ライフサイエンスコーパス: gemini

1 o side chains emanating at C-20 are known as gemini.

2 rticularly sensitive to the structure of the gemini.

3 ce in properties between the two families of geminis.

4 GEMINI 1 met its primary and key secondary efficacy end

5 -masked, randomized, phase 3 clinical study, GEMINI 1, enrolled individuals with presbyopia, aged 40

6 llowed by ChatGPT 4 and Claude (25/30), with Gemini 1.0 scoring lowest (16/30).

7 LLMs (GPT-3.5, GPT-4, Claude 3, Llama 3, and Gemini 1.0) on 11 tasks, and we find robust evidence tha

8 e Opus (Anthropic), Mixtral (Mistral AI), or Gemini 1.5 Pro (Google DeepMind).

9 f 95; 95% CI: 43, 64), respectively, whereas Gemini 1.5 Pro (Google) achieved a score of 36% (34 of 9

10 gnificantly more accurate (P < 0.00033) Than Gemini 1.5 Pro [mean 0.669 (95% CI: 0.581, 0.743)] and C

11 g outperformed the other approaches, whereas Gemini 1.5 Pro with ZS recorded the highest consistency.

12 foundational LLMs-OpenAI's GPT-4o, Google's Gemini 1.5 Pro, Anthropic's Claude 3.5 Sonnet, Meta's Ll

13 the-art LLMs, GPT-4o, Claude 3.5 Sonnet, and Gemini 1.5 Pro, assessing both accuracy and consistency

14 Four of the 5 chatbots (GPT-4o, Gemini 1.5 Pro, Llama 3.2-90B Vision, and Grok Beta) gen

15 MLLMs (ChatGPT-4o, Claude 3.5 Sonnet, Google Gemini 1.5 Pro, Perplexity Llama 3.1 Sonar/Default) alon

16 LLMs) (ChatGPT-4o, Claude 3.5 Sonnet, Google Gemini 1.5 Pro, Perplexity Sonar Large) in detecting and

17 tive Pre-trained Transformer 4 Omni), Google Gemini 1.5, Google PaliGemma (Pathways Language and Imag

18 randomised, non-inferiority, phase 3 trials: GEMINI-1 and GEMINI-2.

19 At week 48 in the GEMINI-1 intention-to-treat-exposed population, 320 (90%

20 e TWT on GPT-4, GPT-3.5, Claude-3-Optus, and Gemini-1-Pro-001.

21 GPT-3.5-turbo, Gemini-1.0-Pro-001 and GPT-4-turbo were also unable to m

22 GPT-4.1-mini, Gemma-3-27b, Qwen-2.5-vl-72b, Gemini-1.5-Pro, Claude-3-Opus).

23 Gemini-19-nor (10(-8) M) strongly induced expression of

24 Gemini-19-nor (10(-8) M, 4 days) caused apoptosis in app

25 Annexin V assay showed that Gemini-19-nor and 1,25(OH)(2)D(3) induced apoptosis in a

26 Gemini-19-nor increased in HL-60 both the proportion of

27 Moreover, Gemini-19-nor stimulated expression of the potential tum

28 In summary, Gemini-19-nor strongly inhibited clonal proliferation in

29 Gemini-19-nor was approximately 40 625-, 70-, 23-, and 3

30 s 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3) (Gemini-19-nor), which has 2 side chains and removal of t

31 e model (LLM) systems, such as ChatGPT(1) or Gemini(2), can show impressive reasoning and question-an

32 nt difference -2.6%, 95% CI -6.7 to 1.5); in GEMINI-2, 335 (93%) of 360 in the two-drug regimen and 3

33 re reported in the two-drug regimen group of GEMINI-2, but neither was considered to be related to th

34 on-inferiority, phase 3 trials: GEMINI-1 and GEMINI-2.

35 GPT-4o, DeepSeek-v3, Claude 3.5-Sonnet, and Gemini-2.0-Pro) and conventional machine learning models

36 he fluorescence of the fluorogenic dye dimer Gemini-552 while preserving the aptamer integrity and fu

37 hat assessed feedback from nearly 20 million Gemini(6) responses, again confirming the preservation o

38 To address these needs, we present Gemini, a novel network integration method that uses mem

39 Data were from Gemini, a population-based birth cohort of twins (n = 48

40 double-blind, multicentre, randomised trial (GEMINI-ACS-1) done at 371 clinical centres in 21 countri

41 ansformer (GPT) setup), GPT-3.5, Claude 3.5, Gemini Advanced, GeneGPT (both slim and full), BioGPT, a

42 f variant filters or prioritization methods, GEMINI allows researchers to compose complex queries bas

43 GEMINI also provides methods for ad hoc queries and data

44 novel bis(alkyl-1,3-diene)-based phosphonium gemini amphiphiles exhibit "normal" hexagonal (H(I)), Ty

45 e evaluation of the bioactivities of the two gemini analogues indicated that the 17,20 threo (20S) co

46 We synthesized two new gemini analogues, UG-480 and UG-481, that incorporate a

47 rs containing the 24(R)-hydroxy group in the gemini and 19-norgemini series.

48 Co-localization studies demonstrated that Gemini and Cajal bodies frequently abut a TRIM8 nuclear

49 e greater than those induced by the parental Gemini and that this is due to the occupancy of the seco

50 ion and whole-body clearance for [(177)Lu]Lu-Gemini and, for comparison, our gold-standard monovalent

51 Unlike multimodal LLMs such as GPT-4, Gemini, and Claude, which process text, audio, and image

52 l LLMs (including OpenAI's ChatGPT, Google's Gemini, and Meta's open-source Llama 3.2 models) were ev

53 hatGPT-3.5 and ChatGPT-4, Bard [now known as Gemini], and Bing) in producing simplified radiology rep

54 Series-B geminis are conical-shaped and pack more readily into sp

55 It was found that Series-A geminis are water insoluble despite the two amides and m

56 In contrast, cationic Series-B geminis are water soluble and form micelles with critica

57 ns emanating at C20, commonly referred to as gemini, are subject to the same phenomenon.

58 ogenic self-quenched dimer (orange Gemini, o-Gemini) based on rhodamine and evaluated its capacity to

59 onstrated by a potent single-dose SARS-CoV-2 Gemini-based vaccine.

60 tial in vivo studies showed that [(177)Lu]Lu-Gemini behaved similarly to [(177)Lu]Lu-DOTA-Bn, with al

61 ry epithelia, Gal-1 localized within nuclear Gemini bodies and drove epithelial invasiveness.

62 er nuclear domains, including coiled bodies, gemini bodies, PML bodies and the perinucleolar compartm

63 alysis (9min) was performed on a C18 column (Gemini C18, 50x2.0mm, 3microm, 110A).

64 Gemini can be accessed at:

65 LLMs, including current state-of-the-art o1, Gemini, Claude, and DeepSeek models, perform poorly comp

66 luding Llama-2-chat, Vicuna, Medllama2, Bard/Gemini, Claude, ChatGPT3.5, and ChatGPT-4, as well as no

67 Data were from the Gemini cohort, which is a population-based sample of twi

68 Participants were 2154 twins from the Gemini cohort.

69 ion occurred at the pro-R side chain in both gemini compounds.

70 (Type I) lyotropic gyroid phase formed by a gemini dicarboxylate surfactant self-assembly using a co

71 In turn, heparinoid-like gemini disaccharides (4a and 4b) were produced by select

72 cA-beta-(1,4)-GlcNAc] and related dimerized (gemini) disaccharides (4a and 4b) via n-pentenyl glycosi

73 u with DOTA-based PRIT (DOTA-PRIT), bivalent Gemini (DOTA-Bn-thiourea-PEG4-thiourea-Bn-DOTA, aka (3,6

74 Gemini eliminates the requirement for LNPs, exhibits enh

75 The improved accuracy and scalability of GEMINI enables the systematic analysis of combinatorial

76 TA-PRIT with 44 MBq (1.2 mCi) of [(177)Lu]Lu-Gemini (estimated tumor-absorbed dose, 200 Gy) induced c

77 This work presents GEMINI-Exos as an immunotherapeutic candidate with promi

78 engaging with distinct checkpoint pathways, GEMINI-Exos elicit robust cellular immunity to CRC tumor

79 GEMINI-Exos represent candidate agents for immunotherapy

80 Here, GEMINI-Exos were evaluated in cellular and animal models

81 multifunctional immune-modulating exosomes (GEMINI-Exos) can not only redirect and activate T cells

82 multifunctional immune-modulating exosomes (GEMINI-Exos) with surface-displayed antibodies against T

83 We have utilized GemiNI for analyzing six data sets of solid cancers (liv

84 ve, leading to absorbed doses of [(177)Lu]Lu-Gemini for blood, tumor, liver, spleen, and kidneys of 3

85 When hydrated or extruded, these geminis form microscopically visible vesicular and tubul

86 ing intron downstream of exon 5 (tae) of the gemini gene switches parthenogenesis from arrhenotoky to

87 The dChip-GemiNI (Gene and miRNA Network-based Integration) method

88 We have developed GEMINI (GEnome MINIng), a flexible software package for

89 -3.5 and GPT-4 (OpenAI) and Bard, now called Gemini (Google), assigned BI-RADS categories using only

90 aude 3 Sonnet and Claude 3 Opus [Anthropic], Gemini [Google]) have received much attention from resea

91 ird period) compared with 76% for the analog Gemini GXLi system (first period, P < 0.001).

92 Widespread interest in geminis has emerged recently from both industrial and ac

93 resent contribution, two related families of geminis have been synthesized, both with trehalose, a di

94 The geminis have the following general structure: long-chain

95 monomolecular films, constructed from these geminis, have interfacial areas that are dominated by th

96 Analogous geminis having two long chains, neither of which are tho

97 In a database with 10(5) samples, GEMINI identifies the nearest neighbor in 0.05 sec compa

98 GEMINI implements a nearest-neighbor search algorithm us

99 nstrate that the use of bivalent [(177)Lu]Lu-Gemini in DOTA-PRIT leads to improved TIs and augmented

100 The use of bivalent [(177)Lu]Lu-Gemini in DOTA-PRIT, as opposed to monovalent [(177)Lu]L

101 The one gemini in the study that does not form a gel is also the

102 Thus, the behavior of Series-A geminis in many ways parallels that of phospholipids and

103 scFv BsAb, a clearing agent, and [(177)Lu]Lu-Gemini) in mouse models.

104 g three luminous red quasars at z ~ 0.4 from Gemini integral field unit observations.

105 Unlike existing tools, GEMINI integrates genetic variation with a diverse and a

106 GemiNI integrates not only gene and miRNA expression dat

107 GEMINI is a fast search engine that uses a query genomic

108 Gemini is a population-based twin cohort among the gener

109 GEMINI is designed for reproducibility and flexibility a

110 2-2-12 2Br gemini (the only one of the three geminis known to form threadlike micelles) shows a marke

111 dose rate of 10(9) Gy/s, generated using the Gemini laser system at the Rutherford Appleton Laborator

112 We find that Gemini leads to more than a 10% improvement in F1 score,

113 These include variants of OpenAI's GPT-4, Gemini, Llama-3.1-70B, and Mixtral 8 x 7B.

114 PH-LLM is a version of the Gemini LLM that was finetuned for text understanding and

115 GEMINI makes use of the observation that only a small fr

116 ar-Earth asteroid and the parent body of the Geminid Meteor Shower.

117 ess-related tasks and improved over the base Gemini model in providing personalized sleep insights.

118 Gemini models failed at the delayed recall task.

119 ane functional group, was synthesized from a gemini monomer through photoreaction in the solid state.

120 d materials, the Q(I) phases formed by these gemini monomers are consistent with four possible bicont

121 The modular design of the gemini monomers used to create polyladderane allowed spe

122 Pre-organized gemini monomers were irradiated with UV light and monito

123 Gemini-N observed the properties of dust ejected from th

124 ed a fluorogenic self-quenched dimer (orange Gemini, o-Gemini) based on rhodamine and evaluated its c

125 mid-latitude clouds from the W. M. Keck and Gemini Observatories show that they cluster near 350 deg

126 on of survival motor neuron (SMN)-associated Gemini of coiled bodies (GEMs) in motor neurons, its abs

127 Cajal bodies and gemini of coiled bodies were closely associated with the

128 these prominent nuclear structures gems, for Gemini of coiled bodies.

129 We tested GEMINI on breast and ovarian cancer gene expression data

130 assistance using popular LLM's like Google's Gemini, OpenAI's GPT and Meta's Llama3, making scRNA-seq

131 the GEnetics of Male INfertility Initiative (GEMINI) or Estonian Andrology (ESTAND) cohorts.

132 4), Philips Allegro PET (n = 5), and Philips Gemini PET/CT (n = 11)-were 0.99, 1.01, 1.00, 0.98, and

133 Every aspect of the Gemini Planet Imager has been tuned for maximum sensitiv

134 The Gemini Planet Imager is a dedicated facility for directl

135 Using the Gemini Planet Imager, we discovered a planet orbiting th

136 s these challenges, this study describes the Gemini platform, an expression system with a bifunctiona

137 We previously reported two gemini pollen (gem) mutants that produced twin-celled po

138 Four independent gemini pollen mutants were isolated which produce divide

139 gemini pollen1 also showed division phenotypes consisten

140 The potential mode of action of GEMINI POLLEN1 and its effects on cell fate are discusse

141 karyokinesis and cytokinesis suggesting that GEMINI POLLEN1 may be required for the localization of p

142 The gemini pollen1 mutant was characterized in detail and sh

143 gemini pollen1 showed an incompletely penetrant phenotyp

144 The division planes in gemini pollen1 were shown to be aligned with the polar a

145 GEMINI preferentially recalls gold-standard interactions

146 In contrast, GPT-4 (via ChatGPT), PaLM 2/Gemini Pro (via Bard), and Llama 2 (via HuggingChat) con

147 Copilot), Google's PaLM 2 and newly released Gemini Pro (via Bard), Anthropic's Claude 2 (via Poe), a

148 Other LLMs (GPT-3.5, Gemini Pro, Mixtral Instruct and Llama2 70b) vary in fun

149 Gemini Pro, using a standard prompt to extract structure

150 GPT-3.5-turbo and GPT-4 (OpenAI), Gemini-pro (Google), and Llama-2-70B-chat (Meta) were pr

151 ave also explored the possibilities of using Gemini-Pro as the LLM component.

152 We conclude that while Gemini readily binds to the VDR and generates unique con

153 ations, we selected as lead compound a 20(R) gemini, related to calcitriol in terms of it is A-ring,

154 flexibility across saRNA and saDNA formats, Gemini represents a versatile next-generation platform w

155 e compared activities of 125D, 20E-125D, and Gemini, respectively, in several assays: binding to wild

156 hundreds of networks from BioGRID, and that Gemini's performance significantly improves when more ne

157 We demonstrate GEMINI's utility for exploring variation in personal gen

158 -derived score (sgRNA-B/NB), Horlbeck score, GEMINI score and MAGeCK score.

159 nergy minimization calculations indicate the Gemini side chain possesses significantly more energy mi

160 Data are from the Gemini Study, a population-based sample of twins (n = 24

161 enomic Medicine in Ill Neonates and Infants (GEMINI) study is a prospective, multicenter clinical tri

162 nomic Medicine for Ill Neonates and Infants (GEMINI) study was a prospective, comparative, multicente

163 ursor and a high concentration of a designed Gemini surfactant (Gem(16-3-16)) that has a large g valu

164 ](6-) decavanadate anions with a dicationic gemini surfactant (gem) leads to the spontaneous self-as

165 A gemini surfactant is an amphiphile possessing (in sequen

166 stitute the first example of a polymerizable gemini surfactant, and the first example of a cross-link

167 ogous series of intrinsically cross-linkable gemini surfactants are described.

168 ydrogen bonding between electrically neutral gemini surfactants of the type CnH2n+1NH(CH2)2NH2 and si

169 This is a study of 10 asymmetric gemini surfactants that self-assemble into vesicles whic

170 ions of three didodecyl dicationic dibromide gemini surfactants with different methylene spacer lengt

171 the design of the shape of the final lipids, gemini surfactants, or lipophilic polycations.

172 The Hubble Space Telescope (HST) and the Gemini Telescope imaged this galaxy 6 to 9 months before

173 The Gemini TF whole-body scanner represents the first commer

174 We develop a variational Bayes approach (GEMINI) that jointly analyzes all samples and reagents t

175 Metabolism Integrated for Network Inference (GEMINI) that links a compendium of candidate regulatory

176 ped a bivalent DOTA-radiohapten, [(177)Lu]Lu-Gemini, that showed improved radiopharmacology for DOTA-

177 ces, we have developed a fast search engine, GEMINI, that uses a genomic profile as a query to search

178 The 12-2-12 2Br gemini (the only one of the three geminis known to form

179 It was shown that gemini, the calcitriol derivative containing two side ch

180 Gemini then mitigates the uneven network distribution th

181 Gemini thereby enables memory-efficient and informative

182 We applied GEMINI to create an integrated metabolic-regulatory netw

183 Pretargeting [(177)Lu]Lu-Gemini to GPA33-expressing SW1222 human colorectal xenog

184 guage models, including ChatGPT, Claude, and Gemini, to bootstrap the probabilities of diagnoses that

185 noninferiority to triple therapy (TT) in the GEMINI trials.

186 ds to improved TIs and augmented [(177)Lu]Lu-Gemini tumor uptake and retention in comparison to monov

187 re from 2054 five-year-old children from the Gemini twin birth cohort, including parental ratings of

188 from 1102 families (2203 children) from the Gemini twin birth cohort.

189 s from 1939 children aged 21 months from the Gemini twin cohort, we assessed prospective associations

190 characterization, and self-assembly of a new gemini-type amphiphilic hexathienocoronene (HTCGemini),

191 three individual components of the systems (geminis, vesicles, and gels) have widespread practical a

192 tigated for the inhibitory effect of a novel Gemini vitamin D analog, 1alpha,25-dihydroxy-20R-21(3-hy

193 The novel Gemini vitamin D analog, BXL0124, represses CD44 express

194 t tumors, suggesting an inhibitory role of a Gemini vitamin D derivative on breast cancer stem cells.

195 We have previously shown that the novel Gemini vitamin D(3) analogue, Ro-438-3582 [Ro3582; 1 alp

196 [(177)Lu]Lu-Gemini was prepared with no-carrier-added (177)LuCl(3) t

197 Methods: Gemini was synthesized by linking 2 S-2-(4-isothiocyanat

198 The specificity of BsAb-(177)Lu-Gemini was verified in vitro.

199 The chemical structures of the resulting 18 geminis were correlated with biological activities.

200 We have recently synthesized two gemini which are related to calcitriol and 19-norcalcitr

201 Data were from Gemini, which is a cohort of UK twins born in 2007.

202 Additionally, gemini with different side chains are susceptible to bio

203 al diastereotopic distortion, we synthesized gemini with equal side chains but introduced deuterium d

204 an effort to analyze the deuterium effect on gemini with minimal diastereotopic distortion, we synthe

205 xy-21-(3-hydroxy-3-methylbutyl)vitamin D(3) (Gemini) with two six-carbon side chains (both 20N and 20

206 ged RNAs, the carboxyrhodamine analogue of o-Gemini without a biotin unit displayed a higher signal a