ライフサイエンスコーパス: genomic RNA

1 , SNPs) and RNA (messenger, micro, and viral genomic RNA).

2 uctural polyprotein precursor Gag with viral genomic RNA.

3 al RdRp pulls this helix open to release the genomic RNA.

4 he 3' untranslated region (UTR) of the viral genomic RNA.

5 he complex secondary structure of the target genomic RNA.

6 ens having 10-12 segments of double-stranded genomic RNA.

7 a single nucleocapsid protein and the viral genomic RNA.

8 ortion of unspliced MoMLV RNA that serves as genomic RNA.

9 th of knowledge acquired regarding the viral genomic RNA.

10 ctural polyprotein Gag associates with viral genomic RNA.

11 as mapped to nucleotides 4164 to 4333 in the genomic RNA.

12 uantities of subgenomic RNAs, in addition to genomic RNA.

13 e the infectivity of transfected coronavirus genomic RNA.

14 rotein (N) associates tightly with the viral genomic RNA.

15 anslated from mRNA produced from replicating genomic RNA.

16 ES) of the encephalomyocarditis virus (EMCV) genomic RNA.

17 virus particles resulting in release of the genomic RNA.

18 teady-state HCV protein expression and viral genomic RNA.

19 ible for replicating hepatitis C virus (HCV) genomic RNA.

20 ring of the conserved 5' and 3' ends of each genomic RNA.

21 cts as a primer for reverse transcription of genomic RNA.

22 rm an immature capsid and also package HIV-1 genomic RNA.

23 hat which occurs during the encapsidation of genomic RNA.

24 Pol proteins or are packaged into virions as genomic RNA.

25 define the RNA secondary structures of CHIKV genomic RNA.

26 ponse to ZIKV infection, which degraded ZIKV genomic RNA.

27 f a 5'-GCCAGCC-3' motif present in the viral genomic RNA.

28 oat protein (CP) encapsidate each of the BMV genomic RNAs.

29 interactions between the capsid and the BMV genomic RNAs.

30 enables the confinement or compaction of the genomic RNAs.

31 ural components of virions and include viral genomic RNAs.

32 about the organization of their encapsulated genomic RNAs.

33 d the nearly complete sequences of the three genomic RNAs.

34 either random cellular RNAs or average viral genomic RNAs.

35 c-length mRNAs of vc sense were detected for genomic RNAs 3, 4, 7, and 8 but not for other RNA specie

36 In transit, FIV Gag and genomic RNA accumulated independently of each other at t

37 complementary (vc)-sense strands of all WMoV genomic RNAs accumulated asymmetrically in infected whea

38 Viral genomic RNA adopts many conformations during its life cy

39 diffusely distributed in the cytoplasm with genomic RNA also in perinuclear vesicle-like structures

40 The N protein molecules sequester the genomic RNA and are linked together by a network of nonc

41 trated the ability to specifically recognize genomic RNA and both viral and host proteins as it traff

42 ase Xrn1 likely loads on the 5' end of viral genomic RNA and degrades processively through approximat

43 ependent RNA polymerase replicates the viral genomic RNA and is a primary drug target for antiviral t

44 , instead, correlated with cleavage of viral genomic RNA and modulation of the host transcriptome.

45 Comparison of genomic RNA and mRNA obtained from isolated lymph node c

46 Genomic RNA and mRNA transcription was detected for repo

47 itative information on the abundance of both genomic RNA and mRNA/antigenomes can be simultaneously d

48 quencing must be used to distinguish between genomic RNA and mRNA/antigenomic RNA because significant

49 xes (RNPs) composed of the viral polymerase, genomic RNA and oligomeric nucleoprotein (NP).

50 hypotheses for the initial structure of the genomic RNA and oligomeric state of integrase are tested

51 zation, which precludes integrase binding to genomic RNA and perturbs the morphogenesis of new viral

52 ERI3 is required for accumulation of DENV-2 genomic RNA and production of infectious particles.

53 get the translational machinery to the viral genomic RNA and provide a framework for modeling the arc

54 -1 capsid (CA) protein lattice encases viral genomic RNA and regulates steps essential to target-cell

55 The HIV-1 core consists of the viral genomic RNA and several viral proteins encased within a

56 Nonstructural proteins are translated from genomic RNA and structural proteins from subgenomic RNA.

57 t the MTE interacts with the 5' UTRs of both genomic RNA and subgenomic RNA1 via long-distance kissin

58 ociated gene 5 (MDA5) colocalized with viral genomic RNA and the nucleoprotein (N) as early as 6 h po

59 lementarity between the 3' terminus of viral genomic RNA and the nucleotides located in the vicinity

60 n the replication and selective packaging of genomic RNA and the transcription and translation of sub

61 ion by binding directly to both sites in the genomic RNA and, at least in part, by stimulating intern

62 oduced similar numbers of infection foci and genomic RNAs and formed virions in inoculated leaves as

63 es harboring a 5' terminal deletion in their genomic RNAs and that these viruses alone or associated

64 he primer binding site sequence of the viral genomic RNA, and is used to prime DNA synthesis.

65 ation relative to the lipid membrane and the genomic RNA, and its interactions with the transmembrane

66 Neutrophil RSV F, G, and N proteins, RSV N genomic RNA, and messenger RNA (mRNA) were quantified.

67 d on the complete CMPV virion, including the genomic RNA, and virus-like nanoparticles (VLPs) based o

68 Within influenza virus infected cells, viral genomic RNA are selectively packed into progeny virions,

69 Viral ribonucleocapsids harboring the viral genomic RNA are used as the template for viral mRNA synt

70 Lentiviral genomic RNAs are encapsidated by the viral Gag protein d

71 c virus (BMV) is an RNA virus, and its three genomic RNAs are encapsidated in separate virions.

72 frames present in the complementary sense of genomic RNAs are expressed through subgenomic- or near-g

73 the cytoplasm of eukaryotic cells, uses its genomic RNA as a template for both viral protein synthes

74 Upon infection, DAI recognizes IAV genomic RNA, associates with RIPK3, and is required for

75 the AIDS retrovirus, HIV, requires that its genomic RNA be packaged in assembling virus particles wi

76 forms a central positively charged cleft for genomic RNA binding.

77 the bunyavirus La Crosse, the 5' end of the genomic RNA binds as a hook-like structure proximal to t

78 in the 5' and 3' cis-acting elements in the genomic RNA by chaperoning the maturation of P200.

79 through the incomplete degradation of viral genomic RNA by the cytoplasmic 5'-3' exoribonuclease Xrn

80 uV P bind NC to participate in access to the genomic RNA by the viral RNA-dependent-RNA polymerase.

81 comprises a ribonucleoprotein complex of the genomic RNA coated by a nucleocapsid protein (N) and ass

82 The RNP core comprises the negative-sense genomic RNA completely coated by the nucleocapsid protei

83 ialized RNA synthesis machine comprising the genomic RNA completely encapsidated by the viral nucleoc

84 All retroviral genomic RNAs contain a cis-acting packaging signal by wh

85 e assembled recombinant MS2 capsids with non-genomic RNA containing the capsid incorporation sequence

86 ion (3(') UTR) of turnip crinkle virus (TCV) genomic RNA contains a cap-independent translation eleme

87 analyze the abundance of viral mRNAs because genomic RNA copurifies with the viral mRNAs.

88 tigenomic RNA because significant amounts of genomic RNA copurify with poly(A)-selected mRNA.

89 s B populations characterized by 5' terminal genomic RNA deletions ranging from 17 to 50 nucleotides

90 mmunodeficiency virus type 1 (HIV-1) Gag and genomic RNA determinants required for encapsidation are

91 lly ligated the VPg-RNA complex to the viral genomic RNA, directed by base pairing.

92 omyocytes demonstrated that deleted forms of genomic RNAs displayed early replication activities in t

93 involving non-sequence-specific packaging of genomic RNA driven by electrostatic interactions.

94 tage of assembly involving compaction of the genomic RNA driven by multiple RNA packaging signal-CP i

95 ubgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication.

96 uring the hierarchical processes directed by genomic RNA during viral infection.IMPORTANCE Enteroviru

97 l for the selection and chaperoning of viral genomic RNA during virion assembly.

98 otein polymerizes along the genomic and anti-genomic RNAs during replication.

99 due partly to enhanced translation of viral genomic RNA early in infection.

100 nted negative-strand RNA viruses comprises a genomic RNA encased within a nucleocapsid protein (N-RNA

101 The viral genomic RNA encodes only the CP, which comprises a beta-

102 ey viral polyproteins Gag and Gag-Pol and as genomic RNA for encapsidation into assembling viral part

103 the PS is pivotal in the selection of viral genomic RNA for incorporation into virions.

104 tion step, wherein dsDNA is synthesized from genomic RNA for subsequent insertion into the host genom

105 al nucleotides (nt) of West Nile virus (WNV) genomic RNA form a penultimate 16-nt small stem-loop (SS

106 packed complexes of nucleocapsid protein and genomic RNA form the core of viruses and assemble within

107 Therefore, in early evolution, genomic RNA fragments could have been significantly shor

108 measurement of the half-life of an incoming genomic RNA from a positive-sense RNA virus.

109 e have characterized the structure of 5' UTR genomic RNA from coxsackievirus B3 using selective 2'-hy

110 cilitates the export of unspliced retroviral genomic RNA from simple type-D retroviruses such as SRV-

111 zation of cis-acting elements present on Ty1 genomic RNA from the GAG region that control reverse tra

112 iral RNA and changed the primary location of genomic RNA from the perinuclear region to the plasma me

113 responsible for the specific capture of the genomic RNA genome during viral assembly.

114 and influenza virus mRNA and negative-strand genomic RNA (gRNA) accumulated to high levels at 8 h aft

115 ) is covalently bound to the 5' end of viral genomic RNA (gRNA) and associates with host eIF4E for su

116 gle copy of the maturation protein binds the genomic RNA (gRNA) and is required for attachment of the

117 idation involves a recognition event between genomic RNA (gRNA) and one or more domains in Gag.

118 omote internal expression of the CP from the genomic RNA (gRNA) both in vitro and in vivo An absence

119 f Gag and Gag-Pol polyproteins plus a single genomic RNA (gRNA) dimer.

120 the phage capsid, priming the Mat-connected genomic RNA (gRNA) for its release from the virions.

121 sor specifically selects the unspliced viral genomic RNA (gRNA) from the bulk of cellular and spliced

122 ctors for reverse transcription of the viral genomic RNA (gRNA) into DNA shortly after viral entry.

123 us, little is known about penetration of the genomic RNA (gRNA) into the cell.

124 rus capsid protein (Cp) selectively packages genomic RNA (gRNA) into the viral nucleocapsid to produc

125 so contributes to selective packaging of the genomic RNA (gRNA) into virions.

126 The HIV-1 Gag protein is responsible for genomic RNA (gRNA) packaging and immature viral particle

127 responsible for annealing tRNA(Lys3) to the genomic RNA (gRNA) primer binding site (PBS).

128 bstitutions in the NS5 protein reduced viral genomic RNA (gRNA) replication rate to achieve a more fa

129 The packaging of retroviral genomic RNA (gRNA) requires cis-acting elements within t

130 Selective packaging of HIV-1 genomic RNA (gRNA) requires the presence of a cis-acting

131 ns assembled around its 4,217 nucleotides of genomic RNA (gRNA).

132 he synthesis of longer sgmRNAs and the viral genomic RNA (gRNA).

133 s (hRSV) nucleocapsid protein (N) with viral genomic RNA (gRNA).

134 stimulate the infectivity of transfected MHV genomic RNA (gRNA).

135 e Gag and Gag-Pol capsid proteins as well as genomic RNAs (gRNAs) packaged by Gag into virions underg

136 The earliest genomic RNAs had to be short enough for efficient replic

137 Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an

138 in cells expressing Ifit1 even though their genomic RNA has a 5' cap lacking 2'-O methylation.

139 obe, Courtney et al. (2019a) find that HIV-1 genomic RNA has much more m(5)C than cellular mRNA.

140 ynamics of primate and nonprimate lentiviral genomic RNAs (HIV-1 and feline immunodeficiency virus [F

141 port here the secondary structure of the HIV genomic RNA-human tRNA(Lys)(3) initiation complex using

142 proteins associated with both DENV and ZIKV genomic RNA in human cells.

143 uncovered a previously unsuspected role for genomic RNA in regulating formation of viral capsids, re

144 The stability of the genomic RNA in the nucleocapsid appears to regulate its

145 iral transcription/replication, however, the genomic RNA in the nucleocapsid must be accessible by th

146 ect the synthesis of viral proteins, but not genomic RNAs, in human and murine cardiomyocytes.

147 those from healthy infants, expressed RSV N genomic RNA, indicating uptake of whole virus; 17 of 20

148 5' and 3' untranslated regions of the viral genomic RNA, inhibition of DENV-vsRNA-5 led to significa

149 Translation of the hepatitis C virus (HCV) genomic RNA initiates from an internal ribosome entry si

150 The viral RdRp uses the genomic RNA inside the viral nucleocapsid as the templat

151 a high-resolution profile of single-stranded genomic RNA inside viral particles.

152 ymerase leads to exposure of the sequestered genomic RNA, instead of large NP domain rotations.

153 ate that the NC-binding aptamers disrupt Gag-genomic RNA interaction and negatively affect genomic RN

154 mers can be an effective tool to perturb Gag-genomic RNA interactions.

155 RNA levels via perturbation of specific Gag-genomic RNA interactions.

156 gulator of innate immunity using comparative genomics RNA interference screens in Caenorhabditis eleg

157 of innate immunity, we performed comparative genomics RNA interference screens in the nematode Caenor

158 Coronaviruses selectively package genomic RNA into assembled virions, despite the great mo

159 cture that allows the selective packaging of genomic RNA into assembled virions.

160 lisation that retroviruses can convert their genomic RNA into DNA provided a route by which they coul

161 te immunity despite reverse transcription of genomic RNA into double-stranded DNA, an activity that m

162 eformation) and the reduced ability to eject genomic RNA into its bacterial host.

163 mbrane-bounded protein lattice that recruits genomic RNA into the virus and forms the shell of a budd

164 argets.The mechanism underlying packaging of genomic RNA into viral particles is not well understood

165 ernative splicing and packaging of unspliced genomic RNA into virions.

166 sm that governs the copackaging of the three genomic RNAs into RVFV particles.

167 Initiation of reverse transcription of genomic RNA is a key early step in replication of the hu

168 plasm where viral proteins are expressed and genomic RNA is delivered to assembling virions.

169 human immunodeficiency virus type 1 (HIV-1) genomic RNA is necessary to produce the complete viral p

170 The 4.8-kb genomic RNA is needed for the formation of spherules 66

171 We find that the genomic RNA is packaged in a high-energy state, suggesti

172 We show that the HIV genomic RNA is rapidly decapped and forms a lariat-like

173 LPs) from ddm1 and ddm1rdr6 mutants in which genomic RNA is reverse transcribed into complementary DN

174 In a negative strand RNA virus, the genomic RNA is sequestered inside the nucleocapsid when

175 ss a ribonucleoprotein template in which the genomic RNA is sequestered within a homopolymer of nucle

176 The production of noncapped viral genomic RNAs is important to the establishment and maint

177 er Picornavirales specifically package their genomic RNAs is poorly understood.

178 o called psi-RNA, in the packaging domain of genomic RNA) is strongly affected by changes in ionic st

179 We further demonstrate that LCMV genomic RNA itself (without other LCMV components) is ab

180 We hypothesized that the aptamers influence genomic RNA levels via perturbation of specific Gag-geno

181 that another factor(s) such as ORF1 or viral genomic RNA may be necessary for proper particle release

182 such capsids and a plausible route by which genomic RNA might exit.

183 econd gag mRNA species that differs from the genomic RNA molecule by the absence of an intron in the

184 Upon infection, this genomic RNA must be able to leave the capsid to initiate

185 In addition, neither HIV-1 genomic RNA nor Gag colocalized with P-body proteins.

186 structural data to generate models of HIV-1 genomic RNA, nucleocapsid and integrase condensed into a

187 egavirales, utilizes a complex consisting of genomic RNA, nucleoprotein, the RNA-dependent RNA polyme

188 tructural proteins of one flavivirus and the genomic RNA of a heterologous strain can be assembled an

189 terfaces between the capsid proteins and the genomic RNA of bacteriophage MS2.

190 The genomic RNA of negative-strand RNA viruses, such as vesi

191 The genomic RNA of retroviruses and retrovirus-like transpos

192 same enzyme (RNase H) is required to remove genomic RNA of the RNA/DNA replication intermediate.

193 (SHAPE) to structural analysis of authentic genomic RNA of the xenotropic murine leukemia virus-rela

194 mutation in a critical 3' UTR hairpin in the genomic RNA of turnip crinkle virus did not directly int

195 nary stable equilibrium exists for the three genomic RNAs of Alfalfa mosaic virus (AMV).

196 We show that the genomic RNAs of alphaviruses are not universally 5' capp

197 Genomic RNAs of both lentiviral genera were observed to

198 m(6)A has been identified in the genomic RNAs of diverse mammalian viruses and, additiona

199 Here, we report that the incoming genomic RNAs of noninfectious SINV particles undergo rap

200 paring the nucleotide sequences of the three genomic RNAs of the modern and ancient viruses showed 98

201 facilitating the nonenzymatic replication of genomic RNA oligonucleotides.

202 An investigation of the impact of genomic RNA on the association of the protein subunits m

203 RNA polymerase, 3Dpol, replicates the viral genomic RNA on the surface of virus-induced intracellula

204 ity that could allow it to degrade the viral genomic RNA or viral reverse-transcribed DNA.

205 ribosomal frameshifting (PRF) signal at the genomic RNA ORF1a/ORF1b junction revealed that PRF in IB

206 y dependent on a cis-acting RNA element, the genomic RNA packaging enhancer (GRPE), found within the

207 for further exploration of the mechanism of genomic RNA packaging.

208 ed sequence at the 5' terminus of hantaviral genomic RNA plays an important role in viral transcripti

209 Full-length unspliced genomic RNA plays critical roles in HIV replication, ser

210 These results suggest that the genomic RNA plays significant roles in defining the prec

211 easiRNA targeted EVADE genomic RNA, polysome association of GYPSY (ATHILA) subg

212 Influenza virus genomic RNAs possess segment-specific packaging signals

213 to chaperone tRNA(3)(Lys) placement onto the genomic RNA primer binding site; however, the timing and

214 viral filaments are produced and loaded with genomic RNA prior to insertion into the plasma membrane.

215 pped, with a significant number of noncapped genomic RNA produced early in infection.

216 short sequences (packaging sites) within the genomic RNA promote rapid and efficient assembly through

217 be a result of an imbalance in the N protein/genomic RNA ratio leading to incomplete encapsidation.

218 lymph node cells showed the highest mRNA-to-genomic-RNA ratios in B cells and dendritic cells (DCs),

219 ter assembling HIV-1 Gag has associated with genomic RNA, recruited critical host factors involved in

220 red after assembling Gag has associated with genomic RNA, recruited critical host factors involved in

221 these two motifs--only four nucleotides per genomic RNA--reduced packaging 100-fold, comparable to t

222 cytosine (m(5)C) is highly enriched in viral genomic RNA relative to uninfected cellular mRNAs, and w

223 Translation initiation on HIV genomic RNA relies on both cap and Internal Ribosome Ent

224 Zika genomic RNA replicates in the cytoplasm of infected host

225 t viruses had a significant decrease in both genomic RNA replication and mRNA transcription.

226 te that EILV is restricted both at entry and genomic RNA replication levels in vertebrate cells.

227 covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infectio

228 the major target for antiviral therapies is genomic RNA replication, which occurs at poorly understo

229 he viral factors responsible for the lack of genomic RNA replication.

230 Thus, lentiviral genomic RNAs require specific Gag binding to accumulate

231 iral assembly process and packaging of viral genomic RNA requires full-length Gag to produce infectio

232 dependently interact with mRNA cap and viral genomic RNA, respectively.

233 The three genomic RNAs (RNA1, -2, and -3) and a single subgenomic

234 FHV has two genomic RNAs; RNA1 encodes multifunctional RNA replicati

235 We further demonstrate that the surrounding genomic RNA secondary structure influences frameshift ef

236 G3A C8U "superpromoter" mutations in the HA genomic RNA segment.

237 cleoprotein (N) encapsidates the three viral genomic RNA segments and plays a crucial role in viral R

238 Little is known about how the three genomic RNA segments are copackaged to generate infectio

239 iruses, while proteins encoded by additional genomic RNA segments displayed no significant homology w

240 intermolecular interaction between two viral genomic RNA segments of an avian influenza A virus using

241 Packaging of the eight genomic RNA segments of influenza A viruses (IAV) into v

242 cation strategy of BPMV RNA2, one of the two genomic RNA segments of this virus, and established an e

243 nfection by delivering into cells a suite of genomic RNA segments, each sheathed by the viral nucleoc

244 virus (WMoV), an Emaravirus, contains eight genomic RNA segments, the most in a known negative-sense

245 ved in the consensus sequences of additional genomic RNA segments.

246 cleocapsid protein but not in the additional genomic RNA segments.

247 viral RNA synthesis were correlated with the genomic RNA sequence.

248 e mechanism of NSV RNA synthesis in that the genomic RNA sequestered in the nucleocapsid serves as th

249 assembled in these experiments with the sub-genomic RNAs show a layer of RNA density beneath the coa

250 Viruses preferentially encapsidate their own genomic RNA, sometimes as a result of the presence of cl

251 n infected cells and virions and encapsidate genomic RNA species to form an NP-RNA complex that, toge

252 ation factor eIF3 and recognition of the HCV genomic RNA start codon, molecular interactions that lik

253 n higher-order structures that form when the genomic RNA strand folds back on itself.

254 -infected tissue attenuated the level of the genomic RNAs, suggesting that they, or their precursors,

255 Cleavage in PB2, PB1, and PA genomic RNAs suggests that viral RNPs are susceptible to

256 The longer genomic RNAs suppress the 5-fold pathway, presumably as

257 pt N-RNA interaction and abrogate both viral genomic RNA synthesis and N-mediated translation strateg

258 TIPs are engineered to express >3-fold more genomic RNA than HIV expresses.

259 wheat, with 10- to 20-fold more virus-sense genomic RNAs than vc-sense RNAs.

260 perative effects between capsid proteins and genomic RNA that would occur in a packaging signal-media

261 into a SINV cDNA clone using sites in nsP3 (genomic RNA), the 3'UTR (genomic and subgenomic RNAs) an

262 k of interactions with positive-strand viral genomic RNA, the envelope membrane protein (M), and othe

263 (tRNA(Lys)(3)) and a region at the 5' end of genomic RNA; the 3' end of the tRNA acts as a primer for

264 rimary and secondary structures of the viral genomic RNA throughout the process.

265 s type 1 (HIV-1) is reverse transcription of genomic RNA to DNA, a process that is primed by cellular

266 Mature C protein assembles onto genomic RNA to form nucleocapsid, followed by prM and E

267 a chaperone for NP, which encapsidates viral genomic RNA to form the NP-RNA complex, the functional t

268 s demonstrate the structural basis for HIV-1 genomic RNA to recruit beneficial cellular cofactor to v

269 wn N-nsp3 interaction in the localization of genomic RNA to the replicase complex at an early stage o

270 enomic RNA interaction and negatively affect genomic RNA transcription, processing, or stability.

271 HCV core or genomic RNA transfected Huh-7 cells modestly increased F

272 Initially, the genomic RNAs undergo rapid and dramatic (approximately 2

273 Secondary structure predictions of the genomic RNA using Mfold showed that only 8 out of 30 of

274 gene expression induced by transfected viral genomic RNA (vgRNA) and reovirus infection, we discovere

275 which preferentially associates with DENV-2 genomic RNA via interactions with dumbbell structures in

276 erizes along the length of the single-strand genomic RNA (viral RNA) or its cRNA.

277 ein (N) is encoded by the smallest S segment genomic RNA (viral RNA).

278 The HTNV genomic RNA (vRNA) copy number and infectious virus were

279 orrespond to the 5' end of each of the viral genomic RNA (vRNA) segments.

280 reover, significantly higher levels of viral genomic RNA (vRNA) were observed during the heat shock p

281 of HMPV positive-sense RNA (+RNA) and viral genomic RNA (vRNA).

282 The location of the encapsidated viral genomic RNA was defined by modeling crystal structures o

283 In contrast, although HIV-1 genomic RNA was detected at the nuclear envelope, HIV-1

284 proviral DNA showed few mutations, the viral genomic RNA was highly mutated, suggesting that errors o

285 om 103 horses were immunoreactive, and viral genomic RNA was present in 8 of the 36 seropositive anim

286 Finally, using RNA probes specific for RSV genomic RNA, we found that viral RNA predominantly local

287 Using purified HIV-1 genomic RNA, we show that this RNA bears more epitranscr

288 rotein, phosphoprotein, and respective viral genomic RNA were clearly observed in human airway epithe

289 Interestingly, when the genomic RNAs were delivered directly into the cells via

290 rus B3 strains with 5'-terminal deletions in genomic RNAs were isolated from a patient suffering from

291 For both lentiviruses, genomic RNAs were seen at the plasma membrane if and onl

292 ific RNA detected in muscle is predominantly genomic RNA, whereas RABV RNA detected in draining lymph

293 '-terminal siRNAs of each of the three viral genomic RNAs, whereas an increased production of siRNAs

294 in RNA packaging by encapsidating only their genomic RNA while avoiding packaging of the more abundan

295 clear envelope, and focal colocalizations of genomic RNA with an intact packaging signal (psi) and Ga

296 s, we identified multiple regions in the pre-genomic RNA with high affinity for core protein dimers.

297 viral integration site analysis.RESULTSHIV-1 genomic RNA with identical sequences were identified in

298 ind that necroptosis requires sensing of the genomic RNA within incoming virus particles via cytoplas

299 es and thereby the binding-register of viral genomic RNA within nucleocapsids.

300 nimal and human pathogens that protect their genomic RNAs within a protective protein capsid.