ライフサイエンスコーパス: gene mapping

1 complex diseases and strategies for disease gene mapping.

2 cted to provide the best-possible guides for gene mapping.

3 es of natural selection, and may aid disease gene mapping.

4 a prerequisite for population-based disease gene mapping.

5 rate (FDR) controlling procedure in disease gene mapping.

6 brium has become important in the context of gene mapping.

7 neglected topics, given their importance in gene mapping.

8 a high-throughput SNP genotyping method for gene mapping.

9 e in medical detection, DNA diagnostics, and gene mapping.

10 t constitutes a novel approach to suppressor gene mapping.

11 ng loci, and be an important tool in disease gene mapping.

12 large-scale association analysis for disease-gene mapping.

13 sociation methods are crucial for successful gene mapping.

14 gnificant practical implications for disease-gene mapping.

15 well to expectations of current methods for gene mapping.

16 lightly different ways, as a methodology for gene mapping.

17 rovide a rapid and robust tool for zebrafish gene mapping, a panel of radiation hybrids (RH) was prod

18 ome, we have also examined the expression of genes mapping adjacent to UBE1.

19 In conclusion, gene mapping, allele sequence data, expression profile a

20 int sequencing, population screening, online gene mapping, allelic discrimination of tumor-associated

21 together with graphical displays of RNAi to gene mappings allow quick intuitive comparison of result

22 7 associated genes (124 new), and functional gene mapping analysis linked 146 additional genes.

23 le phenotypic or diagnostic endpoints into a gene-mapping analysis.

24 Moreover, these reagents will simplify gene mapping and analyses of genomic fragments in fetal

25 genetic markers that may be most useful for gene mapping and association studies.

26 Through functional gene mapping and Bayesian co-localization multi-omics ev

27 , comparative sequence analysis, comparative gene mapping and candidate disease gene identification,

28 hese influences is increasingly important as gene mapping and case-control studies are initiated in S

29 ges offered by reciprocal translocations for gene mapping and cloning, T(2;10)67Gso should prove a va

30 d application of molecular marker assays for gene mapping and discovery in field crops and trees.

31 AB-NAM an important tool for high-resolution gene mapping and discovery of novel allelic variation us

32 Integrated maps are useful for gene mapping and establishing the relationship between r

33 The results presented are useful for gene mapping and evolutionary and comparative genomics o

34 ing designs required by association studies, gene mapping and evolutionary biology, the National Canc

35 ing designs required by association studies, gene mapping and evolutionary biology, the National Cent

36 d that they may be most promising for future gene mapping and for extending pedigrees by phenotyping

37 rtant implications for strategies of disease-gene mapping and for understanding human evolutionary hi

38 advantage, fueling significant exchanges of gene mapping and functional information especially betwe

39 enetic background interactions, we integrate gene mapping and gene mRNA expression data in segregatin

40 segments could have a substantial impact on gene mapping and health.

41 ggestive role for endothelial cells by using gene mapping and heritability enrichment.

42 s have been due to technological advances in gene mapping and in statistical methods that relate gene

43 molecules opens new possibilities in optical gene mapping and in the fundamental study of DNA-protein

44 vent of sophisticated genomic techniques for gene mapping and microarray analysis has provided opport

45 roach that incorporated multi-evidence-based gene mapping and network-analysis-based prioritization.

46 of the longSAGE retina tags enhanced tag-to-gene mapping and revealed alternatively spliced genes.

47 Gene mapping and sequencing data lead to the generalizat

48 ted to a specific gene and require laborious gene mapping and sequencing.

49 e data is an important task for both disease-gene mapping and studies of human evolution.

50 disequilibrium (LD) is of great interest for gene mapping and the study of population history.

51 Our hybrid resources will allow inexpensive gene mapping and we expect that this technology can be t

52 By gene mapping and with the help of a novel cell-based rep

53 escribed on the basis of chromosome studies, gene mapping, and DNA sequencing.

54 gene-based association analysis, functional gene mapping, and genetic correlation estimation.

55 ow here the mouse Hmx1 genomic sequence, its gene mapping, and its expression pattern in the developi

56 Clinical diagnosis of CORD, disease gene mapping, and mutation identification.

57 other omics data with user-provided probe-to-gene mapping annotations.

58 to another gene and suggests that additional genes mapping antisense to known genes may exist.

59 Thus, comparative gene mapping appears to be an efficient strategy for ide

60 linkage analysis (LDLA) is a high-resolution gene mapping approach based on sophisticated mixed linea

61 e data show the power of an integrated human gene-mapping approach for heritable molecular phenotypes

62 computational method, CEGMA (Core Eukaryotic Genes Mapping Approach), for building a highly reliable

63 oth for successful implementation of disease-gene mapping approaches and for inferences about human d

64 Variant-to-gene mapping approaches and mouse gonadotropin-releasing

65 sults from fine-mapping and other variant-to-gene mapping approaches identified 36 credible genes in

66 l power and resolution compared to classical gene-mapping approaches.

67 ng widely recognized as the new currency for gene mapping as increasing numbers are discovered.

68 build a subnetwork of Gc signaling, with 54 genes mapping as nodes, and 6 non-Gc regulated genes inf

69 The algW gene, mapping at 69 min, was isolated on the basis of it

70 Finally, we identified 861 genes mapping at 156 inversions breakpoints, with some s

71 egulators are the products of two paralogous genes mapping at positions adjacent to the corresponding

72 mapping of the 7;18 translocation such that genes mapping at the site of the breakpoint can be ident

73 Effective gene mapping based on genetic association data will requ

74 methods offer a powerful approach to disease gene mapping, based on the association between causal mu

75 is is generally the scenario of interest for gene mapping by LD.

76 Software to perform the gene-mapping calculations, "MALDsoft," is freely availab

77 eural progenitors to carry out a "variant-to-gene" mapping campaign that identified 88 candidate slee

78 ve alternative technique in statistics-based gene mapping, cancer diagnostics, and forensic applicati

79 sorders are caused by mutations in different genes mapping close together within the genome.

80 Variant-to-gene mapping combining ATAC-seq to assay open chromatin

81 NA and protein sequence data, polymorphisms, gene mapping data and genome coordinates, and comparativ

82 The comparative gene mapping data on ECA14 and ECA21 finely align the ch

83 statistics and basic quality assessments for gene-mapping data, accommodating either pedigree or case

84 Using gene mapping, direct genomic sequencing, and extended ha

85 Gene mapping efforts are now focussing on linkage disequ

86 practical implications of these results for gene mapping efforts.

87 a marker for a disease subtype suitable for gene mapping efforts.

88 ding of genetic variation will help to guide gene-mapping efforts.

89 human traits thus far and will guide future gene-mapping efforts.

90 ovel chromosome 21 genes and four paralogous genes mapping elsewhere in the human genome.

91 evaluation, immunologic assays, homozygosity gene mapping, exome sequencing, Sanger sequencing, and f

92 ause its position was estimated from a trait gene mapping experiment, a chromosome segment should be

93 Gene mapping experiments including transfections of UGT1

94 algorithm to define the asthma phenotype in gene mapping family-based studies.

95 The current gene mapping for complex diseases is heavily weighted by

96 dditional 38 LTL-genes using chromatin-based gene mapping for EUR ancestry population.

97 by >=2 criteria from a systematic variant-to-gene mapping framework.

98 Using SNP-to-gene mapping, functional annotation databases, and funct

99 These include studies in gene mapping, functional characterization of previously

100 By transracial gene mapping, genetic susceptibility to anti-Jo-1 and ot

101 esource utilization given a set of SNP-based gene-mapping goals.

102 Gene mapping has identified OS mutations within a protei

103 echnological developments in human and mouse gene mapping, has additionally provoked extensive compar

104 A whole brain immediate early gene mapping highlighted the dorsolateral bed nucleus of

105 standardized gene list and a fully traceable gene mapping history for each gene from the original tra

106 Despite the success in gene mapping, however, cloning of complex trait loci or

107 Gene mapping identified a single base pair deletion in m

108 t serve as a leverage tool for complex trait gene mapping if genomes are screened with the appropriat

109 aphids, and the results indicate that target gene mapping in aphids is feasible.

110 In nature, gene mapping in field pedigrees is required to study soc

111 we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-derive

112 Comparative gene mapping in mammals typically involves identificatio

113 Exome sequencing is a promising tool for gene mapping in Mendelian disorders.

114 s provide a new genomic tool for comparative gene mapping in the cat and related Felidae, and provide

115 reening and should accelerate the process of gene mapping in the future.

116 morphism analysis (SSCP) can be utilized for gene mapping in zebrafish.

117 Cell wall related genes mapping in genomic regions involved into tomato bi

118 Transcription of the acrABDEF genes, mapping in three widely spaced loci, was elevated

119 ry maintenance using ex vivo immediate-early gene mapping, in vivo neuronal recordings and viral-medi

120 By examining differentially expressed genes, mapping information, and genome resequencing, we

121 Gene mapping, linkage disequilibrium, genome-wide associ

122 y on arbitrary thresholds and simplified CpG-gene mappings, making them sensitive to analytical choic

123 V resistance made it possible for functional gene mapping, map-based cloning, and marker-assisted bre

124 kage disequilibrium (MALD) is a whole genome gene mapping method that uses LD from extended blocks of

125 Using a recently developed gene-mapping method, Fine-mapped Locus Assessment Model

126 ics packages that provide a full spectrum of gene mapping methods, ranging from parametric linkage in

127 the accuracy, by using two population-based gene-mapping methods-likelihood-based linkage-disequilib

128 Expression-gene mapping, network analyses and chromatin looping nom

129 netic association studies the mainstream for gene mapping of complex human diseases.

130 Admixture mapping is a powerful approach for gene mapping of complex traits that leverages the divers

131 w this resource can facilitate cross-species gene mapping of complex traits.

132 to characterize the genetic architecture and gene mapping of HCN.

133 esults provide the first physical variant-to-gene mapping of human sleep genes followed by a model or

134 procortistatin and the mRNA distribution and gene mapping of mouse cortistatin.

135 lected at the molecular level by comparative gene mapping of SSC12 and HSA17.

136 Orthologous gene mappings of Drosophila genes to other organisms are

137 enetic studies, the high-resolution (gene-by-gene) mapping of amplicon boundaries and the quantitativ

138 population-based cohort of older persons for gene-mapping of cerebral small vessel disease.

139 to improved biolabeling experiments, such as gene mapping on a nanometer scale or multicolor microarr

140 logy, such as muscle cell transplantation or gene mapping, open exciting possibilities for future nov

141 68, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate bio

142 ver risk alleles and complements established gene-mapping paradigms in neuropsychiatric disease.

143 A composite interval gene mapping procedure for complex binary disease traits

144 additionally provoked extensive comparative gene mapping projects for domestic species of several ve

145 y patterns across ethnic groups may increase gene-mapping resolution.

146 These data, together with other available gene mapping results in SLE, are beginning to allow a pr

147 six orders of placental mammals, confirm the gene-mapping results and indicate that the multiple huma

148 Lineage trajectory inference and spatial gene mapping reveal that Prg4-expressing fibroblasts tra

149 Gene mapping shows that exons 1-16 and the P1 promoter s

150 n (UGT1A complex of genes), using multiomics gene-mapping strategies in diabetes-relevant tissues.

151 rculating inflammasome, and through multiple gene-mapping strategies, we prioritized 259 putative cau

152 A analyses, construction of genetic maps and gene mapping studies aiming to link phenotype and genoty

153 Disease-gene mapping studies and a simulation study gave differi

154 ch for mapped BAC clones that can be used in gene mapping studies and chromosomal mutation analysis p

155 Gene mapping studies demonstrated that, in contrast to t

156 Gene mapping studies in animal mutants with anaemia due

157 gnificant heritability supports their use in gene mapping studies of AgP susceptibility.

158 Phenotype assessment is a crucial issue in gene mapping studies of asthma.

159 aluable strategy for increasing the power of gene mapping studies of complex diseases.

160 millions-of human genomes as part of various gene mapping studies, biobanking efforts, and clinical p

161 human identification and parentage testing, gene mapping studies, cancer diagnostics, and diagnosis

162 Moreover, they show that, in gene mapping studies, genetic data from both parents and

163 or more major genes and thus be suitable for gene mapping studies, segregation analyses were performe

164 ey are not directly observed in most current gene mapping studies.

165 taken in regard to disclosure and consent in gene mapping studies.

166 approach for improving power complex traits gene mapping studies.

167 ar families commonly used in complex disease gene mapping studies.

168 pring trios are widely collected for disease gene-mapping studies and are being extensively genotyped

169 t genotyping errors lead to loss of power in gene-mapping studies and underestimation of the strength

170 Many gene-mapping studies for healing ability have been perfo

171 t assessment of glucose metabolism, enabling gene-mapping studies in large population samples.

172 Previous gene-mapping studies indicating the existence of two loc

173 These results suggest that future gene-mapping studies may identify pleiotropic genetic va

174 riation in molecular population genetics and gene-mapping studies of diseases with complex inheritanc

175 Gene-mapping studies routinely rely on checking for Mend

176 This is especially true for gene-mapping studies that focus on complex diseases that

177 However, despite converging evidence from gene-mapping studies, aspects of the genetic contributio

178 ype imputation is necessary for facilitating gene-mapping studies, especially with the ever increasin

179 They show potential for gene-mapping studies.

180 genetic markers or functional candidates in gene-mapping studies.

181 is mouse model of childhood cancer, we did a gene mapping study with the SWXJ-9 recombinant inbred st

182 Overall, our comprehensive gene-mapping study and preliminary functional evaluation

183 To our knowledge, this is the first gene-mapping study of abnormalities of X-inactivation pa

184 Existing methods for orthologous gene mapping suffer from two general problems: (i) they

185 technologies in combination with traditional gene mapping techniques, such as linkage analysis, can h

186 es a cost-effective strategy for psychiatric gene mapping that complements common variant approaches

187 Our approach unifies two main goals of gene mapping that have generally been treated separately

188 l method, SCENT (single-cell enhancer target gene mapping), that models association between enhancer

189 ptimization Strategy (GOST), for orthologous gene mapping through combining sequence similarity and c

190 We identified RIL, a LIM domain gene mapping to 5q31, a region frequently deleted in acu

191 s a candidate prostate cancer aggressiveness gene mapping to 7q32-q33.

192 OVCA1 is a candidate tumor suppressor gene mapping to a highly conserved region on chromosome

193 iated with a maternally expressed, imprinted gene mapping to chromosome 15q11-13.

194 ndidate prostate cancer tumor aggressiveness gene mapping to chromosome 7q32-q33.

195 LIN-1 as a candidate for a tumour suppressor gene mapping to human chromosome 7q31.1.

196 range of applications from microarray-based gene mapping to identification of chromosomal mutations.

197 We use gene mapping to identify modulators of HSC biology linke

198 en described as a single-locus multi-allelic gene mapping to molecular linkage group (MLG) F.

199 es is useful in studies ranging from disease gene mapping to speciation genetics.

200 Xist, a gene mapping to the X-inactivation centre (Xic), is excl

201 Our findings indicate that a gene mapping to this region is mutated in either C57BL/6

202 expression of 122 (61%) and 88 (27%) of the genes mapping to 1p35-36 and all of 11q, respectively, s

203 Two genes mapping to 9p21, p15 and p16, encode inhibitors fo

204 To facilitate the identification of genes mapping to amplified regions, we have used a techn

205 macaques (80-89%), we observed induction of genes mapping to antiviral and interferon-related pathwa

206 rkers and subsequent evaluation of candidate genes mapping to areas of interest will be increasingly

207 nd frequency of gene amplification affecting genes mapping to ch13q34 in human breast cancer.

208 t that altered transcriptional regulation of genes mapping to chromosome 1 may contribute to disease

209 hit." Alternatively, other tumor suppressor genes mapping to chromosome 10q22-23 could be the actual

210 ing in a haploinsufficiency of RB1 and other genes mapping to chromosome 13, as well as activation of

211 aracterized by significant overexpression of genes mapping to chromosome 1q, and both exhibited a poo

212 vely distinct vascular network, differing in genes mapping to circadian rhythm pathways, and denser s

213 impairs gene transcription, particularly at genes mapping to clusters such as HOX and PCDHB.

214 ic regions containing the orthologs of human genes mapping to human chromosome 20q.

215 ster of genes to be flanked predominantly by genes mapping to human chromosomes 7 and 19.

216 is analysis revealed 44 highly overexpressed genes mapping to localized amplicons on chromosome 13, g

217 On the other hand, genes mapping to loci outside of the major histocompatib

218 t been analyzed in detail; to date, only VZV genes mapping to open reading frames (ORFs) 4, 21, 29, 6

219 hnologs are significantly overrepresented in genes mapping to pathogenic CNVs, irrespective of how CN

220 We also found that genes mapping to PPP-associated intervals were preferent

221 26 genes mapping to the 1q arm show highly significant (P</

222 er of candidate genes was reduced, and a few genes mapping to the BBS3 interval emerged as the best c

223 ohn's disease (CD), showed associations with genes mapping to the cytokine gene cluster on 5q31.

224 Twelve genes mapping to the deleted region were reliably identi

225 has been entirely sequenced and many of the genes mapping to the deletion interval have been studied

226 rs at the same rate as that observed between genes mapping to the distal portion of the circular chro

227 -mb region that included RUNX1, miR-802, and genes mapping to the Down syndrome critical region.

228 rt-range linkage with five orthologous human genes mapping to the Major Histocompatibility Complex (M

229 o H-Y are controlled by immune response (Ir) genes mapping to the MHC.

230 Transcripts for genes mapping to the p38 mitogen-activated protein kinas

231 Additionally, the expression of genes mapping to the Saltol region of chromosome 1 were

232 We show that multiple genes mapping to this region interact to regulate brain

233 In addition, several genes mapping to this region show imprinted expression,

234 the positional cloning of candidate disease genes mapping to Xp22.1 and is therefore of value for th

235 ohnologs between these gene sets and control genes, mapping to CNVs not known to be disease associate

236 Gene expression profiling and gene mapping using 500K single-nucleotide polymorphism (

237 a collection of families for fine-structure gene mapping using allelic association.

238 method for fine-scale linkage-disequilibrium gene mapping using high-density marker maps.

239 r is concerned with efficient strategies for gene mapping using pedigrees containing small numbers of

240 Immediate early gene mapping using zif268 in situ hybridization revealed

241 For disease gene mapping, using both simulated and real data sets on

242 Gene mapping was performed utilizing a polymorphism iden

243 ds mainly rely on sequence-based orthologous gene mapping, which often leads to suboptimal mapping re

244 Finally, gene mapping with a (C57BL/6J x SPRET/Ei)F1 x SPRET/Ei m

245 logistic regression in case-control disease gene mapping with a large number of SNPs (single nucleot

246 de association studies (GWAS) and variant-to-gene mapping with functional follow-up.

247 eexamine the role of random effect models in gene mapping with inbred strains.

248 Gene mapping with microsatellite markers demonstrates th

249 Gene mapping with recombinant inbred BXD strains reveale

250 pport the hypothesis that a tumor suppressor gene mapping within 11q23.3 is commonly inactivated duri

251 Overexpression of CKS1B, a gene mapping within a minimally amplified region between

252 e microrchidia CW-type zinc finger 2 (MORC2) gene mapping within the linkage region.

253 The AF-6 gene, mapping within RMD-1, revealed no mutations in a s

254 Investigators targeting 129/Sv genes mapping within chromosomal regions reported herein

255 Genes mapping within rare CNVs in TS showed significant

256 implicated in copy number pathogenicity: (i) genes mapping within rare disease-associated CNVs, (ii)

257 Eleven of the genes mapping within the SMS common deletion region have

258 Key genes mapping within these deleted regions include PTEN,

259 Key amplified genes mapping within these regions include SKP2, FOXA1,