ライフサイエンスコーパス: gluco

1 configuration binding more tightly than the gluco.

2 cosidase enzymes and compared with natural d-gluco-1-deoxynojirimycin (DNJ).

3 terification of the epoxide derived from the gluco-[13]-macro-dilactone.

4 ontaining mixed-valent Fe1(III)(mu-OH(-))(mu-GluCO(2)(-))(2)Fe2(II) and Fe1(II)(mu-GluCO(2)(-))(2)Fe2

5 -))(mu-GluCO(2)(-))(2)Fe2(II) and Fe1(II)(mu-GluCO(2)(-))(2)Fe2(III)-OH(-) cores.

6 lactose, (2) 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose,

7 ose, and (3) 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-6-O-sulfo-D-galactose,

8 harides, (1) 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-galactose, (2) 2-acet

9 Intestinal infusion with di(glucos-6-yl)poly(ethylene glycol) 600 led to induction o

10 membrane impermeable d-glucose analogue, di(glucos-6-yl)poly(ethylene glycol) 600, was synthesized a

11 so with its alpha-d-manno (84%), and alpha-d-gluco (92%) counterparts used as negative controls.

12 model compounds that mimic alpha-gluco, beta-gluco, alpha-allo, and beta-allo 2-acetamido-2-deoxy-D-a

13 Non-digestible dietary galacto- and gluco-alpha-(1,6)-oligosaccharides from legumes and star

14 s were established for the synthesis of beta-gluco and alpha- and beta-manno-configured phostones of

15 n of 1,2- trans-beta-glycosides with both d- gluco and d- galacto donors, whereas poorly reactive acc

16 trend among glycosyl bromide donors of the d-gluco and d-manno series was observed.

17 on, enforcing a gauche,trans conformation in gluco and galactopyranosides.

18 ituted iminosugars of both configurations (D-gluco and L-ido) with the aim to introduce structural fe

19 previous work, we synthesized a series of D-gluco and L-ido-configured iminosugars N-modified with a

20 ity of both lectins to differentiate between gluco and manno diastereomers was diminished in the C-gl

21 We show that the side chains of gluco and manno iminosugars can be restricted to predomi

22 ly different stereoselectivities in both the gluco and manno, but not the galacto series.

23 nd to the alpha and beta anomers of methyl D-gluco- and D-galactopyranoside as guests.

24 BCE) reaction applied for chirons from the d-gluco- and d-manno-series and provides derivatives with

25 ntiate our findings, we synthesized both the gluco- and galacto-configured 3-GDIs and characterized t

26 tive generation of Ferrier adducts from both gluco- and galacto-configured glycals.

27 oducts of catalysis and in complex with both gluco- and galacto-configured inhibitors O-(2-acetamido-

28 sets of interaction were maintained with the gluco- and galacto-configured inhibitors, the inhibition

29 nyl thioglycosides of 2-azido-2-deoxy-beta-d-gluco- and galactopyranosides from d-N-acetylglucosamine

30 ve evolved to discriminate primarily between gluco- and galactopyranosides.

31 ercise in mammals, with hepatic and muscular gluco- and glyconeogenesis contributing to a lesser exte

32 g finger protein-1 (MuRF1) protected against gluco- and lipotoxicity-induced apoptosis.

33 Both GTDF and metformin protected against gluco- and lipotoxicity-induced osteoblast apoptosis, an

34 ammonium phosphonite-borane complexes in the gluco- and manno-like series have been developed from P(

35 roved strategy for the synthesis of P-chiral gluco- and manno-phosphonite-borane complexes is describ

36 O-benzyl-4,6-O-benzylidene-protected 3-deoxy-gluco- and mannopyranosyl thioglycosides is highly stere

37 2 and BPS were metabolized into a variety of gluco- and sulfo-conjugated metabolites.

38 inding protein which recognizes alpha-linked gluco-and manno-pyranosyl groups of polysaccharide chain

39 stereoselectivity of couplings to galacto-, gluco-, and mannopyranosyl thioglycosides, otherwise pro

40 Previously, antibodies specific to a gluco-asparagine (N-Glc) glycopeptide, CSF114(N-Glc), we

41 nts in four model compounds that mimic alpha-gluco, beta-gluco, alpha-allo, and beta-allo 2-acetamido

42 llenging glycosidic linkages including alpha-gluco, beta-manno, and beta-rhamno have seen obtained wi

43 nd WP400 (2'-bromo-4'-epidaunorubicin, alpha-gluco configuration), is significantly less cytotoxic.

44 The galacto/gluco configurational change takes place at the level of

45 Gluco-configured macro-dilactones gave the R, R epoxide,

46 ls have revealed an inverse relation between gluco-corticoid levels and hippocampus volumes.

47 Their D-gluco-counterparts are also potent inhibitors of intesti

48 ds from simple sugar precursors, including d-gluco-, d-galacto-, and d-mannopyranoside derivatives, i

49 ner-like intake of glucose during subsequent gluco-deprivation.

50 was acetylated prior to isolation while the gluco-dialdehyde afforded a mixture of three stereoisome

51 The reduced affinity of D-gluco-dihydroacarbose (K1 = 10(-8) M) relative to acarbo

52 var. X100 with the pseudotetrasaccharides D-gluco-dihydroacarbose and acarbose have been refined to

53 ic contacts between the nonreducing end of D-gluco-dihydroacarbose and the catalytic water perturb Wa

54 ational distortion of the first residue of D-gluco-dihydroacarbose is consistent with the generation

55 In the case of D-gluco-dihydroacarbose the shift in the position of the 6

56 f the nonreducing end of both acarbose and D-gluco-dihydroacarbose toward a more axial position.

57 For the d-glycero-d-gluco donor, on the other hand, modest axial selectivity

58 ghly favored as they are with an l-glycero-d-gluco donor.

59 - galacto donors but are unselective with d- gluco donors.

60 configuration, ranging from 1.5 to 13, with gluco exhibiting the smallest ratio and gulo the largest

61 In the d- and l-glycero-d-gluco glycosyl donors, the l-glycero-d-gluco isomer with

62 ide derivative of the 6-O-methyl-D-glycero-L-gluco-heptopyranose residue found in the Campylobacter j

63 or l-glycero-d-galacto and d- or l-glycero-d-gluco heptopyranosyl sulfoxides and the influence of the

64 GDP-6-deoxy-D-altro-heptose and GDP-6-OMe-L-gluco-heptose in Campylobacter jejuni.

65 we show that WcaGNCTC is not necessary for L-gluco-heptose synthesis and does not affect its producti

66 dation for elucidation of the more complex L-gluco-heptose synthesis pathway of Campylobacter jejuni

67 /C5 epimer generated by MlghB and produces L-gluco-heptose via stereospecific C4 reductase activity.

68 ycosyl residue, 3-acetimidoylamino-3-deoxy-d-gluco-hexuronic acid was identified and characterized, a

69 sions of these to a range of heparin-related gluco-ido disaccharide building blocks (various C-4 prot

70 e synthase-immunoreactive (ir)-positive) and gluco-inhibitory y-aminobutyric acid (GABA; glutamate de

71 at small intestine to study the secretion of gluco-insulinotropic peptide (GIP), glucagon-like peptid

72 ced by E. coli, while beta-glucosidase (beta-gluco) is produced by Enterococcus spp.

73 he equatorial selectivity of the l-glycero-d-gluco isomer arises from H-bonding between the glycosyl

74 ero-d-gluco glycosyl donors, the l-glycero-d-gluco isomer with the least disarming gauche,gauche side

75 tri-O-benzyl hexofuranosyl donors with the d-gluco, l-ido, d-altro, and l-galacto configurations.

76 Here we address the gluco-, lipo-, and glucolipo-toxicities in beta-cells by

77 (ChREBP) activity, histone acetylation, and gluco-lipogenic gene expression.

78 long with beta-cell function by reduction in gluco-lipotoxicity and possibly directly through PPAR-ga

79 ) putative GTs have also been implicated in (gluco)mannan synthesis, but their roles have been diffic

80 heless, the degree of acetylation of xylan, (gluco)mannan, and xyloglucan as well as overall cell wal

81 ow cellulose synthase-like enzymes elongate (gluco)mannans in orthogonal hosts and highlight the disc

82 nsulin signaling, osteocalcin activation and gluco-metabolic homeostasis has proven to be complex and

83 ogical processes such as catalytic activity, gluco-neogenesis, cell wall organization, and glycolytic

84 the identification of GDP-D-erythro-alpha-D-gluco-octose (GDP-D-alpha-D-octose) as a key intermediat

85 leading to the identification of D-erythro-D-gluco-octose 8-phosphate as a key intermediate.

86 nthesis have suggested GDP-D-erythro-alpha-D-gluco-octose and GDP-D-alpha-D-lincosamide as key interm

87 g in the conversion of GDP-D-erythro-alpha-D-gluco-octose to GDP-D-alpha-D-lincosamide have not yet b

88 amination that convert GDP-D-erythro-alpha-D-gluco-octose to GDP-D-alpha-D-lincosamide.

89 es for the production of distinct glucan and gluco-oligosaccharide structures with potential bioactiv

90 tose, and resulted in the synthesis of novel gluco-oligosaccharides in which alpha1,3-linked glucosyl

91 Soaking with isomaltotriose or gluco-oligosaccharides led to structures in which isomal

92 ersion (ASRDelta2) in complex with different gluco-oligosaccharides pinpointed key residues in bindin

93 role of glucansucrases for the production of gluco-oligosaccharides that can be used as functional in

94 fd-glucosyl units from sucroseto dextrans or gluco-oligosaccharides via the formation of alpha-(1-->2

95 nct maltose/cellobiose derivative acetylated gluco-oligosaccharides were produced detected by TLC, NM

96 tive characteristics of branched dextran and gluco-oligosaccharides were tested by determination of t

97 4-Amino-3-(d-gluco-pentitol-1-yl)-4,5-dihydro-1,2,4-triazole-5-thione

98 increase hemolymph glucose, an indication of gluco-privation, but instead of increasing feeding it ei

99 -4-hydroxymethyl)-phenyl-6-O-caffeoyl-beta-d-gluco-pyranoside (2), protocatechuic acid (3), gallic ac

100 alpha-D-glucopyranosyl-(6d --> 1e)-O-alpha-D-gluco-pyranoside (6) along with two known compounds n-he

101 It is unclear, however, if hepatic gluco-regulation is altered in G4Tg mice in the basal, n

102 bolism in G4Tg mice and to determine whether gluco-regulatory adaptations exist in the non-insulin-st

103 ake in extra-hepatic sites provoke important gluco-regulatory adaptations in the liver.

104 However, how these CNS gluco-regulatory regions modulate peripheral glucose lev

105 the relaxation of this torsion angle in the gluco series.

106 tive providing the alpha-C-glycosides in the gluco-series and the beta-C-glycosides in the manno-seri

107 lylation and a triflate inversion to set the gluco-stereochemistry in addition to Luche reduction and

108 VMN gluco-stimulatory nitric oxide (NO; neuronal nitric oxid

109 ing beta-selective glucosylation followed by gluco to manno epimerization at a late stage of the synt

110 enation, which, together with lesser tubular gluco-toxicity, may preserve tubular function and glomer