ライフサイエンスコーパス: gene promoter

1 erminal center (GC)-rich region of the PD-L1 gene promoter.

2 g protein (pCREB) at two sites in the leptin gene promoter.

3 nts revealed that SREBP-1a binds to the Hamp gene promoter.

4 ent of the histone modifier HDAC1 at the Il9 gene promoter.

5 es THBS1, through SMAD3 binding to the THBS1 gene promoter.

6 ependent kinase inhibitor 2B (CDKN2B or p15) gene promoter.

7 ng to the light-responsive GT1 motifs in the gene promoter.

8 tified an FXR-responsive element on the Tgr5 gene promoter.

9 interacts with TRF2 to recruit it to the RP gene promoter.

10 orresponding to its binding site in the IL-2 gene promoter.

11 n directly and does not catalyze 5hmC at the gene promoter.

12 ce repressive chromatin modifications in the gene promoter.

13 rough NFATc1-mediated regulation of the CD23 gene promoter.

14 like3 and OsNIN-like4) binding to the OsNHX1 gene promoter.

15 e complexity of methylation changes around a gene promoter.

16 t chromatin remodeling complexes to the Ifng gene promoter.

17 pha (hREG3A) in hepatocytes, via the albumin gene promoter.

18 factor 1 alpha subunit (HIF1A) in the VEGFA gene promoter.

19 colitis suppresses the activity of the St14 gene promoter.

20 d protein expression by binding to the DOT1L gene promoter.

21 transcription factor FoxM1 on the cyclin B1 gene promoter.

22 nding to negative regulatory elements in the gene promoter.

23 ibited the transcriptional activity of Smad3 gene promoter.

24 could bind and control activity of the SRSF1 gene promoter.

25 l enhancer in the SRF gene, and at the MYOCD gene promoter.

26 cluding a highly conserved peak at the Csf-1 gene promoter.

27 likely through occupancy at this CRE and the gene promoter.

28 on and repositioning within the somatostatin gene promoter.

29 demethylase Lsd1 to the fatty acid synthase gene promoter.

30 e lysosomal protein transmembrane 5 (Laptm5) gene promoter.

31 DAC2 and LSD1 to the WNT/beta-CATENIN target gene promoters.

32 dian proteins with each other and with clock gene promoters.

33 training gene expression from CGI-associated gene promoters.

34 activity in reporter assays using Wnt target gene promoters.

35 ng to introduce mutations in all three SWEET gene promoters.

36 ressive HIR/Asf1/Rtt106 complex from histone gene promoters.

37 on one end, DNA regions of interest, such as gene promoters.

38 of transcriptional activators to individual gene promoters.

39 to analyze the recruitment of Loz1 to target gene promoters.

40 towards hypermethylation when interrogating gene promoters.

41 tion factor that is rapidly released from RP gene promoters.

42 oth at sites of genetic recombination and at gene promoters.

43 ated domains (PMDs) and occupy developmental gene promoters.

44 ern the organization of epigenetic states at gene promoters.

45 nuclei triggered immediate binding to target gene promoters.

46 s, including p130/p107, still bind to target gene promoters.

47 ng polycomb protein activity on the specific gene promoters.

48 ositioned, hypoacetylated nucleosomes across gene promoters.

49 H3K4) histone trimethylation on inflammatory gene promoters.

50 ancers and leads to altered transcription at gene promoters.

51 the accessibility of RNA polymerases to the gene promoters.

52 ex to increase H3K4 trimethylation at target gene promoters.

53 ange of histone H1 with HMGB1 at AIRE target gene promoters.

54 nteractions between 265 TFs and 108 cytokine gene promoters.

55 says revealed that Msn4 binds beta-oxidation gene promoters.

56 me specifically at the EpCAM, CXCR4 and TFRC gene promoters.

57 aB translocation and binding to inflammatory gene promoters.

58 ription factor NF-kappaB to pro-inflammatory gene promoters.

59 ) at NF-kappaB binding sites on inflammatory gene promoters.

60 enhancers, they largely bind together at MCC gene promoters.

61 uppressed activation of several M. sexta AMP gene promoters.

62 onal algorithm to pair enhancers with target gene promoters.

63 olled by the chromatin state on inflammatory gene promoters.

64 ersistent activation of NF-kappaB-responsive gene promoters.

65 tory elements (CREs) in ER stress-responsive gene promoters.

66 nts, at the CLL risk loci located outside of gene promoters.

67 4me3 chromatin mark on RUNX2, MSX2, and DLX5 gene promoters.

68 ancers, converge on phenotypically important gene promoters.

69 l (CMF) genes and have open chromatin at CMF gene promoters.

70 ear and associates with enhancer regions and gene promoters.

71 n accessibility at several regions distal to gene promoters.

72 (G4) structures that are overrepresented in gene promoters.

73 lysine 4 (H3K4) trimethylation marks active gene promoters(6).

74 e elements (EREs) identified in the DEFbeta4 gene promoter abolished the augmented gene expression su

75 o determine methylation patterns of homeobox gene promoters across gestation.

76 determine their potential in editing a TERT gene promoter-activating mutation, which occurs in many

77 U3 snoRNA expression by affecting U3 snoRNA gene promoter activity, while BMP7 was able to increase

78 P2 required CSRP2BP for robust smooth muscle gene promoter activity.

79 ment binding and Nurr1, controlling synapsin gene promoter activity.

80 Here, we show that most Ribi gene promoters also contain binding sites for one or mor

81 Megakaryocytic gene-promoter analyses suggested that LEN-induced degrad

82 which bound the proximal AP-1 site in the TF gene promoter and activated TF expression.

83 tor gamma t variant (RORgammat) at the IL-17 gene promoter and enhancer, as well as significant alter

84 ified DNA base OG to guide BER activity in a gene promoter and impact cellular phenotype ascribes an

85 ls, suggesting that STAT3 binds to the Wnt5a gene promoter and induces the expression of Wnt5a in CLL

86 nto the locus via a poly(dA:dT) tract in the gene promoter and mediated cohesion before induction.

87 Acetylated TAF9 does not bind to the PU.1 gene promoter and subsequently leads to the disassociati

88 using wild-type sequence deriving from Cxcl2 gene promoter and the same sequence bearing a single syn

89 otein-DNA interactions involving 54 phenolic gene promoters and 568 TFs.

90 binds to zinc responsive elements in target gene promoters and activates gene expression.

91 K27me3 histone marks on extracellular matrix gene promoters and active H3K4me3 marks on interleukin,

92 acetylation (H3K9ac), co-localize on active gene promoters and are associated with active transcript

93 PPA2/4 bind both H3K4me3-marked and bivalent gene promoters and associate with COMPASS- and Polycomb-

94 require coordination between protein-coding gene promoters and cis-regulatory sequences called enhan

95 ions that are flexible and can be warmed-up (gene promoters and coding sequences), from those that re

96 d RNA polymerase II (RNAP II) recruitment to gene promoters and decreased RNAP II C-terminal domain (

97 IX1 and SIX2 target a subset of inflammatory gene promoters and directly inhibit the trans-activation

98 omatin interactions in the nucleus involving gene promoters and distal regulatory elements are curren

99 ow KLF3 can displace KLF1 from key erythroid gene promoters and enhancers in vivo.

100 Specific communication between gene promoters and enhancers is critical for accurate re

101 an join distant regulatory elements, such as gene promoters and enhancers, along the DNA.

102 lel reporter assays on 20 disease-associated gene promoters and enhancers, generating functional meas

103 s, and it co-localizes with HIRA and H3.3 at gene promoters and enhancers.

104 y of the viral preinitiation complex at late gene promoters and found that while sequence-specific bi

105 re associated with the majority of mammalian gene promoters and function to recruit chromatin modifyi

106 to effector-binding elements (EBEs) in SWEET gene promoters and induce SWEET genes.

107 he H3K36me2-depleted state at CGI-associated gene promoters and is dispensable for normal gene expres

108 isrupted the interaction of PU.1 with target gene promoters and led to downregulation of canonical PU

109 Without PRDM9, meiotic DSBs occur near gene promoters and other functional sites.

110 es and cytosine-phosphate-guanines (CpGs) in gene promoters and other regulatory regions by specific

111 d N-Myc protein binding at the ODC1 and E2F2 gene promoters and reduced neuroblastoma cell proliferat

112 acterized transcription factor that can bind gene promoters and regulate target gene transcription in

113 In endothelial cells, ETS1 binds transcribed gene promoters and stimulates their expression by broadl

114 osophila, we find that TAF1 is present at RP gene promoters and that its interaction might also be di

115 ontribute to structural interactions between gene promoters and their enhancer elements.

116 d their binding sites into those proximal to gene promoters and those in distal regions, and develope

117 ed-B and cohesin associate specifically with gene promoters and transcriptional enhancers, or how sis

118 Gene promoters and UTRs harbor more OG-enriched sites th

119 bout how enhancers communicate with specific gene promoters and what molecular mechanisms underlie en

120 of histone deacetylase 1 to specific target gene promoters and, thus, negatively controlled transcri

121 s verified an ATF4-binding site in the LAMP3 gene promoter, and a dual-luciferase assay confirmed tha

122 EMSA revealed that STAT3 binds to the Wnt5a gene promoter, and a luciferase assay showed that STAT3

123 ctivates transcription of the p21(Waf1/Cip1) gene promoter, and overexpression of Foxp1 in neurons re

124 is a common polymorphism in the human PRMT1 gene promoter, and we found that it alters PRMT1 express

125 a, (3) in silico prediction of TF binding on gene promoters, and (4) reverse-engineered regulons from

126 e CpG-rich and located in close proximity to gene promoters, and imprinting status is determined by t

127 arly decreased MLL1, H3K4me3 at inflammatory gene promoters, and inflammatory cytokines compared with

128 an increase in MLL1, H3K4me3 at inflammatory gene promoters, and inflammatory cytokines.

129 egulatory Modules (CRMs), are enriched in DR gene promoters, and the CRMs include cis-elements known

130 ) are generated through the use of different genes, promoters, and alternative splicing, but the func

131 he G-quadruplexes (G4s) formed in PDGFR-beta gene promoter are transcriptional modulators and amenabl

132 We discover that miRNA gene promoters are frequent targets of aberrant DNA meth

133 In patients, tumour suppressor gene promoters are markedly more methylated in hypoxic t

134 lls (ESCs), a subset of silent developmental gene promoters are primed for activation by FBXL19, a Cp

135 Methylation ITH mapping to gene promoter areas or tumor suppressor genes is low.

136 ssive chromatin state of the proinflammatory gene promoter as a result of decreased acetylation (H3K9

137 n conclusion, longer GT repeats in the HMOX1 gene promoter associate with increased risk of AKI after

138 merase II were found to occupy the cyclin B1 gene promoter at reduced levels during infection.

139 ption activation domain (TAD) to an intended gene promoter at the endogenous genomic locus through a

140 letion (DEL) polymorphism in the human PDE3A gene promoter beginning 2,214 nt upstream from the PDE3A

141 naling selectively represses iron-absorptive gene promoters but not the inflammatory or glycolytic HI

142 evels as well as its association with target gene promoters but paradoxically increased the mRNA leve

143 ly that functions by binding to the W-box of gene promoters, but the structural basis of OsWRKY45/W-b

144 mammalian brain, is altered within the Htr2a gene promoter by early life stress and biological sex, a

145 r, SCIRT induced transcription at cell-cycle gene promoters by recruiting FOXM1 through EZH2 to antag

146 via H3 acetylation of the respective GPI-GnT gene promoters by Rtt109.

147 on co-activator complex SAGA is recruited to gene promoters by sequence-specific transcriptional acti

148 g coding gene expression by binding to their gene promoters by using chromatin isolation by RNA purif

149 we predict that a CRM signature within BS-DR gene promoters can be used as a marker for future breedi

150 eries demonstrate that CpG-island associated gene promoters can prime genes for activation by communi

151 Transcriptomic analysis and gene promoter characterization in patients' blood reveal

152 Indeed, Zfp609 and Nipbl co-localize at gene promoters containing paused RNA polymerase 2, and I

153 d binds to a 16-bp cis-element of its target gene promoters containing two conserved CGAA repeat sequ

154 ansgenic mice carrying a bovine tracheal AMP gene promoter-controlled PG-1 transgene.

155 cinomas characterized by extensive, abnormal gene-promoter CpG-island methylation, or the methylator

156 tokine levels, and IL-4, INF-gamma and Foxp3 gene promoter DNA methylation status, and their correlat

157 Our data show that gene promoters do not form mutually exclusive interactio

158 onsisting of the Lucilia sericata bottleneck gene promoter driving expression of the tTA gene and a t

159 id demethylation of the insulin and glucagon gene promoters during differentiation of Neurogenin3(+)

160 ll as the establishment of H3K27me3 at these gene promoters during ESC differentiation.

161 Methylation of developmental gene promoters during tumorigenesis may therefore reflec

162 ein-coding genes in mammals and emanate from gene promoter, enhancer, and termination regions.

163 nded to Abeta insult by binding to the Trib3 gene promoter, enhancing its expression.

164 arks on interleukin, defensin, and chemokine gene promoters, facilitating a rapid inflammatory respon

165 ion and no longer interact with their target gene promoter following gene activation.

166 and FOXH1 prime mesendoderm differentiation gene promoters for activation, and signal-driven SMAD2:S

167 d with cre transgenic lines driven by neural gene promoters for nestin (all neural cells), synapsin (

168 In an unbiased search of core clock gene promoters from 12 species of Drosophila, we discove

169 identification of the first dual BCL2/c-MYC gene promoter G-quadruplex ligand.

170 anscriptional burst frequency in a subset of gene promoters, generating enhanced variability of trans

171 At select gene promoters, H3K9ac loss or SEC depletion reduces gen

172 noncoding RNAs (lncRNAs) transcribed across gene promoters have been detected.

173 t over 50% of silencers are interacting with gene promoters having very low to no expression.

174 it functions as a complex to recognize late gene promoters.IMPORTANCE Kaposi's sarcoma-associated he

175 ivity and NFkappaB-p65 recruitment to target gene promoter in macrophages.

176 methyltransferase Dam, tethered to the Gad1 gene promoter in mouse prefrontal cortex neurons, result

177 DNA methylation at gene promoters in a CG context is associated with transc

178 n complex with PPM1G and NF-kappaB at target gene promoters in a stimuli-dependent manner to provide

179 P2BP synergistically activated smooth muscle gene promoters in an SRF-dependent manner.

180 Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilit

181 lysine 4 (H3K4me3) emerges at developmental gene promoters in E6.5 Epi and positively correlates wit

182 K9/14 hyperacetylation in approximately 5000 gene promoters in glomerular mesangial cells, including

183 of chromosomal interactions involving 22,000 gene promoters in human pluripotent and lineage-committe

184 MHC-I APP gene promoters in MHC-I low cancers harbor bivalent acti

185 the fidelity of transcription initiation at gene promoters in mouse embryonic stem cells.

186 on experiments show that LIN28B binds active gene promoters in neuroblastoma cells through protein-pr

187 andidate causal variants and putative target gene promoters in open chromatin for ~ 17% of the 273 BM

188 the presence of HDAC11 at the Eomes and Tbet gene promoters in resting T cells, where it rapidly disa

189 eveal constitutive binding of CREB to target gene promoters in the absence of neuronal activity, wher

190 2 and 4) bind the stress-response element in gene promoters in the yeast Saccharomyces cerevisiae How

191 st and plants, where DSBs are generated near gene promoters, in many vertebrates DSBs are enriched at

192 Several gene promoters including SFRP1,2,3, PENK, NPY, ALX4, SEP

193 nder normoxia, CHD4 enrichment at HIF target gene promoters increased RNA polymerase II loading throu

194 many of the induced ergosterol and anaerobic gene promoters, increases its association with several r

195 ously showed that HIF-1alpha binds the BZLF1 gene promoter, inducing Zta synthesis, and HIF-1alpha-st

196 Earlier studies suggested that the insulin gene promoter is uniquely unmethylated in insulin-expres

197 NA to yield 8-oxo-7,8-dihydroguanine (OG) in gene promoters is a signaling agent for gene activation.

198 ylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced

199 The occupancy of Stowaway elements in gene promoters is concomitant with an increase in recomb

200 PerR binding to gene promoters is controlled by the presence of iron in

201 ecruitment of Loz1 to the majority of target gene promoters is dependent upon zinc and the motif 5'-C

202 es and reveals that the enrichment of OQs in gene promoters is particular to mammals such as mouse an

203 lation of transcriptional activity at target gene promoters is the only molecular event known to unde

204 his re-targeting, occurring ~182 kb from the gene promoter, is enough to restore the function of the

205 repress an overlapping set of E2F-dependent gene promoters, it remains unclear whether they cooperat

206 receptor driven by the cytokeratin-18 (K18) gene promoter (K18-hACE2) as a model of SARS-CoV-2 infec

207 H3K4me1 histone modification of the fibrotic gene promoter, leading to a decrease in the fibrotic gen

208 T cells type c-1, associated with increased gene promoter levels of the transcriptional repression m

209 sitively correlated with IFN-gamma and Foxp3 gene promoter methylation levels (P<.0011) (P<.0165).

210 SOCS1 gene promoter methylation, with its potential effects on

211 While lost bindings primarily occur near gene promoters, most gained CTCF binding events exhibit

212 ealed that KLF4 associates with the proximal gene promoter of DPYSL2A and directly transactivates its

213 AHR bound and activated the gene promoter of serine palmitoyltransferase small subun

214 current UV signature mutations in individual gene promoters of melanomas and with known cancer driver

215 ins harbor plasmid-borne fusions of selected gene promoters of the E. coli SOS DNA repair system to t

216 ngage in physical contacts with their target-gene promoters, often bridging considerable genomic dist

217 ements (RAREs) in differentiation-associated gene promoters or enhancers.

218 Binding of Nup153 to gene promoters or transcriptional end sites correlates w

219 Antisense transcripts originate either at gene promoters or within the gene body, and they show di

220 t prevent effector binding to susceptibility gene promoters, or that allow effector activation of res

221 acetylation at specific sites at G1/S target gene promoters peaks at the G1-to-S transition, coincidi

222 Variations in the gene promoter play critical roles in the evolution of im

223 Hence, we hypothesized that DRB gene promoter polymorphism might lead to altered DRB gen

224 ression of chromatin on extracellular matrix gene promoters presents a therapeutic opportunity for th

225 nd that the Hox proteins AbdA and Ubx target gene promoters previously bound by the transcription pau

226 ory elements that interact with their target gene promoters (promoter-interacting eQTLs, pieQTLs) in

227 ecombinant endonuclease-deficient Cas9-based gene promoter pulldown approach coupled with mass spectr

228 eterogeneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in Cag

229 DNA methylation at a gene promoter region has the potential to regulate gene

230 ysine 4 di-methylation (H3K4me2), to the AHR gene promoter region, resulting in repression of AHR exp

231 howed that pCREB enrichment on the C/EBPbeta gene promoter regions in rats with gp120 was higher than

232 DNA methylation at the INSR and IGF2 gene promoter regions was detected by the Sequenom's Mas

233 and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate

234 oughout genomes, and are especially found in gene promoter regions.

235 tone mark peaks in relevant tissue types and gene promoter regions.

236 ins and how they coordinate to activate late gene promoters remain largely unknown.

237 ly methylated in both syndromes while escape gene promoters remain unchanged.

238 with TFIID to facilitate assembly on target gene promoters remains elusive.

239 Repression of telomerase gene promoter requires human-specific genomic context an

240 that while sequence-specific binding of late gene promoters requires ORF24, it additionally requires

241 inding to SBE DNA in TGF-beta-responsive SMC gene promoters, resulting in suppression of SMC marker g

242 inding sites in close proximity to the Wnt5a gene promoter's start codon.

243 Herein, we report that the PDGFR-beta gene promoter sequence forms a vacancy G-quadruplex (vG4

244 nine-metabolite-fill-in vG4 based on a human gene promoter sequence.

245 REST binds to RE1 consensus sites in the TH gene promoter, stimulates TH transcription, and increase

246 TEs that are transcribed from a neighboring gene promoter such as within an intron or exon.

247 t of the repressive DREAM complex to the A3B gene promoter, such that loss of p53 through mutation, o

248 Our epigenetic analysis of the Rac1 gene promoter suggested that persistent suppression of R

249 nge interactions between these sites and the gene promoter, suggesting non-redundant enhancers.

250 ptionally active histone modifications at M2 gene promoters than did macrophages from male mice.

251 This can be achieved by using a gene promoter that is only active in embryos to drive ex

252 1-activated SMAD proteins on the human PLOD2 gene promoter that were required for these stimuli to in

253 LUX binds to clock gene promoters that have not been shown before, expandin

254 H3 activation marks on NF-kappaB-associated gene promoters that increase the expression of inhibitor

255 he H3R17me2a histone mark in the vicinity of gene promoters that it regulates.

256 1 combinations of open chromatin regions and gene promoters that map to 38 CAD and 92 BP GWAS loci.

257 ecific "epigenetic" silencing at variegating gene promoters that more fully accounts for the final pa

258 t, to bind certain DNA recognition motifs in gene promoters that regulate gene expression.

259 pport long-range interactions between silent gene promoters that rely on FBXL19 for their induction d

260 We identify a number of activated gene promoters that undergo 2i dependent loss of H3K27me

261 We defined 94 gene promoters that were hypomethylated significantly by

262 F24 and ORF66 occupy the canonical K8.1 late gene promoter, their promoter occupancy requires the pre

263 evented the accessibility of PU.1 to the Il9 gene promoter, thereby restricting its expression.

264 many similarities between enhancers and the gene promoters they control, and we highlight unanswered

265 In human gene promoters, this results from an elevated 5'-GG-3' d

266 hich a two-authentication system mobilizes a gene promoter through a dynamic network of polymeric nuc

267 the opening of the chromatin on inflammatory gene promoters through histone H3K4 trimethylation.

268 studies, that TFIID may not remain bound to gene promoters through the transcription initiation cycl

269 histone modification at the hippocampal FosB gene promoter to cause DeltaFosB induction critical for

270 nsequent recruitment of NF-kappaB to the A3B gene promoter to drive A3B expression.

271 h p53 DNA response elements in the p21(Cip1) gene promoter to suppress p21(Cip1) promoter activity an

272 tion is regulated through binding factors to gene promoters to activate or repress expression, howeve

273 ltransferase (HAT) complex to ERalpha target gene promoters to deposit histone H4K16 acetylation prom

274 al gene regulation relies on the capacity of gene promoters to integrate inputs from distal regulator

275 initiates transcription bidirectionally from gene promoters to produce pre-mRNAs on the forward stran

276 appaB binding sites on inflammatory cytokine gene promoters to suppress transcription.

277 e H3 at lysine 4 (H3K4me3) on immune-related gene promoters underlies robust transcription during tra

278 ctivity assays showed that MUC1 occupied CDA gene promoter upon ER stress induction correlating with

279 We found that Cbx3 binds to gene promoters upon differentiation of murine embryonic

280 activation domain of FoxM1 to the cyclin B1 gene promoter via clustered regularly interspaced short

281 activation domain of FoxM1 to the cyclin B1 gene promoter via CRISPR-catalytically inactive Cas9 (dC

282 RNA-guided epigenetic editing of Sema6a gene promoters via a dCas9-SunTag system with C11orf46 b

283 In epiblast cells, TET1 demethylates gene promoters via hydroxymethylation and maintains telo

284 subset of genes and was recruited to active gene promoters via MeCP2.

285 Methylation of the Dab2 gene promoter was demonstrated in Stage I PDAC tumors an

286 The major G4 formed in the PDGFR-beta gene promoter was previously shown to have a broken G-st

287 o 8-oxo-7,8-dihydroguanine (OG) in mammalian gene promoters was demonstrated to induce transcription.

288 protein (GFP) under an interferon-stimulated gene promoter, we repeatedly observed transgenic larvae

289 e binding of NF-Y proteins to these modules' gene promoters were verified using ENCODE ChIP-Seq data.

290 butyrylation of histone H4 lysine 5 and 8 at gene promoters where acetylation guides the binding of B

291 t pyruvate enhances SIRT1 binding at histone gene promoters where it reduces histone acetylation.

292 he HCF-1:ChREBP complex resides at lipogenic gene promoters, where HCF-1 regulates H3K4 trimethylatio

293 nce for hotspots in the genome, particularly gene promoters, where their association is frequently li

294 elieves its repression of the methylated Lhb gene promoter, which is then hydroxymethylated and activ

295 tone methylation on IL-1beta, IL-6, and MMP2 gene promoters, while SETD1B inhibition decreased H3K4me

296 is reveals predominant R-loop formation near gene promoters with strong G/C skew and propensity to fo

297 itation followed by sequencing to screen for gene promoters with the activating histone 4 acetylation

298 associated with hypermethylation of TEs and gene promoters, with influence observed for methylation

299 of transcription from E-box-containing clock gene promoters within key pacemaker neurons.

300 lished a temporal hierarchy of TF binding to gene promoters within the same family as well as across