ライフサイエンスコーパス: genotypic

1 Prior to treatment, variants with genotypic 3TC resistance (RT-M184I/V) were detected at l

2 irus (HCV) nucleoside inhibitors display pan-genotypic activity, a high barrier to the selection of r

3 tion of the molecule to achieve the best pan-genotypic activity.

4 function; data were stratified according to genotypic African ancestry.

5 To investigate phenotypic and genotypic alterations before and after bone metastasis,

6 Rued et al. combine phenotypic and genotypic analyses of mutant strains that suggest discre

7 Genotypic analysis in 386 participants revealed that 323

8 Genotypic analysis of R5-tropic patient-derived envelope

9 Genotypic analysis of the dual-tropic clones also showed

10 nd bla(OXA-1) was determined, and phenotypic-genotypic analysis of virulence revealed significant het

11 audi Arabia were subjected to phenotypic and genotypic analysis on gene and genome-wide levels.

12 ping of 805 breast cancer tissues revealed a genotypic and allelic frequency of the R337H variant of

13 elucidated through efficient comparisons of genotypic and environmental effects on recombination.

14 ato yield traits, (ii) determine the size of genotypic and genotype by environment interaction (G x E

15 These results were compared to the expected genotypic and mCIM results.

16 g (AST) confirmed a high correlation between genotypic and phenotypic antimicrobial resistance determ

17 The relative ability of genotypic and phenotypic approaches to identify beta-lac

18 Genotypic and phenotypic assays demonstrated a distinct

19 Here we describe a rapid assay for combined genotypic and phenotypic AST through RNA detection, GoPh

20 phenotypic values, the relationships between genotypic and phenotypic change of our analyzed phenotyp

21 ntial to understand the relationship between genotypic and phenotypic change.

22 Our in-depth genotypic and phenotypic characterization identifies the

23 ssed associations between clades and various genotypic and phenotypic combinations.

24 Our studies show both genotypic and phenotypic correlations between plectin an

25 e of family relationships or, alternatively, genotypic and phenotypic data for numerous unrelated ind

26 , are changing the scale and availability of genotypic and phenotypic data for researchers to ask fun

27 and may become useful for efforts to combine genotypic and phenotypic data for risk prediction and to

28 We used genotypic and phenotypic data from 10 760 individuals ag

29 rformance of PRSs, which requires individual genotypic and phenotypic data in an independent GWAS val

30 aroreflex control at HA may be influenced by genotypic and phenotypic differences between lowland and

31 ons of changes in multiplex we generate rich genotypic and phenotypic diversity and characterize clon

32 hisms, provide a rich opportunity to connect genotypic and phenotypic diversity within an ecological

33 ofazimine, or meropenem) drugs and guided by genotypic and phenotypic drug susceptibility testing can

34 Genotypic and phenotypic heterogeneity drives drug resis

35 This multicenter study assembled genome-wide genotypic and phenotypic measures from 14 data sets of t

36 e introduced, and reveal limitations of both genotypic and phenotypic methods.

37 lutionary process characterized by diverging genotypic and phenotypic properties.

38 Genotypic and phenotypic studies of HIV-2 TSMs will impr

39 c features, we performed a detailed clinical genotypic and phenotypic study of 47 patients with GPS a

40 Here, we review current knowledge of plant genotypic and phenotypic traits as well as allogenic and

41 al evolution, and we assessed the associated genotypic and phenotypic traits.

42 Here, we review the genotypic and phenotypic variability of the RBC membrane

43 rms using whole genome sequencing, and their genotypic and phenotypic variation.

44 hitecture of pigmentation, due to their high genotypic and phenotypic variation.

45 using on metabolites, which encompasses both genotypic and phenotypic variations, can enable early pr

46 We studied 2070 Latino children (8-21y) with genotypic and pulmonary function data from the GALA II c

47 aneuploidy is not general but contingent on genotypic and/or developmental context.

48 indings may contribute to the development of genotypic and/or phenotypic markers for EAEC strains of

49 This study examined the phenotypic, genotypic, and biochemical changes that had occurred dur

50 sorders and potential predictive phenotypic, genotypic, and environmental factors.

51 ssue of Blood, Sims et al describe clinical, genotypic, and phenotypic findings in 47 patients with t

52 compounds 20 and 21 have shown superior pan-genotypic anti-HCV activity compared to ledipasvir and d

53 phoramidate nucleotide 16, as a nontoxic pan-genotypic anti-HCV agent.

54 ate diastereomers 27 and 28, as nontoxic pan-genotypic anti-HCV agents.

55 mentation of azithromycin MDA, focusing on a genotypic approach to overcome the limitations of resist

56 LA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae

57 speed by doubling time of the pathogen, and genotypic assays are limited by the ever-growing diversi

58 processes that facilitate the phenotypic and genotypic assessment of AMR and antibiotic susceptibilit

59 e surveillance populations, the seasonal and genotypic associations between sporadic cases and outbre

60 , and that the traits involved in phenotypic/genotypic assortment were highly dynamic over time.

61 We assess patterns of phenotypic and genotypic assortment, and ask whether altered associatio

62 Detection of nucleic acids in genotypic AST can be rapid, but it has not been successf

63 d onset of diseases, depending on individual genotypic background and types of subsequent exposures.

64 erogeneity appearing a greater confound than genotypic background.

65 Females from three distinct genotypic backgrounds were left unmated or singly mated

66 ciprocal design to males from the same three genotypic backgrounds.

67 Coinfecting isolate pairs had different genotypic backgrounds.

68 Inclusion of the snapshot of genotypic, but less-so genetic, diversity improved predi

69 We used clinical and genotypic case definitions to calculate the proportion o

70 d therapeutics will require harnessing pheno-genotypic cell-level data quantitatively and predictivel

71 number of novel phenotypes reachable through genotypic change is highest for organisms with simple ph

72 On the one hand, genotypic change is more likely to yield novel phenotype

73 t (i) interspecific competition drives rapid genotypic change, and (ii) this evolutionary change in o

74 The likely common cause is robustness to genotypic change.

75 edge about resistance-related phenotypic and genotypic changes is critical for the development of new

76 We measured phenotypic and genotypic changes on downstream genes in EAEC strain 042

77 lopment of a comprehensive theory that links genotypic changes to their phenotypic effects.

78 Phenotypic and genotypic characteristics in these patients from birth o

79 erence, at least 50 discussed phenotypic and genotypic characteristics of antimicrobial resistance in

80 cally monophyletic and show strongly bimodal genotypic clustering and no evidence of contemporary mig

81 No genotypic clustering by geographical origin or isolation

82 acterized reoviruses grouped in six distinct genotypic clusters (GC1 to GC6).

83 Despite the stability of viral genotypic clusters that had 98% sequence identity, viral

84 alidate that these populations form discrete genotypic clusters.

85 acer (ITS) to examine ecotype and fine-scale genotypic community dynamics for monthly surface water s

86 women contains multiple HCMV strains of high genotypic complexity and thus constitutes a major source

87 eceptor knockout line to investigate how the genotypic composition of the social environment (G(s)) i

88 sing genetically modified animals, since the genotypic composition of the social environment can eith

89 Furthermore, we find evidence of spousal genotypic concordance for rs1229984, suggesting that spo

90 For HIV-negative couples, genotypic concordance was 30% at baseline (n = 219/725)

91 speed of over 1000 times faster to calculate genotypic correlation.

92 rces using subjects' clinical phenotypic and genotypic criteria.

93 The phenotypic and genotypic data collected were used to conduct a genome-w

94 Genotypic data from 491,265 variants were analyzed for a

95 Genotypic data from 86,930 markers and three traits with

96 Associations were assessed using genotypic data generated by a customized SNP array, impu

97 wever, joint analysis for the phenotypic and genotypic data provided three clusters that could be use

98 Network analysis including T4-like phage genotypic data revealed distinct viral variants correlat

99 bred germplasm and associated phenotypic and genotypic data serve as enduring resources.

100 ics studies the complex associations between genotypic data such as single nucleotide polymorphisms (

101 achine learning model trained with annotated genotypic data to classify variants as benign or pathoge

102 r of methods integrate patient phenotype and genotypic data to prioritise variants as potentially cau

103 Here, we use genotypic data to study range-wide patterns of genetic a

104 ividuals, combining extensive phenotypic and genotypic data with streamlined access for researchers a

105 can be explored through both phenotypic and genotypic data, but up until now it has never been inves

106 The integration of genotypic data, pedigree records and shell formation mod

107 onsidered contaminations when accounting for genotypic data.

108 f interconnectable phenotypic, molecular and genotypic data.

109 he first 5 principal components derived from genotypic data.

110 gorization of patients with a phenotypic and genotypic descriptor that will clarify etiology, provide

111 Several groups have proposed that genotypic determinants in gag and the gp41 cytoplasmic d

112 ignaling dysregulate FAAH activity, and this genotypic difference is normalized with pharmacological

113 his study, we have determined phenotypic and genotypic differences between EAEC strains of sequence t

114 Genotypic differences between the twin pairs-such as cop

115 We also identified genotypic differences in core photosynthesis and reactiv

116 Nitrate hyper-accumulators and wide genotypic differences in Na, K and S concentrations were

117 Using HPV-EM, we demonstrated HPV genotypic differences in recurrence and patient outcomes

118 There were no consistent genotypic differences in two-bottle choice chronic ethan

119 od samples, caused by many physiological and genotypic differences not related to the parasite infect

120 improve understanding of the phenotypic and genotypic differences that exist between patients and th

121 Sterility was higher in 2016 and fewer genotypic differences were found.

122 by agronomists and plant breeders to compare genotypic differences.

123 c CLN3 disease, which may be associated with genotypic differences.

124 VHT and LVNC likely represent a continuum of genotypic disease with differences in severity and varia

125 We analyzed seasonal patterns and genotypic distribution between sporadic pediatric norovi

126 his work provides a rare illustration of how genotypic divergence has led to behavioral phenotypic di

127 ntitative molecular trait despite underlying genotypic divergence.

128 Low plant genotypic diversity also decreased the structural footpr

129 We therefore suggest that genotypic diversity and phenotypic plasticity in cortica

130 icate that bullfrog farms can harbor high Bd genotypic diversity and virulence and may be contributin

131 cosystem functions and that decreasing plant genotypic diversity could destabilise belowground food w

132 Decreasing plant genotypic diversity decreased the abundance of lower, bu

133 Few studies, however, have examined plant genotypic diversity effects across trophic levels.

134 Our study suggests that plant genotypic diversity effects differ across trophic levels

135 We investigated genotypic diversity effects of Phragmites australis on b

136 This study describes rotavirus disease and genotypic diversity in the Australian population compris

137 e to characterize the hemagglutinin and full genotypic diversity of IAV at early-season shows and the

138 We studied the genotypic diversity of lipase induced hydrolytic rancidi

139 This study aimed to quantify how the genotypic diversity of root tip geometry and root diamet

140 sition, spatial organization, and phenotypic/genotypic diversity of the resident microbiota at the va

141 me histopathological subtype, exhibit a high genotypic diversity that impedes therapy stratification

142 enotype distribution fluctuated annually and genotypic diversity varied amongst different age groups.

143 Genotypic diversity was found for cortical cell diameter

144 ss and nematode abundance responses to plant genotypic diversity were uncoupled.

145 We also described Bd genotypic diversity within frog farms by isolating Bd fr

146 mitations including bacterial phenotypic and genotypic diversity, polymicrobial interactions, and imp

147 ape, which highlight the necessity of timely genotypic drug resistance monitoring and molecular surve

148 s and investigated associated phenotypic and genotypic drug resistance patterns.

149 These findings demonstrate that DBS-based genotypic drug resistance testing for HIV-2 is feasible

150 2 infection in Senegal and subjected them to genotypic drug resistance testing.

151 (pDST) is used to define PZA resistance but genotypic DST (gDST) and minimum inhibitory concentratio

152 Genotypic DST and MIC for PZA were not associated with t

153 to their underlying components, constitutive genotypic effect (G), G x D, G x H, and G x H x D, and w

154 , CpG sites, and SNPs by jointly testing for genotypic effect and higher order interaction effects be

155 ence of Na+/H+ exchange activity, the SLC4A7 genotypic effect on net base uptake and steady-state pHi

156 A genotypic effect on response to TNFalpha stimuli was det

157 eQTLs, indicative of sex differences in the genotypic effects on gene expression.

158 ve role of 16-OMD for adaptation, as well as genotypic effects that support a high heritability of th

159 he HCHS/SOL Mexican origin group and whether genotypic effects were similar in other HCHS/SOL groups.

160 w hepatitis C virus (HCV) therapies with pan-genotypic efficacy are needed.

161 ns and reveal a potential role for L1 in the genotypic evolution of tumors characterized by BRCA1 and

162 he differentiation, our results suggest that genotypic evolution resulted in phenotypic changes that

163 relationship between parallel phenotypic and genotypic evolution, the role of plasticity in genotype

164 es were conducted to identify phenotypic and genotypic factors associated with risk of PCOS and to te

165 Here, we review the phenotypic and genotypic features of syndromic forms of EB to delineate

166 The genotypic features of the different phenotypic groups we

167 HLA-DQ genotypic frequencies differ slightly between CD patient

168 ession levels that supersede age-related and genotypic gene expression changes.

169 The discovery of a pan-genotypic hepatitis C virus (HCV) NS3/4A protease inhibi

170 al qAF(8) values (n = 110 [48%]) showed high genotypic heterogeneity.

171 uencing (NGS) is a trending new standard for genotypic HIV-1 drug resistance (HIVDR) testing.

172 es show that different evolutionary paths of genotypic host adaptation resulted in variola viruses th

173 Host genotypic influence on microbiome composition may be due

174 The finding of a genotypic influence on SLC4A7 expression and pHi regulat

175 etics that can obscure the identification of genotypic influences on disorder.

176 We document substantial developmental and genotypic influences on sRNA expression, with varying pa

177 This study uses genotypic information as a causal anchor to help deciphe

178 orld's largest repository for phenotypic and genotypic information for individuals of European ancest

179 Here we demonstrate the use of genotypic information from these accessions using a cost

180 ld's largest repositories for phenotypic and genotypic information in individuals of European ancestr

181 cargo of EVs can provide key phenotypic and genotypic information on the parent tumor cell and its m

182 Because genotypic information was available for only 257 hybrids

183 Phenotypic and genotypic information were obtained from 2614 trios from

184 However, plant-bacteria genotypic interactions can lead to wide variation in nit

185 Genotypic linkage was maintained within hypervariable UL

186 We correlate the appearance of genotypic macrolide resistance with multiple independent

187 Little is known about the genotypic make-up of HIV-1 DNA genomes during the earlie

188 of age in IR(l) degrees (x/lox)/Osx-Cre(+/-) genotypic male and female mice (designated postnatal-OIR

189 ociated with clinical presentations or other genotypic markers.

190 l now it has never been investigated through genotypic measures in ASD.

191 We used both phenotypic and genotypic methodologies to characterize the resistance p

192 nt isolates that are undetectable by current genotypic methods (negative for beta-lactamase genes or

193 yngeal swabs were analyzed by phenotypic and genotypic methods to detect pneumococcal serotypes and a

194 ull (full interaction model with additive or genotypic mode) and SNPassoc in detecting interactions.

195 esents the first step towards a quantitative genotypic model of insecticide resistance that can be us

196 fective number of tests, both phenotypic and genotypic, must be adjusted for the correlations between

197 ral therapies, with or without demonstrating genotypic mutation(s) known to be associated with resist

198 for T-ALL in the specific combination of the genotypic mutations tested (including the developmental

199 with a lower incidence of weakly deleterious genotypic mutations.

200 dentification of a novel class of potent pan-genotypic NS5A inhibitors with good pharmacokinetic prof

201 Pan-genotypic nucleoside HCV inhibitors display a high genet

202 s of C. glabrata isolates, which may lead to genotypic or phenotypic antifungal testing in clinical p

203 ovides information that is not confounded by genotypic or phenotypic heterogeneity of bulk samples.

204 Finally, we compared phenotypic versus genotypic ORs to estimate whether apolipoprotein(a) isof

205 model that accurately predicts base editing genotypic outcomes (R ~ 0.9) and efficiency (R ~ 0.7).

206 Data indicate significant phenotypic and genotypic overlap, plus a common pathogenesis, between t

207 1.13) for AA genotype carriers respectively; genotypic p for interaction = 0.96.

208 ies aim to project phenotypic likelihoods of genotypic patterns.

209 d in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved ou

210 We also propose an ideal genotypic, phenotypic and germplasm 'package' that multi

211 ks to an international network, we collected genotypic, phenotypic, and clinical data from more than

212 ely the oncogenic driver of SSTs, defining a genotypic-phenotypic correlation in ovarian neoplasms.

213 ssociation studies (GWAS) to uncover complex genotypic-phenotypic networks and environmental interact

214 rning method for GWAS to uncover the complex genotypic-phenotypic networks and environmental interact

215 pretive criteria for this assay and analysed genotypic-phenotypic relationships.

216 A genotypic/phenotypic risk score might facilitate earlier

217 biology of an organism is the mapping of its genotypic potential into its phenotypic expression profi

218 ed using tradeoffs in community function and genotypic potential, and changes in bacterial genus comp

219 The genotypic predictions were then compared to phenotypic r

220 riaceae Test performance was compared to the genotypic profile as the reference.

221 These ADSC-TM cells displayed a TM cell-like genotypic profile, became phagocytic, and responded to d

222 n = 13) tested had 100% concordance to their genotypic profiles, whereas all Klebsiella pneumoniae ca

223 phenotypic Fisher's Geometric Model and the genotypic properties, such as modularity and evolvabilit

224 irrigation management, which in turn affect genotypic rankings of transpiration in a time-dependent

225 y impact survival, hatch success, growth, or genotypic ratios.

226 Institutions that use genotypic RDTs to inform therapeutic de-escalation decis

227 opulation from the Taiwan Biobank (TWB) as a genotypic reference.

228 A safe, simple, effective, and pan-genotypic regimen to treat hepatitis C virus (HCV) infec

229 nd adolescents; fast-track evaluation of pan-genotypic regimens; and accelerated approval of paediatr

230 cing of nosocomial MDRPa strains to evaluate genotypic relationships between isolates.

231 e comprehensively examine the phenotypic and genotypic relationships of LDL-C with T2D.

232 Genotypic resistance analyses were conducted using Sange

233 ation published since 2010 on phenotypic and genotypic resistance mechanisms in C. difficile and addr

234 We tested genotypic resistance on stored baseline samples in patie

235 Using BMD as the gold standard, our genotypic resistance prediction approach had a significa

236 ype of InSTI.In 646 patients with a baseline genotypic resistance test of the integrase, we studied t

237 INTERPRETATION: Genotypic resistance testing might not accurately predic

238 Protease genotypic resistance testing was performed when VL >1000

239 spot sample was obtained for viral load and genotypic resistance testing.

240 st 200 copies per mL before treatment and no genotypic resistance to any study drugs; secondary analy

241 Moreover, genotypic resistance to clarithromycin can be predicted

242 uct microbead-based spoligotyping and assess genotypic resistance.

243 With the genotypic restoration of PagP enzymatic activity in Yp,

244 medicine that enhances inference from static genotypic risk assessment.

245 s-to-length ratio was correlated with higher genotypic root elongation rate, whereas root diameter wa

246 te, whereas root diameter was not related to genotypic root elongation.

247 ses are not detected by rapid phenotypic and genotypic routine clinical tests is essential to improve

248 onstrate the potential of highly-mulitplexed genotypic screening for measuring resistance-association

249 A whole-genome regression approach for the genotypic sensitivities led to accurate prediction of yi

250 teraction in these components was modeled as genotypic sensitivity to environmental drivers.

251 E deletion and KO and wild-type alleles in a genotypic series, we determined the amount of Atoh7 need

252 Our results provide crucial evidence for genotypic sex determination facilitating land-water tran

253 Traits did show some evidence of genotypic specificity, with rank-based analyses showing

254 Our findings expand the genotypic spectrum of BSI and the understanding of tempe

255 To expand the genotypic spectrum of BSI, identifying novel TGM1 mutati

256 Our findings expand the genotypic spectrum of congenital NAD deficiency disorder

257 These results expand the phenotypic and genotypic spectrum of EYS-RD, accounting for a high prop

258 dy significantly extended the phenotypic and genotypic spectrums of FAM83H-associated ADHCAI and sugg

259 eoretically expected progeny (EP(ij)), whose genotypic state can be inferred at all homozygous loci f

260 A 6-month prospective phenotypic and genotypic study performed at a single clinical microbiol

261 DGFRA mutations, optimal management of other genotypic subtypes remains unclear.

262 Inconclusive genotypic susceptibility results for both rifampin and i

263 but harbored multiresistant viruses with low genotypic susceptibility scores (median = 1.5).

264 he new data strengthen the interpretation of genotypic testing for cytomegalovirus drug resistance.

265 le of HSV-1 in the patient and conclude that genotypic testing outperformed phenotypic testing.

266 on sequencing approaches are each suited for genotypic testing.

267 further evaluation of shortened-duration pan-genotypic therapy in this setting.

268 ed cardiovascular diseases to illustrate the genotypic underpinnings of (endo)phenotypic diversity.

269 s is on identifying candidates with the best genotypic value for a target population of environments.

270 ubiquity of this phenomenon, known as 'intra-genotypic variability', is increasingly evident and the

271 the gap between empirical evidence of intra-genotypic variability, studies demonstrating its genetic

272 We report a genotypic variability-based genome-wide association stud

273 oportion of variance that is attributable to genotypic variance.

274 In this study, knowledge of pneumococcal genotypic variants improved the clinical risk assessment

275 In patients with genotypic variants, visual symptoms (95% CI, 1.36-21.62;

276 types of M. inflexa, which may be related to genotypic variation among samples, constitutive expressi

277 The SET and SDW exhibited appreciable genotypic variation among wheat genotypes at the anthesi

278 cific variation in leaf functional traits to genotypic variation and phenotypic plasticity.

279 However, the genotypic variation and the genomic regions governing sp

280 Genotypic variation contributed substantially to the var

281 All four loci contributed to genotypic variation for each of the SD and SL measuremen

282 We did, however, find significant genotypic variation in amount, diversity, and compositio

283 Genotypic variation in canopy greenness provides insight

284 stress in silico and their relationships to genotypic variation in hydraulic traits of cotton (Gossy

285 based modeling framework can be used to link genotypic variation in hydraulic traits to differential

286 vides a strong conceptual basis for modeling genotypic variation in response to elevated [CO2 ].

287 These findings indicated that genotypic variation in terpene profiles largely surpasse

288 Genotypic variation in the irradiance at which energy fl

289 We investigated genotypic variation in the production of SET and its rel

290 Microbial symbionts exhibit broad genotypic variation in their fitness effects on hosts, l

291 ana, extensive information on phenotypic and genotypic variation is available, but comparable informa

292 We examined if genotypic variation is related to the climate of genotyp

293 Alternatively, sponge genotypic variation may reflect variation in functional

294 We examined how host genotypic variation relates to host and symbiont functio

295 Our ability to connect genotypic variation to biologically important phenotypes

296 n the genomes which can be used to associate genotypic variation to the phenotype.

297 in brassicaceous microgreens and significant genotypic variation was demonstrated in chlorophyll and

298 Genotypic variation, environmental variation, and their

299 rpene profiles associated with plant sex and genotypic variation.

300 The general goal of GWAS is to link genotypic variations to corresponding differences in phe