ライフサイエンスコーパス: germline stem cell

1 dult mammalian ovary is devoid of definitive germline stem cells.

2 il to mature, and remain as undifferentiated germline stem cells.

3 inate from early-stage germ cells, including germline stem cells.

4 ains male fertility and is sustained by rare germline stem cells.

5 ring asymmetric divisions of Drosophila male germline stem cells.

6 vival, differentiation, and proliferation of germline stem cells.

7 cell overproliferation and dedifferentiated germline stem cells.

8 not required for the maintenance of ovarian germline stem cells.

9 verge on meiotic RNAs to ensure silencing in germline stem cells.

10 ired (Upd), leading to a concomitant loss of germline stem cells.

11 demonstrated that Ago1 regulates the fate of germline stem cells.

12 re translation of the BMP antagonist Brat in germline stem cells.

13 conserved role in promoting self-renewal of germline stem cells.

14 t does not affect the maintenance of ovarian germline stem cells.

15 e stem cell niche in the aging of Drosophila germline stem cells.

16 s is dependent on the continuous activity of germline stem cells.

17 ired for the maintenance of hub cells or the germline stem cells.

18 esulting from caloric restriction or loss of germline stem cells.

19 preventing inappropriate translation in the germline stem cells.

20 rform transcriptome analysis in mouse female germline stem cells.

21 aining the undifferentiated status of female germline stem cells.

22 ing the fundamental features of mouse female germline stem cells.

23 meiosis-like cytological changes in cultured germline stem cells.

24 ry culture system for Caenorhabditis elegans germline stem cells.

25 e of sexual identity when compared with male germline stem cells.

26 pro-apoptotic Smac/DIABLO orthologue, Hid in germline stem cells.

27 In Drosophila male germline stem cells, ACD is prepared by stereotypical ce

28 Transplantation studies show that germline stem cell activity is confined to the Tert(High

29 Adult germline stem cells (AGSCs) self-renew (Thy1(+) enriched

30 dria partition equally on the spindle during germline stem cell and cystocyte divisions.

31 approach to studying the biology of the male germline stem cell and its microenvironment, the stem ce

32 oss of Miwi2, a mouse Piwi homolog, leads to germline stem cell and meiotic defects correlated with i

33 ing (lola) is required cell autonomously for germline stem cell and somatic cyst stem cell maintenanc

34 atin remodeling factors ISWI and DOM control germline stem cell and somatic stem cell self-renewal in

35 of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell prolife

36 h as Drosophila melanogaster neuroblasts and germline stem cells and mammalian skin stem cells.

37 orientation in Drosophila melanogaster male germline stem cells and neuroblasts has brought into sha

38 niche and germline cells to regulate ovarian germline stem cells and oogenesis.

39 clear genome contributed to death of ovarian germline stem cells and reduced egg production, which wa

40 egation of X and Y chromosomes in Drosophila germline stem cells and shed light on the complex mechan

41 ale-specific expression in early germ cells, germline stem cells and spermatogonia in insects, and it

42 erentiated cells can develop into functional germline stem cells and support normal fertility.

43 s with self-renewal of Drosophila neural and germline stem cells and that equalizing centrosomes disr

44 major cell type in the ovary, including the germline stem cells and their niche cells, follicle stem

45 e find that nuclear localization of Zfrp8 in germline stem cells and their offspring is regulated by

46 s, SC proteins are expressed precociously in germline stem cells and their precursors.

47 lonal expansion, maintained the phenotype of germline stem cells, and reconstituted spermatogenesis i

48 ale-specific expression in early germ cells, germline stem cells, and spermatogonia.

49 contrast, rab11 is required to maintain the germline stem cells, and to maintain the vesicle content

50 Adult germline stem cells are capable of self-renewal, tissue

51 Germline stem cells are key to genome transmission to fu

52 The iswi mutant germline stem cells are lost rapidly because of defects

53 We also propose that C. elegans adult germline stem cells are maintained by proximity to the n

54 s critical for production of male and female germline stem cells, as well as sperm versus eggs.

55 t mitotically dividing germ cells--including germline stem cells--become quiescent in the absence of

56 Germline stem cells begin to differentiate by forming in

57 h niche and intrinsic mechanisms to maintain germline stem cells, but its underlying mechanism remain

58 le, most mpk-1 ATS are iATS in hermaphrodite germline stem cells, but most are cATS in differentiatin

59 ural selection also operates at the level of germline stem cell clones.

60 wed the emergence of competitive somatic and germline stem cell clones.

61 We show that in mice germline stem cells compete for gonad niches, and in mic

62 Although no germline stem cells could be identified by SSEA-1 immuno

63 lls, do not adhere to and migrate along with germline stem cell daughters as previously proposed.

64 y and temporally distinct processes by which germline stem cells differentiate into functional oocyte

65 est not only that mago nashi is required for germline stem cell differentiation but that surprisingly

66 miR-184 controls germline stem cell differentiation by tuning the DPP rec

67 d, resulting in germline loss and a block in germline stem cell differentiation.

68 Germline stem cells divide asymmetrically, producing a s

69 During Drosophila melanogaster oogenesis, a germline stem cell divides forming a cyst of 16 intercon

70 ndings reveal that the genetic regulation of germline stem cell division involves dosage-sensitive me

71 ulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that sig

72 nge of developmental processes, ranging from germline stem cell division to epithelial tissue homeost

73 e opposite effects on Caenorhabditis elegans germline stem cell dynamics: FBF-1 restricts the rate of

74 i-induced/Tai-dependent genes, including the germline stem cell factors nanos and piwi.

75 receptor on adjacent germ cells to maintain germline stem cell fate.

76 In germline stem cells, FBF prevents premature meiotic entr

77 s the lineage-specific enhancers involved in germline stem cell features.

78 Zebrafish female germline stem cell (FGSC) cultures were generated from a

79 the growth and survival of zebrafish female germline stem cells (FGSCs) in culture.

80 ctive oocyte progenitor cells, termed female germline stem cells (fGSCs) or oogonial stem cells (OSCs

81 Here we show that the Drosophila male germline stem cells form previously unrecognized structu

82 a strategy to optimize culture conditions of germline stem cells from other species.

83 both the niche and the environment modulate germline stem cell function.

84 etrically distributed during Drosophila male germline stem cell (GSC) asymmetric division.

85 is, the JAK-STAT signaling pathway regulates germline stem cell (GSC) attachment to the apical hub an

86 In Drosophila testes, each Germline Stem Cell (GSC) contacts apical hub cells and i

87 owed that insulin signals directly stimulate germline stem cell (GSC) division and indirectly promote

88 croRNA (miRNA) pathway for proper control of germline stem cell (GSC) division in Drosophila melanoga

89 During Drosophila oogenesis, germline stem cell (GSC) identity is maintained largely

90 The Drosophila male germline stem cell (GSC) lineage provides a great model

91 In the Drosophila male germline stem cell (GSC) lineage, a key differentiation

92 differentiation genes in the Drosophila male germline stem cell (GSC) lineage.

93 nuclear ribonucleoproteins (hnRNPs) regulate germline stem cell (GSC) maintenance and egg chamber pol

94 ed that mitochondrial fusion is required for germline stem cell (GSC) maintenance in the Drosophila t

95 demonstrated that DBHD is required for male germline stem cell (GSC) maintenance in the fly testis.

96 In Drosophila, germline stem cell (GSC) maintenance requires regulation

97 ng integrates the effects of diet and age on germline stem cell (GSC) maintenance through the dual re

98 in that is intrinsically required for female germline stem cell (GSC) maintenance.

99 BMP) signals released by niche cells promote germline stem cell (GSC) maintenance.

100 methylase 1 (Lsd1) regulates the size of the germline stem cell (GSC) niche in Drosophila ovaries.

101 In the Drosophila melanogaster female germline stem cell (GSC) niche, Decapentaplegic (Dpp), a

102 cans (HSPGs) are essential regulators of the germline stem cell (GSC) niches in the Drosophila melano

103 fic reproductive capacity, suggesting that a germline stem cell (GSC) population drives oocyte produc

104 distinct developmental paths with respect to germline stem cell (GSC) production and the types of dif

105 he exocyst functions in the niche to promote germline stem cell (GSC) progeny differentiation in the

106 ath (IGS) cells form a niche for controlling germline stem cell (GSC) progeny differentiation.

107 n of udd or TAF1B results in reduced ovarian germline stem cell (GSC) proliferation.

108 abditis elegans gonad, the broad outlines of germline stem cell (GSC) regulation are the same for bot

109 this study, we show that DNA damage retards germline stem cell (GSC) self-renewal and progeny differ

110 P) signaling activated by the niche promotes germline stem cell (GSC) self-renewal and proliferation,

111 In the Drosophila ovary, germline stem cell (GSC) self-renewal is controlled by b

112 gaster ovary, some intrinsic factors promote germline stem cell (GSC) self-renewal, whereas others st

113 The transition from a Drosophila ovarian germline stem cell (GSC) to its differentiated daughter

114 he, comprising ten hub cells, maintains both germline stem cells (GSC) and somatic stem cells (CySC).

115 ural stem cells (neuroblasts [NBs]) and male germline stem cells (GSCs) [1-3].

116 We found that germline stem cells (GSCs) actively modulate lipid hydro

117 molog String (Stg) is a crucial regulator of germline stem cells (GSCs) and cyst stem cells (CySCs) i

118 ate the self-renewal and maintenance of male germline stem cells (GSCs) and discuss how these factors

119 Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains

120 We previously showed that germline stem cells (GSCs) and follicle stem cells (FSCs

121 We show that Drosophila female germline stem cells (GSCs) and neuroblasts assemble cent

122 ystems for studying stem cell behavior, with germline stem cells (GSCs) and somatic cyst stem cells (

123 pathway in two adjacent types of stem cells: germline stem cells (GSCs) and somatic cyst stem cells (

124 rosophila testes, two stem cell populations, germline stem cells (GSCs) and somatic cyst stem cells (

125 , is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (

126 essor that regulates the competition between germline stem cells (GSCs) and somatic cyst stem cells (

127 ide the behavior and differentiation of both germline stem cells (GSCs) and somatic follicle stem cel

128 Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signali

129 For example, Drosophila ovarian germline stem cells (GSCs) are maintained by exquisitely

130 Throughout the cell cycle, centrosomes in germline stem cells (GSCs) are oriented within their nic

131 Drosophila male and female germline stem cells (GSCs) are sustained by niches and r

132 ntified delayed completion of cytokinesis in germline stem cells (GSCs) as a mechanism that regulates

133 Drosophila male germline stem cells (GSCs) attach to somatic hub cells,

134 enty-hydroxyecdysone (20E) regulates ovarian germline stem cells (GSCs) but was considered dispensabl

135 It was proposed that somatic Piwi maintains germline stem cells (GSCs) by promoting Dpp signaling, p

136 Germline stem cells (GSCs) circulate in the blood and mi

137 large-scale RNAi screen in Drosophila female germline stem cells (GSCs) covering approximately 25% of

138 In Drosophila, germline stem cells (GSCs) descend from a subset of prim

139 In Drosophila ovaries, germline stem cells (GSCs) divide asymmetrically to prod

140 Drosophila male germline stem cells (GSCs) divide asymmetrically, balanc

141 In Caenorhabditis elegans, ablation of germline stem cells (GSCs) extends lifespan, but also in

142 We developed a method to highly purify germline stem cells (GSCs) from the Drosophila ovary, on

143 Fmr1 is required for controlling the fate of germline stem cells (GSCs) has gone unanswered.

144 Drosophila ovarian germline stem cells (GSCs) have been one of the most pro

145 ing to be identified, but Drosophila oogenic germline stem cells (GSCs) have emerged as an important

146 In the Drosophila ovary, two or three germline stem cells (GSCs) have recently been shown to r

147 Studies of Drosophila male germline stem cells (GSCs) have served as a paradigm in

148 Drosophila female germline stem cells (GSCs) have short G1 and long G2 pha

149 morphogenetic protein (BMP) ligands maintain germline stem cells (GSCs) in an undifferentiated state.

150 Germline stem cells (GSCs) in Drosophila are descendants

151 Male germline stem cells (GSCs) in Drosophila melanogaster di

152 sion is required for the maintenance of male germline stem cells (GSCs) in Drosophila melanogaster.

153 Here we address the division frequency of Germline Stem Cells (GSCs) in testes of Drosophila melan

154 Germline stem cells (GSCs) in the Drosophila ovary provi

155 and functions in the niche cells to maintain germline stem cells (GSCs) in the Drosophila ovary.

156 intrinsically required in the regulation of germline stem cells (GSCs) in the Drosophila ovary.

157 Germline stem cells (GSCs) in the Drosophila testis are

158 Germline stem cells (GSCs) in the Drosophila testis have

159 identified an early consequence of aging in germline stem cells (GSCs) in the Drosophila testis.

160 ulates the number and asymmetric division of germline stem cells (GSCs) in the Drosophila testis.

161 In the Drosophila ovary, germline stem cells (GSCs) in the niche continuously sel

162 Germline stem cells (GSCs) must express components of th

163 Here, we challenge the male germline stem cells (GSCs) of Drosophila melanogaster fo

164 The germline stem cells (GSCs) of the Drosophila ovary maint

165 he germarium form an environmental niche for germline stem cells (GSCs) of the Drosophila ovary.

166 Drosophila melanogaster male germline stem cells (GSCs) possess a checkpoint, termed

167 We show that Drosophila female germline stem cells (GSCs) provide a powerful system for

168 The niche for germline stem cells (GSCs) provides a Dpp/Bmp signal, wh

169 In Drosophila females, germline stem cells (GSCs) require Sex lethal (Sxl) to e

170 Drosophila female germline stem cells (GSCs) reside adjacent to a cellular

171 The Drosophila germline stem cells (GSCs) reside in a somatic cell nich

172 Our previous work showed that germline stem cells (GSCs) respond to diet via neural in

173 apical tip of the Drosophila testis, 8 to 10 germline stem cells (GSCs) surround the hub, a cluster o

174 sion of somatic gonad blast cells (SGBs) and germline stem cells (GSCs) to be quiescent or progress d

175 lized the ability of Drosophila melanogaster germline stem cells (GSCs) to survive exposure to low do

176 dult males do indeed possess a population of germline stem cells (GSCs) with properties similar to th

177 adult testis and ovary in Drosophila contain germline stem cells (GSCs) with well-defined niches, and

178 2), is required to maintain a stable pool of germline stem cells (GSCs) within the niche microenviron

179 ds to an increase in the mitotic activity of germline stem cells (GSCs), as well as a decrease in pro

180 Many stem cells, including Drosophila germline stem cells (GSCs), divide asymmetrically, produ

181 asymmetric cell division of Drosophila male germline stem cells (GSCs), histones H3 and H4 are asymm

182 ld" versus "new" histones in Drosophila male germline stem cells (GSCs), we show that preexisting can

183 In the Drosophila ovary, germline stem cells (GSCs), which are adjacent to cap ce

184 Germline stem cells (GSCs), which can self-renew and gen

185 he apical hub form the niche for neighboring germline stem cells (GSCs), with CySCs as the proposed s

186 on the mother centrosome in Drosophila male germline stem cells (GSCs).

187 vary control the number and proliferation of germline stem cells (GSCs).

188 organization of the niche that supports the germline stem cells (GSCs).

189 nd segregation during ACD of Drosophila male germline stem cells (GSCs).

190 , except for a small population of protected germline stem cells (GSCs).

191 te the cell cycle in Drosophila melanogaster germline stem cells (GSCs).

192 ing on regulators of adult Drosophila testis germline stem cells (GSCs).

193 ide in vivo RNAi screen in female Drosophila germline stem cells (GSCs).

194 the stem cell centrosome in Drosophila male germline stem cells (GSCs).

195 ber, ophis, that controls differentiation of germline stem cells (GSCs).

196 ing a reduced pool of actively proliferating germline stem cells (GSCs).

197 would affect the maintenance of stem cells (germline stem cells, GSCs; somatic stem cells, SSCs) in

198 assay system to unequivocally identify male germline stem cells has allowed their in vitro culture,

199 ell systems, including embryonic stem cells, germline stem cells, hematopoietic stem cells, and intes

200 ions between embryonic stem cells and female germline stem cells identifies the lineage-specific enha

201 preventing them from displacing neighboring germline stem cells in a manner that depends on the adhe

202 Our data do not support the existence of germline stem cells in adult human ovaries, thereby rein

203 effector protein TomO, which maintains host germline stem cells in an undifferentiated state.

204 s distal tip cell (DTC) provides a niche for germline stem cells in both hermaphrodites and males.

205 piwi mutants fail to maintain germline stem cells in both male and female gonads.

206 Our studies of circulating competing germline stem cells in colonial protochordates led us to

207 Pumilio controls germline stem cells in Drosophila females, and, in lower

208 A motor protein called Klp10A ensures that germline stem cells in male fruit flies divide to produc

209 n of cystoblasts, the committed daughters of germline stem cells in the Drosophila ovary.

210 As we discuss here, after emerging from germline stem cells in the fetus, they grow in a follicu

211 Here we report that FBF also controls germline stem cells: in an fbf-1 fbf-2 double mutant, ge

212 A new study shows that escaped germline stem cells induce nearby muscle cells to reach

213 A pool of proliferating germline stem cells is essential for gamete production i

214 n invertebrates, the proliferation of female germline stem cells is regulated by nutritional status.

215 However, in mammals, the number of female germline stem cells is set early in development, with oo

216 ion (Jak-STAT) pathway maintains stem cells; germline stem cells lacking Jak-STAT signaling different

217 However, germline stem cells lacking tsunagi/Y14 function are ind

218 promises activation of Dpp signalling within germline stem cells, leading to germline stem cell loss.

219 on to differentiation in the Drosophila male germline stem cell lineage is mediated by translational

220 Here, we show in the Drosophila male germline stem cell lineage that a spermatocyte-specific

221 fate decisions within the Drosophila ovarian germline stem cell lineage.

222 vent marking onset of differentiation in the germline stem cell lineage.

223 lling within germline stem cells, leading to germline stem cell loss.

224 Interactions between the distal tip cell and germline stem cells maintain a proliferative pool of mit

225 It has been suggested that germline stem cells maintain oogenesis in postnatal mous

226 ntermingled cells, which contributes to both germline stem cell maintenance and differentiation niche

227 It is important for germline stem cell maintenance and gametogenesis in male

228 involved in germline-specific events such as germline stem cell maintenance and meiosis.

229 ntrol machinery regulate the balance between germline stem cell maintenance and the differentiation o

230 Despite the early expression of Mov10l1, germline stem cell maintenance appears unaffected in Mov

231 TAT pathway maintains the niche required for germline stem cell maintenance in the testis, providing

232 in a number of defects, including a loss of germline stem cell maintenance, mispositioning of the oo

233 ast, Hbs1 mutants have no obvious defects in germline stem cell maintenance.

234 ne loss, revealing a function for Yb in male germline stem cell maintenance.

235 kine signaling 36E (SOCS36E) is required for germline stem cell maintenance.

236 es not reduce follicle cell proliferation or germline stem cell maintenance.

237 n through meiosis during spermatogenesis and germline stem cell maintenance.

238 at least 3R-TAS1 piRNA and is essential for germline stem-cell maintenance.

239 as well as partly rescuing their defects in germline stem-cell maintenance.

240 eq, by characterizing Caenorhabditis elegans germline stem cell mutation accrual and asking how matin

241 A new study on the Drosophila testicular germline stem cell niche has revealed that BMP signaling

242 The male germline stem cell niche in Drosophila houses two stem c

243 rotrusions of the distal tip cell (DTC), the germline stem cell niche in the gonad.

244 de in the gonadal distal tip cell (DTC), the germline stem cell niche, where it negatively regulates

245 nd the TGF-beta receptor pathway acts in the germline stem cell niche.

246 ts negatively on Notch to restrict the ovary germline stem cell niche.

247 -1(0);fbf(RNAi) animals failed to maintain a germline stem cell niche.

248 In neural and germline stem cells, Nin localizes asymmetrically to the

249 highest expression in hub cells, a niche for germline stem cells of testis.

250 ocus is Notch regulation of transcription in germline stem cells of the nematode C. elegans.

251 istent with separate lineages of somatic and germline stem cells or pluripotent stem cells that diffe

252 ister chromatid segregation is randomized in germline stem cell overproliferation and dedifferentiate

253 Germline stem cells play an essential role in establishi

254 e to modulate developmental expansion of the germline stem cell pool.

255 In Drosophila, a small germline stem cell population is influenced by a complex

256 st germline proliferation that builds up the germline stem cell population; and (2) distinct insulin-

257 d nanotubes are observed specifically within germline stem cell populations, and require intraflagell

258 This limits germline stem cell predation to kin, as the locus has hu

259 The removal of germline stem cells preserves jmjd-3.1 expression, suppr

260 The mago nashi null germline stem cells produce clones over a period of at l

261 re required for the late larval expansion of germline stem cell progenitors in the C. elegans gonad.

262 best known for maintaining undifferentiated germline stem cells/progenitors.

263 allel to Notch signaling, a key regulator of germline stem cell proliferation and differentiation.

264 nstrate here that differential regulation of germline stem cell proliferation rates in Caenorhabditis

265 different contexts [5], but its function in germline stem cell proliferation remains poorly understo

266 Fertility depends on germline stem cell proliferation, meiosis and gametogene

267 ere, we describe a function for autophagy in germline stem cell proliferation.

268 receptor (IIR) signaling pathway to promote germline stem cell proliferation.

269 egardless of their systemic levels, to block germline stem cell proliferation.

270 e fundamental properties of mammalian female germline stem cells remain poorly understood.

271 Notably, when oocytes are depleted, but germline stem cells remain, adult females sex-revert to

272 but not the inappropriate differentiation of germline stem cells, requires the function of the cell d

273 spermatogonia, the mitotic population where germline stem cells reside.

274 exists an exchange of somatic stem cells and germline stem cells, resulting in somatic chimeras and s

275 ntiating progeny, whereas the neuroblast and germline stem cells retain HNE during division.

276 classical mouse mutant luxoid affects adult germline stem cell self-renewal.

277 ntinued production of oocytes by maintaining germline stem cells self-renewal.

278 n, in differentiating daughter cells renders germline stem cells sensitive to IR, suggesting that the

279 found to be necessary for the maintenance of germline stem cells, shows that Stwl is present in a pun

280 ial primordial follicle pool supplemented by germline stem cells (stem cell model).

281 ent deprivation leads to G2 arrest of animal germline stem cells, suggest that carbohydrate availabil

282 legans FBF are essential for self-renewal of germline stem cells, suggesting that a common function o

283 ordial germ cells arise from piwi-expressing germline stem cells that are distinct from somatic stem

284 Spermatogonia are adult germline stem cells that can both self-renew and differe

285 Germline stem cells that produce oocytes in vitro and fe

286 n contains at least one apparently bona fide germline stem cell, the majority of cells exhibit an int

287 While both contain germline stem cells, the testis niche also contains "cys

288 xpression is a fundamental characteristic of germline stem cells, thus explaining the broad dependenc

289 es, suggest that Sxl enables the switch from germline stem cell to committed daughter cell by posttra

290 dUTX also acts in germline stem cells to maintain hub structure through re

291 hat help explain its dual role in regulating germline stem cell totipotency and embryonic cell fate s

292 ymmetrically in Drosophila melanogaster male germline stem cells undergoing asymmetric division.

293 methylation primarily contributes to female germline stem cell unipotency by suppressing the somatic

294 Here, we show that dividing Drosophila male germline stem cells use intracellular mechanisms involvi

295 tigate the Notch transcriptional response in germline stem cells using single-molecule fluorescence i

296 Highly successful germline stem cells usually outcompete less successful c

297 ll that plays a crucial role in signaling to germline stem cells via the Notch signaling pathway.

298 , male viability, and maintenance of ovarian germline stem cells, whereas H3K27 was essential for lat

299 eport cellular analyses designed to identify germline stem cells within the germline mitotic region o

300 elegans Notch signaling maintains a pool of germline stem cells within their single-celled mesenchym