ライフサイエンスコーパス: gene product

1 s of pyroptosis due to the action of its Vpx gene product.

2 ect the abundance or activity of the encoded gene product.

3 onneuronal cells and is repressed by the Us3 gene product.

4 terwoven into networks, rather than a single gene product.

5 many Archaea form homohexamers from a single gene product.

6 n in tsv causes premature termination of the gene product.

7 xnIP promoter, controlling expression of its gene product.

8 tions in at least 1 PI3K pathway gene and/or gene product.

9 spread and possible loss of the therapeutic gene product.

10 ion, abundance, activity, or affinity of the gene product.

11 to have variants that affect function of the gene product.

12 ight on biological functions and pathways of gene products.

13 res and the consequent accumulation of viral gene products.

14 itative modelling of correlation across such gene products.

15 protein-coding RNAs and common AD-associated gene products.

16 ry cellular immune responses to all nine SIV gene products.

17 pyrosequencing and cloning/sequencing hgcAB gene products.

18 is needed for robust accumulation of zygotic gene products.

19 at cannot be transcribed into any functional gene products.

20 rsity on the structure and function of viral gene products.

21 ing behind the more abundant HLA-A and HLA-B gene products.

22 oolkit will prove useful for the analysis of gene products.

23 84 subunits of 11 unique atomic models of 10 gene products.

24 o a gain or loss of conserved domains in the gene products.

25 HMGB1) and the hypoxia upregulated-1 (HYOU1) gene products.

26 frequency-dependent selection (NFDS) on the gene products.

27 used resource to describe the attributes for gene products.

28 molecular identification of the Sm1 and Sm2 gene products.

29 of the predicted protein interactions of the gene products.

30 for the tumor-promoting effects of amplified gene products.

31 ed by maternal inductive signals and zygotic gene products.

32 he effective number of functionally distinct gene products.

33 of MERS-CoV and human interferon-stimulated gene product 15 (hISG15) was probed with isothermal calo

34 moval of ubiquitin and interferon-stimulated gene product 15 (ISG15) from target proteins.

35 Interferon-stimulated gene product 15 (ISG15) is a key component of host respo

36 teins by ubiquitin and interferon-stimulated gene product 15 (ISG15), subsequently facilitating downr

37 quitin (Ub) or Ub-like interferon-stimulated gene product 15 (ISG15).

38 The ssDNA binding protein [gene product 32 (gp32)] of the T4 bacteriophage is a cen

39 m (un)folding intermediate state of T4 phage gene product 45 (gp45, also known as DNA polymerase proc

40 land innervation index of structural protein gene product 9.5 (SGII[PGP9.5]) and peptidergic vasoacti

41 cific enolase [NSE] [ENO2], neuronal protein gene product 9.5 [PGP9.5], and somatostatin receptor 1 [

42 zation showed increased TUBB3(+) and protein gene product 9.5(+) Merkel cells during in vivo repair,

43 edding and antibody staining against Protein-Gene-Product-9.5 or Neurofilament-H in combination with

44 We report that the gamma134.5 gene product, a virulence factor of HSV-1, facilitates n

45 To identify more gene products able to regulate EC1 expression together w

46 This presupposes that gene product abundance is governed by gene dosage and th

47 l genomes suggests that extensive sharing of gene products among symbiont cells must occur.

48 tified 12 VUS that did alter function of the gene product and 28 VUS that did not; the remaining 8 VU

49 e single csoS2 gene yields expression of two gene products and both display an apparent molecular wei

50 -binding adaptor shared by APAF-1, certain R gene products and CED-4) and NACHT (named for NAIP, CIIA

51 ion networks, where nodes stand for genes or gene products and each edge stands for a relationship be

52 activation, upregulation of pro-inflammatory gene products and enhanced transmigration across a blood

53 resulting in misannotation of selenoprotein gene products and failure to predict SCR.

54 s that alter RBP-RNA interactions can affect gene products and functions.

55 anscriptome, revealing previously undetected gene products and isoform-specific protein expression.

56 d sequence similarity between the homologous gene products and MUM2.

57 he current nomenclature to include all viral gene products and provide a genome browser that visualiz

58 wing a more facile characterization of novel gene products and subcellular complexes.

59 fore required to correctly represent recoded gene products and their functions.

60 part of the currently undruggable genes and gene products and to generate entirely new therapeutic p

61 fected on the expression of LHCSR1 or LHCSR3 gene products and/or state 1-state 2 transitions or zeax

62 potential consequences of lowering levels of gene products, and the need to consider both gain and lo

63 ion about interactions between chemicals and gene products, and their relationships to diseases.

64 nal template for the production of all viral gene products, and thus, it is the molecular basis of HB

65 representing essentially all canonical human gene products, and we exemplify the utility of these dat

66 by paralogous genes CLTA and CLTB, and both gene products are alternatively spliced in neurons.

67 A2*05 gene is present in abundance, and its gene products are characterized by low cell-surface expr

68 of pneumonia, indicating that MumR-regulated gene products are crucial for protection against the hos

69 of the T9SS are co-transcribed and that the gene products are distributed in the cell envelope.

70 Intriguingly, homologous WOX gene products are expressed in stem cell-organizing cent

71 However, cyanophage-encoded gene products are hypothesized to maintain or even suppl

72 These gene products are ideal targets to block malaria transmi

73 ently in certain tissues, indicating that LR gene products are important.

74 iated with mutations in NPC1 and NPC2, whose gene products are key players in the endosomal/lysosomal

75 These gene products are regulated by the nuclear factor-kappaB

76 Spermathecal gene products are required for Drosophila sperm storage

77 In the noisy cellular environment, gene products are subject to inherent random fluctuation

78 We consider whether some of these gene products are too crucial to life for mutations to b

79 The gene product, ArsI, is an Fe(II)-dependent extradiol dio

80 Using Gria2 and its associated gene product as an example, we present this proof-of-con

81 expression and correct trafficking of target gene products as assessed by immunofluorescence assays a

82 mbryogenesis shifts from maternal to zygotic gene products as the zygotic genome becomes transcriptio

83 ength SIV genome that expresses all nine SIV gene products, assembles noninfectious SIV virion partic

84 bled into the complex with the mitochondrial gene products ATP6 and ATP8.

85 Borrelia burgdorferi conserved gene products BB0406 and BB0405, members of a common B.

86 The BEST1 gene product bestrophin-1, a Ca(2+) -dependent anion cha

87 The BLM gene product, BLM, is a RECQ helicase that is involved i

88 ss of nuclear expression of MLH1 or MSH2 MMR gene products by immunohistochemistry (IHC).

89 re, we report that the interferon-stimulated gene product C19orf66 (herein named Shiftless) is a host

90 Our findings reveal that a viral gene product can function in distinct cellular subsets t

91 logy in mouse models and that the HTT exon 1 gene product can self-assemble into amyloid structures.

92 Although both gene products can function as potential porins, only BB0

93 KSHV thymidine kinase (TK), the ORF21 gene product, can enhance the production of dTTP and is

94 and biochemical properties of CAPN14 and its gene product CAPN14, and its emerging role in patients w

95 geneous genes, based on the proximity of the gene products' catalyzed reactions in the metabolic netw

96 4, rs3740393) were located near AS3MT, whose gene product catalyzes methylation of iAs to MMA and DMA

97 V UL148.IMPORTANCE In myriad examples, viral gene products cause striking effects on cells, such as a

98 tenance in wild-type mice, PKCiota/lambda, a gene-product closely related to PKMzeta, persistently in

99 Interestingly, transient expression of SPFMV gene products coagroinfiltrated with a reporter gene in

100 d enRep-M9l, encodes a predicted polypeptide gene product comprising a partial myosin9-like (M9l) gen

101 TSV genome revealed a potential three-domain gene product containing an N-terminal leucine-rich repea

102 n order to infer the properties of genes and gene products containing little or no experimental annot

103 The Rf4 gene product contains a nuclear localization signal and

104 The csaA gene product contains a predicted glycosyltransferase do

105 on to the cytoplasmic PMM domain, the Le2152 gene product contains a ~200-aa N-terminal periplasmic d

106 ide repeat-containing proteins 1-4 (TMTC1-4) gene products contribute to the addition of these O-link

107 vel synaptogenic mechanism in which a single gene product coordinates the nuclear transcription and p

108 Based on our findings, we designate the gene product corresponding to ct694-ctl0063translocated

109 nonical defense pathways and how herpesvirus gene products counter them, highlighting the contributio

110 oaches are required to study the function of gene products critical for growth and erythrocyte invasi

111 In this study, we report that the XPE gene product DDB2 (damaged DNA binding protein 2), a nuc

112 espite acting in a common pathway, each PCLD gene product demonstrated distinct effects on polycystin

113 evelopment is driven exclusively by maternal gene products deposited into the oocyte.

114 mer1a, an activity-dependent immediate early gene product, disrupted the persistent mGluR5 activity r

115 enhanced accumulation and detection of these gene products due to mu1 knockdown potentiates receptor-

116 t that potential exposure to DsRed2 and tTAV gene products (e.g. mRNA and encoded proteins) would hav

117 esponse element-containing immunosuppressive gene products (e.g., TGF-beta).

118 BE3A gene and aberrant overexpression of the gene product E6AP protein is a common cause of autism sp

119 Our findings implicate an immediate-early gene product, Egr1, as part of the mechanism mediating o

120 ses against EBV and FLU antigens or HHV-6A/B gene products either not expressed or expressed at low l

121 ing of avirulence genes PWT3 and PWT4, whose gene products elicit defense in wheat cultivars containi

122 Through a systematic analysis of gene products encoded by the SPO1 host takeover module,

123 e of cellular energy in eukaryotes, requires gene products encoded in both the nuclear and mitochondr

124 The cyclin D1 gene product encodes the regulatory subunit of the holoe

125 thetic lethality (ASL): depletion of a third gene product enhances a pre-existing synthetic lethal co

126 r EBV genes and, together with some of those gene products, ensures completion of the lytic cycle.

127 rotein triggering each of the two resistance gene products; epidemiology of RB isolates is discussed

128 and in vitro characterization of the forBCH gene products established their catalytic functions in f

129 f viral DNA amplification, and several early gene products facilitate DNA amplification.

130 Moreover, LXR target gene products facilitated the efflux of lipid and choles

131 ochrome bd oxidase as an essential bacterial gene product for mosquito growth.

132 Gene products for HMOX1, NRF1, PPARGC1A, and TFAM, and m

133 ry mechanism ensures optimal output of these gene products for proper physiological function of the a

134 A mRNA, encouraging their usage as reference gene products for RT-qPCR experiments, when quantifying

135 birds [4], should result in an imbalance of gene products for sex-linked genes [5].

136 ntify activated neurons, the immediate early gene product, Fos protein, was labeled.

137 und that vesicles containing the PKHD1/Pkhd1 gene product, FPC, also contain the NEDD4 ubiquitin liga

138 HIV-1 must express all of its gene products from a single primary transcript, which un

139 aused by the absence of paternally expressed gene products from chromosome 15q11-q13.

140 minate VUS that affected the function of the gene products from those that did not.

141 establishment, an understanding of how viral gene products function in specific B cell subsets to reg

142 Whether and how these viral gene products function in specific cells of the immune s

143 ordinated interactions between diverse human gene products functioning within various pathways underl

144 Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyr

145 t the concomitant knockdown of four of these genes products, GPX2, GLRX, ALDH3A1, and PDK4, significa

146 nhibition of apoptotic activity by the Diap1 gene product has been decreased.

147 ed for designing and synthesizing customized gene products have been steadily decreasing.

148 on of numerous genes downstream of the ERBB2 gene-product, HER2.

149 er might shed light on the mechanisms behind gene product homeostasis.

150 The NE gene products identified here could serve as markers for

151 ignificantly more antibodies against the U90 gene product (IE1) than do non-iciHHV-6-positive individ

152 The ATP7A interactome concentrated gene products implicated in neurodegeneration and neurod

153 ppressor TP53 is the most frequently mutated gene product in human cancer.

154 These results support a role for this gene product in protein secretion as well as in pili for

155 ression of a cytotoxic or prodrug-activating gene product in the cell type of interest.

156 frame (ORF) and accumulation of the reporter gene product in tobacco chloroplasts encoded in the seco

157 an ILK, which compromise the function of the gene product in vitro.

158 nt with this finding, examination of Slc52a3 gene products in adult tissues revealed expression in th

159 icropollutant biotransformation and specific gene products in complex microbial communities, using as

160 we evaluated twelve commonly used reference gene products in human naive (NV) and effector memory (E

161 their likelihood of targeting ageing-related gene products in humans.

162 nfirms the role of lytic DNA replication and gene products in KSHV-mediated tumorigenesis.

163 reviously unknown differential role of STAT5 gene products in lymphocyte lineage regulation.

164 Translation of mitochondrial gene products in Saccharomyces cerevisiae depends on mRN

165 Accumulating MDS gene products, including alternative oxidases (AOXs), af

166 d protein-protein interactions (PPIs) of all gene products, including those of stress-response genes,

167 ption, translation, and degradation of clock gene products, including timeless (tim), but how the cir

168 hat small-molecule antagonists of identified gene products inhibited SARS-CoV-2 infection in monkey a

169 complex inheritance and potentially complex gene product interactions during development, contributi

170 ly transform the sequence of disease-causing gene products into lead modalities.

171 RTA is an essential viral gene product involved in the initiation of gammaherpesvi

172 synthesis using a high throughput screen for gene products involved in capsular alpha-glucan producti

173 t: 1) OmpR regulates mostly membrane-located gene products involved in diverse fundamental biological

174 ional repressor, allowing expression of > 40 gene products involved in DNA repair and cell cycle regu

175 ich upregulates the activity of many thyroid gene products involved in hormonogenesis.

176 n a genome-wide level to identify additional gene products involved in these tRNA trafficking events.

177 ducts and unequivocally define that the Vip1 gene product is a highly selective 1-kinase and 1-pyroph

178 The Arabidopsis thaliana BON1 gene product is a member of the evolutionary conserved e

179 ocus TNIP1, also referred to as ABIN1, whose gene product is a negative regulator of various inflamma

180 ombinant protein is not possible as the NPC1 gene product is an insoluble membrane protein, which inc

181 ures, non-optimal codon use, and those whose gene product is cotranslationally translocated into the

182 etion analysis indicated that only the cel3B gene product is essential for efficient cellodextrin uti

183 o affected individuals shows that the fusion gene product is expressed and stable.

184 Targeted inhibition of oncogenic gene products is considered the "holy grail" of present-

185 opoietin-like 4 (ANGPTL4), a HIF-1-regulated gene product, is increased in the eyes of diabetic mice

186 genome-which encodes potentially inhibitory gene products-is still allowed to enter the cell.

187 Here, we establish that the ISG15 gene product itself directly regulates HCMV replication

188 y a direct effect of the polymorphism on the gene product itself.

189 ses alternative fourth exons to generate two gene products (KRAS4A and KRAS4B) that differ only in th

190 necroptosis requires the detection of viral gene products late in infection; mu1 limits cell death b

191 tion of ubiquitinated SLiPs to the autophagy gene product LC3.

192 When alternative splicing of gene products leads to protein products with different s

193 All of the gene products localize in and around the primary cilium,

194 b Salmonella phage SPN3US genome encodes 264 gene products, many of which are functionally uncharacte

195 nce that these modules and their constituent gene products may play central roles in metabolic inflam

196 ion of the tumor suppressor gene NF2 The NF2 gene product, Merlin, has no intrinsic catalytic activit

197 dingly, any potential drug targeting of this gene product must be strictly assessed for safety.

198 ations in the beta-myosin heavy chain (MYH7) gene product (Myosin-7).

199 X4 and P2X7, with the graded production of a gene product, namely the tumour necrosis factor alpha (T

200 s five reactions catalyzed by the bza operon gene products, namely the hydroxybenzimidazole synthase

201 Five different gene products (NCKX1-5) have been identified in humans,

202 ave been damaged by mutations, rendering the gene product non-functional.

203 Since most NPH gene products (NPHP) function at the primary cilium, NPH

204 hin nuclear-encoded genes with mitochondrial gene products (odds ratio, 1.075; 95% CI, 1.018-1.135; P

205 independent growth, which is mediated by the gene product of its target gene HMGA1, encoding a multip

206 in vitro inhibition of DYRK1A, a triplicated gene product of Trisomy 21 (Ts21).

207 has been growing interest in the homodimeric gene products of CISD1 (mitoNEET) and CISD2 (NAF-1), the

208 of PSAT by annotating the predicted peptide gene products of Herbaspirillum sp. strain RV1423, impor

209 ular structure data for one or more genes or gene products of interest.

210 Gene products of potyviruses include P1, HCPro, P3, 6K1,

211 We found that multiple gene products of the latent locus localize to the mitoch

212 olycistronic mRNA molecule, and the operon's gene products often form molecular complexes or metaboli

213 Individual binding sites of select KSHV gene products on PAN RNA were also identified in in vitr

214 ine the synergistic effects of the various P gene products on pathogenesis in animal models.

215 interventions, targeting either the mutated gene product or the associated molecular pathway.

216 82 highly conserved ORFs that have no known gene products or assigned functions.

217 te of the noncanonical kinase NIK, the nfkb2 gene product p100, transitions from a monomer to a multi

218 led with antibodies directed against protein gene product (pan-neuronal marker; PGP9.5), tyrosine hyd

219 s were cholinergic, colocalized with protein gene product (PGP)9.5, the vesicular ACh transporter, an

220 s associated with a combined deficiency of 2 genes products, PI3-kinase p110delta and SKAP, both of w

221 the P. gingivalis genome, we show that their gene products play no role in growth of the bacterium wi

222 It is unknown whether the Pkd1 gene product polycystin-1-the predominant causal factor

223 Its gene product (pRB) regulates transcription and is a nega

224 r gene RB1 The canonical function of the RB1 gene product, pRB, is to repress the E2F transcription f

225 ion of both androgen receptor and its target gene products, prostate specific antigen (PSA) and ETS-r

226 kinase II, and the Alzheimer's disease risk gene product protein tyrosine kinase 2 beta.

227 ude nucleotide and protein sequences, genes, gene products, proteins, protein domains, protein famili

228 The VHL gene product, pVHL, is the substrate recognition unit of

229 In vitro characterization of gene product PyfQ demonstrated that it is able to cataly

230 sis with cellulosic substrates, seven of the gene products (Ra0185, Ra0259, Ra0325, Ra0903, Ra1831, R

231 izophrenia, alterations in the expression of gene products regulating these properties could disrupt

232 the functions and mechanisms of several clb gene products remain poorly understood.

233 is study and growth studies to confirm novel gene products required for XoxF1 function.

234 ered with optical reporters and tumouricidal gene products retain the capacity to differentiate and i

235 control of another unknown RpoS-independent gene product(s) associated with borrelial replication.

236 of lytic transcripts, and a late lytic KSHV gene product(s) targets IFI16 for degradation during lyt

237 Recently, the ninth gene product, SbnI, was determined to be a free l-serine

238 The gene product serves an essential function in vivo, as bb

239 is suggests that inhibition of ZNF529 or its gene product should be prioritized as a novel candidate

240 open reading frames (ORFs), whose predicted gene products show little homology to proteins with know

241 Associated Proteins (WAPs) introduced herein-gene products significantly associated on protein intera

242 MV utilizes the traditionally IFN-associated gene product, STAT1, to promote these changes.

243 oisomerase-induced DNA breaks and the RecBCD gene products, suggesting a new co-antibacterial strateg

244 ia burgdorferi notably encodes a single HtrA gene product, termed BbHtrA.

245 structure and molecular function of ClbS, a gene product that confers resistance to colibactin toxic

246 O-GlcNAc transferase (OGT) is an X-linked gene product that is essential for normal development of

247 ndividual baboons, the identity of the viral gene product that is the major target of cellular immune

248 d for a total genome-wide screen to identify gene products that affected aggregate formation.

249 t aimed at embedding a large fraction of the gene products that are found altered in cancer cells int

250 is impeded by the proportion (~80%) of their gene products that are functionally uncharacterized.

251 We identified gene products that are important for the antiviral activ

252 ted therapies for cancer focused on drugging gene products that are recurrently mutated in specific c

253 significantly reduces expression of over 600 gene products that are targets of the DREAM complex, whi

254 st takeover module, here we identified eight gene products that attenuated B. subtilis growth.

255 Of the eight phage gene products that attenuated bacterial growth, a 25-kDa

256 ties and interactions between host and viral gene products that can be exploited for the development

257 we identified pathway intermediates and the gene products that catalyze 9M5-FuFA and 9D5-FuFA synthe

258 However, interferon-stimulated gene products that inhibit CoVs are not well characteriz

259 t feature of HCMV is the wide range of viral gene products that it encodes which function to modulate

260 ization of a host, gammaherpesviruses encode gene products that manipulate processes involved in cell

261 rometry to systematically identify microbial gene products that metabolize drugs.

262 taherpesvirus that encodes a number of viral gene products that modulate cellular antiviral signaling

263 The only candidate reference gene products that remained stable during the activation

264 Our work defines the pollen tube gene products that respond to the pistil and are require

265 These viruses encode various gene products that serve to evade innate immune recognit

266 it prevents excessive accumulation of viral gene products that trigger cell death.

267 The tight groups of genes/gene products that work together in a cell can be discov

268 ssociated with an up-regulation of the ALOX5 gene product, the 5Lipoxygenase (5LO), herein we investi

269 results in defective production of the PKD1 gene product, the membrane protein polycystin-1 (PC1).

270 Among KSHV gene products, the latency-associated nuclear antigen (L

271 Although these screens affect thousands of gene products, the typical readout is based on low compl

272 New experimental discoveries about gene products, their function and regulation, new metabo

273 D1) host restriction factor by the HIV-2 Vpx gene product, thereby diminishing abortive infection and

274 asic activation of a traditionally antiviral gene product through an EGFR- and integrin-dependent pat

275 gut microbiome constantly interact with host gene products through numerous bioactive molecules(1).

276 ne Interaction Database search identified 47 gene products to be affected by coxibs.

277 e analysis of the contribution of microbiome gene products to community assembly, host physiology, an

278 USA300 isolates utilize the copBL and copAZ gene products to prevent Cu intoxication.

279 to-zygotic transition, which enables zygotic gene products to replace the maternal supply that initia

280 elopment is passed from exclusively maternal gene products to those encoded by the embryonic genome i

281 m pluripotency and induces numerous aberrant gene products upon differentiation.

282 Although Nef is the viral gene product used by most simian immunodeficiency viruse

283 We confirmed the expression of nine selected gene products using Nanostring's nCounter analysis syste

284 ry function is to regulate the expression of gene products via hybridization to mRNA transcripts, res

285 We report that the evolutionarily conserved gene product, Vip1, possesses autonomous kinase and pyro

286 sease and establish that the Wiskott-Aldrich gene product (WASP) serves an essential role in T regula

287 hare no more than 25% identity with the P450 gene products we identified in Acanthamoeba castellanii,

288 secretory proteins that are Stat3 downstream gene products were identified as a panel of biomarkers f

289 t assays further verified that the virulence gene products were produced and that the T3SS effector E

290 ing in the stabilization of Nrf2, the Nfe2l2 gene product, which controls oxidative homeostasis.

291 uces the abundance of the endogenous C9ORF72 gene product, which functions in endolysosomal pathways

292 The clusters correspond to small sets of gene products, which can be processed quickly to give ca

293 st time that hydin, a hydrocephalus-inducing gene product whose mutation impairs ciliary motility, an

294 ghly conserved ortholog of the DrosophilaEcd gene product whose mutations impair the synthesis of Ecd

295 and may provide important information about gene products with unknown function.

296 probably a result of heterotetramers of Kir2 gene products, with this regulating resting potentials a

297 erties results in the nongenetic transfer of gene products within transformed populations, which can

298 ce that supports biological assertions (e.g. gene product X has function Y as supported by evidence Z

299 EBV's BZLF1 gene product, Zta, usually controls this reactivation sw

300 s produced, is mainly regulated by the viral gene product, Zta.