ライフサイエンスコーパス: general mechanism

1 known to bind regulators, thus suggesting a general mechanism.

2 ond Ago-binding platform, suggesting it is a general mechanism.

3 both sequestration and degradation may be a general mechanism.

4 served in diverse cancer types, suggesting a general mechanism.

5 ly similar across tasks, suggesting a domain-general mechanism.

6 CF-1 coordinated such differentiation by two general mechanisms.

7 o outstanding issues: (1) whether alpha is a general mechanism across sensory systems and (2) which c

8 The biomethods employed and their general mechanisms, advantages and limitations in releva

9 This general mechanism allows for development to be guided by

10 occal surface protein, which may represent a general mechanism among bacterial pathogens for activati

11 effect experiments confirm the hypothesized general mechanism and reveal the role of the phosphate c

12 ative aspect of network formation could be a general mechanism, and additional temporal regulators ma

13 Domain-general mechanisms are evolutionarily ancient, resulting

14 ized "core language network", whereas domain-general mechanisms are implemented in the bilateral "mul

15 together, our results indicate that FD is a general mechanism assisting in the local removal of TFs

16 The general mechanisms associated with photo-cross-linking (

17 This receptor-clamping approach might be a general mechanism-based strategy for engineering cytokin

18 quitination, suggesting this may represent a general mechanism beyond HIV infection and APOBEC3 degra

19 These observations indicate a general mechanism by which AAA+ ATPases may translocate

20 tion of its chaperone activity and suggest a general mechanism by which ATP-independent chaperones wi

21 This work provides a novel and more general mechanism by which attention interacts with choi

22 n of mixed-species communities and suggest a general mechanism by which bacteria could colonize hosts

23 ype of glutamate receptors and demonstrate a general mechanism by which Ca2+ -permeable AMPA receptor

24 vidual enhancers and promoters-may be a more general mechanism by which cells can regulate the access

25 We propose that these bridges provide a general mechanism by which cells interpret different for

26 Taken together, our results suggest a general mechanism by which CpG methylation can modulate

27 c methylome/hydroxymethylome landscapes as a general mechanism by which differentiated cells exit a c

28 ion to relieve IRS1 inhibition may be a more general mechanism by which GPCRs act with the IGF-1R to

29 Our data suggest a general mechanism by which histone marks regulate chromo

30 These results suggest a general mechanism by which Hsp90 can recognize and remod

31 growth factor cell signaling may represent a general mechanism by which IFN-gamma impairs the functio

32 ively regulates RGS17, which may represent a general mechanism by which increased Ca(2+) concentratio

33 tween the CNS and cellular immunity may be a general mechanism by which infectious agents exacerbate

34 of TIMP/metalloproteinase complexes may be a general mechanism by which inhibited metalloproteinases

35 are organized and has offered a tantalizing general mechanism by which many aspects of nuclear funct

36 ent findings on stellate cells, we propose a general mechanism by which mature inhibitory synapses ar

37 quid-liquid phase separation (LLPS) may be a general mechanism by which molecules in the complex cell

38 r gene regulation in bacteria and suggests a general mechanism by which other prokaryotic and eukaryo

39 Thus modulation of inhibition may be a general mechanism by which oxytocin can act throughout t

40 ated endocannabinoid depletion by ABHD2 is a general mechanism by which progesterone exerts its genom

41 The results suggest a general mechanism by which SC factors may cooperate to r

42 ucing CD40-mediated p-P65 induction may be a general mechanism by which some current therapies modula

43 This model suggests a general mechanism by which TAG trafficking is coordinate

44 Our findings suggest a general mechanism by which the microbiota may control ho

45 ongation, described here for p21(CIP1), is a general mechanism by which transcription factor Sp3 fine

46 her transcription factors might constitute a general mechanism by which transcriptional auxin-sensiti

47 In this Review, we highlight the general mechanisms by which nanomaterials can be used to

48 Despite remarkable advances, the general mechanisms by which the immune system differenti

49 3) parallel pathway activation (this is the general mechanism cited in the quote above), 4) perturba

50 ovide proof-of-principle for a novel, likely general mechanism contributing to geographic variation a

51 nce, are supportive of phase separation as a general mechanism controlling activity-dependent transla

52 transcription in activated DCs, we uncover a general mechanism counteracting low MHCI surface express

53 Such usage of yeast Pol II suggests a general mechanism coupling eukaryotic transcription to e

54 bolites that influence health through 1 of 3 general mechanisms: direct antimicrobial effects, enhanc

55 by nonnative interactions, which might be a general mechanism, e.g., in the recognition of histone t

56 This suggests that ZBD relocation may be a general mechanism employed by sigma(70) family factors t

57 tructured inhibition and excitation may be a general mechanism enabling sequence generation in other

58 econd mutations may constitute a more common general mechanism explaining phenotype variability.

59 eract during biogenesis, and may represent a general mechanism facilitating assembly of heteromeric p

60 Overall, our work presents a general mechanism for achieving drastic topological remo

61 between receptor helices H6 and H7 may be a general mechanism for active-state stabilization.

62 egulation of intrinsic excitability may be a general mechanism for adaptive control of behavioral out

63 aging are examined within the framework of a general mechanism for averaging of object rotation.

64 related to recent experience appears to be a general mechanism for binding spatial, temporal and sens

65 ork destabilization hypothesis as a unifying general mechanism for both SOD aggregation and ALS disea

66 extracellular Ca(2+) Our findings provide a general mechanism for Ca(2+) gating among different conn

67 WD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positio

68 sive compounds in high-turgor cells may be a general mechanism for chemical protection of the phloem

69 These findings demonstrate a simple and general mechanism for conferring temporal flexibility up

70 ration of key scaffolding proteins, may be a general mechanism for controlling the formation of RNA g

71 Trigger waves may be an important general mechanism for coordinating biochemical events ov

72 ions between multivalent proteins could be a general mechanism for cytoplasmic adaptor proteins to or

73 SUMO switch of FXR in obesity may serve as a general mechanism for diminished anti-inflammatory respo

74 fusion through gap junctions could provide a general mechanism for diverse cellular processes.

75 ating from specific neural circuits may be a general mechanism for driving regional angiogenesis and

76 This identifies PTGS as a general mechanism for eliminating highly abundant endoge

77 This is likely to be a general mechanism for enabling the wiring between these

78 representation is just one example of a more general mechanism for encoding continuous, task-relevant

79 mbles of transcription factors and suggest a general mechanism for encoding functional specificities

80 egulatory regions of the same RPGs, a likely general mechanism for enhancer-promoter interactions.

81 t buffering of attractant concentration is a general mechanism for ensuring robust cell migration.

82 We propose a general mechanism for environmentally-stimulated CNV and

83 We propose a general mechanism for epoxide selection by ionophore pol

84 main paralogs, we hypothesize that this is a general mechanism for evolving specificity and regulatio

85 These findings demonstrate a potentially general mechanism for exclusion of proteins from the Par

86 output of the lateral amygdala, providing a general mechanism for fear/aversive behavior driven by a

87 ns containing weakly interacting blocks is a general mechanism for forming regulated, membraneless or

88 These data provide a general mechanism for functional inactivation of ARF and

89 tatory and inhibitory activity may provide a general mechanism for generating coherent neuronal dynam

90 ormation with network states may represent a general mechanism for generating variability in behavior

91 The resulting model suggests a general mechanism for how nervous systems and excitable

92 Formation of secondary interfaces may be a general mechanism for increasing affinity and specificit

93 initiated RNA Polymerase II (Pol II) is the general mechanism for inducing promoter-proximal pausing

94 ermore, this approach may prove to be a more general mechanism for inhibiting protein-protein interac

95 lipid-specific binding domains, suggesting a general mechanism for interorganelle tethering.

96 ition of all known CN substrates, implying a general mechanism for KIF1Bbeta in Ca(2+) signaling and

97 This identifies a simple and general mechanism for learning-related regulation of mot

98 een strains and thus cannot be regarded as a general mechanism for light adaptation.

99 suggests that hyperexcited states provide a general mechanism for linking membrane electrical dynami

100 Our findings illustrate how a general mechanism for lysosome dispersal in nonneuronal

101 This finding may represent a general mechanism for M cone degeneration in multiple fo

102 We suggest that multiple Gli CRMs may be a general mechanism for mediating a robust transcriptional

103 Such multimodal regulations may be a general mechanism for metabolic modulation.

104 ing feature of IBD microbiotas, suggesting a general mechanism for microbial contribution to IBD path

105 d suggests that trace gas oxidation may be a general mechanism for microbial persistence.

106 ise EI balance and dynamic EI delays forms a general mechanism for millisecond-range input gating and

107 found during AZ maturation might represent a general mechanism for modulating ribbon size.

108 Our results may provide a general mechanism for modulating the biochemical environ

109 These results support a general mechanism for nanoscale material degradation and

110 A general mechanism for nectar secretion has been establis

111 nstrated this activity, suggesting this is a general mechanism for organizing and maintaining proper

112 Thus, Shot/Patronin ncMTOCs may provide a general mechanism for organizing noncentrosomal microtub

113 counterpart of DsbA, allowing us to devise a general mechanism for oxidative folding that also reflec

114 Targeting sialic acids may be a general mechanism for pleiotropic actions of soluble klo

115 t sequential ITIM phosphorylation provides a general mechanism for precise temporal control over the

116 text, the model circuit presented provides a general mechanism for producing steering signals by comp

117 compartments, thus potentially serving as a general mechanism for prolonged and compartmentalized si

118 the kinase activation T-loop may serve as a general mechanism for protein kinase down-regulation aft

119 function through gene fusion appears to be a general mechanism for providing allostery for this enzym

120 Our results suggest a general mechanism for R2TP to impart specificity by reco

121 comparison with Parkin and HHARI suggests a general mechanism for RBR E3 ligases.

122 e structure of ligand-occupied sKLA reveal a general mechanism for recognition of endocrine FGFs by K

123 olic enzymes is increasingly recognized as a general mechanism for regulating activity, typically by

124 uggesting that DAP-DAP crosslinking may be a general mechanism for regulating bacterial sensitivity t

125 e that such nodes might act as features of a general mechanism for regulating cell-type-specific apop

126 ement during lncRNA transcription could be a general mechanism for regulating memory of previous even

127 ersible ploidy change itself could provide a general mechanism for rejuvenation to promote individual

128 f RF2 may occur on stop codons, suggesting a general mechanism for release-factor-mediated translatio

129 pollen rejection in Zea and may represent a general mechanism for reproductive isolation in grasses.

130 annel to the plasma membrane may represent a general mechanism for restoring phagosome activity in co

131 cell lines with Rnd3 knockdown, suggesting a general mechanism for Rnd3-mediated PKA signaling activa

132 ide is pH-independent, there could be a more general mechanism for sensitization of AE2-depleted chol

133 ugh segregation of inhibition, a potentially general mechanism for sequential motor patterns.

134 le regulators such as CDKG1 is a potentially general mechanism for size control.

135 activation of Cdc42 or Rac GTPases may be a general mechanism for spatial cue-directed cell polariza

136 We propose a general mechanism for substrate recognition by structure

137 band-pass mechanical filter, and provides a general mechanism for symmetrical and rapidly adapting M

138 identical mechanisms of action, suggesting a general mechanism for targeting this group of TLRs.

139 Our results support a general mechanism for the activation of mGluRs in which

140 Collectively, the data support a general mechanism for the amino acid addition reaction c

141 Our approach provides a parsimonious and general mechanism for the emergence of critical-like beh

142 ment of Treg-based therapies and represent a general mechanism for the establishment of epigenetic me

143 -specific CD8 T cell responses and suggest a general mechanism for the formation of transcriptional a

144 This suggests a general mechanism for the generation and stabilization o

145 for alteration in HPA axis functioning as a general mechanism for the health consequences of socioec

146 to vaginal challenge could be a potentially general mechanism for the mucosal immune system to sense

147 A general mechanism for the reaction process and stereoche

148 l properties as well as provides access to a general mechanism for the real-time tracking of supramol

149 suggest that interfacial geometry triggers a general mechanism for the regulation of cancer-cell stat

150 cription factors by external cues could be a general mechanism for the regulation of cell growth by e

151 aryls, heteroaryls, and dienes, as well as a general mechanism for the selective transfer of ligands

152 NA recognition by transcription factors as a general mechanism for the spatiotemporal control of deve

153 etween Brd4 and Hsp90 in ADPKD may also be a general mechanism for the upregulation of Brd4 in cancer

154 Fusion of cellular factors may represent a general mechanism for their asymmetric segregation at di

155 on and specific cell functions may provide a general mechanism for their coordination in time and spa

156 carbon-use efficiency provides a potentially general mechanism for thermal adaptation in phytoplankto

157 extrusion during palate fusion and suggest a general mechanism for tissue fusion in development.

158 pport ATP-driven backward translocation as a general mechanism for transcriptional regulation.

159 SS selection by bacterial RNAP and suggest a general mechanism for TSS selection by bacterial, archae

160 ng is a particularly important set of domain-general mechanisms for constructing human groups - enabl

161 signaling modify neural networks and suggest general mechanisms for generating flexible behavioral ou

162 rol literature, suggesting that there may be general mechanisms for pest control and that biocontrol

163 ation of higher order polymers is one of the general mechanisms for signaling platform assembly in in

164 Our studies illuminate general mechanisms for substrate recognition and catalys

165 We propose general mechanisms for the broad-spectrum inhibition Abe

166 Several general mechanisms for toxin function have been establis

167 e biological distinctions among species, but general mechanisms have been elusive.

168 Two general mechanisms have been suggested for the temporal

169 Developmental plasticity and domain-general mechanisms have important consequences with resp

170 Our results suggest a general mechanism how nucleosomes increase transcription

171 Our study proposes a general mechanism in regulating lineage segregation duri

172 e collapse of transfusion tracheids may be a general mechanism in this group for the protection of le

173 hat RF B cells break tolerance with the same general mechanisms in the TC and the MRL/lpr lupus-prone

174 al regulation is solidly established and the general mechanisms involved in this type of regulation a

175 This general mechanism is also conserved by natural cysteine-

176 In this work, a general mechanism is discovered to form liquid-metal-bas

177 in binding sites but rather, through a more general mechanism, largely mediated through dissociation

178 efect mobility in SP-CSAs is identified as a general mechanism leading to slower growth of large defe

179 soil C input alone, indicating that it is a general mechanism limiting C accumulation in soil.

180 ports the hypothesis that harshness may be a general mechanism limiting local diversity and explainin

181 teria is programmed by a DNA sequence, but a general mechanism limiting resection in eukaryotes has r

182 We study this general mechanism of "collective guidance" computational

183 found for transferrin receptor, suggesting a general mechanism of action.

184 ion suggests conformational selection as the general mechanism of allostery in this canonical signall

185 Such preferential coupling may represent a general mechanism of ANO1 activation in native tissues.

186 of gluten-TG2 complexes, and they outline a general mechanism of autoimmunity with autoantibodies be

187 The GhHOX3-GhTCP4 complex may represent a general mechanism of cellular development in plants sinc

188 the N termini and sheds light on a potential general mechanism of channel and receptor activation.

189 ork suggests that loop extrusion is a viable general mechanism of chromatin organization.

190 velopment of the VWFA, possibly reflecting a general mechanism of cortical development.

191 n complex to derive specific details and the general mechanism of CTS binding and inhibition.

192 reinforcing vascular defects may represent a general mechanism of deep ICH.

193 s in species abundance were in line with the general mechanism of direction and magnitude of long-ter

194 In addition, there is growing support for a general mechanism of DNA-membrane contacts based on tran

195 While the general mechanism of ecdysone-dependent transcription is

196 nes is an evolutionary novelty of flies or a general mechanism of embryonic morphogenesis.

197 These results reveal a general mechanism of HIV-1 neutralization by MPER-specif

198 he membrane, our results point toward a more general mechanism of how active transport can be modifie

199 These data may represent a general mechanism of humoral response-mediated protectio

200 iophysical phenomena and its importance as a general mechanism of hydrophobic self-assembly.

201 re rich in PG, so these data point to a more general mechanism of immune detection of infection- or s

202 Our results point to a general mechanism of inducing collective invasion patter

203 Our work highlights a general mechanism of kinesin inhibition in which small-m

204 These findings suggest a domain-general mechanism of learning through compression in ven

205 To understand the general mechanism of macrolide action, we used genome-wi

206 These results support a general mechanism of Na(+) current inhibition that is wi

207 rved for the imidazoles as expected from the general mechanism of oxidative ring openings of imidazol

208 However, a general mechanism of PFA has remained elusive.

209 Even though the general mechanism of photodynamic cancer therapy is know

210 mechanism of kinase maturation and likely a general mechanism of regulation of CMGC kinases in eukar

211 epression of multiple alternative fates as a general mechanism of repressor action.

212 important in mammals and yeast, and may be a general mechanism of restoring small linear chromosome n

213 These results support a general mechanism of sequestration of pro-apoptotic BCL-

214 s within multi-component assemblies may be a general mechanism of signaling by regulatory IDPs, which

215 nthesis pathways like PERK could represent a general mechanism of sleep and wake regulation and provi

216 e results indicate that phase alignment is a general mechanism of the brain to process rhythmic struc

217 ed on Navier-Stokes equations to uncover the general mechanism of the fluidic hyperuniformity (HU).

218 Although the general mechanism of the NER process is well studied, th

219 gest that multiplexed population coding is a general mechanism of touch encoding common to species as

220 in-induced unfolding is a key element in the general mechanism of toxin inactivation by human defensi

221 is rapid, and regulated proteolysis may be a general mechanism of transducing surface stimuli.

222 he results reveal a previously unappreciated general mechanism of translational quality control, in w

223 de a platform for the integration of primate-general mechanisms of acoustic communication with the fa

224 mmune disease, although the exact origin and general mechanisms of action have remained to be elucida

225 review paper, we provide an overview of the general mechanisms of cardiac fibrosis in AF, difference

226 This finding led us to propose general mechanisms of dependency on plastid organelles i

227 findings allow us to formulate and quantify general mechanisms of genetic suppression.

228 innate nucleic acid sensing, the central and general mechanisms of monitoring both microbial invasion

229 ormation to our growing body of knowledge on general mechanisms of phosphoryl transfer reactions cata

230 es and will further our understanding of the general mechanisms of rotary molecular motors.

231 Although general mechanisms of thrombosis are enhanced in these p

232 identified so far, as well as their basis in general mechanisms of vascular development and stability

233 lope relatively robust in reverberation: one general mechanism operating for all stimuli with small m

234 Such regulation could represent a general mechanism orchestrating long-range neuronal conn

235 Similar heterogeneity tradeoffs might be a general mechanism promoting phenotypic variation in any

236 n during the onset of XCI and functions as a general mechanism regulating chromatin configuration in

237 suggest that finely tuned dynamics may be a general mechanism regulating triplex-mediated functions.

238 ever, unclear whether organisms have evolved general mechanism(s) to deal with this damage.

239 o explain growth differences among families, general mechanisms seem also to be involved, and thus, r

240 Our findings support a general mechanism: sequential binding of DREAM, MMB and

241 In principle, the brain could have evolved a general mechanism that applies the same learning rule to

242 onclude that duplex DNA contact by Exo1 is a general mechanism that controls its activation and that

243 ted capture of similar inhibitors might be a general mechanism that could be applied to other synthet

244 and celiac disease, these results suggest a general mechanism that could contribute to immune-mediat

245 We propose a novel, simple but general mechanism that could give rise to hormesis in sy

246 We predict that this is a general mechanism that detaches myosin V from select car

247 We propose a general mechanism that enables the fine-tuning of the Fe

248 Vesicular transport is a general mechanism that governs intracellular membrane tr

249 s suggest low-frequency phase to be a domain-general mechanism that orchestrates dynamic memory repla

250 ely, effects of reward may be part of a more general mechanism that prioritizes the processing of any

251 pretation, these results reveal an important general mechanism that regulates the activity and substr

252 both language-specific mechanisms and domain-general mechanisms that are engaged in many cognitive pr

253 ted proteins, little is known regarding more general mechanisms that contribute to the generation of

254 ies of specific complexes and in elucidating general mechanisms that explain how quaternary structure

255 we are able to identify and characterize the general mechanisms that give rise to the optical respons

256 Thus, electrical coupling may provide a general mechanism to achieve near-optimal information tr

257 A general mechanism to address the conflict between streng

258 fics and sustaining parental care, or a more general mechanism to attend to living beings.

259 gher-order protein self-association may be a general mechanism to concentrate functional components i

260 ediated inflammatory pathway may represent a general mechanism to control inflammation in inflammator

261 Proenzyme maturation is a general mechanism to control the activation of enzymes.

262 th specific regulatory factors may provide a general mechanism to diversify the functional repertoire

263 tions at other transport steps may provide a general mechanism to drive lipid bilayer merger.

264 is 'tag-team proofreading' represents a more general mechanism to ensure a specific set of proteins i

265 ng regulatory kinases to replisomes may be a general mechanism to ensure spatial and temporal coordin

266 at the packaging of p-RTKs in endosomes is a general mechanism to ensure the fidelity and specificity

267 The results suggest that EVs may be a general mechanism to exchange non-specialized genetic ca

268 This repartitioning could represent a general mechanism to explain changes in product release

269 on factor on rates via clustering provides a general mechanism to facilitate binding to low-affinity

270 roup stabilizes the 4HB stalk as part of the general mechanism to fine-tune F-activation.

271 -based Turing mechanism constitutes a likely general mechanism to guide branching morphogenesis and o

272 nce, we propose that filament formation is a general mechanism to inactivate and store key metabolic

273 The phosphoswitch provides a general mechanism to integrate diverse stimuli to regula

274 its occurrence, and propose that it may be a general mechanism to promote zero-lag synchrony in the b

275 h coherent phase-amplitude coupling may be a general mechanism to regulate neuronal interactions alon

276 tional modification of cryptic residues is a general mechanism to regulate tissue elasticity.

277 Thus, phosphorylation of SNARE domains is a general mechanism to restrict how much cells secrete, op

278 ng proteins to cellular RNAs could provide a general mechanism to shape nascent RNA folding during RN

279 ng to a single coat protein might serve as a general mechanism to trigger efficient capture, or may b

280 or universal prosociality, and that the same general mechanisms underlie both religious and secular e

281 This may not only provide a general mechanism underlying BRCA1's function in maintai

282 suggest that the novel PC site is part of a general mechanism underlying proenzyme maturation of ADA

283 uitment of vesicular thermoTRP channels is a general mechanism underlying sensitization of all nocice

284 chromatin factors in specific contexts, or a general mechanism underlying the establishment of chroma

285 regulation within and across organs may be a general mechanism underlying the observed pleiotropy bet

286 temperature mediated oxygen limitation is a general mechanism underlying the thermal tolerance of em

287 tter volume may be due to alterations in the general mechanisms underlying normal brain development i

288 charged drugs and may also hint toward more general mechanisms underlying the induction of autoantib

289 ion networks of the brain, suggesting domain-general mechanisms underlying the representation of cons

290 We discuss two general mechanisms underlying the weak influence of this

291 We have reviewed general mechanisms underlying variability in drug action

292 naling, suggesting that lncRNA-rSBE may be a general mechanism used by cells to fine-tune Smad3 activ

293 Kinetic gating may be a general mechanism used by site-specific DNA-binding prot

294 These findings support a general mechanism where DNA glycosylases use highly dyna

295 This supports a general mechanism where localized actin polymerization c

296 lts provide a novel example of a potentially general mechanism whereby climate change-mediated range

297 antitoxin can therefore provide insight into general mechanisms whereby protein disorder regulates ev

298 mal physical model for MORPH that suggests a general mechanism which is potentially applicable to a l

299 This general mechanism, which we call "segregation lift," req

300 discuss the most popular theories regarding general mechanisms widely believed to underlie hedonic d