ライフサイエンスコーパス: ginsenoside

1 ontains a lot of bioactive compounds such as ginsenosides.

2 CCS, and some MS/MS fragments) for 579 known ginsenosides.

3 Ginsenoside 20(S)-Rg3 (Rg3) is a steroid glycoside that

4 Ginsenoside 20(S)-Rg3 [Rg3; (2S,3R,4S,5S,6R)-2-[(2R,3R,4

5 Ginsenoside-20(S)-Rg3, containing a disaccharide group (

6 ndings, with bilobetin (-61.72 kcal/mol) and ginsenosides (-47.91 kcal/mol) showing substantially str

7 uctural information could help differentiate ginsenosides and their isomers, enabling more accurate i

8 howed minor potentiation of ATP responses by ginsenosides, and insensitivity to ATP(-) or ATP(+) gins

9 Ginsenosides are active as positive allosteric modulator

10 ively, these results highlight bilobetin and ginsenosides as promising natural inhibitors of CK2 and

11 te of zfP2X4, yielded evidence of a putative ginsenoside binding site in P2X4 in the central vestibul

12 from three diverse plant species, including ginsenoside biosynthesis in ginseng (Panax ginseng C.A.

13 onse to high concentrations of ATP, and that ginsenosides can enhance this process.

14 Potentiation of ATP-mediated responses by ginsenosides CK and Rd caused enhanced ionic currents, C

15 Ginsenosides CK and Rd were demonstrated to enhance ATP

16 Ginsenoside-F1, highly similar to ginsenoside-CK but containing a single additional hydrox

17 potentiation of ATP-induced cell death with ginsenoside-CK in THP-1 and HEK-hP2X7 cells.

18 highest positive modulator activity was with ginsenoside-compound K (CK), containing a monosaccharide

19 udy, we constructed a compendium of purified ginsenoside compounds from Panax ginseng C.A. Meyer, whi

20 Ginsenosides containing monosaccharide attachments perfo

21 molecular docking, among which bilobetin and ginsenosides demonstrated the most favorable binding aff

22 on medium of G. lucidum to produce bioactive ginsenoside enriched biotransformation products.

23 Ginsenoside-F1, highly similar to ginsenoside-CK but con

24 and Sanqi ginseng revealed distinct "sterol ginsenoside" fingerprints, especially in the ratio betwe

25 Rb1, a ginsenoside from ginseng root extract, possesses antiang

26 Accuracy in identifying ginsenosides from diverse ginseng products was greatly i

27 estigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allos

28 Ginsenosides from Panax ginseng have been discovered to

29 The results demonstrate that some of the ginsenosides have neuroprotective activity, and that a p

30 Ginsenoside Rd is the major ginsenoside in the final fermentation product.

31 The changes of ginsenosides in the fermentation products were analysed

32 a dozen biologically active saponins called ginsenosides, including one present in only trace amount

33 sides, and insensitivity to ATP(-) or ATP(+) ginsenoside-induced cell death, indicating a primary rol

34 Accurate characterization of Panax herb ginsenosides is challenging because of the isomers and l

35 isolated from ginseng and found that certain ginsenosides lowered Abeta concentration in a dose-depen

36 a local health food store and analyzed for 7 ginsenosides (marker compounds for Panax species, which

37 ts indicate that ginseng itself, or purified ginsenosides, may have similarly useful effects in human

38 , a multidimensional information library for ginsenosides, namely GinMIL, was established by predicti

39 Another ginsenoside often used to distinguish Asian and North Am

40 y data suggest that no substances other than ginsenosides or eleutherosides were extracted from the p

41 s, identifying new medicinal agents, such as ginsenoside Rb1 (Rb1) as reported here, offers exciting

42 Additionally, the antioxidants ginsenoside Rb1 and ginkgolide A effectively reversed HA

43 tocopherol, Alpha lipoic acid, Orotic acid, Ginsenoside RB1, and Xanthohumol in this study, based on

44 report that the active component of ginseng, ginsenoside Rb1, suppresses NLK expression and improves

45 Ginsenoside Rb1-mediated suppression of NLK occurs throu

46 We also compare ginsenoside Rb1-mediated upregulation of miR-208 with me

47 ed in animals pretreated with the individual ginsenosides, Rb1, Rb3, or Rd.

48 In conclusion, ginsenosides Rb3 and Rd exerted anti-cancer effects by h

49 non-toxic doses of the triterpene saponins (ginsenoside-Rb3 and ginsenoside-Rd) - as prebiotics - th

50 Ginsenoside Rd (Rd) is a bioactive compound predominantl

51 Ginsenoside Rd is the major ginsenoside in the final fer

52 the triterpene saponins (ginsenoside-Rb3 and ginsenoside-Rd) - as prebiotics - that effectively reins

53 Additional studies demonstrated that ginsenoside Re plays a significant role in antihyperglyc

54 This antidiabetic effect of ginsenoside Re was not associated with body weight chang

55 eng berry extract and its major constituent, ginsenoside Re, in obese diabetic C57BL/6J ob/ ob mice a

56 cantly increased, especially Rd, while other ginsenosides (Re, Rb1 and Rc) decreased during fermentat

57 -Rg3, a triterpene natural compound known as ginsenoside, reduced Abeta levels in cultured primary ne

58 nseng products for the presence and ratio of ginsenoside Rf and 24(R)-pseudoginsenoside F11 may be us

59 n the baseline chromatographic separation of ginsenoside Rf and 24(R)-pseudoginsenoside F11, two pote

60 The limit of detection of ginsenoside Rf or 24(R)-pseudoginsenoside F11 was 120 pg

61 In Asian ginseng roots, the ratio of ginsenoside Rf to 24(R)-pseudoginsenoside F11 exceeded 7

62 istinguish Asian and North American ginseng, ginsenoside Rf, was found in abundance in Asian ginseng

63 ing one present in only trace amounts called ginsenoside-Rf (Rf).

64 Composed of Ginsenoside Rg1 and Geniposide, the herbal medicine Tong

65 The ginsenoside Rg1 is a novel natural antioxidant isolated

66 s showed that after 30 days of fermentation, ginsenoside Rg1, Rd, and compound K (CK) significantly i

67 und that three of these isolated components, ginsenoside Rg1, Rg3, and RE, resulted in significant re

68 Some natural products, including ginsenoside Rg3 (Rg3), exhibit robust antioxidant activi

69 oncentration in a dose-dependent manner with ginsenoside Rg3 having an approximate IC50 of under 25 m

70 Diastereomers of ginsenoside-Rg3 and ginsenoside-Rh2 demonstrate the impo

71 Thus, we have identified 20(R)-ginsenoside Rh(2) as a p27(Kip1) inhibitor that may be d

72 In zebrafish and mammalian models, 20(R)-ginsenoside Rh(2) enhanced muscle cell proliferation and

73 20(R)-ginsenoside Rh(2) increased viability in myoblasts and c

74 that enhance cell viability, of which 20(R)-ginsenoside Rh(2) showed the most robust response.

75 Diastereomers of ginsenoside-Rg3 and ginsenoside-Rh2 demonstrate the importance of the locati

76 Pretreatment of nude mice with oral ginsenoside Ro followed by HT29 intravenous inoculation

77 HT29 intravenous inoculation and 40-day oral ginsenoside Ro significantly prevented lung metastasis w

78 Among them, ginsenoside Ro was the most potent in inhibiting embryon

79 and stems, which contains greater levels of ginsenosides than ground root, improved the behavioral s

80 simulations revealed that bilobetin-CK2 and ginsenosides-ULK2 complexes maintained stable conformati

81 ct-to-product variability: concentrations of ginsenosides varied by 15- and 36-fold in capsules and l

82 Furthermore, the biotransformation of ginsenosides was the major reaction in this fermentation

83 the extracts using distinct ratios of the 2 ginsenosides, we demonstrate that the dominance of Rg1 l

84 iring G-proteins, whereas a variety of other ginsenosides were relatively ineffective.