ライフサイエンスコーパス: gene family

1 n the glucose transporter family (GLUT, SLC2 gene family).

2 nfirming it as a member of the heme response gene family.

3 phylogeny, and expression profile of the NLR gene family.

4 little-studied gene and its place in the AIF gene family.

5 events that shaped the diversity of the RLK gene family.

6 ff against evolutionary expansion of the MHC gene family.

7 nt homologs of the spidroin (spider fibroin) gene family.

8 e diversification of this highly polymorphic gene family.

9 ed type I glycoprotein belonging to the RL11 gene family.

10 oded by a member of the GDSL esterase/lipase gene family.

11 ic variants and haplotypes within the GmSHMT gene family.

12 s subfunctionalization within members of the gene family.

13 ins represent novel branches of the spidroin gene family.

14 k-down of genes belonging to the cathepsin B gene family.

15 of GAL4 driver lines of the Ir, Gr, and Ppk gene family.

16 ng to the transient receptor potential (TRP) gene family.

17 haracterize the remaining members of the SRG gene family.

18 oitation of other members of this ubiquitous gene family.

19 ble phylogenetic reconstruction in any large gene family.

20 reconstructed the deepest nodes of the full gene family.

21 transcripts belonged to myosin and myotilin gene families.

22 mong co-orthologs between species and within gene families.

23 o each sample's metagenome and corresponding gene families.

24 hes to revealing specific functions in other gene families.

25 ften involve genes that are members of large gene families.

26 of some LRR-RLK variants as members of other gene families.

27 o the expanded cytochrome P450 and chitinase gene families.

28 el the physiological significance of complex gene families.

29 e, lysine decarboxylase, and acyltransferase gene families.

30 occurring primarily in genomically clustered gene families.

31 philia mothers against decapentaplegic (MAD) gene families.

32 ion in representative genes in each of these gene families.

33 m Helical Interspersed Sub-Telomeric (PHIST) gene families.

34 hantia that consists of conserved land plant gene families.

35 ion mutants of multiple genes from different gene families.

36 guides precise expression of multiple venom gene families.

37 nctional diversification of members of large gene families.

38 enes can be a strategy to discover candidate gene families.

39 ltiple tandem duplication events in multiple gene families.

40 ations in sorghum are derived from ancestral gene families.

41 are linked to radiations of lineage-specific gene families.

42 gree of variation than the majority of other gene families.

43 r subunits originate from different genes or gene families.

44 ython library for programmatic processing of genes families.

45 omes contained a core set of 103 orthologous gene families absent from all other ammonia-oxidizing ar

46 g NLR (RNL) subclass of CNLs is encoded by 2 gene families, ACTIVATED DISEASE RESISTANCE 1 (ADR1) and

47 genes Dicer, Dgcr8, and the entire Argonaute gene family (Ago1, 2, 3, and 4).

48 ophic interactions by performing comparative gene family analyses across 18 species representative of

49 Gene family analyses reveal lineage-specific duplication

50 Gene family analysis showed a significant loss of diseas

51 Nearly 300 conserved gene families and >70 functional groups contained develo

52 Analyses of clustered gene families and gene collinearity show that jute under

53 patterns identified significantly regulated gene families and genes at the population level includin

54 were encoded by a diverse range of variable gene families and Ig classes, including IgA, and several

55 ragmented assemblies, contamination, diverse gene families and mis-assemblies accumulate over the pop

56 teflies, the new Rickettsia species has more gene families and pathways, which may be important facto

57 se of saprotrophic Mucoromycota, to identify gene families and processes associated with these lineag

58 ) covers 131 complete genomes organized into gene families and subfamilies; evolutionary relationship

59 overcoming the issue of redundancy in these gene families and will undoubtedly advance auxin researc

60 The Piwi-like genes belong to the Argonaute gene family and are conserved in plants, animals and hum

61 S) genes, as well as variations of the CsTPS gene family and differential expression of terpenoid and

62 Gene family and gene ontology functional enrichment anal

63 gs to the achaete-scute complex-like ( ASCL) gene family and is a homologue of ASCL5.

64 to the voltage-gated calcium channel (VGCC) gene family and may help explain complex genetic syndrom

65 ethylation across arthropods and examples of gene family and protein domain evolution coincident with

66 analysis revealed thirteen members of TaCLPB gene family and their expression patterns in various tis

67 xpansion and functional divergence of the ST gene family and will enable the further investigation of

68 We use bla(CTX-M) (the most widespread ESBL gene family) and 16S rRNA (a proxy for bacterial load) a

69 ps (Gene Ontology terms, metabolic networks, gene families, and predicted interacting proteins) exhib

70 nd toward differential replaceability inside gene families, and rarely observe replaceability by all

71 BnMS5 belongs to a Brassicaceae-specific new gene family, and has gained a novel function that is ess

72 HT LIGHT-INDUCIBLE AND CLOCK-REGULATED (LNK) gene family, and this effect was attenuated in eds4.

73 ps; however, a comprehensive methodology for gene family annotation is currently lacking, preventing

74 which belongs to TALE-type class of homeobox gene family, appeared as one of the key regulators of he

75 With this gene-family approach, we identified 465 regions enriched

76 enetic analyses indicate that almost all the gene families are derived from lineage-specific gene dup

77 The most conserved plasmid gene families are predominantly vertically inherited, wh

78 Gene families are sets of structurally and evolutionaril

79 Currently, plant gene families are typically identified using one of two

80 istributions of other enzymes in these large gene families are unknown.

81 tification and subsequent analyses of entire gene families are widely employed in the fields of evolu

82 s III homeodomain-leucine zipper (HD-ZIPIII) gene family are critical players in the determination of

83 n, members of the distal-less (Dlx) homeobox gene family are expressed in, and regulate the developme

84 RAD51 and its gene family are key regulators of DNA fidelity through d

85 tate, including members of the sod3 and nqo1 gene families, are expanded, probably as evolutionary ad

86 surge in information about the roles of this gene family as leading actors in the transcriptional con

87 entify the nitric oxide synthase (Nos1 to 3) gene family as the closest target to Nox4 Indeed, when c

88 gen-binding breadth and expansion of the MHC gene family, associated autoimmunity trade-offs, hitchhi

89 abilities, the expression levels of specific gene families belonging to the glycoside hydrolase categ

90 We identified a novel gene family, blitzschnell (bls), that consists of de nov

91 The loss-of-function mutants of the BON1 gene family, bon1bon2bon3, are impaired in the induction

92 In summary, our gene-family burden analysis approach identified novel PE

93 llele-specific effect within an IgH variable gene family, but was not consistent with general decay o

94 this diversity is exemplified by the variant gene family called var, which encodes the major surface

95 The evolutionary history of gene families can be complex due to duplications and los

96 r genes with redundant functions in the same gene family can be examined by assembling multiple CRISP

97 sporter within the solute carrier 29 (SLC29) gene family, cause an expanding spectrum of human geneti

98 bility Complex (MHC) region contains several gene families characterized by highly polymorphic loci w

99 was found in plastid-targeted protein-coding gene families compared with Arabidopsis, but an addition

100 re genes lost and 212 unique genes (from 197 gene families) conserved among cable bacteria.

101 The SLC12 gene family consists of SLC12A1-SLC12A9, encoding electr

102 The allograft inflammatory factor (AIF) gene family consists of two identified paralogs - AIF1 a

103 We identified 14 fish-specific gene families containing multiple ISGs, including finTRI

104 edicted protein-coding genes, which reflects gene family contractions and expansions that are consist

105 Plant BiPs belong to a multi-gene family contributing to development, immunity, and r

106 BAX, a member of the BCL2 gene family, controls the committed step of the intrinsi

107 y, deregulation among multiple auxin-related gene families converged upon the re-establishment of cel

108 al regions and from cancer-testis ampliconic gene families (CT-X and GAGE).

109 ide sugar transporters, encoded by the SLC35 gene family, deliver nucleotide sugars throughout the ce

110 port that the knockout of the entire AtLURE1 gene family did not affect fertility, indicating that At

111 genome, followed by phylogenetic analyses of gene families, did not identify two key regulatory eleme

112 evolutionary trajectories are accompanied by gene-family diversification and homoeolog expression div

113 Analysis of gene family dynamics and signatures of positive selectio

114 ene transfers from bacteria and expansion of gene families (e.g. carbonic anhydrase, anti-oxidative r

115 The NLGN gene family encodes single-pass transmembrane postsynapt

116 duplications and diversification of nuclear gene families encoding phycobilisome linker proteins tha

117 We report here the identification of a gene family encoding for three small plastidial proteins

118 sually belong to young and recently expanded gene families enriched in survival functions, which migh

119 Our study illustrates the dynamics of gene family evolution by integrating insights from seque

120 zed these high-quality annotations to assess gene family evolution within Juglans, and among Juglans

121 ur software, CAFE (Computational Analysis of gene Family Evolution), have allowed researchers to esti

122 This gene family exhibits virtually limitless diversity when

123 occurred at different times in the course of gene family expansion and gave rise to the three major c

124 ave-dwelling species P. huaijiensis to study gene family expansion and gene retention following WGDs.

125 Gene family expansion in D. epigaea may enhance adaptati

126 rming diatom Seminavis robusta, showing that gene family expansions are responsible for a quarter of

127 By postulating that gene family expansions can be used to detect candidate g

128 dentifies putative adaptive lineage-specific gene family expansions that accompany the dietary shift

129 nclusion, all members of the opioid receptor gene family express circRNAs, with Oprm1 circRNA levels

130 nia-oxidizing archaea and, for most of these gene families, expression could be demonstrated in labor

131 upport for the selection hypothesis on large gene families for glutathione S-transferase and carboxyl

132 ver, all of these genes are members of multi-gene families for which Ash1 contains other copies.

133 ceptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-appro

134 amily is considered to be the most important gene family for sugar accumulation, but limited informat

135 0 Mya, only 35% of the ancestral orthologous gene families from the cyanobacterial endosymbiont remai

136 tial expression of individual members within gene families functioning in a plethora of cellular proc

137 ted pathogenic missense variants in the FXYD gene family (FXYD1, FXYD6, and FXYD6-FXYD2 readthrough).

138 In soybean, five members constitute the SNAP gene family: GmSNAP18, GmSNAP11, GmSNAP14, GmSNAP02, and

139 Gene family grouping was then performed in parallel usin

140 wever, the underlying model assumed that all gene families had the same rate of evolution, despite ev

141 The intron-exon structure of the NPIP gene family has changed dramatically throughout primate

142 shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expande

143 ein Septin 9 (SEPT9), a member of the septin gene family, has been proposed to have oncogenic functio

144 results showed that the GPAT, AGPAT and LPIN gene families have 2, 7 and 2 members, respectively, and

145 containing functionally annotated genes and gene families have been developed for model organisms an

146 er the past decade, numerous large and small gene families have been implicated in target recognition

147 HSEs of the HSP70 gene family have largely remained conserved in canonical

148 ons of OMA standalone, including identifying gene families having undergone duplications/losses in sp

149 e JavaScript widget to visualize and explore gene family history encoded in HOGs and python HOG analy

150 and coalescent methods to interrogate >3,000 gene families in archaea and eukaryotes.

151 indicate that the expansion of PP2A subunit gene families in both flowering plants and animals was d

152 The largest gene families in eukaryotes are subject to allelic exclu

153 l and two large subunits each coded by small gene families in higher plants.

154 We found notable contractions in several gene families in J. hindsii, including disease resistanc

155 NLRs are encoded by one of the most variable gene families in plants, but the true extent of intraspe

156 lysis has been conducted to characterize the gene families in poultry.

157 The MAP3K gene families in seven plant species, including two curr

158 cies-specific genes and six rapidly evolving gene families in the P. trifoliata genome.

159 riated muscle myosins are encoded by a large gene family in all mammals, including humans.

160 70s allowed us to suggest that the hsp/hsc70 gene family in Amphipoda diversified into cognate and he

161 omponents, which comprise a greatly expanded gene family in C. elegans Here we use coimmunoprecipitat

162 RAS and HRAS) is the most frequently mutated gene family in cancers, and, consequently, investigators

163 work reports for the first time the PYP/XES gene family in Citrus and strongly suggests its involvem

164 is shows expansions in each clade of the TPS gene family in each lineage (and inferred losses), accom

165 formed a genome-wide search of the CBF/DREB1 gene family in lettuce (Lactuca sativa L.) and identifie

166 lar evolutionary properties of the CBF/DREB1 gene family in lettuce and a reference for genetic impro

167 study, we systematically investigated the MC gene family in maize and identified 11 ZmMCs belonging t

168 However, the role of the VEGF gene family in neuroprotection is complex due to the num

169 xists in human and chicken, Pax6 occurs as a gene family in other vertebrates, with two members in el

170 ounds, we studied the sulfotransferase (SOT) gene family in P trichocarpa (PtSOT).

171 ine-rich-repeat) form the largest resistance gene family in plants, with lineage-specific contingents

172 ne protease homologs form the second largest gene family in the Drosophila melanogaster genome.

173 obtained revealed a conserved role of SlBBX gene family in the light signalling cascade and identifi

174 Cas9 editing of the seven-member phytochrome gene family in the model bryophyte Physcomitrium (Physco

175 Thus, the FAD2 gene family in tomato is important both to primary fatty

176 Additionally, we sequenced the Na(v) channel gene family in toxic newts and found that newts expresse

177 Members of a paralogous gene family in which variation in one gene is known to c

178 bioinformatics analysis of the Capsicum ANK gene family including gene chromosomal localization, Cis

179 nces in syntenic properties of all annotated gene families, including BUSCO genes, between the two cl

180 e comprises 6 categories of approximately 40 gene families, including cell-adhesion molecules, transm

181 ne duplication and differential evolution of gene families, including glycosyltransferase family 25,

182 Gene families, including SLFN genes, contained UV/oxidat

183 It is well documented that four gene families, including the glycerophosphate acyltransf

184 psychiatric disorder-associated pathways and gene families, including Wnt signaling, ribosome functio

185 athways contain multiple members of the same gene family, individual mutations might be overlooked, a

186 ganization analysis grouped the Capsicum ANK gene family into ten subfamilies distributed across all

187 owlesi, the only two Plasmodium species with gene families involved in antigenic variation, are uniqu

188 with stress chaperones, and the induction of gene families involved in primary plant physiological pr

189 this sea ice alga include massively expanded gene families involved in unsaturated fatty acid biosynt

190 ive genome-wide analysis of a putative GLCAT gene family involved in AGP biosynthesis by examining it

191 ehyde hydrogenases (ALDHs) belong to a large gene family involved in oxidation of both endogenous and

192 into Nitrososphaerales and the fate of these gene families is highly lineage-specific, being lost in

193 yotic translation initiation factor 2 (eIF2) gene family is a likely candidate for control of viral r

194 he Arabidopsis (Arabidopsis thaliana) PI-PLC gene family is composed of nine members.

195 tissue inhibitors of metalloprotease (TIMP) gene family is essential for normal bone growth after bi

196 *We discovered that the LRR-RLK gene family is even larger than previously thought, and

197 At least one member of each gene family is expressed within the syncytium during the

198 The RAS gene family is frequently mutated in human cancers, and

199 The GIMAP gene family is massively expanded in fish genomes and ma

200 The association with rare variants in FXYD gene family is novel and highlights the interest of expl

201 A notable example of an extended gene family is the chalcone synthase (CHS) family of gen

202 SNHG7, a member of the small nucleolar host gene family, is a highly-expressed lncRNA that is consis

203 in of photosynthesis both at the genomic and gene family levels.

204 der abiotic stress of several expanded ICE-L gene families, likely reflecting adaptive changes among

205 Furthermore, we identify a gene family, likely acting as a taxonomic marker for an

206 ing a total of 267 genes of which 28 were in gene families linked to metabolic insecticide resistance

207 rotein 1 associates with variantly expressed gene families localised at subtelomeric regions and vari

208 e-specific amplification of testis-expressed gene families, making it the most gene-dense Y Chromosom

209 , genetic variation was observed in specific gene families, many of which are known to be involved in

210 ith the possibility that members of the ABCF gene family may encode disaggregases needed for aggregat

211 previously for elephant shark, suggests this gene family may underlie the keen odorant reception of c

212 insulin receptor-beta; decreased Ras homolog gene family member A activation; and induced apoptosis.

213 hosphorylation and activation of Ras homolog gene family member A.

214 The myeloid translocation gene family member MTG16 is a transcriptional corepresso

215 Of note, MMP7 was the only MMP gene family member whose expression was down-regulated a

216 relates with increased levels of Ras homolog gene family, member A (RhoA), a KCTD13/CUL3 ubiquitin li

217 on of small GTPases such as the Ras homology gene family, member A (RHOA).

218 ncreased semaphorin 6A (SEMA6A); Ras homolog gene family, member A (RhoA); phosphatase and tensin hom

219 idative phosphorylation or RhoA (Ras homolog gene family, member A) signaling and disease functions l

220 also discuss how misregulation of the RAD51 gene family members contributes to disease and consider

221 etter for the identification and analysis of gene family members in several monocots/dicots, diploid

222 In this study, the sequences of gene family members in the glycerophosphate pathway were

223 Our results suggested that highly homologous gene family members may function antagonistically in the

224 meobox 1 (Meis1) and Meis homeobox 2 (Meis2) gene family members were identified by our approach, and

225 k presents a comprehensive study of the SHMT gene family members, including synteny, phylogeny, subce

226 (GRCD) genes, including previously unstudied gene family members.

227 Here, we show that removal of all PXY and ER gene-family members results in profound cell division an

228 ons for protein function are conserved among gene-family members, and genetic variants within these r

229 icroRNA BLINDBEN belongs to the TOE-type AP2 gene family, members of which control flowering time in

230 D gene (npd2) or all five members of the NPD gene family (npd1-5) differentially altered the frequenc

231 s one of the most rapidly evolving human-ape gene families, nuclear pore interacting protein (NPIP).

232 We also compared the gene families of geographically co-occurring D. cochinch

233 This gene family of early light-induced proteins (ELIPs) expa

234 e, duplications and losses of genes within a gene family of interest.

235 identification of the terpene synthase (TPS) gene family of the panicoid food and bioenergy model cro

236 the serine hydroxymethyltransferase (GmSHMT) gene family, of which the cytosolic-targeted GmSHMT08c m

237 flexible and dynamic interrogation of entire gene families or essential genes without the need for ex

238 Genes from different gene families or genes with redundant functions in the s

239 Our gene families pages are now known as 'gene groups' and h

240 urgdorferi genome harbors several paralogous gene families (pgf) that can encode immunogenic proteins

241 We found gene families potentially involved in the degradation of

242 gene retentions following the D event led to gene family proliferation (e.g. WRKYs) that probably fac

243 as MTG16 or ETO2) is a myeloid translocation gene family protein that functions as a master transcrip

244 Here, we generated 2871 gene-family protein sequence alignments involving 9990 g

245 mmonalities that promote infection, specific gene-family radiations contribute to distinct infection

246 rbivorous insects express their own PG multi-gene families, raising the question whether PGIPs also i

247 y between all measured loci; second, several gene families/regions show "clustering": strong three-di

248 ecies-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing i

249 e that the X-linked Slx and Slxl1 ampliconic gene families represent mouse-specific neofunctionalized

250 co-positioned with multiple members of theR gene family, revealing the evolutionary pressure acting

251 embers of a common B. burgdorferi paralogous gene family, share 59% similarity.

252 ertically inherited, while accessory plasmid gene families show significantly increased mobility.

253 An updated phylogeny of the CsTPS gene family showed three cannabis-specific clades, inclu

254 P. margaritaceum has expanded repertoires of gene families, signaling networks, and adaptive response

255 thermore, we studied the correlation between gene family size and number of cold-responsive genes as

256 It is well known that in cancer gene families some members are more frequently mutated i

257 ntegrated gene expression analyses to define gene family structures in multiple plant species.

258 has extremely reduced environmental response gene families such as those involved in chemoreception a

259 more, some of these differentially regulated gene families, such as cuticle proteins, were also signi

260 Molecular dating analysis of the Cpt gene family suggests that a horizontal gene transfer eve

261 Structural analyses showed that one antibody gene family targeted a previously subdominant, occluded

262 mber of the TERMINAL FLOWER 1/CENTRORADIALIS gene family (termed StCEN) in the negative control of tu

263 ered new lineage-specific genes and expanded gene families that are potentially informative in studie

264 We identify many novel gene families that arose early in the evolution of arthr

265 We also identified expansions in several gene families that have been implicated in parasitism in

266 yeast genes with their human orthologs from gene families that have undergone lineage-specific dupli

267 t of copy number variation in multicopy ChrY gene families that influence susceptibility to other imm

268 or mutated, functional sequence positions in gene families that were mutually exclusive (in patients)

269 Metagenomics identified more than 22,000 gene families that were significantly different between

270 owing that the NM-R genome lacks an expanded gene family that controls NK cell function in several ot

271 und that they define a Brassicaceae-specific gene family that has expanded partly via multiple tandem

272 t paralog, TSO1, revealing complexity in the gene family that may enable customization of cell divisi

273 previously undescribed host-responsive aphid gene family that operate as virulence factors.

274 TAC1 and LAZY1 are members of a gene family that regulates lateral shoot orientation in

275 We tested the efficacy of APTi with two gene families, the actin-dependent motor, myosin XI (a,b

276 ter understand the evolution of this complex gene family, the DNA sequence of a 1.75-Mb genomic regio

277 While not belonging to a gene family, TMEM206 has orthologs in probably all verte

278 valuating targeted degradation across entire gene families to accelerate understanding of TPD beyond

279 ontribution of the male secreted short (mss) gene family to male mating success, sex ratio, and popul

280 ased on the extensive library of over 15 000 gene family trees from the PANTHER database, and are upd

281 Here we show that the Spok gene family underlies the Psks.

282 ngly, we observed differences in Vbeta-Jbeta gene family usage between hereditary and idiopathic CP a

283 clusters of somatic mutations across entire gene families using protein domain models.

284 of TALENs by disrupting the H2A.B multi-copy gene family using only one pair of TALENs.

285 d45 (Growth arrest and DNA-damage-inducible) gene family, very little is known about how this family

286 In the second case study, a target gene family was searched in many organisms, by analyzing

287 cellular, and genetic analysis of the EPSIN gene family, we identify EPSIN1 and MODIFIED TRANSPORT T

288 described nodule-specific PLAT domain (NPD) gene family, we show how inoculating plants with a mixed

289 pression, structural variations and expanded gene families were responsible for speciation and the ev

290 c modularity of LRR domains of several human gene families, which is a precondition for alternative s

291 plied this pipeline to the STIMATE (TMEM110) gene family, which has recently been reported to play an

292 icly available gene expression data for each gene family, which will aid in the identification of aux

293 arkable expansions of protease and cell wall gene families, while divergent infection strategies are

294 nd expression shifts are reconstructed using gene-family-wise phylogenetic Ornstein-Uhlenbeck models.

295 inactivation of members of the HIPM and DIPM gene families with a role in fire blight susceptibility

296 tes, such as the expansion of a large set of gene families with unknown Pfam domains and a number of

297 We identified a single gene family with dramatic expansion in all sequenced res

298 We screened ten ORs from the Olfr740 gene family with ~800 perfumery-related odorants spannin

299 es, we identified a novel direct ATF4 target gene, family with sequence similarity 129 member A (FAM1

300 Members of the novel aphid gene family Ya are differentially expressed in aphids on