ライフサイエンスコーパス: gluconeogenic

1 Male LERKO mice displayed elevated hepatic gluconeogenic activity and fasting hyperglycemia.

2 se-6-phosphatase, and the neonate's pools of gluconeogenic alanine and lactate are each diminished by

3 To examine this possibility, we used the gluconeogenic amino acid proline, which is metabolized t

4 contributed to by decreased metabolism from gluconeogenic amino acids.

5 tically investigated factors influencing the gluconeogenic and anaplerotic reaction kinetics.

6 Overall, our data show that gluconeogenic and citric acid cycle intermediates cannot

7 vels, with evidence of altered expression of gluconeogenic and glycolytic enzymes.

8 ellular metabolism during the switch between gluconeogenic and glycolytic growth conditions.

9 erse direction (pyruvate to PEP) during both gluconeogenic and glycolytic growth.

10 nd corrected excessive expression of hepatic gluconeogenic and lipogenic enzymes.

11 insulin signaling and reduced expression of gluconeogenic and lipogenic enzymes.

12 Similarly, a set of key gluconeogenic and lipogenic genes was regulated nearly n

13 glucose intolerance, decreased expression of gluconeogenic and lipogenic genes, and reduced hepatic s

14 signaling, and reduced hepatic expression of gluconeogenic and lipogenic genes.

15 a novel role for cyclin D1 as a regulator of gluconeogenic and oxidative phosphorylation (OxPhos) gen

16 sive activation of aPKC-dependent lipogenic, gluconeogenic and proinflammatory pathways increases the

17 aracrine/autocrine regulation of the hepatic gluconeogenic and/or lipogenic programs, respectively.

18 uitable tracer to assess hepatic glycolytic, gluconeogenic, and mitochondrial metabolism in vivo.

19 sensitivity, rapid normalization in hepatic gluconeogenic capacity and basal hepatic glucose product

20 Liver-specific deletion of Prmt1 reduced gluconeogenic capacity in cultured hepatocytes and in th

21 to HF diet has the potential to program the gluconeogenic capacity of offspring through epigenetic m

22 cles, we show that a substantial fraction of gluconeogenic carbon leaves the liver as citric acid cyc

23 This cataplerotic efflux of gluconeogenic carbon may contribute to renal gluconeogen

24 ectedly, an Mtb mutant lacking GLPX grows on gluconeogenic carbon sources and has detectable FBPase a

25 re differentially affected on glycolytic and gluconeogenic carbon sources, discriminating between the

26 the DeltaacuM mutant had impaired growth on gluconeogenic carbon sources.

27 Gluconeogenic cells in the colony produce and provide a

28 In gluconeogenic cells, aspartate is a carbon source for tr

29 been shown to be necessary for growth under gluconeogenic conditions in Bacillus subtilis.

30 Under gluconeogenic conditions the E3 ligase is composed of si

31 ates the expression of virulence genes under gluconeogenic conditions, suggesting that colonization o

32 red the ability of B. subtilis to grow under gluconeogenic conditions.

33 ng growth of a TIM-deficient bacterium under gluconeogenic conditions.

34 is for the epidemiologic association of anti-gluconeogenic drugs with improved CRC metastasis outcome

35 evidence includes (a) the identification of gluconeogenic enzyme activities in various organs, espec

36 ffects of glucagon on stimulating hepatocyte gluconeogenic enzyme expression and glucose output and b

37 ERK inhibition restores FoxO1, gluconeogenic enzyme expression and glucose production.

38 ial ROS, ERK activation and increases FoxO1, gluconeogenic enzyme expression and hepatocyte glucose p

39 n methylation is required for both SEPP1 and gluconeogenic enzyme expression and that inhibition of p

40 and adipose tissue, and can in part suppress gluconeogenic enzyme expression in the liver.

41 l hepatic TG levels and partially normalized gluconeogenic enzyme expression, without changing matern

42 glucose output in hepatocytes by suppressing gluconeogenic enzyme expression.

43 ow here that hepatocyte-specific loss of the gluconeogenic enzyme fructose 1,6-bisphosphatase 1 (FBP1

44 tarved cells, substantial amounts of the key gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase

45 The key gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase

46 ic gene set analysis and determined that the gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1

47 The gluconeogenic enzyme fructose-1,6-bisphosphatase has bee

48 esult from 10-25-fold higher activity of the gluconeogenic enzyme fructose-1,6-bisphosphatase when gr

49 is by salidroside as the protein levels of a gluconeogenic enzyme G6Pase and a co-activator PGC-1alph

50 -CBP-TORC2 transcription complex and reduces gluconeogenic enzyme gene expression.

51 or complex controls transcription of hepatic gluconeogenic enzyme genes.

52 nished FoxO1-dependent expression of the key gluconeogenic enzyme glucose-6-phosphatase (G6pase).

53 e RNA, we demonstrate that repression of the gluconeogenic enzyme glucose-6-phosphatase in HepG2 cell

54 e, DYRK1B promoted the expression of the key gluconeogenic enzyme glucose-6-phosphatase.

55 et al. (2015) describe the unique role of a gluconeogenic enzyme in regulation of glucose catabolism

56 static colonization capacity upregulated the gluconeogenic enzyme PCK1, which enhanced liver metastat

57 ction and enhances the expression of the key gluconeogenic enzyme Pck1.

58 4 protein expression and upregulation of the gluconeogenic enzyme PCK2 in HCV-infected hepatocytes.

59 Here we report gluconeogenic enzyme phosphoenolpyruvate carboxykinase (

60 Recent structural studies of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (

61 agonizing glucagon-induced expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (

62 Moreover, the basal hepatic levels of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase 1

63 ion correlates with an increase in the liver gluconeogenic enzyme phosphoenolpyruvate carboxykinase e

64 osphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and

65 Pck1, the fourth gluconeogenic enzyme, contains Pro at position 2; Gid4 d

66 he insulin-stimulated down regulation of the gluconeogenic enzyme, glucose-6-phosphatase.

67 The key gluconeogenic enzyme, phosphoenolpyruvate carboxykinase

68 is coincided with up-regulation of the first gluconeogenic enzyme, phosphoenolpyruvate carboxykinase,

69 athway genes (Phgdh, Psat1 and Psph) and the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase-

70 thermore, OLZ-ICV rats had increased hepatic gluconeogenic enzymes and elevated hypothalamic neuropep

71 r methylation processes enable expression of gluconeogenic enzymes and metabolism of the nutrient sel

72 Initiating mechanisms that impair gluconeogenic enzymes and spare lipogenic enzymes in die

73 lso exhibited elevated hepatic expression of gluconeogenic enzymes and transcription factors.

74 Gluconeogenic enzymes are induced when Saccharomyces cer

75 ession of glycolytic genes and downregulated gluconeogenic enzymes by enhancing the translation of th

76 reversed the increased hepatic expression of gluconeogenic enzymes characteristic of rats with uDM.

77 ide concentrations and expression of hepatic gluconeogenic enzymes compared with vehicle (P < 0.05),

78 yeast Saccharomyces cerevisiae targeted the gluconeogenic enzymes Fbp1, Icl1, and Mdh2 for degradati

79 grows on a nonfermentable carbon source, its gluconeogenic enzymes Fbp1, Icl1, Mdh2, and Pck1 are exp

80 Increased expression of gluconeogenic enzymes glucose-6-phosphatase (G6PC) and p

81 s accompanied by an up-regulation of the key gluconeogenic enzymes glucose-6-phosphatase and phosphoe

82 ns of G6pc, Pepck, and Fbp1 encoding the key gluconeogenic enzymes glucose-6-phosphatase, phosphoenol

83 e examined hepatic expression of these 2 key gluconeogenic enzymes in 2 rodent models of fasting hype

84 ociated with increased expression of hepatic gluconeogenic enzymes in female and male mice.

85 d the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens an

86 at certain types of cancer cells utilize the gluconeogenic enzymes phosphoenolpyruvate carboxykinase

87 glucose production and in the expression of gluconeogenic enzymes seen with variation of dietary iro

88 d of glucose for a prolonged period of time, gluconeogenic enzymes such as fructose-1,6-bisphosphatas

89 s where they associate with the promoters of gluconeogenic enzymes such as G6Pase.

90 Substrates of this pathway include gluconeogenic enzymes that bear either the N-terminal Pr

91 esize glucose if deprived of it, and destroy gluconeogenic enzymes upon return to glucose-replete con

92 Furthermore, hormone-dependent induction of gluconeogenic enzymes was reduced by inhibition of prote

93 hermore, the effects of glyburide on EGP and gluconeogenic enzymes were abolished in rats by intracer

94 tocytes by inhibiting the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase and the cyt

95 In this report we show that two additional gluconeogenic enzymes, isocitrate lyase and phosphoenolp

96 vity of key glucocorticoid-regulated hepatic gluconeogenic enzymes, phosphoenolpyruvate carboxykinase

97 tly increased the expression of two critical gluconeogenic enzymes, phosphoenolpyruvate carboxykinase

98 rk that regulates the expression/activity of gluconeogenic enzymes.

99 ng a key role in promoting the expression of gluconeogenic enzymes.

100 b inhibited gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (H

101 belonging to the ED, the EMP (operating in a gluconeogenic fashion), and the pentose phosphate pathwa

102 Gluconeogenic flux can be rapidly inhibited by high insu

103 othesized HexR role as a master regulator of gluconeogenic flux from pyruvate via the transcriptional

104 or the same enzymes, and (c) measurements of gluconeogenic flux in the small intestine.

105 Gluconeogenic flux of benzoate-derived carbons from the

106 lates energy consumption linked to increased gluconeogenic flux through cytosolic phosphoenolpyruvate

107 No further diminution in gluconeogenic flux to G6P occurred over the remaining 4.

108 Insulin reduced gluconeogenic flux to glucose-6-phosphate (G6P) but only

109 appear to have little or no acute effect on gluconeogenic flux.

110 to gluconeogenic products distinguished the gluconeogenic from glycogenolytic state in these functio

111 o methods to rapidly distinguish livers in a gluconeogenic from glycogenolytic state.

112 that the LKB1-SIK pathway functions as a key gluconeogenic gatekeeper in the liver.

113 disease, increased apoptosis, and changes in gluconeogenic gene expression and chromatin structure in

114 generally accepted model for suppression of gluconeogenic gene expression and glucose output.

115 co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in

116 predicted alterations in PGC-1alpha-mediated gluconeogenic gene expression and glucose production in

117 The ability of apoA-IV to lower gluconeogenic gene expression and glucose production was

118 rmone were preserved, including reduction of gluconeogenic gene expression and hepatic glucose produc

119 ed the effect of a maternal HF diet on fetal gluconeogenic gene expression and potential regulation m

120 /EBPbeta, and pCREB in promoting HCV-induced gluconeogenic gene expression and suggest that increased

121 , the downstream signaling events repressing gluconeogenic gene expression are not as well understood

122 After glucagon induction, CRTC2 stimulated gluconeogenic gene expression by an association with p30

123 ight-day transition, when it reduced fasting gluconeogenic gene expression by blocking glucagon-media

124 utrient signals are also thought to modulate gluconeogenic gene expression by promoting epigenetic ch

125 After their activation, InsP(3)Rs enhanced gluconeogenic gene expression by promoting the calcineur

126 higher hepatic glucose production and higher gluconeogenic gene expression in apoA-IV(-/-) mice.

127 ttenuate the inhibitory effect of CARHSP1 on gluconeogenic gene expression in hepatocytes.

128 recruits a co-repressor complex to regulate gluconeogenic gene expression in HepG2 cells.

129 mechanism, suppresses glucose production and gluconeogenic gene expression in primary hepatocytes at

130 and allows for normal suppression of HGP and gluconeogenic gene expression in response to insulin, de

131 Metformin also inhibits gluconeogenic gene expression in the liver of mice admin

132 PGC-1alpha's activation of gluconeogenic gene expression is dependent upon its acet

133 llel decreases in insulin signalling augment gluconeogenic gene expression through the dephosphorylat

134 Triggering of the cAMP pathway stimulates gluconeogenic gene expression through the PKA-mediated p

135 r data suggest that CARHSP1 inhibits hepatic gluconeogenic gene expression via repression of PPARalph

136 iggering of the cyclic AMP pathway increases gluconeogenic gene expression via the de-phosphorylation

137 gnaling in the liver, and suppressed hepatic gluconeogenic gene expression without altering EGP or gl

138 MP analog to stimulate CREB phosphorylation, gluconeogenic gene expression, and HGP in primary hepato

139 Plasma hormone and substrate levels, hepatic gluconeogenic gene expression, and measures of tissue in

140 at increase PGC-1alpha acetylation, suppress gluconeogenic gene expression, and reduce glucose produc

141 Depletion of KAT2B or WDR5 decreased gluconeogenic gene expression, consequently breaking the

142 pite the known role of CRTC2 in coordinating gluconeogenic gene expression, CRTC2 KD in a rodent mode

143 antly, LTCFDN hepatocytes displayed elevated gluconeogenic gene expression, gluconeogenesis, and loss

144 tiating hepatic insulin signaling with lower gluconeogenic gene expression, higher glycogen storage a

145 anides to regulate AMPK, glucose production, gluconeogenic gene expression, mitochondrial respiration

146 state, which could be attributed to reduced gluconeogenic gene expression, resulting in reduced basa

147 PRMT5 lowers hepatic glucose production and gluconeogenic gene expression, these results demonstrate

148 Inhibition of CDK4 enhances the gluconeogenic gene expression, whereas cyclin D1-mediate

149 ssion of both hepatic glucose production and gluconeogenic gene expression, with no change of glucose

150 ay control substrate availability as well as gluconeogenic gene expression.

151 ize the role of CARHSP1 in the regulation of gluconeogenic gene expression.

152 n from inhibiting glucose output or reducing gluconeogenic gene expression.

153 in liver and a marked suppression of hepatic gluconeogenic gene expression.

154 oteasome-dependent degradation and, in turn, gluconeogenic gene expression.

155 uce the nuclear FOXO1 abundance and suppress gluconeogenic gene expression.

156 We now show that YAP can also suppress gluconeogenic gene expression.

157 rough reduction of hepatic FOXO1 protein and gluconeogenic gene expression.

158 lucose appearance (Ra), or increased hepatic gluconeogenic gene expression.

159 d-type TCF7L2, increased gluconeogenesis and gluconeogenic gene expression.

160 patic PGC-1alpha acetylation, suppressed the gluconeogenic gene program, and lowered glycemia, indica

161 etion in primary hepatocytes potentiates the gluconeogenic gene response to glucagon and dexamethason

162 the insulin-mediated suppression of hepatic gluconeogenic gene transcription but blunted the inducti

163 how that MAPK phosphatase-3 (MKP-3) promotes gluconeogenic gene transcription in hepatoma cells, but

164 A key mediator of gluconeogenic gene transcription is PGC-1alpha.

165 D1-mediated activation of CDK4 represses the gluconeogenic gene-expression program in vitro and in vi

166 tylation at Lys 9 (H3K9Ac) was elevated over gluconeogenic genes and contributed to increased hepatic

167 d an HI diet, due to decreased expression of gluconeogenic genes and decreased substrate (lactate) fr

168 ssion (GRbeta-Ad) resulted in suppression of gluconeogenic genes and hyperglycemia in mice on a regul

169 row cells results in increased expression of gluconeogenic genes and impaired glucose tolerance.

170 MUP1 inhibited the expression of both gluconeogenic genes and lipogenic genes in the liver.

171 rt6 levels; ectopic re-expression suppresses gluconeogenic genes and normalizes glycemia.

172 D suppression of glucose output, NAD(+), and gluconeogenic genes and stabilized PGC1alpha.

173 Insulin represses the expression of gluconeogenic genes at the mRNA level, but the hormone a

174 IL-13 inhibited transcription of gluconeogenic genes by acting directly on hepatocytes th

175 tivator 2 (CRTC2) regulates transcription of gluconeogenic genes by specifying targets for the transc

176 ain glucose homeostasis through induction of gluconeogenic genes by the CREB coactivator CRTC2.

177 resulting in decreased transcription of the gluconeogenic genes glucose-6-phosphatase (G6pase) and p

178 Expression of gluconeogenic genes has been reported in other organs of

179 ms had significantly higher mRNA contents of gluconeogenic genes in addition to the elevated plasma g

180 XR-mediated trans-activation of promoters of gluconeogenic genes in human liver cells, thereby enhanc

181 phorylatable CREB allele failed to attenuate gluconeogenic genes in response to DNA damage or fully a

182 Altered AKT signaling and expression of gluconeogenic genes in the fed state contributed to an i

183 In addition, PST peptides activated gluconeogenic genes in the following order: PST-297S app

184 ng (CREB) phosphorylation, and expression of gluconeogenic genes in the liver and primary hepatocytes

185 Down-regulation of apoA-IV on gluconeogenic genes is mediated through NR1D1, as illust

186 Induction of the gluconeogenic genes Ppargc1a, Pck1, and G6pc by glucagon

187 ound 17beta-estradiol (E2) inhibited hepatic gluconeogenic genes such as phosphoenolpyruvate carboxyk

188 glucose levels and the expression of hepatic gluconeogenic genes was first examined.

189 The expression of gluconeogenic genes was measured by quantitative real-ti

190 cogen synthase 2 (GYS2); while expression of gluconeogenic genes were found down regulated.

191 ion levels of several critical lipogenic and gluconeogenic genes were significantly decreased in HFD-

192 e promoter of FOXO1 (transcription factor of gluconeogenic genes).

193 re triglyceride, expression of lipogenic and gluconeogenic genes, and activity of protein kinases dow

194 and -2 on glucose production, expression of gluconeogenic genes, and phosphorylation of Akt, c-Src,

195 In the fruit fly, one of the gluconeogenic genes, glucose-6-phosphatase (G6P) is excl

196 translocation of FoxO1 and activation of key gluconeogenic genes, glucose-6-phosphatase and phosphoen

197 not significant] vs. w0) by reducing hepatic gluconeogenic genes, including G6Pase, PEPCK, and FOXO1.

198 transcriptional level to negatively regulate gluconeogenic genes, including the glucose-6-phosphatase

199 c in liver and downregulation of the hepatic gluconeogenic genes, Pepck and G6pase.

200 (TR) to induce the expression of the hepatic gluconeogenic genes, phosphoenolpyruvate carboxykinase (

201 epatic glucose production, expression of key gluconeogenic genes, phosphoenolpyruvate carboxykinase (

202 lved in catabolic pathways and activation of gluconeogenic genes, was for the first time predicted by

203 lso reflected by the decreased expression of gluconeogenic genes.

204 ptional PGC-1alpha targets such as OXPHOS or gluconeogenic genes.

205 functions to stimulate transcription of key gluconeogenic genes.

206 in vivo by increasing the expression of key gluconeogenic genes.

207 etylates and inhibits PGC-1alpha activity on gluconeogenic genes.

208 ma glucagon levels and hepatic expression of gluconeogenic genes.

209 and disassembling the CREB-CBP complex from gluconeogenic genes.

210 a participates in the hormonal regulation of gluconeogenic genes.

211 content, and impaired insulin suppression of gluconeogenic genes.

212 bsequent recruitment to the promoters of key gluconeogenic genes.

213 yte cultures by inhibiting the expression of gluconeogenic genes.

214 and thereby inhibiting CRTC2 occupancy over gluconeogenic genes.

215 omitant with decreased expression of hepatic gluconeogenic genes.

216 sponsive elements and thereby down-regulates gluconeogenic genes.

217 creased insulin levels, and elevated hepatic gluconeogenic genes.

218 G2 cells also causes similar upregulation of gluconeogenic genes.

219 ced expression of hepatic glycogenolytic and gluconeogenic genes.

220 llular signaling and molecular inhibition of gluconeogenic (GNG) enzyme mRNA expression.

221 s; however, in vivo regulation of PK flux by gluconeogenic hormones and substrates is poorly understo

222 ependent enzymes that convert amino acids to gluconeogenic intermediates, suggesting that it may cont

223 carboxylic acid cycle-derived metabolites to gluconeogenic intermediates.

224 These gluconeogenic, lipogenic, and inflammatory pathway trans

225 o N-deprived conditions turning on a largely gluconeogenic metabolic state, which then transitions to

226 osphate, an essential step in glycolytic and gluconeogenic metabolism.

227 Alterations of gluconeogenic metabolites and fluxes in T2DM are discuss

228 e and stationary phase yeast switched into a gluconeogenic mode in which metabolism was reoriented to

229 The gluconeogenic module operates through assisted loading,

230 ding E. coli EDL933 uses both glycolytic and gluconeogenic nutrients and needs the ability to perform

231 strain that outcompetes O157:H7 strains for gluconeogenic nutrients could render them nonpathogenic.

232 nd 5 days postfeeding, appears to stop using gluconeogenic nutrients thereafter in a large, long-term

233 a probiotic strain, uses both glycolytic and gluconeogenic nutrients to colonize the mouse intestine

234 starve the O157:H7 E. coli strain EDL933 of gluconeogenic nutrients, even though E. coli Nissle 1917

235 rs to other glycolytic substrates but not to gluconeogenic ones.

236 nditions were designed to establish either a gluconeogenic or a glycogenolytic state.

237 nstraints drive cells into groups exhibiting gluconeogenic or glycolytic states.

238 s frequently suppressed in tumors arising in gluconeogenic organs and reexpression of a gluconeogenes

239 7 increases the expression of enzymes of the gluconeogenic pathway in HepG2 cells.

240 hat PEPCK has poor control strength over the gluconeogenic pathway in vivo.

241 Here we investigated whether the gluconeogenic pathway is significantly modulated in hepa

242 nly regulatory step of the common glycolytic-gluconeogenic pathway that appears to exert significant

243 , with feeding, and assemble glucose via the gluconeogenic pathway, in response to fasting, are criti

244 ing the expression of enzymes in the hepatic gluconeogenic pathway, thereby reducing gluconeogenesis

245 lar probe that allows measurement of hepatic gluconeogenic pathways in vivo and in a noninvasive mann

246 s VirF and VirB, and both the glycolytic and gluconeogenic pathways influence steps in S. flexneri in

247 ppreciated as a crucial energy source, major gluconeogenic precursor and signalling molecule but ther

248 e extraction is important, and later reduced gluconeogenic precursor availability plays a role.

249 Here we use the gluconeogenic precursor dihydroxyacetone (DHA) to delive

250 of carbohydrate restriction on the origin of gluconeogenic precursors (GNG from glycerol [GNG(glycero

251 including substrate contribution of various gluconeogenic precursors to glucose production.

252 methylcitrate cycle intermediates, depletes gluconeogenic precursors, and results in defects of memb

253 hepatocytes challenged with high glucose or gluconeogenic precursors.

254 GK in the nucleus, which removes GK from the gluconeogenic process and prevents a futile cycle of glu

255 ancy, we demonstrate that TrmB regulates the gluconeogenic production of sugars incorporated into the

256 A ratio of glycolytic to gluconeogenic products distinguished the gluconeogenic f

257 ed genes are largely involved in the hepatic gluconeogenic program and lipid metabolism.

258 of obese mice reversed CRTC2 effects on the gluconeogenic program and lowered hepatic glucose output

259 Glucagon stimulates the gluconeogenic program by triggering the dephosphorylatio

260 Whether ER stress also modulates the gluconeogenic program directly, however, is unclear.

261 of-function of PRMT1V2 clearly activated the gluconeogenic program in hepatocytes via interactions wi

262 hibiting the CREB-mediated activation of the gluconeogenic program in response to glucagon.

263 KAT2B and WDR5 stimulated the gluconeogenic program through a self-reinforcing cycle,

264 iggering of the cAMP pathway upregulates the gluconeogenic program through the phosphorylation of cAM

265 mia because of constitutive induction of the gluconeogenic program.

266 glucose production through induction of the gluconeogenic program.

267 in diabetes, leading to upregulation of the gluconeogenic program.

268 ns during fasting, due to attenuation of the gluconeogenic program.

269 n and when FOXO1 supported expression of the gluconeogenic program.

270 uitment of CREB and its coactivator CRTC2 to gluconeogenic promoters by up-regulating ATF3, a transcr

271 ion that enhanced chromatin accessibility at gluconeogenic promoters.

272 ulin and glucagon concentrations and hepatic gluconeogenic protein expression.

273 r->asp)) exhibited apparent correlation with gluconeogenic pyruvate carboxylase (PC) activity in hepa

274 However, fasting increased the fluxes in gluconeogenic reactions whereas it decreased fluxes asso

275 ing poor control strength for this enzyme in gluconeogenic regulation in canines.

276 r results illustrate how the exchange of two gluconeogenic regulators during fasting maintains energy

277 ne the relative importance of its effects on gluconeogenic regulatory sites, and 3) to correlate thos

278 , our model simulations predict a restricted gluconeogenic response of the liver under impaired hormo

279 protein expression and impairs FOXO1-driven gluconeogenic response.

280 In eukaryotes only one gluconeogenic route has been described from organic acid

281 iron homeostasis, showing that Hepcidin is a gluconeogenic sensor in mice during starvation.

282 We investigated whether gluconeogenic signals directly control Hepcidin, an impo

283 Beginning in a uniformly gluconeogenic state, cells exhibiting a contrary, high p

284 at the loss of Pib1 results in an imbalanced gluconeogenic state, regardless of glucose availability.

285 ains other cells in the trehalose producing, gluconeogenic state.

286 This gluconeogenic statin-PXR-SGK2 signal is not present in m

287 e gene that encodes Hepcidin) in response to gluconeogenic stimuli using small interfering RNA, lucif

288 There is a switch of gluconeogenic substrate preference to glycerol that quan

289 etabolic stress, alanine is the main hepatic gluconeogenic substrate, and its availability is the rat

290 oles of lactate in delivery of oxidative and gluconeogenic substrates as well as in cell signalling.

291 The reduction in key gluconeogenic substrates in the postprandial state may c

292 via enhanced anaplerosis, the metabolism of gluconeogenic substrates results in an increase in both

293 rophore secretion is higher during growth on gluconeogenic substrates than during growth on glycolyti

294 verse hepatic metabolic responses, including gluconeogenic suppression and induction of glycogen synt

295 PK-related kinase family, play a key role as gluconeogenic suppressors downstream of LKB1 in the live

296 vate transcription from the promoters of its gluconeogenic targets, and the effects of YAP are blunte

297 PEPCK-M was acutely silenced in gluconeogenic tissues of rats using antisense oligonucle

298 ever, PEPCK-M is present in a variety of non-gluconeogenic tissues, including tumors of several origi

299 Using the major gluconeogenic transcription factor Rds2 as a candidate,

300 the glucose-dependent down-regulation of the gluconeogenic transcription factors is limited.