コーパス検索結果 (１語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 e blocked by geranylgeraniol, a precursor of geranylgeranyl diphosphate.
2 aker responses to farnesyl pyrophosphate and geranylgeranyl diphosphate.
3 e formation of both farnesyl diphosphate and geranylgeranyl diphosphate.
4 e bond of the universal diterpene precursor, geranylgeranyl diphosphate.
5 in the cytosol that synthesizes omega,E,E,E-geranylgeranyl diphosphate.
6 de novo synthesis of phytyl-diphosphate from geranylgeranyl-diphosphate.
8 complex cyclization-rearrangement of (E,E,E)-geranylgeranyl diphosphate (8, GGPP) to a mixture of abi
9 hway-intermediates, farnesyl diphosphate and geranylgeranyl diphosphate, also reduced endometrial cel
10 etic evaluation of abietadiene synthase with geranylgeranyl diphosphate and (+)-copalyl diphosphate p
11 l, mechanistically distinct cyclizations, of geranylgeranyl diphosphate and of copalyl diphosphate, i
12 sidues deleted from the preprotein converted geranylgeranyl diphosphate and the intermediate (+)-copa
13 Plastidial TPS-a enzymes using the 20-carbon geranylgeranyl diphosphate are known from other plant fa
15 nant Escherichia coli-expressed protein used geranylgeranyl diphosphate as substrate and catalyzed th
19 for renal function, identifying dysregulated geranylgeranyl diphosphate biosynthesis as a potential d
21 iphosphate, which is made from the all-trans geranylgeranyl diphosphate by copal-8-ol diphosphate syn
22 the enzymatic product generated from [10-2H1]geranylgeranyl diphosphate confirmed the intramolecular
23 ps from the universal diterpenoid progenitor geranylgeranyl diphosphate derived by the plastidial met
24 ays use [(3)H]farnesyl diphosphate and [(3)H]geranylgeranyl diphosphate, electrophoretic mobility shi
25 se (FPS) into synthases capable of producing geranylgeranyl diphosphate (F112A), geranylfarnesyl (C25
26 ding substrate channeling, since most of the geranylgeranyl diphosphate generated by the prenyltransf
28 r for protein geranylgeranylation reactions, geranylgeranyl diphosphate (GGDP), is the product of the
29 ilic substitution reaction between the C(20) geranylgeranyl diphosphate (GGPP) and a protein-derived
30 of approximately 55 carbons in length using geranylgeranyl diphosphate (GGPP) and isopentenyl diphos
32 diphosphates farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) are intermediates in t
33 In plants, farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) are precursors to many
34 hypothesis, the current study identifies C20 geranylgeranyl diphosphate (GGPP) as a precursor for lyc
35 alized) metabolism via cycloisomerization of geranylgeranyl diphosphate (GGPP) by diterpene synthases
36 (MpGPS.SSU) on production of monoterpene and geranylgeranyl diphosphate (GGPP) diversities, and plant
37 prenyltransferase (PT) domain that generates geranylgeranyl diphosphate (GGPP) from dimethylallyl dip
38 LSU produced GPP, farnesyl diphosphate, and geranylgeranyl diphosphate (GGPP) from dimethylallyl dip
40 PS2) of specialized metabolism that converts geranylgeranyl diphosphate (GGPP) into labda-7,13E-dieny
42 logues suggests that the C-10 locus of bound geranylgeranyl diphosphate (GGPP) is in close proximity
43 es a bifunctional farnesyl diphosphate (FPP)/geranylgeranyl diphosphate (GGPP) synthase (TgFPPS) that
44 uced elsewhere in the plant cell derive from geranylgeranyl diphosphate (GGPP) synthesized by GGPP sy
45 clization of the linear isoprenoid substrate geranylgeranyl diphosphate (GGPP) to form taxa-4(5),11(1
46 talyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene di
47 lation of (S)-glyceryl phosphate [(S)-GP] by geranylgeranyl diphosphate (GGPP) to produce (S)-geranyl
48 ynthase catalyzes the cyclization of (E,E,E)-geranylgeranyl diphosphate (GGPP) to taxa-4(5),11(12)-di
49 bon farnesyl diphosphate (FPP), or 20-carbon geranylgeranyl diphosphate (GGPP) via a dioxygenase- or
53 ynthase catalyzes the synthesis of all-trans-geranylgeranyl diphosphate (GGPP), an isoprenoid used fo
54 te synthase (CPS), whose substrate, (E,E,E,)-geranylgeranyl diphosphate (GGPP), is also a direct prec
55 Notably, however, when provided with (E,E,E)-geranylgeranyl diphosphate (GGPP), LlTPS gave sobralene
56 assembles 5-carbon precursors to form C(20) geranylgeranyl diphosphate (GGPP), which is then convert
57 PC/KRAS mutant CRC, accompanied by increased geranylgeranyl diphosphate (GGPP)-a metabolite necessary
58 nthesis, is composed of a chlorin ring and a geranylgeranyl diphosphate (GGPP)-derived isoprenoid, wh
61 ne synthase-catalyzed cyclization of (E,E,E)-geranylgeranyl diphosphate (GGPP, 7) to taxadiene (5) is
62 e presence of either farnesyl diphosphate or geranylgeranyl diphosphate, GST-lHDAg was preferentially
63 ne of the expressed proteins was active with geranylgeranyl diphosphate; however, one truncated prote
64 ct derived by enzymatic cyclization of [1-3H]geranylgeranyl diphosphate in 2H2O indicated little inco
65 the new enzymes catalysed the cyclisation of geranylgeranyl diphosphate into 11-hydroxy vulgarisane,
66 tional class I diTPS PxaTPS8, which converts geranylgeranyl diphosphate into a previously unknown 5,7
67 In M. tuberculosis, however, omega,E,E,E-geranylgeranyl diphosphate is not utilized for the synth
68 decaprenyl diphosphate, and the omega,E,E,E-geranylgeranyl diphosphate is utilized by a membrane-ass
69 fold), and in planta geranyl diphosphate and geranylgeranyl diphosphate levels (4- to 8-fold) were si
71 iterpenoid biosynthesis, converting a common geranylgeranyl diphosphate precursor into different bicy
72 hosphate synthase, shown here to produce the geranylgeranyl diphosphate precursor, providing a critic
73 oding isoprenoid isopentenyl diphosphate and geranylgeranyl diphosphate-producing enzymes, DXS3, DXR,
74 hesis and forces reevaluation of the role of geranylgeranyl diphosphate reductase in tocopherol biosy
75 ich is produced from the substrate all-trans geranylgeranyl diphosphate, represents a so far unidenti
76 f lipid groups from farnesyl diphosphate and geranylgeranyl diphosphate, respectively, to a cysteine
77 of modifying the chain length specificity of geranylgeranyl diphosphate synthase (but not, apparently
78 gal IDSs, putative ILTPSs that belong to the geranylgeranyl diphosphate synthase (GGDPS) family of ID
79 sed on the development of inhibitors against geranylgeranyl diphosphate synthase (GGDPS), which gener
80 rotein that could be identified as the mouse geranylgeranyl diphosphate synthase (GGPP synthase) base
81 highly regulated step of carotenogenesis and geranylgeranyl diphosphate synthase (GGPPS) acts as a hu
83 h-rescue" and enzyme-inhibition experiments, geranylgeranyl diphosphate synthase (GGPPS) is shown to
84 large subunit, which may be either an active geranylgeranyl diphosphate synthase (GGPPS) or an inacti
86 of farnesyl diphosphate synthase (FPPS) and geranylgeranyl diphosphate synthase (GGPPS), the two enz
87 report the inhibition of a human recombinant geranylgeranyl diphosphate synthase (GGPPSase) by 23 bis
88 oding geranyl diphosphate synthase (LiGPPS), geranylgeranyl diphosphate synthase (LiGGPPS) and farnes
89 t levels two key HGL-DTG biosynthetic genes: geranylgeranyl diphosphate synthase (NaGGPPS) and gerany
90 s the activity of a prenyltransferase family geranylgeranyl diphosphate synthase (product of the subD
91 way by generating combinatorial mutations in geranylgeranyl diphosphate synthase and levopimaradiene
92 ave expressed in Escerichia coli the enzymes geranylgeranyl diphosphate synthase and phytoene synthas
93 tional spruce IDS, a geranyl diphosphate and geranylgeranyl diphosphate synthase in white spruce (Pic
94 acts with a catalytic large subunit, such as geranylgeranyl diphosphate synthase, and determines its
95 e known to serve as inhibitors of the enzyme geranylgeranyl diphosphate synthase, and their activity
96 In contrast, a strain of E. coli carrying geranylgeranyl diphosphate synthase, phytoene desaturase
97 including farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase, that catalyzes the
98 Unlike farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase, which are homodimer
100 the first bifunctional farnesyl-diphosphate/geranylgeranyl-diphosphate synthase identified in eukary
101 o enzymes, farnesyl-diphosphate synthase and geranylgeranyl-diphosphate synthase, required for the pr
103 -erythritol-4-phosphate (MEP) pathway genes, geranylgeranyl diphosphate synthases 3 (GGPPS3) and GGPP
104 ound in polyprenyl synthases including FPPS, geranylgeranyl diphosphate synthases and hexaprenyl diph
105 ll subunit with the phylogenetically distant geranylgeranyl diphosphate synthases from Taxus canadens
106 f amino acid sequence identity (56-75%) with geranylgeranyl diphosphate synthases of plant origin.
107 eam pathways for isopentenyl diphosphate and geranylgeranyl diphosphate synthesis and the downstream
108 This study suggests that, in osteoclasts, geranylgeranyl diphosphate, the substrate for prenylatio
109 tive sites, the first for the cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate an
110 se residues in catalyzing the cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate.
111 andis), is synthesized by the cyclization of geranylgeranyl diphosphate to (-)-abieta-7(8),13(14)-die
112 that was catalytically active in converting geranylgeranyl diphosphate to a diterpene olefin that wa
113 y distinct cyclizations in the conversion of geranylgeranyl diphosphate to a mixture of abietadiene d
114 eaction involving the initial cyclization of geranylgeranyl diphosphate to a transient verticillyl ca
116 g diterpene cyclases that together transform geranylgeranyl diphosphate to ent-kaurene, the olefin pr
117 converts the universal diterpenoid precursor geranylgeranyl diphosphate to syn-CPP catalyzes the comm
118 ynthesis of Taxol involve the cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene fol
119 has been shown to involve the cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene.
120 atalyzes the transfer of a prenyl group from geranylgeranyl diphosphate to the carboxy-terminal cyste
121 oth the protonation-initiated cyclization of geranylgeranyl diphosphate to the intermediate (+)-copal
122 rming the ubiquitous isoprenoid intermediate geranylgeranyl diphosphate to the parent olefin with a t
123 hase) for conversion of the acyclic, achiral geranylgeranyl diphosphate to the polycyclic, chiral abi
124 , converts the universal diterpene precursor geranylgeranyl diphosphate to the stable bicyclic interm
126 ranyl diphosphate, farnesyl diphosphate, and geranylgeranyl diphosphate, to the parent structures of
128 ate from the universal diterpenoid precursor geranylgeranyl diphosphate was also mapped to this same
129 ubation of Ypt1p with PGGTase-II, Msi4p, and geranylgeranyl diphosphate was digested with trypsin.
131 e prenyltransferase domain of PaFS generates geranylgeranyl diphosphate, which the cyclase domain the
132 ega,E,Z-farnesyl diphosphate, or omega,E,E,E-geranylgeranyl diphosphate, with Km values for the allyl
133 or 5',6' bond positions of lycopene but not geranylgeranyl diphosphate, zeta-carotene, or phytoene.