ライフサイエンスコーパス: genome sequencing

1 that 41 carried mcr-9 (validated using whole genome sequencing).

2 s with genetic information (imputed or whole-genome sequencing).

3 K1 open reading frame Sanger and KSHV whole-genome sequencing.

4 ng multilocus typing of five genes and whole-genome sequencing.

5 ic test with whole-exome sequencing or whole-genome sequencing.

6 ily selected, from single mutations to whole-genome sequencing.

7 cing panels as well as whole-exome and whole-genome sequencing.

8 diabetes, six by exome sequencing and one by genome sequencing.

9 e exome sequencing, and more recently, whole genome sequencing.

10 were previously categorized via PCR or whole-genome sequencing.

11 e not proved tractable with short-read whole genome sequencing.

12 een analysed by both transcriptome and whole-genome sequencing.

13 gin and evolution of this system using whole genome sequencing.

14 ates from each sample were subjected to full genome sequencing.

15 n of structural variants in the era of whole-genome sequencing.

16 ultural obligations that are associated with genome sequencing.

17 e and antibiotic resistance assays and whole-genome sequencing.

18 related to the main outbreak strain by whole-genome sequencing.

19 t by genome-wide association study and whole-genome sequencing.

20 gene sequencing and most recently, exome and genome sequencing.

21 ources in NYS were characterized using whole-genome sequencing.

22 Cultured isolates underwent whole-genome sequencing.

23 lutionary process, we interrogated, by whole genome sequencing, 25 samples collected at autopsy from

24 Whole genome sequencing (30X) and digital droplet PCR (ddPCR)

25 mbers of individuals have undergone elective genome sequencing, a comprehensive study surveying genom

26 With further, more accurate human genome sequencing, additional mutation hotspots, mechani

27 Whole genome sequencing alerted us to the existence of greater

28 d short-read aligner, can compute WGS (whole-genome sequencing) alignments ten times faster than comp

29 ches that reduced the complexity and time of genome sequencing along with development of gene editing

30 However, the wide adoption of whole-genome sequencing also poses new challenges for public-h

31 Here we performed whole-genome sequencing analyses of 426 individuals-comprising

32 in MMR-deficient gliomas, single-cell whole-genome sequencing analysis of post-treatment hypermutate

33 n on canine chromosome 33, followed by whole-genome sequencing analysis that revealed a long interspe

34 e approach, followed by a more refined whole genome sequencing analysis.

35 aution to address systematic biases in whole-genome sequencing and alignment.

36 re confirmed using pathogen isolation, whole-genome sequencing and antibiotic susceptibility testing,

37 Here we report genome sequencing and assembly for true jellyfish Sander

38 hts several of the opportunities provided by genome sequencing and bioinformatics, challenges associa

39 High-throughput genome sequencing and computation have enabled rapid ide

40 Whole genome sequencing and cytogenetics of experimentally evo

41 , fluorescence-activated cell sorting, whole-genome sequencing and data analysis.

42 Eukaryotic genome sequencing and de novo assembly, once the exclusi

43 provides results on the integration of whole-genome sequencing and deep phenotyping for clinical asse

44 er kidney cancer subtypes, integrating whole-genome sequencing and DNA methylation data.

45 into its biosynthesis were provided by whole genome sequencing and gene deletion studies, while bioac

46 mutations can be identified by comprehensive genome sequencing and might have clinical significance.

47 Whole-genome sequencing and phylogenetic analysis of 388 sampl

48 By combining genome sequencing and population genetics, we investigat

49 V discovery in non-model species using whole genome sequencing and report 15,483 high-confidence SVs

50 Whole-genome sequencing and SNP-level analysis was conducted.

51 lyclonal nature of strains revealed by whole-genome sequencing and the apparent lack of epidemiologic

52 Data from whole-genome sequencing and transcriptome studies were then in

53 Through a combination of whole-genome sequencing and transcriptomics, we showed that to

54 Using whole-genome sequencing and tribal fishery sampling of Chinook

55 Transcriptomics, genome sequencing, and metabolomics analyses in these Zn

56 [range 20 to 89+]; 70.6% European) had whole-genome sequencing, and were deeply phenotyped using meta

57 es mutational signatures identified by whole genome sequencing, and will ultimately allow the study o

58 omic data from whole exome sequencing, whole genome sequencing, and/or array-based imputation.

59 Thus, using a cohort-based whole-genome-sequencing approach in the diagnosis of PID can i

60 Whole-exome and whole-genome sequencing are becoming financially feasible but

61 l resistance determination, such as by whole-genome sequencing, are required.

62 However, the increasing application of whole-genome sequencing as a diagnostic tool is leading to the

63 ected, adopting whole-exome sequencing/whole-genome sequencing as a first-line test should be conside

64 and genome assembly increasingly facilitate genome sequencing as a means of characterizing new varie

65 and duplications were genotyped using whole-genome sequencing-based data.

66 create the largest, to our knowledge, whole-genome-sequencing-based structural variant resource so f

67 The explosive growth of genome sequencing brings a new set of challenges and iss

68 Furthermore, rapidly deployable viral genome sequencing can be an integral part of outbreak re

69 Whole-genome sequencing can be used to estimate subclonal popu

70 GCs they carry, suggesting that strain-level genome sequencing can uncover high levels of BGC diversi

71 ing for five lipid traits in two UK10K whole genome sequencing cohorts, hypothesizing that cis-expres

72 no reference maps of SVs from high-coverage genome sequencing comparable to those for SNVs.

73 Whole-genome sequencing confirmed distinct species identities

74 Viral genome sequencing confirmed four reinfections out of 12

75 Surveillance strategies based on whole genome sequencing could help with the early identificati

76 Whole genome sequencing coupled with an outbreak-strain-specif

77 Genetic variants were examined using whole-genome sequencing data among survivors of African ancest

78 ignals for potential SV breakpoints in whole genome sequencing data and proposes a probabilistic form

79 s (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common

80 Short-read whole-genome sequencing data are often applied to large-scale

81 Utilizing high-coverage whole-genome sequencing data as part of the Trans-Omics for Pr

82 Whole genome sequencing data did not identify a strain genotyp

83 Our interrogation of the whole-genome sequencing data for 215 breast tumors catalogued

84 Using public whole-genome sequencing data from 2,606 samples from different

85 Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumo

86 e Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumo

87 RNA-seq, and then integrate these with whole genome sequencing data from 232 OCs.

88 s (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor

89 s (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor

90 s (PCAWG) Consortium, which aggregated whole-genome sequencing data from 2658 cancers across 38 tumou

91 We analyze whole-genome sequencing data from 268 patients to catalog gene

92 We analyzed whole-genome sequencing data from 43 202 Icelanders.

93 Whole genome sequencing data from cases and controls were comp

94 We applied SBMClone to single-cell whole-genome sequencing data from two breast cancer patients o

95 ariant caller utilizing low-depth (8X) whole-genome sequencing data generated by Oxford Nanopore Tech

96 The multi-tissue gene expression and whole genome sequencing data generated by the Genotype-Tissue

97 ing dense imputation from multi-ethnic whole-genome sequencing data in admixed Hispanics/Latinos.

98 ill allow for better interpretation of whole genome sequencing data in the large number of patients a

99 theoretical framework that, applied to whole-genome sequencing data of healthy tissue and cancer, all

100 bility of using Oxford Nanopore MinION whole-genome sequencing data of Mycobacterium tuberculosis iso

101 Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-contro

102 sequence and structural diversity from whole-genome sequencing data remains highly challenging.

103 Methods: We used admixture-mapping and whole-genome sequencing data to discover genomic regions assoc

104 iers have successfully been applied to whole-genome sequencing data to identify genetic determinants

105 AH we integrated deep phenotyping with whole-genome sequencing data using Bayesian statistics.

106 Here, we combine long- and short-read whole-genome sequencing data with recent assembly approaches i

107 We combined genome sequencing data with single-cell mRNA sequencing

108 his gap, we extend TWAS to integrating whole genome sequencing data with transcriptomic data for low-

109 Using matched whole-genome sequencing data, we associated several categories

110 Using the GTEx whole genome sequencing data, we identify 20,545 high-quality

111 -80% of indels detected in human brain whole-genome sequencing data.

112 ructural variant (SV) breakpoints from whole-genome sequencing data.

113 rately assemble organelle genomes from whole genome sequencing data.

114 poson insertions for both targeted and whole-genome sequencing data.

115 ,658 tumors from 38 cancer types using whole-genome sequencing data.

116 so applied our methodology to a TOPMed whole-genome sequencing dataset with 897 asthmatic trios from

117 inferred D genes by analyzing diverse whole genome sequencing datasets and haplotyping heterozygous

118 for genetic differences, we performed whole genome sequencing, deep mitochondrial DNA (mtDNA) sequen

119 Unbiased whole genome sequencing demonstrates high specificity of base

120 Genome sequencing did not identify any genetic differenc

121 teristics, and performed mycobacterial whole-genome sequencing, dormancy phenotyping and drug-suscept

122 K ("Bird 10,000 Genomes") consortium's whole-genome sequencing effort, we have included 363 annotated

123 pproach is readily applicable to large-scale genome sequencing efforts across the tree of life.

124 n detected as the result of extensive cancer genome-sequencing efforts and are linked to a restricted

125 Genome sequencing enabled us to identify a chaperone-ush

126 It highlights the role of whole-genome sequencing, expanded phenotypic drug susceptibili

127 RNA sequencing, followed by additional whole-genome sequencing experiments.

128 US) is essential in clinical applications of genome sequencing for diagnosis and personalized care.

129 A key goal of whole-genome sequencing for studies of human genetics is to in

130 nteric diarrhea and endorse the use of whole-genome sequencing for sustained surveillance of NTS inte

131 We performed whole genome sequencing for two American minks with Moyle (m/m

132 reference distribution was built using whole-genome sequencing from 1,522 Indian individuals, and a f

133 ntative S. mutans isolates were selected for genome sequencing from a large-scale epidemiological stu

134 This study used imputed whole-genome sequencing from the Trans-Omics for Precision Med

135 Massive genome sequencing has allowed extraction of specific fea

136 Viral genome sequencing has emerged as a powerful approach to

137 Whole-genome sequencing has enhanced surveillance and facilita

138 Genome sequencing has established clinical utility for r

139 An explosion of genome sequencing has facilitated a deep understanding o

140 Genome sequencing has fundamentally changed how plant bi

141 The application of exome and genome sequencing has greatly improved the rate of genet

142 As access to whole-genome sequencing has grown, greater amounts of molecula

143 Genome sequencing has identified a host of deleterious g

144 The rapid progress in genome sequencing has led to high availability of genomi

145 Microbial genome sequencing has revealed a plethora of uncharacter

146 Genome sequencing has revealed an increasing number of g

147 Short- and long-read whole-genome sequencing highlighted a duplication involving 2

148 While whole genome sequencing holds promise, it is not yet feasible

149 and characterizing the viral load, RSV whole-genome sequencing, host immune response, and transcripto

150 Here, we describe in situ genome sequencing (IGS), a method for simultaneously seq

151 Through genome sequencing in 3 subjects from 2 families with non

152 address these challenges by performing whole-genome sequencing in a large PID cohort of 1,318 partici

153 Rapid trio genome sequencing in family 1 and exome sequencing in fa

154 49,960 participants highlight the promise of genome sequencing in large population-based studies and

155 Whole genome sequencing in multiplex families, proband-parent

156 Whole-genome sequencing in one affected dog and its obligatory

157 and PRSS56 testing in 20 families and whole-genome sequencing in one family.

158 We also show that Hi-C can supplement whole-genome sequencing in structure variant detection by loca

159 rated and analyzed, and how SARS-CoV-2 whole-genome sequencing, in combination with epidemiological d

160 Genome sequencing indicated pronounced population struct

161 saline flushes were highly related by whole-genome sequencing, indicating a common source.

162 Our work shows that genome sequencing is a powerful epidemiological tool to

163 (RP17) was delineated through genotyping and genome sequencing, leading to the identification of stru

164 of the entire cohort, in parallel with whole-genome sequencing, methylation, and other 'omics assays.

165 Through whole-genome sequencing of 13 melanoma metastases sampled at a

166 yzed 6.8 million variants derived from whole genome sequencing of 160 islet autoantibody positive sub

167 braziliensis species complex based on whole-genome sequencing of 67 isolates from 47 localities in P

168 Therefore, whole-genome sequencing of 756 child-parent trios of European,

169 Shallow whole-genome sequencing of 777 biopsies, sampled from 88 patie

170 ccurring on palms, soles or nail beds, whole genome sequencing of 87 tumors with matching transcripto

171 Genome sequencing of actinomycetes reveals an untapped r

172 We conducted whole-genome sequencing of all 1,575 available GAS macrolide-r

173 High-throughput genome sequencing of both isolates and metagenomic sampl

174 By genome sequencing of CHO-MG cells, we identified mutatio

175 Here we used whole-genome sequencing of clonal cell isolates that developed

176 Whole-genome sequencing of clonal organoids before and after t

177 Here we have performed whole genome sequencing of consecutive M. tuberculosis isolate

178 Since whole-genome sequencing of many crops has been achieved, crop

179 Here, Whole-Genome Sequencing of Mycobacterium bovis isolated from t

180 Genome sequencing of NRRL 8095 identified the acrophiari

181 Whole genome sequencing of paired isolates was used to identif

182 SWGA enables the successful whole genome sequencing of samples with low parasite density (

183 Genome sequencing of SARS-CoV-2 allows the reconstructio

184 Whole genome sequencing of select transformants demonstrated t

185 this workflow to perform targeted and whole-genome sequencing of small populations of cells (typical

186 However, genome sequencing of specimens is challenging because of

187 Full genome sequencing of the ANDV strain involved in this ou

188 Recent genome sequencing of the constitutive model CAM species

189 A full-genome sequencing of the cpDNA revealed mutations in the

190 esponding constant environments, followed by genome sequencing of the evolving populations.

191 e performed a genetic screen from deep whole genome sequencing of the large NIMH family-based Alzheim

192 Viral genome sequencing of the paired first-positive and reinf

193 MIC, pDST and whole genome sequencing of the pncA, rpsA and panD genes were

194 We performed whole-genome sequencing of the SKBR3 breast cancer cell line a

195 Single-cell barcoding technologies enable genome sequencing of thousands of individual cells in pa

196 Whole-genome sequencing of uncultured eukaryotic genomes is co

197 Metagenomic techniques have enabled genome sequencing of unknown viruses without isolation i

198 ion AST with seven antibiotics and for whole-genome sequencing of up to 5,000 isolates.

199 Using whole-genome sequencing of zebrafish mutants isolated in an un

200 We performed whole-genome sequencing on food and clinical isolates.

201 We performed whole genome sequencing on isolates from early pediatric CF pu

202 of a genome, are readily obtained from whole-genome sequencing or microarrays.

203 intervention in a model that compared whole-genome sequencing plus current practice versus current p

204 c testing have grown increasingly reliant on genome sequencing, population references such as the Gen

205 The large-scale availability of whole-genome sequencing profiles from bulk DNA sequencing of c

206 Whole-genome sequencing projects are increasingly populating t

207 ger sequence reads, which when used in whole-genome sequencing projects have yielded better repeat re

208 ting phylogenies from the copious amounts of genome sequencing projects that target related viral, ba

209 istance (AMR), classic genotyping, and whole-genome sequencing results.

210 Whole genome sequencing revealed differences in putative virul

211 Whole-genome sequencing reveals the absence of off-target muta

212 Rapid whole genome sequencing (rWGS) of peripheral blood has been us

213 randomized, controlled trial of rapid whole-genome sequencing (rWGS) or rapid whole-exome sequencing

214 APOR retrieved references for 257 real whole-genome sequencing samples with a mean of >99.8% identity

215 At present, based on whole genome sequencing, sequences and genes annotation of the

216 tients were examined by culture, qPCR, whole genome sequencing, serotyping, and reverse transcription

217 Viral genome sequencing showed that the majority of HCWs had t

218 Large-scale whole-genome sequencing studies have enabled the analysis of r

219 Cancer genome-sequencing studies have revealed a remarkably hig

220 nd assess the impact of affordable and rapid genome sequencing systems increasingly being deployed in

221 The success of genome sequencing techniques has resulted in rapid explo

222 The accelerating pace of genome sequencing throughout the tree of life is driving

223 In this study, we used whole-genome sequencing to analyze a large collection of 451 d

224 yphi isolates from India were found by whole genome sequencing to be closely related to the 2016 XDR

225 Here, we used whole genome sequencing to characterise Pseudomonas aeruginosa

226 by interview and combined with isolate whole-genome sequencing to determine likelihood of household t

227 osa bloodstream isolates and performed whole-genome sequencing to identify accessory genomic elements

228 al surveillance with influenza A virus (IAV) genome sequencing to identify and contain a large IAV ou

229 We performed whole-exome and shallow whole-genome sequencing to identify genes and pathways prefere

230 d by foldback inversions combined with whole-genome sequencing to study their formation.

231 Here we use C. elegans whole genome sequencing to systematically quantify the contrib

232 lonization on NF admission, we applied whole-genome sequencing to track the spread of 4 ARO species a

233 japonica was elucidated by integrating whole genome sequencing, transcriptomic analysis and biochemic

234 hods: Within a prospective multicenter whole-genome sequencing trial (NCT01855477), 69 mPC patients u

235 ot randomized and received ultra-rapid whole-genome sequencing (urWGS).

236 mic data, particularly when annotating whole-genome sequencing variants against a huge database with

237 Whole genome sequencing was performed on 20 matched blood and

238 Whole-genome sequencing was performed on 388 isolates, includi

239 Whole-genome sequencing was performed on blood-derived DNA fro

240 Viral genome sequencing was performed on donor and recipient s

241 etect potential transmission clusters, whole genome sequencing was performed on nasopharyngeal swabs

242 Long-read whole genome sequencing was performed using Pacific Bioscience

243 -PCR primers/probe were developed, and whole genome sequencing was performed.

244 Whole genome sequencing was used to uncover a frame-shift inse

245 Here, by whole-exome/genome sequencing we identify heterozygous, autosomal-do

246 Using whole-genome sequencing we now identified a single rare nonsyn

247 By parent-offspring whole genome sequencing, we estimate a mutation rate (3.38 x 1

248 a combination of short- and long-read whole-genome sequencing, we found no significant association b

249 Through genome sequencing, we identified 2 different large chrom

250 Using whole genome sequencing, we identified a heterozygous frameshi

251 Using clinical whole genome sequencing, we show that AR binding sites have a

252 nucleotide polymorphisms identified by whole genome sequencing were used to design a specific polymer

253 Multilocus Sequence Typing (MLST) and Whole Genome Sequencing (WGS) analysis.

254 me wards within 7 days were chosen for whole-genome sequencing (WGS) and a phylogenetic analysis was

255 Whole genome sequencing (WGS) and antimicrobial susceptibility

256 enomic landscape of myeloma using deep whole-genome sequencing (WGS) and develop a model that identif

257 We performed whole-genome sequencing (WGS) and pan-genome analysis on all b

258 Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) acro

259 Here, we leverage whole-genome sequencing (WGS) and whole-genome bisulfite seque

260 Whole-genome sequencing (WGS) can improve assessment of low-fr

261 Whole genome sequencing (WGS) can potentially provide a more c

262 Whole-genome sequencing (WGS) can support surveillance by pinp

263 Whole-genome sequencing (WGS) costs are falling, yet, outside

264 Whole-genome sequencing (WGS) data from 853 rhesus macaques id

265 - and DLM-resistant phenotypes using a whole-genome sequencing (WGS) data set from a collection of 4,

266 arison of P. aeruginosa isolates using whole-genome sequencing (WGS) data.

267 Bulk whole genome sequencing (WGS) enables the analysis of tumor ev

268 Whole-genome sequencing (WGS) has emerged as a powerful tool f

269 For the analysis, we used whole genome sequencing (WGS) Human datasets for which the gol

270 Whole-genome sequencing (WGS) identified preincarceration tran

271 c relevance through high-depth (22.5x) whole-genome sequencing (WGS) in 1328 individuals.

272 Here we used whole-genome sequencing (WGS) in a national health system to s

273 Whole-genome sequencing (WGS) is now routinely performed in cl

274 Here we perform whole-genome sequencing (WGS) of 103 UM from all sites of the

275 We undertook whole-genome sequencing (WGS) of 660 pneumococcal isolates col

276 Whole-genome sequencing (WGS) of cfDNA allowed ultra-sensitive

277 We present SNVs discovered by whole genome sequencing (WGS) of three Moroccans.

278 n neuroblastoma using a combination of whole-genome sequencing (WGS) of tumor-normal pairs (n = 135)

279 Here we assemble a set of 719 deep whole genome sequencing (WGS) samples (mean 42x) from 477 dist

280 We apply whole-genome sequencing (WGS) to identify non-coding mutations

281 nt here an unbiased approach combining whole genome sequencing (WGS) with patient-induced pluripotent

282 typing results by latex agglutination, whole-genome sequencing (WGS) with PneumoCaT, and DNA microarr

283 ew sequencing approaches, particularly whole-genome sequencing (WGS), have dramatically changed the l

284 rative genomic hybridization (CGH) and whole-genome sequencing (WGS), have greatly advanced the ident

285 Whole genome sequencing (WGS), on the other hand, allows for i

286 using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively.

287 on to whole-exome sequencing (WES) and whole-genome sequencing (WGS).

288 , but there are plans for implementing whole genome sequencing (WGS).

289 s performed for specific pathogens and whole-genome sequencing (WGS).

290 gh throughput SNP-based genotyping and whole-genome sequencing (WGS).

291 and characterization were performed by whole genome sequencing (WGS).

292 samples based on low-coverage clinical whole-genome sequencing (WGS).

293 throughput genotyping (31,811 SNPs) or whole-genome sequencing (WGS, 8.7 million SNPs).

294 la oxytoca infection was identified by whole-genome sequencing (WGS; later found to be part of a clus

295 With the advent of whole genome-sequencing (WGS) studies, family-based designs en

296 Established methods for whole-genome-sequencing (WGS) technology allow for the detecti

297 solubility limit were then analyzed by whole genome sequencing, which revealed prevalent point mutati

298 methods using both real and synthetic whole-genome sequencing, whole-exome sequencing, and deep targ

299 microbe hunters are combining pathogen whole-genome sequencing with epidemiological data to enhance e

300 restoration genomics approach based on whole-genome sequencing with replicated space-for-time substit