ライフサイエンスコーパス: genomically

1 istant T. concentricum microbiologically and genomically.

2 ive neurogenetic syndrome phenotypically and genomically.

3 Genomically, ~15% of the FoxA1 interphase target sites a

4 ngle CN V axons in LgDel+/- mouse embryos, a genomically accurate 22q11.2DS model, and 3D imaging to

5 the TIR-type NLR-encoding CSA1 locus located genomically adjacent to CHS3 was found to be fully requi

6 am (TAP), to delineate gene structures using genomically aligned EST sequences.

7 Using genomically aligned ESTs, a computational tool (TAP) was

8 lorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, a

9 maintenance of epithelial cell polarity, is genomically amplified and overexpressed in serous epithe

10 cription factor OTX2 is overexpressed and/or genomically amplified in most medulloblastomas, but the

11 n cassette, leaving behind a single neutral, genomically anchored FF3 unit.

12 ere is potential to derive highly effective, genomically anchored medicines that assist in maintainin

13 To improve upon this situation, we studied genomically and clinically annotated, prospectively recr

14 represent a novel genomic disorder distinct genomically and clinically from the well-known DGS/VCF d

15 In Streptococcus pneumoniae, we find a genomically and ecologically distinct subset, held at a

16 Clinically, genomically and epigenetically, NEPC resembles other typ

17 Mouse hESCs are genomically and karyotypically stable, are innately immo

18 Tumors are frequently characterized by genomically and phenotypically distinct cancer cell subp

19 This finding demonstrates that multiple genomically and phenotypically distinct primary prostate

20 her showed that A. latus hybrid isolates are genomically and phenotypically heterogeneous but also di

21 nfirming the feasibility of modeling the LS7 genomically and pointing to an important role of genetic

22 large family of druggable proteins that are genomically and proteomically altered in many human canc

23 rgeted therapies across large collections of genomically and transcriptomically characterized cancer

24 etrial tumors, and uterine sarcomas that are genomically and/or pharmacologically annotated and explo

25 oteomic and phosphoproteomic analyses of 105 genomically annotated breast cancers, of which 77 provid

26 s-of-function screening in a large number of genomically annotated cancer cell lines.

27 ated genes were ultimately used to propose a genomically based model of the early events in cervical

28 rial design, and continued drug development, genomically based therapies will become more common in t

29 PTNFL was otherwise genomically bland and specifically lacked recurrent muta

30 antitatively measured the sensitivity of 242 genomically characterized CCLs to an Informer Set of 354

31 Using a cohort of 551 genomically characterized EACs with matched RNA sequenci

32 Testing of genomically characterized human cell populations may off

33 We genomically characterized mammary adenocarcinomas from t

34 rare in mycobacteriophages, and only 1 of 30 genomically characterized mycobacteriophages (Che9c) enc

35 anscriptional and translational mutants in a genomically characterized Nocardiopsis, a soil-derived a

36 study, 10 new pelagiphages were isolated and genomically characterized.

37 lvement of undergraduates in discovering and genomically characterizing bacteriophages (PHIRE) and cl

38 e LINbase, a web server that allows users to genomically circumscribe any group of prokaryotes with m

39 A streptococcal (iGAS) infection, linked to genomically closely related group A streptococcal (GAS)

40 ation, with variation occurring primarily in genomically clustered gene families.

41 measured strain diversity within and between genomically clustered isolates.

42 ochrome P450 monooxygenase (CYP99A17), which genomically clustered with SiTPS8, catalyzes the C19 hyd

43 eptor alpha3, alpha5, and beta4 subunits are genomically clustered.

44 nting the miR-143 and miR-145 stem loops are genomically clustered.

45 Some of these signatures involve genomically co-localized genes resulting from the presen

46 rence of Natural Selection from Interspersed Genomically coHerent elemenTs analysis indicated that th

47 ion of specialized metabolites and are often genomically colocalized with BGCs.

48 leading cause of targeted therapy failure in genomically complex cancers.

49 Genomically conferred sensitivity to the social environm

50 Our studies provide the first genomically-confirmed assessments of CDI relative risk f

51 lity-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family.

52 likelihood-based gap filling to predict more genomically consistent solutions.

53 Genomically controlled hIL-10 expression rescued Il10(-/

54 ique and complex regulatory state pattern is genomically controlled.

55 Genomically, cryptochromes 1 and 2 associate with a gluc

56 Using a clinico-genomically curated cohort, together with breast cancer

57 e leading to the cell cycle exit or death of genomically damaged differentiated pericentral hepatocyt

58 there are multiple spermatogenic targets for genomically defective sperm with substantially variable

59 initiate the study of Na+-H+ exchangers in a genomically defined and genetically tractable model syst

60 Our results show that measurement of genomically defined clonal population dynamics will be h

61 ld standard for relapse vs. new infection of genomically defined ISLs.

62 logic and gene expression characteristics of genomically defined luminal A and B subtypes.

63 Importantly, we identify a genomically defined MM subgroup (17% of newly diagnosed

64 elices and beta-sheets being confined to the genomically defined structural tethers that separate the

65 roved targeted therapies for the most common genomically defined subset of non-small cell lung cancer

66 ne), whereas termination does not seem to be genomically defined.

67 We identified seven genomically-defined CLL subgroups that have distinct bio

68 inical relapse and identify the emergence of genomically-defined therapy-resistant clones.

69 nt one, or PC1) was strongly correlated with genomically determined tumor fraction (r = -0.96; P < 10

70 with TNBC with residual disease after NAC to genomically directed therapy versus treatment of physici

71 Genomically directed therapy was not superior to TPC for

72 ibed in a highly regulated manner from seven genomically dispersed operons.

73 ar in closely related isolates, suggesting a genomically disruptive process specific to an individual

74 RNA controls the activity and methylation of genomically distal regulatory elements to modulate large

75 Thus, Ig locus contraction juxtaposes genomically distant elements to mediate efficient recomb

76 ar iron transporter (NEAT) proteins that are genomically distant from the genetically linked Isd locu

77 ate transcription by modulating chromatin at genomically distant loci.

78 ose of 'fractal globules,' and even the most genomically-distant parts of the chromosome can be physi

79 upported the hypothesis that transmission of genomically distinct A. marginale strains predominates i

80 We demonstrate that genomically distinct isolates, which can be categorized

81 s with radiation resistance across dozens of genomically-distinct models of GBM, we find that purine

82 from gene content to metabolite dynamics for genomically diverse bacteria.

83 Progenies of the tetraploid rice were genomically diverse due to genome-wide HEs that affected

84 facing Escherichia coli (AEEC) strains are a genomically diverse group of diarrheagenic E. coli strai

85 sary to facilitate long-term response across genomically diverse HR+ breast cancers.

86 Melanoma is a complex and genomically diverse malignancy, and new genes and signal

87 In this study, a group of genomically diverse P. aeruginosa isolates were compared

88 A panel of genomically diverse T21 and euploid induced pluripotent

89 solates causing recalcitrant bacteremia were genomically diverse, indicating that strain-specific sig

90 Pancreatic ductal adenocarcinoma (PDAC) is a genomically diverse, prevalent, and almost invariably fa

91 Our study provides genomically driven insight into the rise of ecological i

92 alterations and adds to an expanding list of genomically driven therapies for oncogenic subsets of NS

93 However, few examples exist of successful genomically-driven drug repositioning.

94 ne of over 50% of malignancies, there are no genomically-driven radiosensitizers for clinical use.

95 imately, cultivation-independent genomic and genomically enabled approaches could provide a way to di

96 ls contain a novel type of sRNA that has non-genomically encoded 5' poly(U) tails.

97 y G and C nucleotides and reside upstream of genomically encoded A-rich tracts.

98 t extend beyond editing per se and that even genomically encoded ADARs that are catalytically inactiv

99 ne-to-inosine (A-to-I) RNA editing, in which genomically encoded adenosine is changed to inosine in R

100 HT(2C)R) undergo RNA editing events in which genomically encoded adenosine residues are converted to

101 These substrates were found by chance, when genomically encoded adenosines were identified as guanos

102 for prediction of the chemical structures of genomically encoded antibiotics, including all classes o

103 PLZF-AR is able to bring about silencing of genomically encoded AR-regulated genes and inhibit the a

104 segment surrounding maize site IV (which is genomically encoded as a T in tobacco) does not confer e

105 s permitted an analysis of the complement of genomically encoded ATP-binding cassette (ABC) proteins.

106 Genomically encoded backup control circuitry thus provid

107 A clones analyzed containing one to four non-genomically encoded C or A residues; 83% of these cDNAs

108 chloroplast transcripts are edited from the genomically encoded C to U, often resulting in changes o

109 We here study metabolisms, genomically encoded complex networks of enzyme-catalyzed

110 palindromic repeats (CRISPR) system utilizes genomically encoded CRISPR RNA (crRNA), derived from inv

111 ting in plants, animals, and humans modifies genomically encoded cytidine or adenosine nucleotides to

112 The structure and mechanism of action of the genomically encoded FosX enzyme from Listeria monocytoge

113 ch changes the codon at position 2153 from a genomically encoded glutamine (CAA) to an in-frame stop

114 A 2 (GRIA2), modifies a codon, replacing the genomically encoded glutamine (Q) with arginine (R); thu

115 Subsequent studies led to the discovery of a genomically encoded homologue in the pathogen Pseudomona

116 meric GABA(A) receptors (Gabra3), in which a genomically encoded isoleucine codon (ATA) is converted

117 dicted to be edited based on the presence of genomically encoded mismatched nucleotides in their amin

118 pairs are edited in the absence of any other genomically encoded mismatches.

119 post-transcriptional mechanism that modifies genomically encoded nucleotides at the RNA level.

120 Non-genomically encoded nucleotides were detected in 27% of

121 for rps12, cox2 and atp9 indicated that non-genomically encoded nucleotides were present at the 3'-t

122 e show that the Piwi Argonaute PRG-1 and its genomically encoded piRNA cofactors initiate permanent s

123 approximately 20-kb transcript containing a genomically encoded poly(A)-rich tract at its 3'-end.

124 he nascent MALAT1 transcript downstream of a genomically encoded poly(A)-rich tract to simultaneously

125 of signal-specific barcodes (symbols) into a genomically encoded recording unit.

126 The network specifies genomically encoded regulatory processes between early c

127 MicroRNAs (miRNAs, miRs) are genomically encoded small approximately 22 nt RNA molecu

128 MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regu

129 lta effector T cell function correlates with genomically encoded T cell antigen receptor (TCR) chains

130 Isolation of genomically encoded tagged beta or beta' from yeast extr

131 es pairs of codons that are read by the same genomically encoded tRNAs, we hypothesize, and show by d

132 tegies of microbes with different niches are genomically encoded: Specialists have smaller genomes th

133 ever, in most Bacteria and Archaea, G(-1) is genomically encoded; thus post-transcriptional addition

134 speed single-molecule microscopy we observed genomically-encoded fluorescent constructs of the access

135 reparation method will speed-up screening of genomically engineered strains for CFPS applications, ma

136 ) and heme A synthase (HAS), were separately genomically epitope-tagged in Saccharomyces cerevisiae,

137 optically-controlled intrabodies to regulate genomically expressed protein targets and validate the p

138 HC8 knockout cells and in mutation carriers, genomically extended telomerase RNA (TR) accumulated at

139 utations that affect the expression of genes genomically far away.

140 Brazilian strains differ genomically from other C. posadasii lineages.

141 ucation efforts may be needed to ensure that genomically guided cancer care is adequately delivered.

142 eases, so will the possibility of developing genomically guided therapeutic interventions.

143 The promise of such genomically guided therapies heralds a new era in the ma

144 in patients with CUP who could have received genomically guided therapies.

145 vity and could provide a framework to design genomically-guided clinical trials in radiation oncology

146 vity and could provide a framework to design genomically-guided clinical trials in radiation oncology

147 Genomically heterogeneous AML has a tendency to evolve,

148 ategy to overcome therapy resistance in this genomically heterogeneous disease.

149 Clinical samples are often genomically heterogeneous due to low sample purity or th

150 We find that ExPEC E. coli are highly genomically heterogeneous, consistent with pan-genome an

151 y indicates that the vertebrate brain can be genomically heterogeneous.

152 is facing significant challenges due to the genomically heterogenous nature of HCC.

153 therapeutic index, with enhanced killing of genomically high-risk CLL cells that are typically unres

154 Genomically, human medulloblastomas were closest to mous

155 nisation, we review the spectrum of existing genomically humanised mouse models and the insights such

156 n-time of flight mass spectrometry were also genomically identified as C. macclintockiae.

157 aling and suggest a therapeutic strategy for genomically identified patients with the aggressive form

158 temporal data from hospital records assessed genomically-identified clusters for potential transmissi

159 lthough many human embryos are aneuploid and genomically imbalanced, often as a result of meiotic err

160 icantly low synonymous substitution rates in genomically imprinted genes suggests a link between hemi

161 Although WT1 is not genomically imprinted in kidney, we have previously show

162 X-inactivation that may also apply to other genomically imprinted loci.

163 led to the widely accepted hypothesis that a genomically imprinted NB suppressor gene is the target o

164 Remarkably, both approaches identify the genomically imprinted VTRNA2-1 as a top environmentally

165 recently showed the production of pigs with genomically inactivated PERVs.

166 not 5-FU accumulation, thus indicating that genomically incorporated 5-FU plays a major role in the

167 nome; however, it remains unclear how either genomically incorporated U or 5-FU contributes to killin

168 fine subtypes of disease that are otherwise genomically indistinguishable.

169 oteogenomic integration not only prioritized genomically inferred targets, such as copy-number driver

170 provide essential background for developing genomically influenced testable hypotheses for the evolu

171 een cell lines and tumours can be bridged by genomically informed choices of cell line models for all

172 tury ago, that has led to the current use of genomically informed methods for selection of targeted t

173 induce the pathophysiological abnormality of genomically inherited P/Q-type channel disorders.

174 f the immune system may improve treatment of genomically instable cancers.

175 lower expression marked more aggressive and genomically instable disease and cellular phenotypes.

176 can greatly enhance the characterization of genomically instable tumors.

177 sea urchin embryos with high efficiency and genomically integrate at a copy number of one per cell.

178 ane yeast two-hybrid (MYTH) technology using genomically integrated "bait" constructs, hence the desi

179 es of the plasmid and (b) the plasmid is not genomically integrated and consequently poorly chromatin

180 We constructed three genomically integrated circuits that use bistable autore

181 f Cre protein as measured by activation of a genomically integrated Cre-mediated recombination report

182 the GAL4 DNA binding domain transactivates a genomically integrated GAL4 responsive reporter gene.

183 d in HEK293T cells using a library of 11,776 genomically integrated protospacer-sgRNA pairs containin

184 Using a HeLa-derived cell line with a genomically integrated recombination substrate, we expre

185 enine base editors (CBEs and ABEs) on 38,538 genomically integrated targets in mammalian cells and us

186 ified genes into uniform and unique sites in genomically integrated transcription units.

187 First, a landing pad cell line with a genomically integrated, Tet-inducible cassette containin

188 ling ATPase, is critical for repression of a genomically integrated, TR-regulated reporter gene.

189 knockout model in human lung tumor cells by genomically integrating RNA destabilizing elements using

190 C with pN0 high genomic risk or pN1 EBC with genomically intermediate- to high-risk disease.

191 sed on a sparse data model, that can support genomically labeled matrices at any resolution.

192 rpuratus were determined and compared to the genomically linked CyI and CyIIb actin genes.

193 Together, these results indicate that genomically linked odorant receptor genes are not coordi

194 Fewer genomically-linked cases were observed for index cases w

195 Here, we report both genomically local and distal RNA-dependent roles of Dali

196 Here, we describe the genomically local and more distal functions of Paupar, a

197 rose subsequent to the genome duplication by genomically local tandem duplication.

198 actor ESX, an 11 kb fragment from the 1q32.2 genomically localized human gene was cloned and analysed

199 Patients were enrolled on genomically matched clinical trials at a rate of 11%.

200 Gonadal hormones have primarily slow, genomically mediated effects, but copulation requires ra

201 Tetraploidy constitutes a genomically metastable state that can lead to aneuploidy

202 Genomically minimal cells, such as JCVI-syn3.0 and JCVI-

203 Genomically minimal cells, such as JCVI-syn3.0, offer a

204 tributions of genes to cell division in this genomically minimal context.

205 rganization, and sequence is indicative of a genomically monomorphic subspecies and explains the inab

206 quencing and assembly efforts in this as yet genomically neglected group of crucifer plants.

207 the taxonomically defined Fungi represents a genomically non-uniform assemblage of species.

208 st a new model of AD pathogenesis in which a genomically orchestrated up-regulation of tumor suppress

209 Two new studies show that genomically paired plant immune receptors have incorpora

210 bacteria to study in microbiology: they are genomically, phylogenetically and functionally diverse y

211 ion of macaque A-to-I editing sites that are genomically polymorphic in some animals or encoded as no

212 The precision of interlocus distance of genomically-proximate loci was better than 4% of the cel

213 ng approaches to discover vulnerabilities in genomically quiet cancers.

214 ibe the exceptional molecular phenotype of a genomically quiet kidney tumor, clear cell papillary ren

215 d a set of UAGN (N = A, G, U, C) codons in a genomically recoded E. coli strain that lacks any endoge

216 describe an in vivo evolution approach in a genomically recoded Escherichia coli strain for the sele

217 e the construction and characterization of a genomically recoded organism (GRO).

218 we describe the construction of a series of genomically recoded organisms (GROs) whose growth is res

219 dically altered genetic codes will allow for genomically recoded organisms that have expanded chemica

220 Here using a genomically recoded strain of E. coli with a flexible UA

221 platform that employs crude extracts from a genomically recoded strain of Escherichia coli for site-

222 ted protein and improve ncAA-protein yields, genomically recoded strains of Escherichia coli lacking

223 CRISPR thus stores genomically recoverable timelines of virus-host coevolut

224 rvariability(6-8), are prominent features of genomically reduced organisms from the bacterial candida

225 pidemiological links were identified between genomically related clinical and water isolates.

226 For genomically related susceptible and reduced susceptibili

227 MT), in which the two parts of the tumor are genomically related to one another, as opposed to the me

228 us polyoma virus (CPV), is antigenically and genomically related to simian virus 40 (SV40).

229 mic analysis, these hybrid isolates are more genomically-related to EPEC, but appear to have acquired

230 ready" version of a GABA(A) receptor subunit genomically replaces its wild-type counterpart, ensuring

231 etion mutants, and two independently derived genomically rescued variants of the mutants were analyze

232 fied an hnRNP E1 consensus-binding motif and genomically resolved a subset of genes in which it is co

233 the parental strains, the mutants, and their genomically restored counterparts, eliminating disparate

234 50-bp deletion in the ICP0 promoter, and the genomically restored isolate, DeltaTfiR.

235 on of highly informative models that we call genomically rewritten and tailored GEMMs (GREAT-GEMMs).

236 multilocus allele frequency data for making genomically robust inferences.

237 These findings support genomically selected clinical trials directed toward MET

238 s," or histology-agnostic clinical trials in genomically selected patients, represent one important r

239 Genomically similar L-lactate-producing lactic acid bact

240 ith nonmutagenic chemotherapy exposures were genomically similar to de novo acute myeloid leukemia.

241 y, histologically, immunophenotypically, and genomically similar to human HGSOC.

242 rare cells (as few as 1 in 15,000) that were genomically similar to the dominant blast populations at

243 gically similar, and humans, to which gar is genomically similar.

244 ze the chromosomal instability (CIN) and the genomically stable (GS) subtypes of human gastric cancer

245 ent of gene silencing in a newly created and genomically stable allotetraploid cotton, of genotype AA

246 ted with ground-truth proliferation rates in genomically stable but not unstable cells.

247 However, the existence of genomically stable cancers and the emergence of mutation

248 Cultures derived from genomically stable iPSCs exhibited reduced variance and

249 tric cancers are uniquely characterized by a genomically stable landscape and lower tumor mutational

250 the ability to maintain long-term growth of genomically stable multilineage pre-stasis HMEC populati

251 to a more differentiated, slow growing, and genomically stable phenotype.

252 nts had a significantly larger proportion of genomically stable subtype tumors compared with Asian an

253 These aggressive cancers are among the most genomically stable, suggesting an epigenetic mechanism b

254 at arise following SNF5 loss are diploid and genomically stable.

255 ereas ER(+) typical-risk tumours are largely genomically stable.

256 ntly unconsidered therapeutic modalities for genomically stratified melanoma patient subsets.

257 nical applicability of genomic data: (1) the genomically stratified model originates from the "one te

258 ined at very low levels unless the cells are genomically stressed.

259 d and further validated utilizing a panel of genomically subtyped KRAS mutant PDCLs.

260 in 12/14 (86%) subjects but missed 2/6 (33%) genomically supported reinfections.

261 -based assessments failed to identify 33% of genomically supported reinfections.

262 rs that regulate its site of methylation, we genomically tagged Set2 and identified its associated pr

263 igated the activity of a broad collection of genomically targeted epigenetic regulators that could wr

264 All genomically targeted therapeutic SPUs obtained over a 5-

265 Genomically, the treatment-resistant tumor uniquely harb

266 essed proteins from the dominant member of a genomically uncharacterized, natural, acidophilic biofil

267 ides these characteristics, CCS has remained genomically uncharacterized.

268 slated compared to HRAS due to enrichment in genomically underrepresented or rare codons.

269 archaeia, ANME-1 and GoM-Arc1) or previously genomically undescribed (ANME-2c) archaeal lineages.

270 these approaches are invariably transformed, genomically unstable and display cellular properties tha

271 Ovarian tumor cells are often genomically unstable and hypersensitive to cisplatin.

272 Moreover, cancers are genomically unstable and may readily compensate for the

273 and that viable daughters of these cells are genomically unstable as evidenced by spontaneous DNA dam

274 pe stasis and continue to proliferate become genomically unstable before encountering a second more s

275 PARP inhibitors with DNA-damaging agents in genomically unstable cancer cells (regardless of homolog

276 nd continued proliferation of the resulting, genomically unstable cancer cells.

277 her scenarios, such as lethal mutagenesis or genomically unstable cancer, where increased mutagenesis

278 Currently, it is unclear how genomically unstable cancers, including BRCA1/2-mutant t

279 nd identified recurrently disrupted genes in genomically unstable cancers.

280 ragmentation serves as a method to eliminate genomically unstable cells.

281 species (ROS) are frequently associated with genomically unstable clones.

282 ignant transformation in cultured cells, and genomically unstable mammary carcinomas in transgenic mi

283 ture of genomic events encourages the use of genomically unstable murine cancer models in the discove

284 rogenitor tumor stem cell that gives rise to genomically unstable progeny in malignant melanoma.

285 The genomically unstable subtype shows proliferation through

286 We recently demonstrated the presence of a genomically unstable tetraploid population in PARP(-/-)

287 Cells derived from genomically unstable tumors exhibit evidence for a parti

288 rentiate the three major subtypes: urobasal, genomically unstable, and SCCL.

289 The majority of human cancers are genomically unstable, often with gains or losses of whol

290 human cancers have complex genotypes and are genomically unstable, they often remain dependent on the

291 withstanding, clonal PCs in AL (n = 11) were genomically unstable, with a median of 9 copy number alt

292 ic tumors are highly genetically complex and genomically unstable.

293 ) in 10 replicate populations, despite being genomically unstable.

294 group is enriched in higher CD3, PD-L1, and genomically-unstable molecular subtype, suggesting it ma

295 y determined by polymerase chain reaction or genomically via targeted sequencing.

296 us loci between ambystomatid salamanders and genomically well-characterized vertebrate model organism

297 es that have diverged in polygenic traits is genomically widespread and much higher overall, consiste

298 tory network (GRN) subcircuitry explains the genomically wired mechanism by which community effect si

299 ithin 1 h) by tagging the endogenous protein genomically with the auxin degron.

300 are analyzed and subtyped proteomically, and genomically, with numerous biomarkers.