ライフサイエンスコーパス: genome stability

1 ocalised signalling pathway to help preserve genome stability.

2 somes to ensure complete DNA replication and genome stability.

3 regression with fork restoration to maintain genome stability.

4 hat plays a multifaceted role in maintaining genome stability.

5 omplex would explain how it acts to maintain genome stability.

6 is fundamental to cellular proliferation and genome stability.

7 omoting cell differentiation and maintaining genome stability.

8 hich could impede replication and compromise genome stability.

9 and DNA processing enzyme that has roles in genome stability.

10 rand break (DSB) repair pathways to preserve genome stability.

11 needs to be carefully controlled to maintain genome stability.

12 g, chromosome segregation, and protection of genome stability.

13 me alignment in mitosis and thereby ensuring genome stability.

14 nation can have catastrophic consequences on genome stability.

15 y damaged DNA bases is essential to maintain genome stability.

16 us recombination (HR) is crucial to maintain genome stability.

17 isms regulating RNF8 homeostasis to preserve genome stability.

18 ication and mitosis, are crucial to maintain genome stability.

19 particularly sensitive to factors affecting genome stability.

20 rant protein-linked DNA breaks, jeopardising genome stability.

21 egation of broken chromosomes and preserving genome stability.

22 tion (for double HJ) or resolution to ensure genome stability.

23 n blocks are critical for the maintenance of genome stability.

24 us pathway, essential for the maintenance of genome stability.

25 errors in base pairing and acts to maintain genome stability.

26 DNA replication has severe consequences for genome stability.

27 ulation of metabolism, stress responses, and genome stability.

28 mediates is essential for the maintenance of genome stability.

29 nerate novel signaling platforms involved in genome stability.

30 rdinate optimal gene expression and maintain genome stability.

31 elicases are essential in the maintenance of genome stability.

32 olytic degradation, potentially compromising genome stability.

33 role in unwinding DNA structures to maintain genome stability.

34 n required for mammalian DNA replication and genome stability.

35 d excises damaged DNA bases to help maintain genome stability.

36 regulate heterochromatic DNA replication and genome stability.

37 ing the mechanisms governing replication and genome stability.

38 Faithful DNA replication is essential for genome stability.

39 cleus at the end of mitosis is essential for genome stability.

40 ate its DNA-unwinding activity, and maintain genome stability.

41 ilences transposable elements and influences genome stability.

42 hat has a critical role in maintaining human genome stability.

43 ys roles in transcription and maintenance of genome stability.

44 epair or apoptosis, which serves to maintain genome stability.

45 ARP-1/PARP-2-dependent processes that govern genome stability.

46 the inserted gene may have an impact on PIV5 genome stability.

47 proper balance of RAD51 activity to maintain genome stability.

48 selectivity of the nuclease active site for genome stability.

49 ed breaks (DSBs), and thus helps to maintain genome stability.

50 ion occurs in all organisms and is vital for genome stability.

51 link between MLH1, telomerase, telomere and genome stability.

52 rosomes and impair spindle morphogenesis and genome stability.

53 eventing aberrant DNA repair and maintaining genome stability.

54 NA methylation change, ensuring longstanding genome stability.

55 ation, R-loop suppression and in maintaining genome stability.

56 ssible roles of RecQ4 in DNA replication and genome stability.

57 As directly contribute to the maintenance of genome stability.

58 orphology, heat tolerance, and mitochondrial genome stability.

59 ion at stalled replication forks to maintain genome stability.

60 h events are normally suppressed to maintain genome stability.

61 plication fork progression, thereby ensuring genome stability.

62 , has acquired novel functions in regulating genome stability.

63 and plays a more general role in maintaining genome stability.

64 DNA replication is essential for maintaining genome stability.

65 manner without increasing H2O2 scavenging or genome stability.

66 the cellular DDR involved in preserving the genome stability.

67 ctions in multiple DDR processes to maintain genome stability.

68 he maintenance of epigenetic inheritance and genome stability.

69 r PTEN has multiple functions in maintaining genome stability.

70 tic reprogramming during DNA replication and genome stability.

71 lation of gene expression and maintenance of genome stability.

72 o cell growth, proliferation, metabolism and genome stability.

73 quences that pose significant challenges for genome stability.

74 by which transcription and RNA contribute to genome stability.

75 ical for accurate chromosome segregation and genome stability.

76 acterise human EBLN1 as a novel regulator of genome stability.

77 DNA repair mechanisms that together maintain genome stability.

78 n an accurate and timely fashion to preserve genome stability.

79 ted in diverse chromatin regions to maintain genome stability.

80 ssential for DNA replication progression and genome stability.

81 the DSB response thus significantly affects genome stability.

82 (D)J recombination but is a potent threat to genome stability.

83 during meiosis, but also present a threat to genome stability.

84 ronuclei, with catastrophic consequences for genome stability.

85 ed in the regulation of stress responses and genome stability.

86 acilitate replisome progression and maintain genome stability.

87 inining ssDNA is associated with maintaining genome stability.

88 ctly required for chromosome segregation and genome stability.

89 olymerase (Prim-Pol) superfamily to maintain genome stability.

90 ation of the genome is essential to maintain genome stability.

91 NA damage repair, epigenetic regulation, and genome stability.

92 ultivation of tick cells can influence their genome stability.

93 ir and is thus central to the maintenance of genome stability.

94 that cells utilize to regulate and maintain genome stability.

95 ay signaling required for DNA ICL repair and genome stability.

96 y, cause cell fusion, and thereby compromise genome stability.

97 Oxidative DNA damage is a threat to genome stability.

98 ion of cell division is required to maintain genome stability.

99 Telomeres are essential for genome stability.

100 -) cells restores efficient fork restart and genome stability.

101 t amenable to DNA repair and thus compromise genome stability.

102 lution of these obstructions is critical for genome stability.

103 , chromosome segregation, and maintenance of genome stability.

104 s in safeguarding fork structure to maintain genome stability.

105 ks and stalled replication forks to maintain genome stability.

106 romote homologous recombination and maintain genome stability.

107 DNA double-strand breaks (DSBs) to maintain genome stability.

108 , potentially with distinct consequences for genome stability.

109 tant new means by which Snf2 enzymes promote genome stability.

110 interruption of DNA replication and loss of genome stability.

111 in controlling the level of Cyclin E ensures genome stability and a mechanism for linking directly DN

112 ies have shown that piRNAs are linked to the genome stability and a variety of human cancers.

113 double-strand breaks (DSBs) pose a threat to genome stability and are repaired through multiple mecha

114 isomerase (topo) IIalpha and IIbeta maintain genome stability and are targets for anti-tumor drugs.

115 elomere lengths in youth, which may decrease genome stability and augment the susceptibility to disea

116 entromere regions has a pronounced impact on genome stability and basic chromosomal function.

117 lear genome are a well-established threat to genome stability and can result in DNA strand breaks whe

118 ountered by replicative polymerases threaten genome stability and cell cycle progression.

119 l established to have profound influences on genome stability and cell phenotype, yet there are few t

120 er as apical proteins in the DDR to maintain genome stability and cell survival in the face of potent

121 te repair of DNA damage is crucial to ensure genome stability and cell survival of all organisms.

122 and chemotherapeutics, and pose a threat to genome stability and cell survival.

123 e broken replication forks, thereby ensuring genome stability and cell survival.

124 aling at the forks necessary for maintaining genome stability and cell survival.

125 f damaged DNA within the nucleus can promote genome stability and cell survival.

126 SBs) are common genome lesions that threaten genome stability and cell survival.

127 etic differentiation poses a major threat to genome stability and cell viability in the absence of th

128 pying of DNA during S phase is essential for genome stability and cell viability.

129 rough PARylation of TRF1, thereby protecting genome stability and cell viability.

130 chanisms can lead to catastrophic effects on genome stability and cell viability.

131 g DNA replication as well as their impact on genome stability and cellular viability in normal and ca

132 tDNAs are rapidly evolving and have roles in genome stability and chromosome segregation.

133 applied to specific research fields such as genome stability and developmental biology and to test c

134 w defects in DNA replication progression and genome stability and display extensive changes in genome

135 e the contribution of human BRD proteins for genome stability and DNA double-strand break (DSB) repai

136 y influence gene expression and translation, genome stability and dynamics, and human health and dise

137 Multiple DNA repair pathways maintain genome stability and ensure that DNA remains essentially

138 of mechanisms by which ncRNAs contribute to genome stability and even potentially fuel evolution by

139 uclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxi

140 is robust and finely controlled to maintain genome stability and function in stressful environments.

141 ent deacetylase of histone H3 that regulates genome stability and gene expression.

142 arried out within it, such as maintenance of genome stability and gene expression.

143 rigins, which has important implications for genome stability and gene regulation.

144 conserved among eukaryotes, contributing to genome stability and genetic diversity.

145 nts, representing a significant challenge to genome stability and genome integrity over the life of a

146 -related) is a protein kinase that maintains genome stability and halts cell cycle phase transitions

147 itherto unknown MMR mechanism that modulates genome stability and has implications for cancer therapy

148 ssing of stalled forks that is essential for genome stability and health.

149 ilencing euchromatic transposons to maintain genome stability and in modifying genetic recombination

150 These actin-based functions contribute to genome stability and integrity while affecting DNA repli

151 DNA repair is critical for genome stability and is maintained through conserved pat

152 an become trapped on DNA or RNA, threatening genome stability and limiting free enzyme pools, but how

153 ately provide insight into the mechanisms of genome stability and mutagenesis.

154 ular mechanism by which SPRTN contributes to genome stability and normal cellular homeostasis.

155 being mainly involved in the maintenance of genome stability and organelle function and multicopy ge

156 mechanisms by which different tissues manage genome stability and parallels with human microcephaly.

157 Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA

158 t roles for RFWD3 localization in protecting genome stability and preserving human health.

159 lying DNA replication is key for maintaining genome stability and preventing tumorigenesis.

160 segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy.

161 air (MMR) is required for the maintenance of genome stability and protection of humans from several t

162 between the molecular pathways that sustain genome stability and proteostasis.

163 hat is essential for chromosome segregation, genome stability and regulation of gene expression.

164 ng stalled replication forks are critical to genome stability and require coordinating DNA replicatio

165 poses cells to replication stress, impacting genome stability and response to genotoxic drugs.

166 screen uncovers several lncRNAs involved in genome stability and reveals a lncRNA that controls micr

167 PG as an HRR protein with important roles in genome stability and suggest how XPG defects produce sev

168 formation is crucial for the preservation of genome stability and the cell type-specific silencing of

169 ry conflict between the pressure to maintain genome stability and the need to adapt to mounting exter

170 epair pathway involved in the maintenance of genome stability and thus in the prevention of human dis

171 on of toxic replication structures to ensure genome stability and to maintain telomere integrity.

172 which is enriched for proteins critical for genome stability and transcriptional silencing.

173 Ribonucleotides represent a threat to DNA genome stability and transmission.

174 ether ATF3 contributes to the maintenance of genome stability and tumor suppression remains unknown.

175 nical pathways that regulate cell signaling, genome stability and tumorigenesis.

176 to the replication of UV-damaged DNA and to genome stability, and examined the incidence of UV-induc

177 cell proliferation, apoptosis, angiogenesis, genome stability, and immune responses, among other canc

178 CQ1), a DNA repair helicase, is critical for genome stability, and loss-of-function mutations in the

179 ing global gene transcription and protecting genome stability, and may play a role in tumor suppressi

180 tion promotes ATM activation, DSB repair and genome stability, and potentially serves as a therapeuti

181 fy CDK18 (PCTAIRE 3) as a novel regulator of genome stability, and show that depletion of CDK18 cause

182 ross-talks between nuclear and mitochondrial genome stability, and shows how strains have genetically

183 oles in nuclear architecture, DNA repair and genome stability, and silencing of transposon and gene e

184 ple CRISPR perturbations and measurements of genome stability, and to other goals requiring high-thro

185 one lysine 20 (H4K20me3), in development and genome stability are largely unknown.

186 that, in C. albicans, mechanisms regulating genome stability are plastic as different environmental

187 Our data highlight how mechanisms regulating genome stability are rewired in C. albicans.

188 Heritability and genome stability are shaped by meiotic recombination, wh

189 lts suggest that the Smc5/6 complex promotes genome stability as a DNA micro-compaction machine.

190 re our discovery of a new member in guarding genome stability at replication forks.

191 We propose that Rrm3 and Pif1 promote genome stability at tDNAs by displacing the stable multi

192 first time, we analyse mechanisms promoting genome stability at the rDNA locus and subtelomeric regi

193 that wh is a new member of the guardians of genome stability because it regulates FEN1's potential D

194 ed deregulation of various genes involved in genome stability but were not directly predictive of spe

195 itosis likely represent important threats to genome stability, but experimental identification of the

196 is a tumor suppressor protein that maintains genome stability, but its Delta133p53beta and Delta160p5

197 sing mutants have been broadly implicated in genome stability, but mechanistic links are often unclea

198 ir bulky nature, DPCs pose severe threats to genome stability, but previous methods to measure formal

199 Human telomerase maintains genome stability by adding telomeric repeats to the ends

200 Here, we manipulate somatic genome stability by conditional Knl1 deletion from embry

201 ing by CRISPR systems may contribute to host genome stability by eliminating cells undergoing active

202 has an important role in the maintenance of genome stability by interacting with RAD51 recombinase t

203 hway is an adaptive mechanism that maintains genome stability by repression of selfish genomic elemen

204 MEJ thus helps to sustain cell viability and genome stability by rescuing chromosome break repair whe

205 d for MiDAS and suggest that RTEL1 maintains genome stability by resolving conflicts that can arise b

206 lation of gene expression and maintenance of genome stability by silencing repetitive DNA elements an

207 (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germli

208 ithful genetic inheritance, SMCs can disrupt genome stability by trapping DNA topological stress.

209 ese findings demonstrate that maintenance of genome stability by ZMYND8 causes breast cancer cells to

210 y, TONSL ARD mutants are toxic, compromising genome stability, cell viability and resistance to repli

211 al applications for the study of polyploidy, genome stability, chromosome segregation, and bioenergy.

212 sor of a mutation in the essential Smc5-Smc6 genome stability complex and is thought to act in a bypa

213 quired for the accumulation of the Smc5-Smc6 genome stability complex in foci during replication stre

214 stress responses through gene regulation and genome stability control.

215 ty, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific f

216 To ensure genome stability, DNA polymerases must discriminate agai

217 itical and well-studied roles in maintaining genome stability, DNA repair pathways including base exc

218 ng in protecting both gene transcription and genome stability.DNA double-strand breaks (DSBs) induced

219 nts (TEs) constitute a significant threat to genome stability due to their mobility.

220 name, we assessed its central metabolism and genome stability during a long-term cultivation experime

221 lation, highlighting ZEB1 as a key player in genome stability during cancer progression via its repre

222 is tightly regulated in eukaryotes to ensure genome stability during cell division and is performed b

223 ation between MDC1 and TOPBP1 in maintaining genome stability during cell division.

224 All three of these functions maintain genome stability during cell division.

225 fically, the FA pathway functions to protect genome stability during DNA replication.

226 r these events are important for maintaining genome stability during mitosis.

227 silence euchromatic transposons to maintain genome stability during polyploid wheat evolution.

228 ty or protein stability, but greatly affects genome stability, even in the absence of induced DNA dam

229 ) C-terminal domain kinase, CDK12, regulates genome stability, expression of DNA repair genes, and ca

230 L in mitochondrial function, biogenesis, and genome stability has been studied, recent findings indic

231 Transcription and genome stability have somewhat of a love-hate relationsh

232 gical regulator of growth, proliferation and genome stability in animals.

233 FEN1 in mediating TGS as well as maintaining genome stability in Arabidopsis.

234 TR dependent pathway involved in maintaining genome stability in developing embryos by controlling ES

235 ethylation in regulating DNA replication and genome stability in Drosophila cells.

236 hromatin formation, telomere maintenance and genome stability in eukaryotes.

237 Peptidase (GCNA) as a conserved regulator of genome stability in flies, worms, zebrafish, and human g

238 e requirement for MLL2 in the maintenance of genome stability in genes helps explain its widespread r

239 t orientation and R-loop formation influence genome stability in human cells.

240 the fidelity of chromosome segregation, and genome stability in larval neuroblasts of mps1-null muta

241 a key role in maintaining trans-generational genome stability in mammals.

242 noncoding RNA (lncRNA) that is required for genome stability in mammals.

243 lant-specific protein involved in organellar genome stability in mitochondria and plastids.

244 and the meiotic protein HIM-5 in maintaining genome stability in the C. elegans germline.

245 erative, roles for each kinase in preserving genome stability in the nervous system.

246 size that the molecular adaptive emphasis on genome stability in white and whale sharks may reflect t

247 bination is essential for the maintenance of genome stability, in which the RAD51 recombinase plays a

248 in multiple pathways that promote bacterial genome stability including the suppression of conflicts

249 The maintenance of genome stability is an essential cellular process to pre

250 small RNAs on gene expression regulation and genome stability is arousing increased interest and is b

251 In the absence of Mms1, genome stability is at risk at these G-rich/G4 regions a

252 Understanding how cellular activities impact genome stability is critical to multiple biological proc

253 Genome stability is essential for engineering cell-based

254 The maintenance of genome stability is essential for the cell as the integr

255 This function of HELLS in maintenance of genome stability is likely to contribute to its role in

256 an exciting, direct role of lncRNAs in p53's genome stability maintenance function.

257 Our findings provide insights into genome stability maintenance in actively transcribing ch

258 as DNA replication, telomere maintenance and genome stability maintenance.

259 s important to the ATR signaling cascade and genome stability maintenance.

260 ases involved in diverse processes including genome stability, metabolic homeostasis, and tumorigenes

261 tionships among chromatin state, DNA repair, genome stability, mutagenesis, and carcinogenesis.

262 Unlike many helicases involved in genome stability no hUPF1 binding to DNA structures stab

263 re11-Rad50, a nuclease complex essential for genome stability, normal development, and viability in m

264 refore, the BLM-TopBP1 interaction maintains genome stability not by controlling BLM protein levels,

265 Ligase 3-mediated end-joining maintains genome stability of human embryonic stem cells.

266 ree DNA damage-responsive kinases coordinate genome stability, particularly in a physiological contex

267 of DNA damage in the nervous system and the genome stability pathways that prevent human neurologic

268 ns revealed new homologous recombination and genome stability pathways, providing a framework to unde

269 s, allowing cells to mitigate the threats to genome stability posed by replication stress.

270 he delicate interplay of factors controlling genome stability, premature aging, and cancer.

271 5q cooperated with TP53 mutations to perturb genome stability, promoting acquisition of structural an

272 ude unique biological mechanisms involved in genome stability, protein stability, oxidative metabolis

273 Beginning with a cytological screen of genome stability proteins, we find that the splicing fac

274 ine balance between replication fidelity and genome stability, Rad18 levels and activity have a major

275 gene-content enrichments regarding important genome stability-related genes and functional categories

276 Genome stability relies on proper coordination of mitosi

277 nd whether it plays a role in maintenance of genome stability remain to be determined.

278 What underlies their wide-ranging effects on genome stability remains poorly understood.

279 Maintenance of genome stability requires control over the expression of

280 Maintenance of genome stability requires that DNA is replicated precise

281 ighly repetitive DNA elements pose a risk to genome stability since they can undergo nonallelic excha

282 data reveal a role of PHF2 as a guarantor of genome stability that allows proper expansion of neural

283 racterize multiple deregulated mechanisms of genome stability that lead to CIN in ovarian cancer and

284 To maintain genome stability, the SAC must be strong to delay anapha

285 owever, it was reported that NORAD regulates genome stability through an interaction with the RNA bin

286 ovel role for UBTF1 and UBTF2 in maintaining genome stability through coordinating the expression of

287 ase 1, and tankyrase 2) function to maintain genome stability through diverse mechanisms.

288 repair protein that is well-known to promote genome stability through the resection of endogenous DNA

289 ike small RNAs involved in the regulation of genome stability through the targeting of TE transcripts

290 ique insights into cellular requirements for genome stability, tissue renewal, and tumorigenesis as w

291 sm by which planarians maintain telomere and genome stability to ensure their immortality and shed li

292 Haploinsufficiency of factors governing genome stability underlies hereditary breast and ovarian

293 bserved in cancer, exert profound effects on genome stability via MRE11 with potential implications f

294 In contrast, telomere protection and genome stability were maintained in all heterozygous clo

295 is process impair chromosome segregation and genome stability, which are also compromised by p53 inac

296 Ialpha and topo IIbeta cooperate to maintain genome stability, which may be distinctly modulated by t

297 Spindle Assembly Checkpoint (SAC) maintains genome stability while also ensuring timely anaphase ons

298 d a RAG DSB-dependent checkpoint to maintain genome stability while iteratively assembling Igl chain

299 evidence points to RNA as a key modulator of genome stability, with seemingly opposing roles in promo

300 s play essential roles in the maintenance of genome stability, yet their mode of action is not fully