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1 e conclusion that each of them encodes a XyG glucan synthase.
2 ive to caspofungin, an inhibitor of beta-1,3-glucan synthase.
3 n, an antifungal drug that inhibits beta-1,3-glucan synthase.
4 nd for activity and regulation of beta(1-->3)glucan synthase.
5 h the cell wall biosynthesis enzyme beta-1,3-glucan synthase.
6 ene, ags1(+), which encodes a putative alpha-glucan synthase.
7 activation of FKS2, which encodes a beta-1,3 glucan synthase.
8 se resistant mutants may have alterations in glucan synthase.
9 utative (HvCslF3 and HvCslF9) (1,3;1,4)-beta-glucan synthases.
10 r aspergilli by targeting cell wall 1,3-beta-glucan synthases.
11 over a wide range of related processive beta-glucan synthases.
12 ce blocks conserved in 28 known or predicted glucan synthases.
13 al., 1999) with a D277N substitution in beta-glucan synthase 1 (Cps1/Bgs1) was reported to arrest wit
14 candins, which noncompetitively inhibit beta-glucan synthase, a membrane-bound protein complex that c
16 ent report that pgs1Delta cells have reduced glucan synthase activity and diminished levels of Fks1p,
20 entified and implicated in the regulation of glucan synthase activity from Candida albicans, Aspergil
22 ylation of Rho1p by exoenzyme C3 inactivates glucan synthase activity specified by FKS1 and FKS2 as d
23 ty to other antifungal agents; (ii) in vitro glucan synthase activity that is more resistant to pneum
25 ding protein Rho1 is required for beta(1-->3)glucan synthase activity, for activation of protein kina
31 n yeast Schizosaccharomyces pombe, the alpha-glucan synthase Ags1 produces alpha-1,3-glucan chains es
32 cooperation between the alpha- and beta(1-3)glucan synthases Ags1 and Bgs for cell wall and septum a
33 oxidative stress, and regulation of the Fks1 glucan synthase, all of which play critical roles in vir
34 ponent of the yeast cell wall, beta(1-->3)-D-glucan synthase (also known as 1,3-beta-glucan synthase)
35 combined with co-expression of heterologous glucan synthase and a glucan branching enzyme, may in fu
36 cell wall synthesis (FKS1 encoding beta-1,3-glucan synthase and CHS3 encoding chitin synthase) can s
37 and arabinosyltransferases, a mixed-linkage glucan synthase and hydroxycinnamate acyltransferases.
38 ts roles as a positive regulator of 1,3-beta-glucan synthase and of the cell integrity MAP kinase cas
39 y with the well-characterized yeast beta-1,3-glucan synthase and transgenic plant cells over-expressi
40 rified with plasma membrane markers 1,3 beta-glucan synthase and vanadate-sensitive ATPase, indicatin
41 ed sequence homology with the yeast 1,3-beta-glucan synthases and is distinct from plant cellulose sy
42 major cell wall-related genes such as FKS1 (glucan synthase) and mutations in any of the Golgi glyco
43 mutants were defective in GTP stimulation of glucan synthase, and the defect was corrected by additio
44 i-associated synthases, (1-->3),(1-->4)-beta-glucan synthase behaves as a topologic equivalent of cel
46 Sid2p/Mob1p and Clp1p phosphatase, and beta-glucan synthase Bgs1p accumulated slowly at the cleavage
47 st complex to tether vesicles containing the glucan synthases Bgs4 and Ags1 along the cleavage furrow
48 involve allosteric activation of the ML beta-glucan synthase BgsA by c-di-GMP binding to its C-termin
50 up of antifungal agents that target 1,3-beta-glucan synthase, causing disruption of mold growth at ce
51 idopsis (Arabidopsis thaliana), the 1,4-beta-glucan synthase, Cellulose Synthase-Like C4 (CSLC4), and
52 KS1 and FKS2 are alternative subunits of the glucan synthase complex, which is responsible for synthe
54 reduced maximum catalytic capacity of their glucan synthase complexes and thicker cell walls attribu
55 bor an S645Y mutation in the CaFks1 beta-1,3 glucan synthase drug target, suggesting potential therap
56 he biochemical activity of membrane spanning glucan synthases encoded by the CSLH and CSLF cellulose
57 ts identify the membrane-spanning subunit of glucan synthase, encoded by the FKS genes, as the molecu
58 Post-transcriptional inhibition of alpha-1,3-glucan synthase expression, using double-stranded RNA in
59 specifically defective in activation of the glucan synthase Fks1/2 does not internalize alpha-factor
61 to regulate the accumulation and dynamics of glucan synthases for successful septum formation in cyto
62 ions in the Candidozyma (Candida) auris beta-glucan synthase gene (FKS1) altering S639 are frequently
64 We functionally characterized the beta-1,3-glucan synthase gene GLS1 of the maize (Zea mays) pathog
65 Cryptococcal cells disrupted in their alpha glucan synthase gene were sensitive to stresses, includi
67 able putative catalytic subunits of 1,3-beta-glucan synthase (GS), an enzyme that synthesizes an esse
68 functional P. carinii kre6 (Pckre6) beta-1,6 glucan synthase in Pneumocystis that, when expressed in
72 ynthesis, exhibits synergy with the beta-1,3 glucan synthase inhibitor caspofungin or the calcineurin
73 ce were treated with caspofungin, a beta-1,3-glucan synthase inhibitor that is known to reduce the nu
74 synthase inhibitor), caspofungin (a beta-1,3-glucan synthase inhibitor), or FK506 (a calcineurin inhi
75 p, a novel, first-in-class oral triterpenoid glucan synthase inhibitor, has demonstrated broad fungic
77 fficient, new, and scalable semisynthesis of glucan synthase inhibitors 1 and 2 from the fermentation
79 glucan, and treatment of PcP with beta-1,3-D-glucan synthase inhibitors, such as anidulafungin, resul
80 ing (i) cross-resistance to other 1,3-beta-D-glucan synthase inhibitors, such as papulacandin and ech
81 mple, the mixed-linkage (1-->3)(1-->4)beta-D-glucan synthase is found specifically in grasses and pos
85 CHOR encodes a putative callose synthase, GLUCAN SYNTHASE-LIKE 8 (GSL8), that is required for call
86 polymerase chain reaction of transcripts for GLUCAN SYNTHASE-LIKE, Cellulose Synthase, and CELLULOSE
89 zymatic properties of the mixed-linkage beta-glucan synthases not only provide special insight into t
90 from reduced activity against C. neoformans glucan synthase or from yet undiscovered mechanisms of a
91 1 also serves as a regulatory subunit of the glucan synthase, our results define a regulatory circuit
92 of FKS2, the alternate catalytic subunit of glucan synthase, partially restoring glucan synthase act
93 Deletion of KRE6a, which encodes beta-1,6-glucan synthase, reduces echinocandin susceptibility in
94 3)-D-glucan synthase (also known as 1,3-beta-glucan synthase), requires a guanosine triphosphate (GTP
96 Rho1p was found to copurify with Fks1p, a glucan synthase subunit, in preparations of the enzyme p
97 re similar to the effects of inhibiting beta-glucan synthase, suggesting that the abnormal cell wall
98 catalytic domain of the (1-->3),(1-->4)-beta-glucan synthase synthesizes cellotetraosyl units and hig
99 a) CSLD3 is a UDP-glucose-dependent beta-1,4-glucan synthase that forms protein complexes displaying
100 the gene responsible for encoding 1,3-beta-d-glucan synthase that is a target for echinocandins.
101 ho1, is required for activity of beta (1-->3)glucan synthase, the enzyme that catalyzes the synthesis
104 at collaborate nonredundantly with the alpha-glucan synthase to build a properly organized alpha-gluc
105 ed RNAi targeting AGS1 (encoding alpha-(1,3)-glucan synthase) to deplete levels of alpha-(1,3)-glucan
106 aydis class VII chitin synthase and 1,3-beta-glucan synthase travel in Mcs1-containing vesicles, and
107 s1p were co-immunoprecipitated from purified glucan synthase under conditions that maintained enzyme
108 ose that cytosolic glucan synthesized by the glucan synthase was immediately hydrolysed to maltose by
110 hot spot" regions of FKS-encoded subunits of glucan synthase, which decreases the sensitivity of enzy