ライフサイエンスコーパス: gating mechanism

1 of the channel and vacuolar anion tune this gating mechanism.

2 motions of the channel and to elucidate its gating mechanism.

3 and hampered in silico investigation of the gating mechanism.

4 that act to close Cx26 hemichannels via this gating mechanism.

5 the evolutionary flexibility of the voltage-gating mechanism.

6 sitions characteristic of the intrinsic loop gating mechanism.

7 d share a common calcium/calmodulin-mediated gating mechanism.

8 ealing an agonist-independent, light-induced gating mechanism.

9 ssion could serve a role in a time-dependent gating mechanism.

10 riction at the lower gate, suggesting a dual gating mechanism.

11 ering-length lipid chains using a cleft-like gating mechanism.

12 ter permeability of AqpB, hinting at a novel gating mechanism.

13 s subunit boundaries, suggesting a concerted gating mechanism.

14 n in NMDA receptors-controls this activation gating mechanism.

15 nt conformational changes, suggesting a dual gating mechanism.

16 entual identification of the channel and its gating mechanism.

17 role of Ca(2+) and Na(+) ions in the channel gating mechanism.

18 omain is associated with the channel pore or gating mechanism.

19 the nAChR and provide new insights into the gating mechanism.

20 bably activates the channel through a direct gating mechanism.

21 is no consensus kinetic model for the GABAR gating mechanism.

22 rs (IP(3)Rs) may be critical for the channel gating mechanism.

23 regions, suggesting that they share a common gating mechanism.

24 D transport at night, suggesting a circadian gating mechanism.

25 is essential to understanding the Cl(-) ion gating mechanism.

26 basis of ion channel function, including the gating mechanism.

27 cacies of agonists, suggesting a role in the gating mechanism.

28 s an essential component of the ISOC channel gating mechanism.

29 sting state and a complete voltage-dependent gating mechanism.

30 n and most likely lead to disturbance of the gating mechanism.

31 ovide touchstones for an emerging allosteric gating mechanism.

32 lies on PKC-dependent ClC-1 inhibition via a gating mechanism.

33 anges in symmetry that are important for the gating mechanism.

34 processivity may be controlled by different gating mechanisms.

35 e strength of electrical coupling mostly via gating mechanisms.

36 unction relationships, perm-selectivity, and gating mechanisms.

37 , and outer vestibule play a crucial role in gating mechanisms.

38 ls obeying equilibrium versus nonequilibrium gating mechanisms.

39 conserved structure for ion selectivity and gating mechanisms.

40 s, and thus offers a novel approach to study gating mechanisms.

41 for understanding ion filtration and channel-gating mechanisms.

42 de chain at position 241 interferes with its gating mechanisms.

43 ed by bistable activation states and dynamic gating mechanisms.

44 sed by T cells have adopted novel regulation/gating mechanisms.

45 e cation channels (SOCs) display multi-modal gating mechanisms.

46 annels, predicting novel ion-selectivity and gating mechanisms.

47 t based on the conditional information using gating mechanisms.

48 tivation is thought to target these specific gating mechanisms.

49 ind and modulate MscL: insights into channel gating mechanisms.

50 cules but less is known about the underlying gating mechanisms.

51 (4,5)P(2)) depletion when exploring the TRPL gating mechanism?

52 bserved pore closure by a novel "hydrophobic gating" mechanism: A dewetting transition of the hydroph

53 in REM sleep suggests drastically different gating mechanisms across sleep stages.

54 hese processes are conditional upon critical gating mechanisms actively enforced by the default state

55 rostatic trapping could provide a protective gating mechanism against reactive oxygen species formati

56 s the crucial elements in the EMRE-dependent gating mechanism among metazoan MCUs.

57 suggesting an S4-S5 linker-mediated PtdInsP2 gating mechanism among TRPML channels.

58 structural insight into the general voltage-gating mechanism among voltage-gated channels.

59 ls are thought to have two primary conserved gating mechanisms: an inactivation (or C-type) gate at t

60 onformational excursions during this dynamic gating mechanism and are likely evolutionarily conserved

61 This study proposes a unique channel gating mechanism and delivers detailed molecular insight

62 Here, we study the gating mechanism and energy coupling of OpuA reconstitut

63 ) is a foundation for understanding the AChR gating mechanism and for engineering both the ligand and

64 mportant implications for both the channel's gating mechanism and its regulatory adaptation mechanism

65 targets for SAR studies to shed light on the gating mechanism and locus of bastadin-5 binding on thes

66 To explore the connection between the gating mechanism and the influx and efflux of water mole

67 common core architecture but show different gating mechanisms and fine-tuned conductive properties.

68 tigating the structural basis of TRP channel gating mechanisms and pharmacology, and, despite the lar

69 Our results offer additional insights into gating mechanisms and suggest revisions to prevailing mo

70 2+) binding sites involved in gating and the gating mechanism are not fully known.

71 p ligand-gated ion receptors that govern the gating mechanism are still not well understood.

72 to determine channel opening and that these gating mechanisms are allosterically coupled.

73 e entrance to active sites and let alone the gating mechanisms are not always obvious from X-ray crys

74 of MSNA through increased sensitivity of a 'gating' mechanism, as indicated by an increase in the sl

75 cytosolic components is tightly regulated by gating mechanisms at the cilium base; however, the mecha

76 and implicates selective attention as a main gating mechanism between sensory and memory systems.

77 t on gating, illustrating differences in the gating mechanisms between connexin isoforms.

78 hyte ACRs, indicating differences in channel gating mechanisms between the two ACR families.

79 cations not only on our understanding of the gating mechanism but also on the general experimental de

80 y membrane depolarization via an SF-mediated gating mechanism, but we found here that only very stron

81 logical firing frequencies, acting thus as a gating mechanism by which activity-dependent release fro

82 Thus, we propose that NMDARs may act as a gating mechanism by which activity-dependent release fro

83 onent Ca(2+)-uptake machinery and reveal the gating mechanism by which MICUs control uniporter activi

84 xchange/MS and functional studies, suggest a gating mechanism by which NP opens to accept RNA.

85 g subunit have been recently identified, the gating mechanism by which Orai1 channels conduct Ca(2+)

86 he channel domain, thereby being part of the gating mechanisms by which the IP(3)-induced conformatio

87 plasma-membrane Ca(2+) currents with dynamic gating mechanisms, Ca(2+)-buffering reactions with diffu

88 mitter receptors with similar structures and gating mechanisms can exhibit strikingly different funct

89 he sensory gating hypothesis posits that the gating mechanism continues to be necessary for retrieval

90 quantitatively characterized an alternative gating mechanism controlled by a cluster of hydrophobic

91 oteasome activity occurs, in part, through a gating mechanism controlling the sizes of pores at the t

92 results suggest that a phosphorylation-based gating mechanism controls cargo selection by yeast retro

93 These results suggest that a loop-gating mechanism controls the catalytic reaction.

94 The prevailing view is that different BK gating mechanisms converge to determine channel opening

95 A gating mechanism dependent on polo-like kinase-1 (PLK1)

96 odulation is a functionally relevant sensory gating mechanism deployed by attention.

97 icated that activation by menthol involves a gating mechanism distinct and separable from gating by c

98 bition of CEm cells is mediated by an active gating mechanism downstream of the BLA.

99 esults provide evidence of a 'conformational gating' mechanism driven by the interactions between the

100 This two-stage hand-and-elbow gating mechanism elucidates distinct tissue-specific mod

101 This "super-float-gating" mechanism enables very high sensitivity photodet

102 may underlie the conserved rectification or gating mechanisms exhibited by these channels.

103 gentamicin binding, supporting a stochastic gating mechanism for antibiotic binding, rather than an

104 as been implicated in this brain region as a gating mechanism for behavioral responses to emotional s

105 al conformation switch of the ISP provides a gating mechanism for bifurcated ET, which is essential t

106 enerating preceding inhibition may provide a gating mechanism for conditional corticothalamic feedbac

107 and these results also support a hydrophobic gating mechanism for control of ion permeation.

108 oherent neuronal oscillations may serve as a gating mechanism for flexibly modulating communication b

109 The crystal structure also suggests a gating mechanism for GlpG that controls substrate access

110 The structure reveals an alternative gating mechanism for K(v) channels and provides a templa

111 e-amplitude coupling is a manifestation of a gating mechanism for movement execution mediated by the

112 Here we report that a gating mechanism for Pi release controlled by the inter-

113 The results suggest a possible gating mechanism for proton movement that includes key r

114 uctive olfactory cues that may function as a gating mechanism for sensory activation of defensive res

115 perception threshold and may thus serve as a gating mechanism for the access to conscious experience.

116 scure ER-PM junctions, driving an allosteric gating mechanism for the Orai channel.

117 mechanism is unlikely to represent a final, gating mechanism for these channels.

118 have provided important clues regarding the gating mechanism for this family of proteins.

119 asis of K(+) selectivity and suggest a novel gating mechanism for this large and important family of

120 m of voltage sensing and provides a complete gating mechanism for voltage sensor function, pore openi

121 t the plasma membrane and suggesting similar gating mechanisms for both TRPML channels.

122 Here, we discuss possible gating mechanisms for electron transfer across the endos

123 ionary in TRPV1, highlighting differences in gating mechanisms for these structurally related channel

124 sidues), inactivation (one residue), or both gating mechanisms (four residues).

125 mportant role in Ca(2+) homeostasis, but its gating mechanisms, functions, and regulation are still u

126 Overall, this ion-flux gating mechanism generates a one-way "check valve" withi

127 This hydrophobic gating mechanism has implications for CRAC channel funct

128 effect of the TS mutation on other L-channel gating mechanisms has yet to be investigated.

129 thermal sensation and nociception, but their gating mechanisms have remained elusive.

130 selectivity, the transport pathway, and the gating mechanism-have remained unanswered for this prote

131 The mechanistic details of its voltage gating mechanism, however, remains elusive despite much

132 This gating mechanism in a neural circuit is further demonstr

133 lectron microscopy to identify the molecular gating mechanism in calcium-activated potassium channels

134 ls by selective disruption of the binding or gating mechanism in certain subunits.

135 bute to our understanding of the electrolyte gating mechanism in complex oxides and may be relevant f

136 The suppression of this gating mechanism in mature animals represents a new form

137 These results suggest that the gating mechanism in PIP1;4 may be more sensitive to prol

138 PV4 contains an additional voltage-dependent gating mechanism in series with the main intracellular g

139 We propose that (i) G272R disrupts a gating mechanism in the core chamber that regulates subs

140 e we probe the central features of the STIM1 gating mechanism in the human CRAC channel protein, ORAI

141 -ray structures of the two end-points of the gating mechanism in the same pentameric ligand-gated ion

142 mechanical coupling and coordination of the gating mechanism in transporters, which might be expecte

143 ative spliced isoforms may represent a major gating mechanism in vivo, therefore conferring important

144 his finding is consistent with an allosteric gating mechanism in which ligand shifts the equilibrium

145 We propose a two-section gating mechanism in which the S1 helix coarsely adjusts,

146 for our understanding of voltage-sensing and gating mechanisms in channels.

147 ombined results of the ion translocation and gating mechanisms in KR2 may provide a basis for the rat

148 odel that will enable the study of potential gating mechanisms in more detail.

149 t, our results suggest drastically different gating mechanisms in NREM and REM sleep.

150 Joint disruptions of the binding and gating mechanisms in the same or alternate subunits of a

151 tep toward understanding the fundamentals of gating mechanisms in this class of channels.

152 e observations provide support for kinesin-1 gating mechanisms in which one head stimulates the rate

153 hed experimental data and points to a simple gating mechanism: in the closed state, the His-37 and Tr

154 Moreover it is apparent that several gating mechanisms including calmodulin, protein kinase C

155 d that within the seven-state single-channel gating mechanism, inhibition of TRPM8 by short sM8-6 iso

156 dentified, and it has been hypothesized that gating mechanisms involve conformational changes in the

157 mic deactivation, which may reflect a limbic gating mechanism involved in modifying interactions betw

158 The structural basis for this unique gating mechanism involves an insert near the nucleotide

159 Based on these findings, we propose a unique gating mechanism involving a helical turn upon the bindi

160 for TRPC1 channel opening through a similar gating mechanism involving PKC and PI(4,5)P2.

161 ect distinct Rab substrates through a steric gating mechanism involving their hypervariable tails.

162 The ITDP gating mechanism is based on recent experimental finding

163 Previous studies suggested that this gating mechanism is controlled by a beta-hairpin and an

164 An attention-gating mechanism is incorporated into a discriminator ne

165 Our study indicates that the loop-gating mechanism is likely to be a source of the substra

166 of chronic itch, including alloknesis, this gating mechanism is lost.

167 Its gating mechanism is poorly understood due to the tiny vo

168 Thus, a channel-gating mechanism is suggested through enhancing the NBD-

169 and lipid composition that is determined by gating mechanisms localized at the base of the cilium.

170 trant FAAH inhibitors, which strengthen this gating mechanism, might offer a new approach to pain the

171 A CFTR gating mechanism model based on adenylate kinase activit

172 We propose that a regulatory "gating" mechanism normally blocks multiple rounds of str

173 These data suggest that a common gating mechanism occurs, coupling neurotransmitter bindi

174 Here the gating mechanism of a P2X receptor was studied by normal

175 methods can be used to identify not only the gating mechanism of a protein, but also associated physi

176 The gating mechanism of an enzyme is therefore very importan

177 of RCK2 likely underlie the Ca(2+)-dependent gating mechanism of BK(Ca) channels.

178 gest a unifying mechanism that describes the gating mechanism of both CLC subtypes.

179 that this SthK model will help elucidate the gating mechanism of CNG channels.

180 h is frequently invoked as a hallmark of the gating mechanism of Cys-loop receptors, is minimal, if a

181 which suggests that an additional molecular gating mechanism of high Q10 - which is not present in t

182 Our work provides insights into the gating mechanism of human TRPM2 and its pharmacology.

183 , disrupting the recently proposed K(+)-flux gating mechanism of K(2P) channels, which results in an

184 The gating mechanism of K(v) channels is not known.

185 ing module of lysenin, which may explain the gating mechanism of lysenin at a molecular level.

186 Understanding the gating mechanism of mechanosensitive channels is challen

187 ubstituted residues suggest that the overall gating mechanism of MscK is comparable to that of MscS,

188 L6 loop is not the primary voltage-dependent gating mechanism of MspA.

189 The detailed assembly process and the gating mechanism of Mtb proteasome have remained unknown

190 These results provide new insight into the gating mechanism of P2X receptors and establish a versat

191 ns for the role of subunit interfaces in the gating mechanism of P2X receptors and points to a role o

192 This study illuminates the gating mechanism of PapC ushers and its importance in ma

193 We assessed the gating mechanism of PS modulation of GluN1/GluN2A recept

194 structure, allow us to elucidate the ligand gating mechanism of RCK-regulated K(+) channels.

195 The molecular identity and the gating mechanism of SOC and CRAC channels have remained

196 llectively, these results support a stepwise gating mechanism of STIM1-operated Orai1 channels; the i

197 These results shed light on the gating mechanism of the AChR and present a complementary

198 imental data, and by comparison to the known gating mechanism of the bacterial KirBac channel.

199 Ca(2+) influx, a direct demonstration of the gating mechanism of the Cch1 channel remains elusive.

200 re of a Kir3.1 chimera revealed the possible gating mechanism of the G loop gate.

201 Here, we investigate the gating mechanism of the human CRAC channel Orai1 by its

202 odels of the structure and voltage-dependent gating mechanism of the KvAP bacterial K+ channel that a

203 Understanding the gating mechanism of the nicotinic acetylcholine receptor

204 icroscopy to obtain deeper insights into the gating mechanism of the NPC as the basis of a new transp

205 Here we have characterized the gating mechanism of the rat TRPM8 reconstituted in plana

206 autonomous assembly which contributes to the gating mechanism of the uniporter.

207 The gating mechanism of this pathway is still unclear.

208 A fundamental question about the gating mechanism of voltage-activated K+ (Kv) channels i

209 Atomic-scale models on the gating mechanism of voltage-gated potassium channels (Kv

210 Furthermore, both fast and slow gating mechanisms of Cx40 exhibit a negative gating pola

211 In Part II of this study, the detailed gating mechanisms of E. coli-MscL under various types of

212 his has broad implications for understanding gating mechanisms of EAG and related ERG and ELK K(+) ch

213 eparate connexin domains partake in proposed gating mechanisms of gap junction channels.

214 ational dynamics, and water molecules in the gating mechanisms of K(+) channels.

215 for understanding toxin-VSD interaction and gating mechanisms of K(v) channels in membranes.

216 cular framework for understanding the ligand gating mechanisms of K+ channels.

217 This study aims to explore gating mechanisms of mechanosensitive channels in terms

218 iotic target, but also give insight into the gating mechanisms of MscL, and they may have implication

219 1 will serve as a paradigm for understanding gating mechanisms of other channels.

220 The general folding pattern and gating mechanisms of our current models are similar to s

221 view we summarize the diverse properties and gating mechanisms of SOCs in smooth muscle.

222 between the substrate translocation and the gating mechanisms of the EAAT-associated anion channel.

223 EM) approach is used to explore the detailed gating mechanisms of the MscL in Escherichia coli embedd

224 ovides the structural bases for assembly and gating mechanisms of the Mtb proteasome.

225 However, the gating mechanisms of the Panx3 channels remain unclear.

226 The gating mechanisms of the related TRPV2 channel are poorl

227 ve provided many important insights into the gating mechanisms of thermoTRPV channels.

228 the CTDs of N1, 2A, or 2B and determined the gating mechanisms of these receptors.

229 l starting point for elucidating the complex gating mechanisms of TRPM4 and reveal the molecular arch

230 vided a powerful tool to establish the basic gating mechanisms of voltage-dependent K(+) channels, im

231 Our findings have implications for the gating mechanisms of voltage-gated ion channels, suggest

232 er column in the entry channel as the likely gating mechanism on the luminal side.

233 nel gating, suggest either an entropy-driven gating mechanism or a role for enthalpy-entropy compensa

234 The unique gating mechanism overcomes the drawback of charge screen

235 This particular anion channel gating mechanism predicts the existence of mutant transp

236 Existing models for the gating mechanism propose a role for the microtubule latt

237 ed on similar structural principles, and the gating mechanism recently emerging for the transporters,

238 ibition for the BIS; the attention/emotional gating mechanism regulating cortical sensory input for t

239 uss the impact of such interactions on TRPA1 gating mechanisms, regulation by the lipid environment,

240 te depicted by its crystal structure and its gating mechanism remain unclear.

241 roton backflow, but the number and nature of gating mechanisms remain elusive, as does the mechanism

242 ailed structural basis for voltage-dependent gating mechanisms remain obscure.

243 recently are insensitive to ADPR, and their gating mechanisms remain unclear.

244 tructure of the closed state is unknown, the gating mechanism remains controversial.

245 and vital role in many cell functions, their gating mechanism remains to be elucidated.

246 bolism to cellular excitability, whereas the gating mechanism remains unclear.

247 re-function studies on these proteins, their gating mechanism remains unclear.

248 Our results define a unique gating mechanism shared by K(2P) family members and sugg

249 ests the possibility of a unified mechanical gating mechanism stemming from membrane deformation indu

250 ut in certain CF mutants constitute the only gating mechanism, stimulated by ivacaftor, a clinically

251 TrkH resembles a K(+) channel and may have a gating mechanism substantially different from K(+) chann

252 We suggest that this gating mechanism synchronizes the binding of the two sub

253 nnels exhibit two distinct voltage-dependent gating mechanisms termed slow and fast gating.

254 Our results support a unique gating mechanism that allows the repertoire of Lon subst

255 The Aqy1 case reveals a gating mechanism that connects the inner channel gating

256 ong support for a proposed strain-controlled gating mechanism that enhances processivity.

257 led proton translocation reaction requires a gating mechanism that ensures bifurcated electron flow.

258 We reveal a gating mechanism that involves two ion-conducting pathwa

259 To solve this dilemma, we propose a gating mechanism that leads to a hundredfold enhancement

260 o control ammonium flux, potentially using a gating mechanism that limits flux to protect against amm

261 ants likely allow Mn(2+) entry via loss of a gating mechanism that normally holds the transporter in

262 These data taken together support a gating mechanism that regulates acyl-ACP binding and sub

263 nput to the DRN controls a serotonergic self-gating mechanism that regulates innate defensive respons

264 this conformational change is coupled to the gating mechanism that regulates ion conduction.

265 ssue injury, and may be part of a peripheral gating mechanism that regulates the access of nociceptiv

266 Here we introduce a gating mechanism that uses a capillary-stabilized liquid

267 oduce fluent speech by providing an external gating mechanism that yokes a ventral language network t

268 etric, which precludes a direct extension of gating mechanisms that close canonical fourfold symmetri

269 cough, and an almost binary output suggests gating mechanisms that encode and modulate this defensiv

270 lose synaptic plasticity but rather acquire gating mechanisms that prevent the induction of synaptic

271 expected to affect both front and rear head gating, mechanisms that underlie processive walking.

272 The theory is used to predict the gating mechanism, the pathway for backward stepping, and

273 a allow a molecular movie of the ferroxidase gating mechanism to be developed and provide further ins

274 Acquisition of a physical gating mechanism to control catalytic function through g

275 activity of PV+ neurons may thus serve as a gating mechanism to enhance feedforward, but not lateral

276 rine organ-specific, nutritionally regulated gating mechanism to help ensure productive metamorphosis

277 However, the contribution of each gating mechanism to oxidative stress-induced TRPM2 activ

278 This processive motility requires gating mechanisms to coordinate the mechanochemical cycl

279 beta subunits that appear to target specific gating mechanisms to regulate the channel activity.

280 gand-gated channel that obeys an equilibrium gating mechanism uncoupled from its enzymatic activity.

281 ndent inactivation, which suggests different gating mechanisms underlie these two types of voltage-de

282 SKOR, indicating that a voltage-independent gating mechanism underlies the K+ sensing process.

283 al Na+ channel NaV1.1 to explore and explain gating mechanisms underlying cellular excitability and p

284 However, very little is known about the gating mechanisms underlying KCNQ1 channel activation.

285 zing >40 engineered variants to identify the gating mechanism used by rhomboid proteases.

286 Using this gating mechanism, we now investigate TRPM8 inhibition in

287 To investigate ciliary gating mechanisms, we developed a system to clog the por

288 To elucidate potential cooperation of these gating mechanisms, we replaced the Cx43NT with the Cx37N

289 tion could, for instance, act as the primary gating mechanism when stimuli are still visible.

290 Moreover, we observed a remarkably potent gating mechanism when the animal was standing on its hin

291 c has an intrinsic phosphorylation-dependent gating mechanism where the SH2 domain adopts an open con

292 results suggest that Rad4/XPC uses a kinetic gating mechanism whereby lesion selectivity arises from

293 These findings substantiate a gating mechanism whereby the TRP domain acts as a coupli

294 so open undamaged DNA, suggesting a 'kinetic gating' mechanism whereby lesion discrimination relied o

295 es proposed signal transduction pathways and gating mechanisms which link physiological stimuli to op

296 This gating mechanism, which defines the constitutive activit

297 s are maintained out of phase by a series of gating mechanisms, which lead to processive runs averagi

298 nnel Na(+) currents to quantify the receptor gating mechanism while simultaneously monitoring ionomyc

299 of the selectivity filter may be a universal gating mechanism within K(+) channels.

300 Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metab