ライフサイエンスコーパス: genomic sequence

1 class both spatially and linearly along the genomic sequence.

2 nsional chromosome organisation is linked to genomic sequence.

3 s and predict splicing outcome directly from genomic sequence.

4 ucts encoded trans-frame with respect to the genomic sequence.

5 shows protein annotations in the context of genomic sequence.

6 exon order inconsistent with the underlying genomic sequence.

7 regions that differ in terms of their linear genomic sequence.

8 nd germline, that do not overlap with coding genomic sequences.

9 reverse complementarity to 322 published RV genomic sequences.

10 ons can be useful parameters for analysis of genomic sequences.

11 driver mutations can occur within noncoding genomic sequences.

12 er, to distinguish enhancers from background genomic sequences.

13 eting the approximately 23 kb of intervening genomic sequences.

14 nd generates high-quality LTR libraries from genomic sequences.

15 leading to the reproducible loss of specific genomic sequences.

16 ate functional annotation of uncharacterized genomic sequences.

17 pression despite displaying nearly identical genomic sequences.

18 accurate and consistent characterization of genomic sequences.

19 tions, and assist the assembly of fragmented genomic sequences.

20 struction of RGN reagents to target specific genomic sequences.

21 of mutants by obtaining >500 bp of flanking genomic sequences.

22 the straightforward modification of desired genomic sequences.

23 to effectively and efficiently compress the genomic sequences.

24 tudy the problem of RNA motif search in long genomic sequences.

25 ence sequence, rather than with the complete genomic sequences.

26 nscription factor (TF) binding affinities to genomic sequences.

27 refers Dnmt3b2 over Dnmt3a2 in remethylating genomic sequences.

28 ability of data for the traits, markers, and genomic sequences.

29 ased on transmission electron microscopy and genomic sequences.

30 rowth temperatures of prokaryotes using only genomic sequences.

31 how they build representations of regulatory genomic sequences.

32 hile still keeping nearly all of the genuine genomic sequences.

33 adequately informed to consent to diagnostic genomic sequencing.

34 e linked to the same stool donor by means of genomic sequencing.

35 reverse transcription-quantitative PCR, and genomic sequencing.

36 ticles evaluated the entire microbiome using genomic sequencing.

37 ttern matching in a Levenshtein automata for genomic sequencing.

38 DNA methylation, when analyzed by bisulfite genomic sequencing.

39 g of the utility and limitations of pathogen genomic sequencing.

40 nfirmed with the nitrate reductase assay and genomic sequencing.

41 a complete assembly line PKS identified via genomic sequencing.

42 ion by integrating heterogeneous features of genomic sequences, 16 histone modifications with a multi

43 ral RNA substrate bearing the authentic DENV genomic sequence (5'-(m7)G0pppA1G2U3U4G5U6U7-3'), and S-

44 aVE) is a database of curated papillomavirus genomic sequences, accompanied by web-based sequence ana

45 describe the application of population-based genomic sequencing after chemical mutagenesis to map bac

46 Coalescent-based simulation software for genomic sequences allows the efficient in silico generat

47 s the information derived from comparison of genomic sequences alone.

48 se results demonstrate that cis-variation in genomic sequences among Arabidopsis accessions was the d

49 Genomic sequencing analyses in seven affected individual

50 Comparative genomic sequence analysis showed that key elements of -2

51 Genetic MLST clustering was confirmed by genomic sequence analysis, indicating that the MLST sche

52 sification has emerged as a new challenge in genomic sequence analysis.

53 Large genomic sequencing analysis as part of precision medicin

54 As) can induce mutations in 90% of the miRNA genomic sequences analyzed.

55 Observations were validated using matched genomic sequence and expression data from lymphoblasts f

56 ved annotations to the latest version of the genomic sequence and its annotations.

57 e challenge of the overwhelming abundance of genomic sequence and other biological data is the use of

58 a transformation function between the static genomic sequence and the primary spatial specification p

59 ir cognate transcription factors (TFs) using genomic sequence and transcriptomic data.

60 n Chinese genomes and detected 29.5 Mb novel genomic sequences and at least 188 novel protein-coding

61 splacement amplification and FACS, to obtain genomic sequences and cell size information from unculti

62 t genomic sequencing, we are able to analyze genomic sequences and cell sizes of hundreds of individu

63 accelerated with the genetic revolution, as genomic sequences and genetic tools became available for

64 g advantage of the large number of available genomic sequences and growth temperature data, we presen

65 ed NGS is useful and robust to acquire viral genomic sequences and may provide important ways to defi

66 Here, we analyze genomic sequences and predict that sediment-associated M

67 The new RSV genomic sequences and the novel sequencing method report

68 predict the functions of isoforms from their genomic sequences and then refining the prediction using

69 e improvements may permit real-time benchtop genomic sequencing and antimicrobial resistance gene det

70 Advances in genomic sequencing and computational approaches are revo

71 Developments in high-throughput microbial genomic sequencing and other systems biology techniques

72 e-invasive and invasive components for panel-genomic sequencing and recognize three evolutionary traj

73 found by chance only once in 7x10(10) bp of genomic sequences, and can thus form a near bioorthogona

74 ec1 recombinases, including endogenous human genomic sequences, and confirmed their ability to recomb

75 Here we present six nearly complete HSV-2 genomic sequences, and, with the addition of two previou

76 mic sequences, as the relative activities of genomic sequences are best explained by the predicted oc

77 nary, instructive genetic code directing how genomic sequences are compiled into transcripts.

78 Accurate full-length genomic sequences are important for viral phylogenetic s

79 on of swine-associated genes and swine virus genomic sequences are not available from the exposure so

80 Fourth, at least 40 Kbp missing genomic sequences are recovered in the C. elegans genome

81 The first approach uses a PWM and background genomic sequence as input to estimate lambda for a speci

82 constructs containing complete agt and Taf1 genomic sequences as well as various chimeric constructs

83 This grammar plays only a small role for genomic sequences, as the relative activities of genomic

84 Previous research identified genomic sequences associated with maleness in each speci

85 be adapted to future viruses within days of genomic sequence availability.

86 is not reflected in the conservation of the genomic sequences, but is associated with conserved epig

87 corporate metabolic pathways discovered with genomic sequencing, but direct comparisons between model

88 finition of splice site ambiguity due to the genomic sequence by introducing equivalent junction, whi

89 The Cas9 endonuclease can be targeted to genomic sequences by programming the sequence of an asso

90 n-associated RNAs (caRNAs) with their target genomic sequences by proximity ligation, forming RNA-DNA

91 Genomic sequences can be targeted consistently with extr

92 In conclusion, rapid genomic sequencing can be performed as a first-tier diag

93 Genomic sequencing can potentially expand the screening

94 r the past 15 years for identifying within a genomic sequence candidate CRMs consisting of clusters o

95 Comprehensive genomic sequencing (CGS) enables us to detect numerous g

96 nd other RTK fusions from a large commercial genomic sequencing company database was published, follo

97 d by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains.

98 However, despite genomic sequence conservation, changes in protein intera

99 The importance of genomic sequence context in generating transcriptome div

100 ervice, researchers are able to retrieve the genomic sequence coordinates for proteins in UniProtKB.

101 We also illustrate how application of whole-genomic sequencing could document whether vaccines prote

102 A new study demonstrates that genomic sequencing coverage of plasma DNA fragments arou

103 Using genomic sequence data and polymerase chain reaction-base

104 g amounts of unprocessed bacterial and viral genomic sequence data are stored in the global archives.

105 Furthermore, analysis of genomic sequence data enabled identification of the loca

106 precedented scale of data: >390,000 bases of genomic sequence data from each of 198 species of living

107 51 donors, with integrated transcriptome and genomic sequence data from the same lines.

108 Using available genomic sequence data on coagulation factor VIII and pre

109 y demonstrates the use of publicly available genomic sequence data to evaluate a PCR assay for distin

110 y, public-health agencies are using pathogen genomic sequence data to support surveillance and epidem

111 Genomic sequence data was contextualised through compari

112 logy has led to an explosive accumulation of genomic sequence data.

113 the concept of rational vaccine design from genomic sequence data.

114 40 single-cell transcriptomes, combined with genomic sequence data.

115 eloped to aid the quality control process of genomic sequence data.

116 igh accuracy from paired-end high-throughput genomic sequencing data and pinpoints their breakpoints

117 ng capabilities to identify neoantigens from genomic sequencing data are a limiting factor for unders

118 y relevant findings from a broad analysis of genomic sequencing data as well as the need for periodic

119 The quality of whole-genomic sequencing data is comparable across all samples

120 Noise in genomic sequencing data is known to have effects on vari

121 n an ultra-fast, high-throughput manner from genomic sequencing data.

122 epresentation, compression and management of genomic sequencing data: the Moving Picture Experts Grou

123 ulates phylogenies inferred from much larger genomic sequence datasets.

124 ring information, such as lab collections or genomic sequencing datasets.

125 ant benefits that continue to be gained from genomic sequencing, dedicated efforts are needed to avoi

126 diagnosed diseases, and we discuss how these genomic sequencing diagnoses could change clinical manag

127 Functional enhancers can be mapped by genomic sequence disruption, but this approach is limite

128 rus (CCHFV, Nairoviridae) exhibits extensive genomic sequence diversity across strains (Deyde et al.,

129 icing-modulator, albeit less frequently than genomic sequence diversity.

130 o analyses of several features of SARS-CoV-2 genomic sequence (e.g., codon usage, codon pair usage, d

131 Modern genomic sequencing efforts are identifying potential dia

132 representation of racial minorities in large genomic sequencing efforts is unclear, and could have an

133 Through major genomics sequencing efforts such as the Personal Genome

134 rovides a real-time and portable solution to genomic sequencing, enabling better assembly, structural

135 e absent in plants, C. reinhardtii possesses genomic sequences encoding TRP proteins.

136 We focus on the role of clinical genomic sequencing (exome and genome) in aiding patients

137 Manipulation of genomic sequences facilitates the identification and cha

138 ference of the evolutionary history of short genomic sequence features by combining the necessary ste

139 The genomic sequence flanking editing sites is highly conser

140 Genomic sequences flanking the 3'-side of L1s were ampli

141 cture and additional signals of selection on genomic sequence for the loci that affect traits.

142 Targeted genomic sequence for WNT4 and WNT5A was determined in 10

143 Having genomic sequences for at least six EPNs opens the possib

144 sequence-specific molecular tool for editing genomic sequences for basic research in life sciences an

145 e novo whole-genome sequence of R. bieti and genomic sequences for the four other species.

146 from 17,071 patients surveyed with clinical genomic sequencing for cardiomyopathy, epilepsy, or RASo

147 hlight the benefits and limitations of using genomic sequencing for NBS and the challenges of using s

148 compact data structure for storing multiple genomic sequences, for storing polymorphisms or for mapp

149 Noncoding genomic sequences-for which molecular functions cannot u

150 sequence assemblers then construct the whole genomic sequence from these reads.

151 The PhytoPath resource contains data for 135 genomic sequences from 87 plant pathogen species, and 13

152 We used viral genomic sequences from isolates collected from exhibitio

153 We used genomic sequences from our exhibition swine surveillance

154 re we report phylogenic analysis using whole genomic sequences from seven genotype 1E and three genot

155 puting technology makes it possible to build genomic sequences from the billions of reads within a mi

156 Recent progress in genomic sequencing from patient samples has allowed for

157 ovides the necessary context to evaluate how genomic sequence gain and loss contribute to species-spe

158 trapolations by phylodynamic models of HIV-1 genomic sequences gathered mostly over recent decades.

159 As genomic sequencing has become more widely available, the

160 Genomic sequencing has driven precision-based oncology t

161 Next-generation genomic sequencing has identified multiple novel molecul

162 Genomic sequencing has implicated large numbers of genes

163 Human genomic sequencing has potential diagnostic, prognostic,

164 Although genomic sequencing has provided a better understating of

165 Advances in genomic sequencing have enormous potential to revolution

166 biopsy programmes combined with advances in genomic sequencing have provided new insights into the m

167 These surprising results (confirmed through genomic sequencing) highlight the importance of advancin

168 orthologue of the mouse Rosa26 locus through genomic sequence homology analysis.

169 Genomic sequencing identified >99.5% homology between SE

170 Genomic sequencing identified a single nucleotide polymo

171 rs with the ability to manipulate nearly any genomic sequence in human cells and model organisms.

172 Whether RIP affects core genomic sequence in important ways is unknown.

173 ing revealed the presence of identical HPIV3 genomic sequence in the two of the cases with hospital-a

174 e iteratively integrated into the repetitive genomic sequences in a modular manner using robotic auto

175 Here we use a library of Xenopus tropicalis genomic sequences in bacterial artificial chromosomes (B

176 Whilst knowledge of genomic sequences in crops is increasing rapidly, the sc

177 ded DNA oligonucleotides to capture specific genomic sequences in cross-linked chromatin fragments an

178 on of five genes was quantified by bisulfite genomic sequencing in d-200 dorsal prostates across BPA

179 plant one-box and composite REs in a single genomic sequence, in a pair of aligned homologous sequen

180 Transformation of an 8-kb genomic sequence including CNL13 into the susceptible wh

181 and validated by transformation of a c.10-kb genomic sequence including WTK2 into susceptible common

182 G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natura

183 By integrating genomic sequence information to the MS-based plasma prot

184 We present the full genomic sequences, insertion sites and phylogenetic anal

185 era of "next-gen cytogenetics," integrating genomic sequencing into the prenatal diagnostic setting

186 Large scale genomic sequencing is now widely used to decipher questi

187 Genomic sequencing is rapidly transitioning into clinica

188 rises insertion, deletion and duplication of genomic sequence, is an informative type of genetic vari

189 hod estimates the proportion of fixed length genomic sequence (k-mers) from whole genome sequence dat

190 rapy-resistant brain tumours, which, despite genomic sequencing, lack effective molecular targets.

191 atin immunoprecipitation followed by massive genomic sequencing led to the identification of CaMKII-d

192 produced indels, linear molecules, and large genomic sequence loss around the gRNA target site.

193 well as inter- and intra-assembly-associated genomic sequences (NCs, NTs and NWs), supporting robust

194 lenges of interpreting and reporting newborn genomic sequencing (nGS) results need to be addressed fo

195 We determine draft-level genomic sequence of 50 diverse military isolates and con

196 The genomic sequence of CpMMS19 is 62 kb, consisting of 20 e

197 not due to differences in signaling, nor the genomic sequence of genes or their regulatory elements.

198 The genomic sequence of Spirodela polyrhiza, the smallest an

199 evailed during the epidemic period, complete genomic sequences of 23 HAdV-D8 isolates were generated

200 Recovering the genomic sequences of all isoforms of a given gene across

201 Based on the genomic sequences of bacteriomes and viromes from the sa

202 We test the measures on well-studied genomic sequences of different sizes drawn from differen

203 bust, and cost-efficient, and generates full genomic sequences of diverse strains of HIV without bias

204 ws the conditional, site-specific removal of genomic sequences of essential and non-essential genes b

205 Here, partial genomic sequences of four novel algal viruses were assem

206 We built phylogenetic trees based on genomic sequences of functional genomic regions and tiss

207 Due to the large redundancies among genomic sequences of individuals from the same species,

208 MtBNN is capable of extracting features from genomic sequences of large-scale chromatin-profiling dat

209 Genomic sequences of M. tuberculosis isolates displayed

210 l conclusion, by characterizing the complete genomic sequences of modern and historic population samp

211 study, comparative analyses of all available genomic sequences of North American (NA)-type PRRSVs (n

212 curring bacteriophages by analyzing the full genomic sequences of over 100 isolates of Synechococcus-

213 Here, partial and complete genomic sequences of recent virulent isolates of genotyp

214 he applications of our results by clustering genomic sequences of several vertebrate and tree species

215 Here, we analyze genomic sequences of Staphylococcus aureus USA300 isolat

216 ecipitation system (LIPS), combined with the genomic sequences of the viruses, we gained the insights

217 ing (NGS) is a powerful technology to define genomic sequences of the viruses.

218 of human pathogenic E. coli, we carried out genomic sequencing of 162 isolates obtained from patient

219 Genomic sequencing of 18 YFV genomes revealed the estima

220 ions contribute to brain metastases and that genomic sequencing of a sufficient number of metastatic

221 Genomic sequencing of CDV isolated from one of the infec

222 Extensive genomic sequencing of gliomas, different cell types, bra

223 Recent intensive genomic sequencing of hematopoietic malignancies has ide

224 omized, controlled trial of rapid diagnostic genomic sequencing of infants in regional ICUs.

225 We confirmed this hypothesis by genomic sequencing of progeny from young and old plants.

226 on cellular context, stimulating deletion of genomic sequence or insertion of non-homologous DNA at t

227 conclusion, molecular phylogeny of complete genomic sequences proved a monophyletic HAdV-D8 epidemic

228 Genomic sequencing provides many opportunities in newbor

229 s represent the largest number of KSHV whole-genomic sequences published to date and the first time t

230 Rapid diagnostic genomic sequencing recently became feasible for infants

231 The novel sequencing method and the new RSV genomic sequences reported here expand our knowledge bas

232 ology is limited by dominance of unannotated genomic sequences representing taxonomic and functional

233 Characterization of full genomic sequences revealed the existence of a single rec

234 Genomic sequencing revealed a G->A point mutation in int

235 Genomic sequencing revealed HAdV-7d, a genome type recen

236 Genomic sequencing revealed that all four individuals ca

237 Bisulfite genomic sequencing revealed that this transient knockdow

238 Genomic sequencing revolutionized the epidemiological un

239 Genomic sequencing revolutionized the epidemiological un

240 ian surveys of the clinical utility of rapid genomic sequencing (RGS).

241 While genomic sequencing routinely identifies oncogenic altera

242 ific DNA marker (NM4182) located on a single genomic sequence scaffold.

243 We conducted transcriptomic and/or genomic sequence search, subsequent phylogenetic analysi

244 eparated by tens of million bases (Mb) along genomic sequence show a significantly higher tendency to

245 ses with RNA genomes are abundant, and their genomic sequences show astonishing variation.

246 Here we present single-cell genomic sequencing (SiC-seq), which uses droplet microfl

247 shotgun sequencing reveals a small number of genomic sequences, some with homology to transposable el

248 ely defend against phages by acquiring short genomic sequences (spacers) that target specific sequenc

249 Genomic sequencing studies have highlighted key differen

250 Recent genomic sequencing studies have identified many recurren

251 to lack of well-defined targets, and recent genomic sequencing studies have revealed a paucity of TN

252 Genomic sequencing studies of breast and other cancers h

253 Large genomic sequencing studies open doors for accurate molec

254 Genomic sequencing studies, including RNA sequencing and

255 ion between donor nucleic acids and acceptor genomic sequences subjected to double-stranded DNA break

256 alysis of the matches of the motifs in human genomic sequences suggested novel roles for many RBPs.

257 These parasites have similar biology and genomic sequence, suggesting that all three diseases cou

258 Viral genomic sequencing supported this transmission hypothesi

259 argeted BAC clones, we generated orthologous genomic sequences surrounding the DEP1 locus, a major gr

260 s derived from chemical structure (drugs) or genomic sequence (targets).

261 ts many advantages, scRNAseq, like any other genomic sequencing technique, is susceptible to the infl

262 Advances in genomic sequencing technologies have improved the abilit

263 Innovations in both tumor genomic sequencing technology and the development of dru

264 With advances in genomic sequencing technology, the number of reported ge

265 f telomere addition is increased at specific genomic sequences termed sites of repair-associated telo

266 spiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, partic

267 imes being separated by tens of Mb along the genomic sequence than those belonging to different class

268 s has revealed a class of non-protein-coding genomic sequences that display an extraordinary degree o

269 We concentrate on nuclear genomic sequences that have been published in the past f

270 These elements can capture ectopic genomic sequences that lead to the formation of new gene

271 When combined with results from genomic sequencing, these studies have established parad

272 cs can leverage the vast amount of available genomic sequences to reconstruct and analyze transcripti

273 Transcription factors recognize specific genomic sequences to regulate complex gene-expression pr

274 or leap from merely describing and comparing genomic sequences to surveying them for direct indicator

275 led 32 pseudomolecules (supercontigs) of the genomic sequences to the 20 chromosomes of S. polyrhiza.

276 uorescence-activated cell sorting (FACS) and genomic sequencing to assign taxonomy to BONCAT-labeled

277 a by combining spatiotemporal analytics with genomic sequencing to detect and characterize viral resp

278 We used reduced representation meta-genomic sequencing to examine genetic relationships with

279 We used genomic sequencing to identify potentially pathogenic ge

280 The use of genomic sequencing to investigate microbes has expanded,

281 estingly, there is a correlation between the genomic sequence type and virulence factor profiles base

282 The excision of genomic sequences using paired CRISPR-Cas nucleases is a

283 The evidence base supporting genetic and genomic sequence-variant interpretations is continuously

284 The measured abundances of intra-genomic sequence variants were in the integral ratios ex

285 mportance, review approaches to interpreting genomic sequence variants, identify publicly available t

286 t from genome bins and show that substantial genomic sequence variation is present in a real metageno

287 ents felt that first-tier, rapid, diagnostic genomic sequencing was beneficial for infants lacking et

288 Using a high-resolution Ae. aegypti genomic sequence, we found that vDNAs integrated in the

289 ily of statistics in comparative analyses of genomic sequences, we developed a new statistic D2R that

290 onrandom variation in the ages of background genomic sequences, we find that mammal-specific enhancer

291 By swapping genomic sequences, we found that the genomic location of

292 positive for Zika virus and appropriate for genomic sequencing, we also tested samples from a 2017 s

293 rated index-cell sorting and high-throughput genomic sequencing, we are able to analyze genomic seque

294 ing a combination of microarray analysis and genomic sequencing, we mapped the breakpoints of mitotic

295 origin, flow cytometry characterization, and genomic sequencing, we show that cancer cells can be det

296 Changes in genomic sequence, weight, temperature, histopathologic f

297 These 116 genomic sequences were placed within the phylogenetic co

298 y of C. salicifolius, comprising 820.1 Mb of genomic sequence with a contig N50 of 2.3 Mb and contain

299 etween synthetic cis-regulatory elements and genomic sequences with comparable binding site configura

300 ncy, transcription factor binding sites, and genomic sequence within an easily navigated user interfa