ライフサイエンスコーパス: gene

1 elevated levels of WNT16, a NF-kappaB target gene.

2 WFhb1-c1) as a candidate for FHB resistance gene.

3 null (CC) genotype at rs2814778 in the ACKR1 gene.

4 rofibromatosis type 1 (NF1) tumor suppressor gene.

5 IF2B5-mediated translation of ubiquitination genes.

6 ted by the expression patterns of associated genes.

7 oson-mediated effects on expression of these genes.

8 of sporadic tumors show alterations in these genes.

9 diated repression of Snail epithelial target genes.

10 ctions in repression of specific HSF1 target genes.

11 n targeted knockdowns of specific monolignol genes.

12 ptions and biological functions shared among genes.

13 nd identified 2,196 differentially expressed genes.

14 is associated with expression of 28 adjacent genes.

15 .2%), while 476 (62.6%) had GAs in caretaker genes.

16 distal sites harboring virulence-associated genes.

17 and are often cotranscribed with their host genes.

18 omes 3 and 7 for Mn containing six candidate genes.

19 terfering with the branching-inhibitory BRC1 genes.

20 chromatin, and activation of thermal stress genes.

21 orates four colocalizing melanocyte cis-eQTL genes.

22 transcriptional regulator of ETT2 associated genes.

23 ostly in cancer (40%) and cardiac (27%) risk genes.

24 We identify 48 genes (25 newly reported) showing significant burden of

25 repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune s

26 d differences in DNA methylation in selected genes, across all three generations, indicating epigenet

27 nd to define the kinetics and selectivity of gene activation in response to microbial ligands; howeve

28 art from the histone "tails," which modulate gene activity.

29 racting with a region upstream of the DDIT4L gene and changing the chromatin accessibility of a DDIT4

30 es in new cancer treatment modalities (e.g., gene and immune therapies) are profoundly changing the o

31 ROs, and differential expression of regional genes and a retinal enhancer RNA at this locus was asses

32 ules of the network revealed that 76% of the genes and all gene modules participate partially in RKS1

33 More than 125 000 genomes, 516 million genes and almost 100 million unique protein sequences ar

34 and recovery, unveiling plausible candidate genes and biological mechanisms underlying ventricular e

35 and changes in the concentration of pathogen genes and host-specific fecal markers.

36 rations encompassing numerous multi-enhancer genes and multi-genic enhancers engaged in the control o

37 Significantly dysregulated genes and pathways were determined, and those in common

38 ul genetic system that shares many conserved genes and pathways with humans.

39 ulation of the Ealpha on the proximal Valpha genes, and its deletion impaired the Tcra rearrangement.

40 variants, relevant cell types/states, target genes, and mechanisms by which variants can cause diseas

41 enome is sequenced and assembled, structural gene annotation is often the first step in analysis.

42 Surprisingly, CLL driver genes are characterized by specific local wiring pattern

43 (Arabidopsis thaliana), although GAMYB-like genes are constitutively transcribed during vegetative g

44 cies of these and other functionally related genes are largely unknown, particularly in cancers not c

45 We also discovered that formative TF target genes are marked by permissive epigenomic signatures in

46 xpressed in craniofacial tissues, as well as genes associated with known autosomal dominant OFC syndr

47 and/or fatty levels, and by the ablation of genes associated with type 2 diabetes risk in genome-wid

48 eport state-of-the-art results on 12 disease-gene associations and on a time-stamped benchmark contai

49 uction of an inflammatory bowel disease risk gene ATG16L1 and Paneth cell lysozymes in patients with

50 ever, with an increasing number of circadian genes being discovered, there is a pressing need for met

51 divergence of different avian lineages, most genes belong to an avian-specific gamma-c clade, within

52 Finally, knockout mutants for 41 genes belonging to the different functional modules of t

53 red methylation in promoters, enhancers, and gene bodies, as well as in polycomb repressive complex o

54 n approach to identify additional AF-related genes by integrating multiple omics data.

55 to fine-tune the temporal expression of its genes by preventing their premature accumulation.IMPORTA

56 ion affecting the alpha-L-iduronidase (IDUA) gene (c.19_20insCGGCCCCC), a mutation confirmed in anoth

57 consideration of BGC-associated transporter genes can inform predictions of specialized metabolite s

58 uent mutations in IRF4 and NF-kappaB pathway genes (CARD11, CD79B, and MYD88), losses of 17p13 and ga

59 ouble-stranded RNA molecules can silence the gene carrying the same code as the particular RNA of int

60 man primates (NHPs) (baboons) by silencing a gene (caspase-3) responsible for induction of apoptosis.

61 The human gene catalogue is essentially complete, but we lack an e

62 hus, we propose that mutations in centrosome genes cause microcephaly by delaying mitosis and patholo

63 erentiation in the CO(2) vent population for genes central to calcification, including genes for calc

64 This gene-centric model has shaped the field of cancer biolog

65 niches of microbes and antibiotic resistance genes characterized by biofilm-forming and human-microbi

66 logenetic analyses revealed that while a few genes cluster with those of other sauropsid species in a

67 derstanding of both the activation of silent gene clusters and the ecological function of the produce

68 Multiple differentially expressed gene clusters in pathways involving metabolism and circa

69 el structure on the body wall resulting from gene co-option, or evolved from an exite (outgrowth; for

70 We identified specific gene combinations that were associated with distinct MDS

71 These cellular genes contribute to lytic susceptibility to various degr

72 cies, suggesting frequent duplication and/or gene conversion events.

73 Utilizing an evidence-based framework, 3 gene curation teams blinded to each other's work scored

74 Mice with myeloid-specific gene deletion of Traf3ip3 have increased RNA virus-trigg

75 in mice bearing the Asah1 podocyte-specific gene deletion.

76 discuss the recent discoveries on non-viral gene delivery systems.

77 Genes differentially expressed in depression were identi

78 gnificant burden of ultra-rare (MAF < 0.01%) gene-disruptive mutations (FDR 5%), six of which reach f

79 Hypermethylation of the TET2 gene down-regulated its transcription.

80 lates of depression imaging phenotypes track gene down-regulation in postmortem cortical samples of p

81 Linking ex vivo gene down-regulation with in vivo neuroimaging, we find

82 ers a proof of principle for the design of a gene drive in viruses.

83 S) gene, with minor contributions from EPSPS gene duplication/overexpression.

84 ng sites are associated with cancer-specific gene dysregulation.

85 ed nicking retains target protein dosages in gene-edited cell populations and expands gene editing to

86 we describe a platform for efficient Cas12a gene editing in Drosophila We show that Cas12a from Lach

87 ot Acidaminococcus spec., can mediate robust gene editing in vivo.

88 in gene-edited cell populations and expands gene editing to chromosomal tracts previously not possib

89 en observed in patients with variants in the gene encoding a member of this complex, EMC1.

90 e secreted ETT2 effectors as well as eilA, a gene encoding a putative transcriptional regulator of ET

91 and additional rare variant genotypes in the gene encoding alpha-1 antitrypsin, SERPINA1 (serpin pept

92 ors with exonuclease domain mutations in the gene encoding DNA polymerase epsilon (POLE) have incredi

93 Gain-of-function mutations in KCNT1, the gene encoding Slack (K(Na)1.1) channels, result in epile

94 solates carried a mutation that affected the gene encoding the carbon storage regulator CsrA.

95 d that INSeq screens successfully identified genes encoding known receptors for previously characteri

96 it the epigenetic modifications of the FOXP3 gene enhancer CNS2, necessary for indelible expression o

97 CZ classification accuracy and that combined gene-environment stratification would improve the discri

98 Most gene-environmental studies have focused on breast cancer

99 t gene expression profiles of protein-coding genes expressed in peripheral white blood cells (PWBCs),

100 ear genes involved with global regulation of gene expression (SATB1) and the estrogen receptor alpha

101 Gene expression analyses of these plants reveal a trade-

102 ial respirometry, enzyme activity assays and gene expression analyses.

103 Gene expression analysis indicated VCP expression was pa

104 Through a combination of proteomics and gene expression analysis, we identify enzymes involved i

105 hort tandem repeats that are associated with gene expression and human traits.

106 vity in the regulation of RSC proliferation, gene expression and in the repression of endogenous retr

107 e plasma membrane to modulate BDNF-dependent gene expression and neuronal dendritic growth mediated b

108 t studies have shown that the integration of gene expression and protein interaction data improves th

109 Mitochondrial metabolism and gene expression are highly regulated to accommodate thes

110 presses HIV-1-driven aberrant cancer-related gene expression at the integration site.

111 cle biopsies, while our two late DUX4 target gene expression biomarkers associate with macroscopic in

112 alization analysis to identify loci at which gene expression could potentially explain breast cancer

113 numerous studies examining how CodY controls gene expression directly or indirectly, virtually nothin

114 that has investigated genome-wide changes in gene expression during the normal physiological fasting-

115 oved accuracy, precision, and reliability of gene expression estimation, which lead to the improved d

116 the molecular mechanisms and determinants of gene expression evolution in natural populations, we ana

117 tion on molecular changes in cancer-specific gene expression facilitates efficient targeted therapies

118 CD29 also marked T cells with cytotoxic gene expression from different tissues in single-cell RN

119 This data was integrated with gene expression from E2F2 knockout tumors in an MMTV-Neu

120 ) as a novel regulator of fetal gamma-globin gene expression in human cells by repressing BCL11A tran

121 ompletely reversed elevated pro-inflammatory gene expression in macrophages.

122 sm but leads to a reprogramming of circadian gene expression in the liver in analogy to what is obser

123 er, RNA sequencing analysis revealed altered gene expression in Tph1 deficient ILC2s including induci

124 decades, knowledge of mechanisms that induce gene expression is limited.

125 n = 135,458 cases, n = 344,901 controls) and gene expression levels from 21 tissue datasets (brain; b

126 The control of gene expression noise is important for improving drug tr

127 beta-oxidation of fatty acids and stimulated gene expression of acyl-CoA dehydrogenases in the liver.

128 examination of mRNA transcript abundance and gene expression patterns in the internal organs of decea

129 A specific gene expression profile, referred to as ECM3 (Extracellu

130 e has examined social status-dependent brain gene expression profiles across vertebrates, yet social

131 Here, we tested the hypothesis that gene expression profiles of protein-coding genes express

132 R cell effector molecule through single-cell gene expression profiling.

133 ccRCC shows a gene expression signature consistent with adipogenesis,

134 We demonstrate a novel viral gene expression strategy to target cells with specific m

135 ane-associated TNF and dampened inflammatory gene expression through reverse signaling.

136 Accordingly, ChREBP target gene expression was rescued by re-expressing WT but not

137 The increase in CRF gene expression was similar across all groups; however,

138 og-sensitive CDK12 reduces DNA damage repair gene expression, but selective inhibition of endogenous

139 ation (H3K27me3) are linked to repression of gene expression, but the functions of repressive histone

140 has been extensively linked to regulation of gene expression, but the mechanisms behind this directed

141 sulted in differential changes of core clock gene expression, demonstrating an exercise and clock int

142 Small RNAs (sRNAs) regulate gene expression, play important roles in epigenetic path

143 long with increased body temperature and BAT gene expression, specifically Cox8b.

144 We showed that H19X regulates DDIT4L gene expression, specifically interacting with a region

145 at it is required for Pnr- and Srp-dependent gene expression, suggesting general GATA cofactor functi

146 e of DNA or RNA which can enhance or repress gene expression, yet the underlying molecular mechanism

147 Using a machine learning approach, we built gene expression-based models to predict drug sensitivity

148 ation, which lead to the improved downstream gene expression-based prediction of disease outcome.

149 such as enhancers, but regions that repress gene expression-silencers-have not been systematically s

150 nd the roles of these decay pathways in KSHV gene expression.

151 afficking, including genome organization and gene expression.

152 chromatin play important roles in regulating gene expression.

153 ed mice was associated with enhanced Adora2b gene expression.

154 sting, and direct multiplexed measurement of gene expression.

155 in post-transcriptional steps of chloroplast gene expression.

156 Recent work has shown that gene-expression patterns within the mTEC compartment are

157 n of protein functions involves differential gene expressions, post-translation modifications, and si

158 emmal cysts is one of the most common single gene familial diseases in humans.

159 We tested the efficacy of APTi with two gene families, the actin-dependent motor, myosin XI (a,b

160 hosphorylation and activation of Ras homolog gene family member A.

161 embers of a common B. burgdorferi paralogous gene family, share 59% similarity.

162 The precise roles of the five remaining genes (Flcn, Map1lc3b, Me2, Prkd2, and Scarb2) remain to

163 thereby increase the potential for adaptive gene flow between species so that adaptive introgression

164 ng can evolve and facilitate speciation with gene flow.

165 UBASH3A has been suggested as the underlying gene for a human T1D associated region on chromosome 21.

166 ogenes is unusual because it carries all the genes for both pathways.

167 or genes central to calcification, including genes for calcium management (calmodulin, calcium-bindin

168 construct the top 10% specifically expressed genes for each of 53 tissues followed by linkage disequi

169 ginosa genomes to curate a set of 4,440 core genes found in each isolate, representing ~64% of the av

170 references, and provides information on 6780 genes from 268 pathogens, tested on 210 hosts in 13,801

171 olved a massive and asymmetrical movement of genes from a distantly related AFC lineage into An. fune

172 ies have revolutionized our understanding of gene function in complex biological settings, including

173 ch as drug repurposing, disease modeling and gene function prediction.

174 Therefore, we characterized the human ERICH3 gene functionally and identified ERICH3 mRNA transcripts

175 Direct DNA repair gene GAs were identified in 109 patients (14.2%), while

176 ns (102C > A), in the first exon of the GBE1 gene (GBE1(102C>A)).

177 wer seizure prevalence relative to the other gene group.

178 gnificant excess of loss-of-function DNMs in genes highly expressed in craniofacial tissues, as well

179 ed c-Jun binding, and upregulation of nearby genes implicated in progeria pathophysiology.

180 Peptidase inhibitor 3 (PI3), a gene in the antimicrobial peptide pathway and known to b

181 dism (IHH) associated with variants of these genes in humans.

182 nd enforces silencing of H3K27me3-demarcated genes in mammalian cells.

183 Spatial repositioning of genes in nuclear space has been extensively linked to re

184 evealed defects in cardiomyopathy-associated genes in patients with HLHS, which may portend impaired

185 Thus, the study of regulatory genes in these species during inflorescence and floral d

186 Frequently recombining genes include those associated with heptose biosynthesis

187 lls (HSCs) occasionally acquire mutations in genes including DNMT3A that enable them to outcompete ot

188 The ST16 clone carried up to 14 resistance genes, including blaKPC-2 in an IncFIBpQIL plasmid, KL51

189 tified multiple new candidate PID-associated genes, including IVNS1ABP.

190 Differentially expressed and/or methylated genes, including RPS27L, were associated with pulmonary

191 hypertonicity by increasing transcription of genes, including those that lead to cellular accumulatio

192 The X-linked and autosomal genes independently influence mitosis such that their ph

193 the recently characterized, immune-inducible gene Induced by Infection (IBIN) was diminished in osa k

194 To validate the implication of these genes into A. thaliana growth, six of them were further

195 rmicutes ratios and an elevated abundance of genes involved in bacterial growth and division.

196 The mutated genes involved in cavefish vestigial eye formation have

197 Furthermore, genes involved in central and energy metabolism and ribo

198 transcription factor that globally activates genes involved in erythroid cell development.

199 el genome-wide significant associations near genes involved with global regulation of gene expression

200 R) pathways, it remains unknown how the APE2 gene is altered in the human genome and whether APE2 is

201 The expansion mutation in the C9orf72 gene is the most common known genetic cause for amyotrop

202 The regulation of the expression of these genes is ablated by p63 small interfering RNA as well.

203 Identification of differentially expressed genes is necessary for unraveling disease pathogenesis.

204 e expression of opsins and phototransduction genes known to play a role in light detection in most an

205 Zygotic transcription of these genes largely retained features of their regulation in s

206 Mutations in the lamin A/C gene (LMNA) are identified in patients with various type

207 The murein lipoprotein gene lpp promoted capsule retention through a mechanism

208 Spatiotemporally regulated targeted gene manipulation is a common way to study the effect of

209 STING (STimulator of INterferon Genes) mediates protective cellular response to microbia

210 the need for computational reconstruction of gene models.

211 low target accessibility or nature/extent of gene modification).

212 demonstrate deep conservation of a nucleolus gene module across very divergent organisms, and in the

213 twork revealed that 76% of the genes and all gene modules participate partially in RKS1-mediated resi

214 inal center B-cell (GCB) subtype and carried gene mutations similar to the adult counterpart (eg, SOC

215 CAR-T cells targeting tumour-specific driver gene mutations, such as the four-nucleotide duplication

216 is C virus SVR decreased monocyte interferon genes MX1, IFI27, and CD169 in coinfection and MX1, LGAL

217 n excess of differentially expressed primate genes near the breakpoints of large (>100 kilobases (kb)

218 The activation of gene networks associated with adaptive immunity was link

219 mutation in the co-transcriptional regulator gene NODULE ROOT1 (MtNOOT1) converts legume-type nodules

220 We analysed the mitochondrial COI gene of 84 butterfly species out of 90 documented in Sic

221 ptional reprogramming of specific structural genes of the pathway.

222 , weight, histology, or expression of marker genes of the thyroid gland.

223 achieved by the assembly of a functional AgR gene on one allele, with subsequent feedback inhibition

224 nsights into the contribution of triplicated genes or groups of genes to the many clinical manifestat

225 The gene order is identical to that reported for most caride

226 trolled overexpression and repression of all genes owing to saturation of inserts adjacent to all ope

227 hile the age at onset of carriers with other gene pathogenic/likely pathogenic variants was similar t

228 f estrogen receptor (ESR1/ER) and its target genes (PGR, KRT8/CK8, BCL2), which are all luminal marke

229 ated with acylsugar accumulation, except two genes previously reported to be involved in acylglucose

230 the transcription of several ABA-responsive genes, probably through promoting the recruitment of RNA

231 wing a more facile characterization of novel gene products and subcellular complexes.

232 Borrelia burgdorferi conserved gene products BB0406 and BB0405, members of a common B.

233 DNA and cDNA 16S rRNA gene profiling demonstrated that the microbial community

234 Myc, which in turn stimulated a pathological gene program.

235 n, which broadly attenuates pro-inflammatory gene programs in macrophages.

236 protein (GFP) under an interferon-stimulated gene promoter, we repeatedly observed transgenic larvae

237 erminal center (GC)-rich region of the PD-L1 gene promoter.

238 al gene regulation relies on the capacity of gene promoters to integrate inputs from distal regulator

239 Five prosomatostatin genes (PSST1, PSST2, PSST3, PSST5, and PSST6) have been

240 pression levels of known and novel candidate genes (putatively encoding beta-ketoacyl-(acyl-carrier-p

241 e immune responses rely on rapid and precise gene regulation mediated by accessibility of regulatory

242 Appropriate developmental gene regulation relies on the capacity of gene promoters

243 Key components of the photosynthesis gene regulatory network differentially accumulated betwe

244 Genes related to thermogenesis responded inconsistently

245 r's work scored the level of evidence for 17 genes reported to cause LQTS.

246 suggests that CALCOCO1 and ZC3H10 are target genes repressed by the HOTAIR regulatory element and tha

247 Finally, we discover that Polycomb-mediated gene repression requires PRC1 catalytic activity.

248 ecrease in the expression of many of the key genes required for intracellular accommodation of arbusc

249 The genes required for survival and proliferation in blood h

250 ignificant tobacco smoke exposure using deep gene resequencing and alpha-1 antitrypsin concentrations

251 not in immune-evasive Yp Analysis of Yp pagP gene sequences identified a single-nucleotide polymorphi

252 Gene set enrichment patterns showed conservation between

253 The intellectual disability gene set was significantly associated with ADHD risk in

254 Conclusions: Twelve genes showed diverse phenotypes indicating differential

255 Furthermore, an RA-responsive gene signature in human monocytes correlates with an imm

256 st RNA to Spen and results in strictly local gene silencing in cis.

257 that SPs are central chromatin regulators of gene silencing that establish immune cell identity and f

258 Gene silencing through RNAi has been used successfully i

259 me clones collectively containing all 17 SLF genes, SLFLike1, and S-RNase.

260 ommunities by the sequencing of housekeeping genes such as that encoding the small subunit ribosomal

261 anscriptional repressor of flowering-related genes, such as FLOWERING LOCUS T (FT), FLOWERING LOCUS C

262 d new protein synthesis was not required for gene suppression by HDACi.

263 In both species, predicted gene targets of differentially expressed miRNAs are invo

264 omplex with three other proteins, encoded by genes Tb927.11.4900, Tb927.8.1500, and Tb927.7.3040.

265 vely regulates the transcription of the MCM6 gene that is involved in DNA replication by directly bin

266 that Mcub is a protective cardiac inducible gene that reduces mitochondrial Ca(2+) influx and permea

267 ound that disease-causing mutations in known genes that are implicated in monogenic PID occurred in 1

268 epeats in the coding region of the causative genes that are otherwise unrelated.

269 ploited resource to extract RNA and identify genes that characterize active (endocapillary-extracapil

270 tified QTL regions suggest candidate meiotic genes that could be manipulated in order to control this

271 However, genes that define electrophysiological properties in fai

272 s "supergene" consisting of several distinct genes that determine different traits of the syndrome an

273 Bi-allelic loss-of-function variants in genes that encode subunits of the adaptor protein comple

274 This work elucidates host genes that render microglial cells susceptible to reovir

275 ematopoietic stem and progenitor cell (HSPC) gene therapy has emerged as an effective treatment modal

276 ciated virus (AAV) is a promising vector for gene therapy, but its broad tropism can be detrimental i

277 ity found within humans, our ability to link genes to phenotypes is based upon a handful of model mic

278 ntribution of triplicated genes or groups of genes to the many clinical manifestations in DS.

279 ral feature format (GFF) or its descendants, gene transfer format (GTF) and GFF3.

280 application of viral- and non-viral-mediated gene transfer to liver, heart, skeletal muscle, and the

281 l cord glioma model in pigs using lentiviral gene transfer.

282 Because the majority of genes undergo pre-mRNA splicing, most cellular processes

283 wn germline pathogenic cancer susceptibility gene variant should be offered individualized genetic ri

284 ation is a common way to study the effect of gene variants on phenotypic traits, but the Cre/loxP and

285 uantification of mRNA and protein of a given gene via dual fluorescent reporters in single, live cell

286 g mechanisms and pathways modulated by these genes, we find that they are involved in three main proc

287 ndrogen receptor (ar) and cytochrome P450 1A genes were associated with large shifts in allele freque

288 The selected genes were either from human BC studies (n = 294) or fro

289 ally methylated regions corresponding to 443 genes were identified.

290 6 alternatively spliced transcripts from 125 genes were significantly differentially expressed in rib

291 We previously identified wheat gene WFhb1-1 (aka WFhb1-c1) as a candidate for FHB resis

292 cell type or stimulation, and 31% and 52% of genes with cis-eQTLs have response eQTLs (reQTLs) in mye

293 re revealed remarkably strong connections to genes with established effects on CFTR trafficking and f

294 enced species, the challenge to characterize genes with functional information is even more important

295 Genes with increased translational efficiency following

296 ractions formed at genomic regions harboring genes with prominent roles in T cell development in both

297 yruvylshikimate 3-phosphate synthase (EPSPS) gene, with minor contributions from EPSPS gene duplicati

298 transcription factors (TFs) and their target genes, with a method able to handle both the high number

299 nly pipeline if the history was atypical for genes within the targeted panel.

300 ort for 23,865 splice isoforms across 14,611 genes, without the need for computational reconstruction