ライフサイエンスコーパス: geminivirus

1 ES activity of the capsid protein of a plant geminivirus.

2 5 atxr6 mutants display robust resistance to Geminivirus.

3 is the first report of an aphid-transmitted geminivirus.

4 natural antiviral defense mechanism against geminiviruses.

5 f the rate of nucleotide substitution in the geminiviruses.

6 ences gene silencing for single-stranded DNA geminiviruses.

7 wo heterologous species of cassava-infecting geminiviruses.

8 ployment of transgenic strategies to control geminiviruses.

9 transposon, not found in the GRD5 family or geminiviruses.

10 (TGS) is a natural antiviral defense against geminiviruses.

11 ding common region sequences of heterologous geminiviruses.

12 oligomers with the Rep proteins of the other geminiviruses.

13 determinants of genome size in the bipartite geminiviruses.

14 ective management of crop diseases caused by geminiviruses.

15 and elucidating mechanisms of resistance to geminiviruses.

16 2 locus confers resistance to cassava mosaic geminiviruses.

17 cipate in defense against the DNA-containing geminiviruses.

18 (WDV), which are important cereal-infecting geminiviruses.

19 nts uniquely show enhanced susceptibility to geminiviruses.

20 tion (RdDM) as an epigenetic defense against geminiviruses.

21 tial role for TIFY4B in host defense against geminiviruses.

22 develop crops that are resistant to diverse geminiviruses.

23 istone H3 and the capsid proteins of various geminiviruses.

24 g in the GRD3 family, involved a free-living geminivirus, a Helitron and perhaps also GRD5.

25 nsferred to plants to make them resistant to geminiviruses, a damaging family of DNA viruses.

26 chanisms besides gene silencing also control geminivirus accumulation at high temperatures.

27 When challenged with geminiviruses, accumulation of viral DNA was reduced by

28 Thus, Geminiviruses adapt to healthy plants by hijacking DNA r

29 ults, in addition to the large host range of geminiviruses, advocate the use of replicons for plant g

30 replication-associated protein (AC1) of the geminivirus African cassava mosaic virus (ACMV) from Cam

31 Three sequence motifs conserved among geminivirus AL1 proteins and initiator proteins from oth

32 Geminivirus AL2 and L2 proteins cause enhanced susceptib

33 By examining geminivirus AL2 and L2 suppressor activities, we show th

34 Geminivirus AL2/C2 proteins play key roles in establishi

35 towards recurrent dynamic interplay between geminivirus and plant DNA in evolution.

36 of recombination between distinct bipartite geminiviruses and establish that the bipartite genome ca

37 eplication in viruses, such as crop ravaging geminiviruses and human disease causing parvoviruses.

38 Evidence is emerging that geminiviruses and plant pararetroviruses can interact wi

39 These results showed that geminiviruses and RNA viruses interface with the host pa

40 olling infection of single-stranded (ss) DNA geminiviruses and ssRNA viroids, respectively, but both

41 as distantly related to the plant-infecting geminiviruses and the fungi-infecting Sclerotinia sclero

42 Plant DNA viruses-- both the ssDNA geminiviruses and the reverse-transcribing pararetroviru

43 he intricate evolutionary interplays between geminiviruses and their crop hosts and inform novel mana

44 ngle-stranded DNA animal circoviruses, plant geminiviruses, and nanoviruses may have evolved from pro

45 They also indicate that geminiviruses are able to modify host metabolism to thei

46 p, including both wild and cultivated hosts, geminiviruses are attractive models for the study of the

47 Geminiviruses are devastating viruses of plants that pos

48 Geminiviruses are DNA viruses that cause severe crop los

49 Geminiviruses are DNA viruses that replicate and transcr

50 Geminiviruses are important crop pathogens worldwide for

51 The DNA-containing geminiviruses are no exception, and the AL2 protein (als

52 r pathway may be considered essential, since geminiviruses are particularly prone to recombination.

53 Geminiviruses are plant ssDNA viruses that replicate thr

54 Geminiviruses are plant viruses with circular single-str

55 Geminiviruses are plant-infecting viruses with small cir

56 Geminiviruses are single-stranded DNA (ssDNA) viruses th

57 Geminiviruses are single-stranded DNA viruses that cause

58 Geminiviruses are single-stranded DNA viruses that infec

59 Geminiviruses are small DNA viruses that replicate in th

60 Geminiviruses are small DNA viruses that use plant repli

61 Geminiviruses are ssDNA viruses that infect a range of e

62 Like most plant viruses, geminiviruses are targeted by RNA silencing and encode s

63 During the infection, geminiviruses are targets of the post-transcriptional an

64 This work highlights the utility of geminiviruses as models for de novo RdDM and places DRB3

65 Here, we use geminivirus-based replicons for transient expression of

66 Moreover, integration of geminivirus-based vectors enables precise gene editing t

67 ctors interacting with the NSP and MP of the geminivirus Bean dwarf mosaic virus (BDMV).

68 hesis, the DNA-A and DNA-B components of the geminiviruses bean dwarf mosaic virus (BDMV) and tomato

69 gulating the nuclear export of the bipartite geminivirus (Begomovirus) DNA genome was recently sugges

70 ses of tomato caused by whitefly-transmitted geminiviruses (begomoviruses) cause substantial economic

71 All characterized whitefly-transmitted geminiviruses (begomoviruses) with origins in the New Wo

72 Emergence of B. tabaci-transmitted geminiviruses (begomoviruses), ipomoviruses, and torrado

73 Consequently, nonrecovery-type geminiviruses behaved like recovery-type viruses under h

74 lts indicate that Ty-1 confers resistance to geminiviruses by increasing cytosine methylation of vira

75 ene silencing (VIGS) vector derived from the geminivirus Cabbage leaf curl virus (CaLCuV) to assess n

76 ve developed a system based on the bipartite geminivirus cabbage leaf curl virus (CbLCV) that allows

77 Similar results were seen with another geminivirus, cabbage leaf curl virus (CaLCuV), carrying

78 A-Seq analysis of plants inoculated with the geminivirus, cabbage leaf curl virus (CaLCuV, Begomoviru

79 Recent discoveries of unclassified bipartite geminiviruses call for a reevaluation of these hypothese

80 In addition, our results establish that geminiviruses can be useful models for genome methylatio

81 to yellow leaf curl China virus (TYLCCNV), a geminivirus, can phenocopy to a large extent disease sym

82 Dicot-infecting geminiviruses carry genes that encode multifunctional AL

83 t detail on the composition and diversity of geminivirus communities to precipitate major advances in

84 Geminiviruses constitute a diverse group of plant viruse

85 Geminiviruses constitute a large family of single-strand

86 Members of four genera of geminiviruses contain a C4 gene (AC4 in geminiviruses wi

87 The single-stranded, circular DNA genomes of geminiviruses contain iterated motifs of five to six nuc

88 (Gossypium hirsutum) was developed from the geminivirus Cotton leaf crumple virus (CLCrV).

89 tion as a defense against DNA viruses, which geminiviruses counter by inhibiting global methylation.

90 However, how geminiviruses counter RdDM-mediated defense is largely u

91 kout plants show increased susceptibility to geminivirus, cucumovirus, and potyvirus.

92 To understand how geminiviruses defeat host mechanisms that limit infectiv

93 ediated plant innate immunity contributes to geminivirus defense responses and identified a new host

94 Our results demonstrate that geminivirus-derived vectors can be used to study genes i

95 rgely unknown whether and by which mechanism geminiviruses directly inhibit RdDM-mediated TGS.

96 Studies on the epidemiological features of geminivirus diseases have traditionally focused primaril

97 functional variation and contribute to both geminivirus diversification and host jumping.

98 diverse functions that may be important for geminivirus diversification.

99 gulating the nuclear export of the bipartite geminivirus DNA genome was recently suggested by the fin

100 Geminiviruses encapsidate single-stranded DNA genomes th

101 All geminiviruses encode a conserved protein (Rep) that cata

102 Most dicot-infecting geminiviruses encode a replication enhancer protein (C3,

103 rt that expression in transgenic plants of a geminivirus-encoded AC4 protein from African cassava mos

104 The combined properties of the geminivirus-encoded movement protein and plasmodesmata w

105 irus as suppressors of PTGS, indicating that geminiviruses evolved differently in regard to interacti

106 Like all members of the geminivirus family, CMBs have small, circular single-str

107 golden mosaic virus (TGMV), a member of the geminivirus family, encodes one essential replication pr

108 golden mosaic virus (TGMV), a member of the geminivirus family, has a single-stranded DNA genome tha

109 Tomato golden mosaic virus, a member of the geminivirus family, has a single-stranded DNA genome tha

110 golden mosaic virus (TGMV), a member of the geminivirus family, is essential for viral replication i

111 The geminivirus-focused metagenomics approach we applied in

112 amino acid sequence conservation across all geminivirus genera.

113 ate in a nuclear siRNA pathway that leads to geminivirus genome methylation.

114 n rates contribute to the rapid evolution of geminivirus genomes in plants.

115 The DNA genomes of geminiviruses have a limited coding capacity that is com

116 lant kinases contributes to the evolution of geminivirus-host interactions.

117 -4 did not confer resistance to the reporter geminivirus; however, it did activate a resistance-relat

118 on chromosome 1, which is designated gip-1 (geminivirus immunity Pla-1-1).

119 ome-mediated gene silencing from a bipartite geminivirus in Nicotiana benthamiana.

120 nome for isolates of five species of cassava geminiviruses in cassava (Manihot esculenta, Crantz) and

121 yed by these AC2 and AC4 proteins of cassava geminiviruses in regulating anti-PTGS activity and their

122 Some geminiviruses in the genus Begomovirus exhibit phloem li

123 Here, we report the effect of temperature on geminivirus-induced gene silencing by quantifying virus-

124 ure can have a major impact on the extent of geminivirus-induced gene silencing.

125 Cassava geminivirus-induced RNA silencing increased by raising t

126 ic requirements of rapidly growing cells and geminivirus-infected cells that have been induced to ree

127 roteins only accumulate in young tissues and geminivirus-infected mature leaves, the GRIK-SnRK1 casca

128 plants expressing the viral proteins and in geminivirus-infected plant tissues.

129 nctions of these host factors in healthy and geminivirus-infected plants are discussed.

130 processes during early plant development and geminivirus infection by activating SNF1-related kinases

131 Nevertheless, knowledge of geminivirus infection in wild plants, and especially at

132 Together, these results demonstrate that geminivirus infection induces the accumulation of a host

133 e importance of AL1-pRBR interactions during geminivirus infection of plants.

134 B in N. benthamiana increases in response to geminivirus infection, which would result in suppression

135 n are regulated during plant development and geminivirus infection.

136 eficient host plants are hypersusceptible to geminivirus infection.

137 way components, or ADK are hypersensitive to geminivirus infection.

138 f the replication initiator protein (Rep) of geminiviruses is essential for viral replication.

139 ggest that the high evolutionary rate of the geminiviruses is not primarily due to frequent recombina

140 cular single-stranded DNA of phytopathogenic geminiviruses is propagated by three modes: complementar

141 tion of plants with diverse RNA viruses or a geminivirus lacking a functional L2 gene.

142 t originated from a CP encoded by an ancient geminivirus lineage, distinct from begomoviruses.

143 To promote viral replication, geminiviruses manipulate the host cell cycle.

144 Geminiviruses may counter this defense response through

145 -circle initiators and support the idea that geminiviruses may have evolved from plasmids associated

146 Moreover, certain plant monopartite geminiviruses may operate similarly to mammalian DNA vir

147 en response via a common mechanism, and that geminiviruses modulate plant cell cycle status by differ

148 The geminivirus movement protein NSP is essential for virus

149 the flow of genetic material among different geminiviruses occurring in the same geographical region.

150 AL2 and L2 are related proteins encoded by geminiviruses of the Begomovirus and Curtovirus genera,

151 SEGS-1 has no homology to geminiviruses or their associated satellites, but the ca

152 the largest group of emerging pathogens, and geminiviruses (plant viruses with circular, single-stran

153 Most whitefly-transmitted geminiviruses possess bipartite DNA genomes, and this fe

154 While most geminiviruses possess monopartite genomes, the genus Beg

155 The bipartite geminiviruses possess two movement proteins, BV1 and BC1

156 ty and evolution in wild and crop plants and geminiviruses' potential to emerge in crops.

157 The single-stranded DNA geminiviruses produce transcripts from both strands (vir

158 The geminivirus protein AL1 initiates viral DNA replication,

159 Here we present evidence that the related geminivirus proteins AL2 and L2 are able to suppress thi

160 that the inactivation of ADK and SNF1 by the geminivirus proteins represents a dual strategy to count

161 llow us to propose that as a countermeasure, geminivirus proteins reverse TGS by nonspecifically inhi

162 support RNA silencing, and indicate that the geminivirus proteins suppress silencing by a novel mecha

163 irected silencing in a manner similar to the geminivirus proteins.

164 e genetic diversity reflected in present-day geminiviruses provides important insights into the evolu

165 ly, we discovered multiple direct repeats of geminivirus-related DNA (GRD) sequences clustered at a s

166 Nicotiana, gave rise to multiple repeats of geminivirus-related DNA, GRD, in the genome.

167 Thermophoretic studies show GEMINIVIRUS REP INTERACTING KINASE1, an activating kinas

168 and GRIK2, which were first characterized as geminivirus Rep interacting kinases, are phylogeneticall

169 fs-motifs I, II, and III-in the N termini of geminivirus Rep proteins are essential for function.

170 ng sequence and structural homology to other geminivirus Rep proteins.

171 dentified a fourth sequence, designated GRS (geminivirus Rep sequence), in the Rep N terminus that di

172 Geminivirus Rep-Interacting Kinase (GRIK)1 and GRIK2 pho

173 Geminivirus Rep-interacting kinase 1 (GRIK1) and GRIK2 c

174 eling revealed that upon binding of KIN10 to GEMINIVIRUS REP-INTERACTING KINASE1 (GRIK1), KIN10's act

175 AL2/C2 proteins interact strongly with host geminivirus Rep-interacting kinases (GRIKs), which are u

176 Geminiviruses replicate in nuclei of mature plant cells

177 Geminiviruses replicate single-stranded DNA genomes thro

178 nce of these results for AL1 function during geminivirus replication and transcription is discussed.

179 The geminivirus replication factor AL1 interacts with the pl

180 in interactions is discussed with respect to geminivirus replication in plant cells.

181 proteins had no effect on the efficiency of geminivirus replication in transient-replication assays,

182 air template and pleiotropic activity of the geminivirus replication initiator proteins.

183 The geminivirus replication protein (Rep) is a good target f

184 The geminivirus replication protein AL1 interacts with retin

185 at a truncated version of GRIK1 binds to the geminivirus replication protein AL1.

186 o acid sequence is strongly conserved across geminivirus replication proteins, plays a role in pRBR b

187 this lysine potentially has a broad role in geminivirus replication, but its role in nuclear import

188 planta system for functional analysis of the geminivirus replication-associated protein (Rep) in tran

189 of C3-C3, C3-C1, and C3-PCNA interactions in geminivirus replication.

190 ycle, providing an environment conducive for geminivirus replication.

191 Here, we use geminivirus replicons to create heritable modifications

192 We demonstrate the feasibility of using geminivirus replicons to generate plants with a desired

193 tion of the tomato genome was achieved using geminivirus replicons, suggesting that these vectors can

194 le to native Cas9 when they are delivered on geminivirus replicons.

195 v. Othello) were identified by inoculating a geminivirus reporter (Bean dwarf mosaic virus expressing

196 The geminiviruses represent a family of DNA viruses that has

197 Effectively combatting diseases caused by geminiviruses represents a major challenge and opportuni

198 o virus X vector and that reversal of TGS by geminiviruses requires L2 function.

199 pecies and mapped the major resistance locus Geminivirus Resistance of Pla-1 1 (GRP1) to chromosome 1

200 a to activate HR in the tomato, resulting in geminivirus resistance.

201 Cabbage leaf curl virus (CaLCuV) to infect a geminivirus-resistant Arabidopsis thaliana accession.

202 e Pla-1 is resistant to infection by diverse geminivirus species and mapped the major resistance locu

203 o movement proteins encoded by the bipartite geminivirus squash leaf curl virus, was immunolocalized

204 For the nuclear replicating bipartite geminiviruses such as squash leaf curl to systemically i

205 The movement of bipartite geminiviruses such as squash leaf curl virus (SqLCV) req

206 ruses, and suggest that SGS2/SDE1 may reduce geminivirus symptoms by targeting viral mRNAs.

207 quence designated SEGS-2 (sequence enhancing geminivirus symptoms).

208 Here, we used the geminivirus system to show that DRB3 is involved in meth

209 modate two newly discovered highly divergent geminiviruses that presently have no known vector.

210 culoviruses, adenoviruses, parvoviruses, and geminiviruses) that infect a wide range of hosts and are

211 and repeat patterns are conserved across all geminiviruses, their sequence identities are highly dive

212 Tomato leaf curl geminivirus (ToLCV) requires coat protein (CP) for the a

213 The geminivirus tomato golden mosaic virus (TGMV) amplifies

214 The genome of the geminivirus tomato golden mosaic virus (TGMV) consists o

215 The A genomic component of the geminivirus tomato golden mosaic virus (TGMV) contains a

216 e A component of the bipartite genome of the geminivirus tomato golden mosaic virus (TGMV) encodes th

217 The geminivirus tomato golden mosaic virus (TGMV) replicates

218 The geminivirus Tomato golden mosaic virus (TGMV) replicates

219 em where two nuclear-replicating agents, the geminivirus tomato yellow leaf curl Sardinia virus (TYLC

220 ranscriptome, sRNAome and methylome from the geminivirus Tomato yellow leaf curl virus-infected tomat

221 is a platform of constructs driven from the geminivirus Tomato yellow leaf curl virus.

222 The closely related geminiviruses tomato golden mosaic virus and bean golden

223 The replication proteins of the geminiviruses tomato yellow leaf curl virus and cabbage

224 nism of resistance and its durability toward geminiviruses under natural field conditions is discusse

225 methylation as an epigenetic defense against geminiviruses, using an RNA-directed DNA methylation (Rd

226 Notably, Geminivirus V2 protein can disrupt the calmodulin-CAMTA3

227 iew, we address the most relevant aspects of geminivirus variability and evolution in wild and crop p

228 d missense tRNA(Lys) suppressor genes from a geminivirus vector capable of replication promoted 30-80

229 ng an autonomously replicating Agrobacterium/geminivirus vector have enabled identification of AU-ric

230 study, the tomato golden mosaic virus (TGMV) geminivirus vector was used to silence NbRBR1 in Nicotia

231 t five distinct species of cassava-infecting geminiviruses were capable of triggering PTGS by produci

232 DNAs comprised a Ds element that harbored a geminivirus, wheat dwarf virus (WDV), origin of replicat

233 virus (DSV) but not with another subgroup I geminivirus, wheat dwarf virus.

234 a of geminiviruses contain a C4 gene (AC4 in geminiviruses with bipartite genomes).

235 in planta for two distinct fully infectious geminiviruses with respect to the three replication mode