34 due pair in the lower pore is detrimental to gating and selectivity, although this interaction might

35 ral biology, yielding insight into substrate gating and trapping the protease in the active state.

36 le and lower pore were more likely to affect gating and/or ion selectivity than those in the upper po

37 ng numerical simulation of noisy three-qubit gates, and show that it produces highly accurate charact

38 tion for capsaicin-mediated TRPV1 activation gating, and reveals multiple ligand-channel interactions

39 we observed that the low activity of the SF gate appears to arise from the inefficiency of K(+) in s

40 g domain 2 (VSD2) and that each of the three gating arginines in VSD2 reduces the activation threshol

41 NanoThermoMechanical AND, OR, and NOT logic gates as an alternative, and showed their ability to be

42 three aortic levels on three retrospectively gated axial gradient-echo (GRE) data sets.

43 n our dataset involves rotation of the inner-gate backbone along residues S168-G169-I170.

44 res by demonstrating long spin lifetimes(6), gate-based spin readout(7) and coherent single-spin cont

45 ndings establish p75NTR as a novel regulator gating behavioral response to food scarcity and time-of-

46 may be used to generate long-range two-qubit gates between spatially separated spins.

47 with weak mechanical stimuli (0-16 mN) at a gate bias of 1 V.

48 As we lower the electron density via gate bias, we find a sequence of phases, qualitatively c

49 two-input AND, OR, NAND, NOR, XNOR, and NOT gates built from de novo-designed proteins.

50 fficking during homeostatic upscaling can be gated by a single phosphorylation site on the GluA2 subu

51 A study demonstrates that Hrd1 is gated by autoubiquitination and a soluble ERAD substrate

52 ied endolysosomes via connexin 43 (Cx43) and gated by cAMP-EPAC-RAP1-PP2A signaling.

53 Unlike classic HCN channels, HCNL1 is not gated by cyclic nucleotides.

54 the human siesta, is a "hard-wired" property gated by specific neurons of the master clock to favor s

55 tional change indicates Kir channels are not gated by the canonical mechanism.

56 (3,8,9), but the mechanistic basis for TASK2 gating by pH is unknown.

57 al models had suggested that several voltage-gated Ca(2+) channels (VGCCs) regulated critical signali

58 In previous studies, T-type voltage-gated Ca(2+) channels (VGCCs) were implicated in this pa

59 To determine whether Cav1.2 voltage-gated Ca(2+) channels contribute to astrocyte activation

60 microenvironment of the presynaptic voltage gated Ca(2+) channels revealed that alkalinization also

61 hat BsYetJ/TMBIM6 is a pH-dependent, voltage-gated calcium channel.

62 For example, presynaptic voltage-gated calcium channels (VGCCs) and postsynaptic ligand-g

63 were mediated, in part, by dendritic voltage-gated calcium channels (VGCCs): pharmacological manipula

64 deletions in the significant set of voltage-gated calcium channels among CNVs called from both exome

65 und that the alpha2delta2 subunit of voltage-gated calcium channels negatively regulates axon growth

66 -adrenergic augmentation of Ca(V)1.2 voltage-gated calcium channels(1-4).

67 ation including glutamate receptors, voltage-gated calcium channels, the dopamine D2 receptor, and co

68 and enter the cytosol mostly through voltage-gated calcium channels.

69 Voltage-gated calcium currents were unchanged between the genoty

70 Based on these gates, Cello 2.0 was used to build circuits with up to 1

71 These gating changes could be fully reversed by acute CaMKII i

72 ralogs differs from the voltage- and calcium-gated channel CALHM1.

73 polarization-activated and cyclic nucleotide-gated channel HCN2 in the family of so-called pacemaker

74 Gene expression of KCNA5 (potassium voltage-gated channel subfamily A member 5; encoding Kv1.5) was

75 4 palmitoylates the Shaker-like K(+) voltage-gated channel subunit (Kv1.1), thereby regulating Kv1.1

76 rom the receptor guanylate cyclase to a cGMP-gated channel that serves as a perfect chemo-electrical

77 s 1 represent a unique, large group of light-gated channels (viral channelrhodopsins, VirChR1s).

78 yperpolarization-activated cyclic nucleotide-gated channels(5), and may represent an unexpected link

79 The total gating charge displacement associated with this transiti

80 , decreased single-channel open probability, gating charge movement, and its coupling to channel open

81 We discovered these gating checkpoints in the middle and cytosolic extended

82 CLC-2 is a voltage-gated chloride channel that is widely expressed in mamma

83 sis supports allosteric binding to glutamate-gated chloride channels similar to ivermectin.

84 both Brugia osm-9 and the cyclic nucleotide-gated (CNG) channel subunit tax-4 in larval chemotaxis t

85 Cyclic nucleotide-gated (CNG) channels convert cyclic nucleotide (CN) bind

86 , TALP-3 and ANKR-26 form a complex with key gating component DYF-19, the homolog of FBF1.

87 sual stimulation reveal an intrinsic voltage-gated conductance that profoundly alters the integrative

88 um disulfide and hafnium dioxide in a bottom-gate configuration, enhanced the electrical performance

89 Manual biaxial gating confirmed increased frequencies of conventional d

90 ite S4 of the selectivity filter of the open-gate conformation and also the site S2, but no binding i

91 We demonstrate that the gate conformation of the two opposite ends of 20S are co

92 , but no binding is detected with the closed-gate conformation.

93 Structural analysis reveals open and closed gate conformations of the KcsA channel.

94 o-electron microscopy structure of an export gate containing the switch protein from a Vibrio flagell

95 d both light- and energetic/oxidative stress-gated control of this interaction.

96 Here we report the observation of a gate-controlled switching between two electronic states

97 not alter the degree of electrophysiological gating cooperativity between Nav1.5 alpha-subunits.

98 enting distinct functional states during the gating cycle.

99 s was accompanied by increased NMDA receptor gating, dependent on mGluR5 and linked to enhanced Ca(2+

100 mplex media using a lifetime-based or a time-gated detection scheme.

101 ure of twisted bilayer graphene using a back-gated device architecture for angle-resolved photoemissi

102 interaction of PAX with the BK channel pore gate domain guided by recently available liganded (open)

103 voltage sensor domain (VSD), a central pore-gate domain, and a large cytoplasmic domain (CTD) that c

104 teracted with glycine 165, located in loop D gating domains surrounding the intracellular vestibule o

105 o a strengthened donor effect and a weakened gating effect caused by the introduction of MoS(2) layer

106 chieve a controlled functionalisation of the gate electrode and avoid contamination or physisorption

107 amically detected by the DGTFT where the top gate electrode was connected to the extended MZO(nano) s

108 f 5-HT(3A), the allosteric regulation of ion gating elements by 5-HT binding is indicative of a preac

109 hmic regrowth separates the source/drain and gate fabrication, providing a viable means to improve oh

110 muli-mechanical and acid triggers-in an "AND gate" fashion.

111 it to operate an ultra-sensitive electrolyte-gated field-effect transistor (EGOFET) as a sensor and f

112 y observe membrane thinning near the lateral gate for all proteins.

113 ggest a new role for mEC LV as a bifurcation gate for feedforward (telencephalic) and feedback (entor

114 ondrial membrane (TOMM) complex is the entry gate for virtually all mitochondrial proteins and is ess

115 de that confidence shapes a selective neural gating for choice-consistent information, reducing the l

116 ent aspects of Ca(V) channel trafficking and gating for this purpose.

117 F-helices and switches an electron transfer gate formed by LysF7, GlnE7, and water.

118 ructure, reveal a double-barrier hydrophobic gate formed by two S6 amino acids in the central cavity.

119 Bill and Melinda Gates Foundation (OPP1111147) (Study 2).

120 ergency Plan for AIDS Relief, Bill & Melinda Gates Foundation, and Gilead Sciences.

121 Novartis Foundation, Bill & Melinda Gates Foundation, and Horchow Family Fund.

122 itute of MGH, MIT, & Harvard, Bill & Melinda Gates Foundation, and Janssen Vaccines & Prevention.

123 Health and Human Development, Bill & Melinda Gates Foundation, and Worldwide Antimalarial Resistance

124 Bill & Melinda Gates Foundation, Trond Mohn Foundation, and Norwegian A

125 tor Control Consortium, and Bill and Melinda Gates Foundation.

126 University of Antwerp and Bill & Melinda Gates Foundation.

127 n Reproduction (HRP), and The Bill & Melinda Gates Foundation.

128 Critically, the gated generation of a fluorescent product allows for flu

129 trification serving as a rewritable floating gate has demonstrated different modulation effects by an

130 In recent years, DNA logic gates have been extensively applied in developing multip

131 yperpolarization-activated cyclic nucleotide-gated (HCN) and small conductance calcium-activated pota

132 The voltage-gated Hv1 proton channel is a ubiquitous membrane protei

133 the operation of a reversible supramolecular gate, i.e., an ensemble of various components linked by

134 tive hot spot was reduced by 24% in the dual gated images compared to non-gated images.

135 24% in the dual gated images compared to non-gated images.

136 Until now, time-gated imaging could not be used to develop LFM on porous

137 Verification of the functioning of the AND gate in a mixture of 12 components was thus accomplished

138 hat the energy necessary to open the lateral gate in BamA/TamA varies by species, but is always lower

139 at S4-S5(L)/S6(T) interaction stabilizes the gate in the closed state.

140 ined to be five respiratory and four cardiac gates in the phantom and patient studies.

141 hway of the protein by internal and external gates in their closed states.

142 egions required for channel formation and pH gating in planar lipid bilayers.

143 ant for H(+) transport and voltage-dependent gating in the CLC exchangers.

144 a Get2/CAML cytoplasmic helix that forms a "gating" interaction with Get3/TRC40 important for TA ins

145 ening and sliding of the beta-strands at the gate interface for N. gonorrhoeae, indicating that the g

146 into the separation capillary through a flow-gating interface.

147 of an osmoticant agent suggest that channel gating involves a change in solute-inaccessible volume i

148 Intracellular gating involves lysine protonation on inner helices and

149 discuss our current understanding of ligand-gated ion channel and G protein-coupled receptor complex

150 mitochondrial calcium uniporter is a Ca(2+)-gated ion channel complex that controls mitochondrial Ca

151 Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antith

152 otonin type 3 receptor (5-HT(3)) is a ligand-gated ion channel that converts the binding of the neuro

153 otonin type 3A receptor, a pentameric ligand-gated ion channel, is crucial for regulating conductance

154 GlyRs) are anion-permeable pentameric ligand-gated ion channels (pLGICs).

155 s are affected as well, particularly voltage-gated ion channels (VGICs).

156 Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled receptors, has

157 Voltage-gated ion channels endow membranes with excitability and

158 T Changes in dendritic function, and voltage-gated ion channels in particular, are increasingly the f

159 receptor-like (GLR) channels are amino acid-gated ion channels involved in physiological processes i

160 vary in their selectivity for human voltage-gated ion channels involved in the ventricular action po

161 ium channels (VGCCs) and postsynaptic ligand-gated ion channels such as AMPA receptors (AMPARs) are o

162 NMDA receptors (NMDARs) are glutamate-gated ion channels that mediate fast excitatory synaptic

163 5-HT(3) receptors are pentameric ligand-gated ion channels that regulate synaptic activity in th

164 ASICs have become bona fide neurotransmitter-gated ion channels, activated by the smallest neurotrans

165 onship among gating modifier toxins, voltage-gated ion channels, and the lipid membrane surrounding t

166 action potential depends on several voltage-gated ion channels, including Na(V), Ca(V), and K(V) cha

167 Ion packets introduced from gates, ion funnel traps, and other conventional ion inje

168 and fundamental aspects of channel assembly, gating, ion selectivity and pharmacology remain obscure.

169 face for N. gonorrhoeae, indicating that the gate is dynamic.

170 Mcm2-7 on DNA is complete and the DNA entry gate is fully closed.

171 rtially activated, and the fast-inactivation gate is partially closed.

172 nsor product structure of non-stable quantum gates is not controllable in terms of control theory.

173 sensor domain (VSD), and the cNMP-dependent gating is mediated by the intracellular cyclic nucleotid

174 Respiratory gating is the standard to prevent respiration effects fr

175 ndent glycosylation of SIRT1 is essential to gate its functions and maintain physiological fitness.

176 ense variant in KCNA2, which encodes voltage-gated K(+) channel K(V) 1.2.

177 Voltage-gated K(+) channels function in macromolecular complexes

178 The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembl

179 matogenic dissemination, rendering platelets gate-keepers of the inflamed microvasculature.

180 irmed by native mass spectrometry, makes the gates largely insensitive to stoichiometric imbalances i

181 ns, the simulations reveal how a six-residue gate-like region can limit P/E formation, where sub-angs

182 ith hierarchical structures containing logic gates linked to self-immolative motifs.

183 20S are coupled: binding one ATPase opens a gate locally, and also opens the opposite gate allosteri

184 effect transistors are examined using pulsed-gate measurements, which identify the time scales of ele

185 onformational excursions during this dynamic gating mechanism and are likely evolutionarily conserved

186 This two-stage hand-and-elbow gating mechanism elucidates distinct tissue-specific mod

187 An attention-gating mechanism is incorporated into a discriminator ne

188 ests the possibility of a unified mechanical gating mechanism stemming from membrane deformation indu

189 We reveal a gating mechanism that involves two ion-conducting pathwa

190 nnel Na(+) currents to quantify the receptor gating mechanism while simultaneously monitoring ionomyc

191 so open undamaged DNA, suggesting a 'kinetic gating' mechanism whereby lesion discrimination relied o

192 annels, predicting novel ion-selectivity and gating mechanisms.

193 These observations describe a mechanism for gating membrane fusion.

194 etween CMR-FT and the three echocardiography gating methods (p > 0.05 for all).

195 cumferential ramp, self-organizes around tip-gated microcantilevers to form contracting CaMiRi.

196 e model analysis to investigate how SF-level gating modalities control selective cation transport in

197 In line with mutagenesis studies, these gating modalities resulted from dynamic interaction netw

198 ation of arbitrary computational problems in gate-model quantum computers.

199 ng procedures and measurement apparatuses in gate-model quantum computers.

200 As some gating modifier toxins have affinity for model lipid bil

201 id bilayers, a tripartite relationship among gating modifier toxins, voltage-gated ion channels, and

202 istration of contrast media, and non-cardiac-gated multidetector CT with and without contrast media t

203 ing its application in high-performance back-gated n-type MoS(2) and p-type WSe(2) transistors with s

204 an influx of sodium (Na(+)) ions via voltage-gated Na(+) channels.

205 lanar lipid bilayers at acidic pH to form pH-gated nonselective cation channels that are opened upon

206 propose that L4 restricts disinhibition and gates OD plasticity independent of a canonical cortical

207 However, when AAA4 is bound to ATP, the gating of AAA1 by AAA3 prevails and dynein motion can oc

208 ignature sequence in the U-type inactivation gating of hKv2.1 and hKv3.1.

209 E-M coupling mechanism in voltage-dependent gating of K(V)7.1 as triggered by VSD activations to the

210 a are traditionally analyzed by (subjective) gating of subpopulations on two-dimensional plots.

211 We take advantage of a femtosecond temporal gating of the electron pulse mediated by an infrared las

212 strikingly, the V990M mutation affected the gating of the non-canonical pore of TRPM3, resulting in

213 I hair cells results from the interdependent gating of three conductances.

214 The initial activation step in the gating of ubiquitously expressed Orai1 calcium (Ca(2+))

215 force necessary to activate the CB molecular gate on the time scale of 100 ms is approximately 2 nN.

216 allelism and the implementation of two-qubit gates on arbitrary pairs of qubits(6).

217 e, the system has to be compatible with fast gates on the encoded qubit and a quantum non-demolition

218 y inducible (YES gate) or to act as an IMPLY gate (only expressed in absence of inducer).

219 We also see occasional spontaneous lateral gate opening and sliding of the beta-strands at the gate

220 large amount of C(2) H(2) and CO(2) through gate-opening and only negligible amount of C(2) H(4) .

221 Here, we show that AND-gate optical imaging probes that require the processing

222 ts of 11S RP binding, or the introduction of gate or allosteric pathway mutations at one end of the b

223 dynamic tunnel lining, with implications for gating or substrate translocation.

224 ence factor, to be externally inducible (YES gate) or to act as an IMPLY gate (only expressed in abse

225 calizes to ER-PM junctions, and recruits and gates ORAI1 channels.

226 e investigate solution processed Electrolyte Gated Organic Field Effect Transistors (EGOFETs) based o

227 a label-free sensor based on an Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) integrate

228 p device integrating a multigate electrolyte gated organic field-effect transistor (EGOFET) with a 6.

229 y used for cell monitoring while Electrolyte-Gated Organic Field-Effect Transistors (EGOFETs) have ne

230 Periodic ozone exposure during gate oxide ALD on SiGe is shown to reduce the integrated

231 to diffusion of reactant species through the gate oxide.

232 is tightly linked to the opening of voltage-gated P/Q-type Ca(2+) channels, the activation of which

233 xtracellular ATP, or inactivation of the ATP-gated P2X7R channel also compromised the effects of MerT

234 sensory processing in cortical networks and gates plasticity enabling adaptive behavior.

235 Voltage-gated potassium (Kv) channels display several types of i

236 Voltage-gated potassium 11.1 (K(v)11.1) channels play a critical

237 idine (4AP) is a specific blocker of voltage-gated potassium channels (K(V)1 family) clinically appro

238 of action is via blockade of axonal voltage gated potassium channels, thereby enhancing conduction i

239 However, in several voltage-gated potassium channels, using specific S4-S5(L)-mimick

240 through the activation of associated calcium-gated potassium channels.

241 the last decade has revealed that the Orai1 gating process is highly cooperative and strongly allost

242 al ensembles-coupling distant brain regions, gating processing windows, and providing a reference for

243 d self-inhibitory because of ClC-5's voltage-gated properties, but shunt conductance facilitated furt

244 We conclude that TWIK-1 displays unique SF gating properties among the family of K2P channels.

245 egration of ion channels with newly designed gating properties into cardiomyocytes.

246 conflicting reports on the permeability and gating properties of TPC2 and they establish a new parad

247 ine 351 and glutamate 355, that influence pH gating properties, as well as a single residue, aspartat

248 nonselective channel that has some peculiar gating properties, but also exhibits behavior typically

249 Voltage-gated proton channels (H(V)1) are essential for various

250 This cell cycle gating provides a temporal compartmentalization of feedb

251 ting quantum processor, building three-qubit gate reconstructions from two-qubit tomographic data.

252 ssays determined a conserved tyrosine steric gate regulates ribonucleotide insertion into telomeres.

253 atum to train striatal projection neurons to gate relevant and suppress distracting cortical inputs.

254 aI has an extended sensor paddle that during gating relocates relative to the pore concomitant with b

255 ts into the biogenesis of a functional cilia gate remain elusive.

256 s, in the presence of a primer, P(1), to the gated replication of the scaffolds and to the displaceme

257 staining or abrogating the light- and stress-gated response.

258 lfactory cortex can actively and dynamically gate sensory throughput to higher brain centers.

259 permeates this tunnel and leverages upon the gating side chains triggering the CD loop to furl, which

260 Voltage-gated sodium (Na(V)) channels are pore-forming transmemb

261 osa) use tetrodotoxin (TTX) to block voltage-gated sodium (Na(v)) channels as a chemical defense agai

262 Voltage-gated sodium (Na(V)) channels drive neuronal excitabilit

263 the consequence of the properties of voltage-gated sodium and potassium channels.

264 Missense variants in the SCN8A voltage-gated sodium channel gene are linked to early-infantile

265 Nav1.6 is the primary voltage-gated sodium channel isoform expressed in mature axon in

266 The voltage-gated sodium channel isoform Na(V)1.7 is highly expresse

267 Voltage-gated sodium channel Na(v)1.5 generates cardiac action p

268 estigated the effect of LITAF on the voltage-gated sodium channel Nav1.5, which is critical for cardi

269 in (TTX), a neurotoxin that binds to voltage-gated sodium channels (Na(v) proteins), arresting electr

270 Voltage-gated sodium channels comprise an ion-selective alpha-su

271 The common dependence on gating state with distinct binding sites raises the poss

272 ucible alternative to labor intensive manual gating strategies.

273 also demonstrate light- and cellular stress-gated switch function in cultured hippocampal neurons.

274 3 (CDH23), form the tip-links, whose tension gates the hair cell mechanoelectrical transduction chann

275 Electronic Boolean logic gates, the foundation of current computation and digital

276 ing, interface modulation, and electrostatic gating, there is as of yet no analogue of these effects

277 utes and that of a checkpoint located at the gate to the T zone.

278 Then, the ubiquitous entry gate to within the cells' cytoplasm is macropinocytosis.

279 tively, and modify genetic NOT and NOR logic gates to allow their transitions between states to be va

280 control intracellular and selectivity filter gates to modulate TASK2 activity.

281 concept that the system can implement logic gating to specifically detect breast cancer cells and ex

282 Our findings may open a new gate toward therapeutics.

283 genes, as well as genes specific to voltage-gated transmembrane ion transporters.

284 uper)paramagnetic ferritin nanoparticles can gate TRPV1, a non-selective cation channel, in a magneti

285 Their atomically thin structure facilitates gate tunability just like graphene does, but unlike grap

286 Inwardly rectifying, voltage-gated, two-pore domain, and related K(+) channels are lo

287 regions of interest.Objectives: Respiratory-gated, ultrashort echo time magnetic resonance imaging w

288 cy as well as chemical inhibitors on channel gating using a Ca(2+)-sensitive promoter to express a se

289 ling kinetics during regeneration, showing a gated versus graded response, respectively.

290 s, we show that the application of a minimal gate voltage bias can induce stress in the channel layer

291 rrent as a result of the emanating effective gate voltage modulations.

292 ve Dirac band is slightly carrier doped by a gate voltage, the edge state starts to dissipate and exh

293 offering optimal carrier density without any gate voltages, in true-equilibrium.

294 ection spectra of the modulator at different gate voltages.

295 xtended MZO(nano) sensing pad and the bottom gate was used for biasing the device into the optimum ch

296 Based on our study, the optimal number of gates was determined to be five respiratory and four car

297 GABAergic inhibition gates weak nociceptive encodings from being decoded, whe

298 th a selectivity filter situated above and a gate with four parallel helices located below; however,

299 ls that FlhB/SctU extends the helical export gate with its four predicted transmembrane helices wrapp

300 programmable and can generate expandable AND gates with two, three, and four inputs.