ライフサイエンスコーパス: glucuronate

1 genase (UGDH) catalyzes the formation of UDP-glucuronate.

2 etermined in the presence of the substrate D-glucuronate.

3 )) for galacturonate was lower than that for glucuronate.

4 erates in a pathway distinct from that for d-glucuronate.

5 mination of fluoride from 3-deoxy-3-fluoro-D-glucuronate.

6 lohexan-(1,2,3,4,5,6-hexa)-ol substrate to d-glucuronate.

7 e [myo-inositol (MI)] by four electrons to d-glucuronate.

8 talyzes the formation of UDP-xylose from UDP-glucuronate.

9 but grew on the more oxidized carbon source glucuronate.

10 ate, and malate, and increased succinate and glucuronate.

11 to identify and functionally express a UDP-D-glucuronate 4-epimerase (GAE1) from Arabidopsis.

12 ssays on cell extracts localized total UDP-D-glucuronate 4-epimerase and recombinant GAE1 activity ex

13 ursor UDP-D-glucuronic acid by the action of glucuronate 4-epimerases (GAEs).

14 h) (EC 1.1.1.22) converts UDP-glucose to UDP-glucuronate, a critical component of the glycosaminoglyc

15 to reduce their formation; protecting the d-glucuronate acceptor at the anomeric position with a par

16 drogenase (UGDH) oxidizes UDP-glucose to UDP-glucuronate, an essential precursor for production of hy

17 uperfamily, catalyzes the isomerization of D-glucuronate and D-fructuronate.

18 hat unlike Bh0705, Bh0493 can utilize both d-glucuronate and d-galacturonate as substrates.

19 P2 controls eda induction on glucuronate and galacturonate and is regulated by KdgR.

20 to Escherichia coli and Erwinia chrysanthemi glucuronate and galacturonate metabolic genes were found

21 t grow on fructuronate but grows normally on glucuronate and gluconate.

22 was reduced to 25-35 mM by replacement with glucuronate and may, therefore, be attributed to Cl(-)-H

23 fects on the kinetic constants with [2-2H]-D-glucuronate and the effects of changes in solvent viscos

24 CA cycle, the interconversion of pentose and glucuronate, and alanine, and aspartate and glutamate pa

25 rms UDP-d-xylose by decarboxylation of UDP-d-glucuronate, and has therefore been named UDP-d-apiose/U

26 ketoglutarate and increased glucuronate, UDP-glucuronate, and non-esterified DHA.

27 ose, not glucose 6-phosphate; therefore, UDP-glucuronate arose predominantly by the action of UDP-glu

28 e enzymes, the turnover number (k(cat)) with glucuronate as a substrate was higher than that with gal

29 cherichia coli mutant incapable of consuming glucuronate as the sole carbon source but capable of gro

30 gulated by the availability of activated UDP-glucuronate, as determined by relative Udpgdh expression

31 ipid metabolites (eg, hydroxyphenylpyruvate, glucuronate), associate with WMH in a general population

32 The use of d-glucuronate-based acceptors for dehydrative glycosylatio

33 Glucuronate, because it proceeds through a fructuronate

34 ibrium between UDP-D-galacturonate and UDP-D-glucuronate but did not epimerize UDP-D-Glc or UDP-D-Xyl

35 d-apiose (UDP-d-apiose) is formed from UDP-d-glucuronate by decarboxylation and re-arrangement of the

36 being located adjacent to genes involved in glucuronate catabolism, gntP does not encode a glucurona

37 Based on the determination of the OccK2-glucuronate co-crystal structure, we identify the channe

38 t in the transport of GS conjugates but also glucuronate conjugates after heterologous expression in

39 anticancer drugs and efflux glutathione and glucuronate conjugates from the cell.

40 ione and the cyclopentapeptide BQ123 but not glucuronate conjugates such as 17beta-estradiol 17-(beta

41 cocholate as well as several glutathione and glucuronate conjugates.

42 in health and disease via the metabolism of glucuronate-containing carbohydrates and drugs.

43 genesis and uncover a mechanism by which UDP-glucuronate controls hepatocyte apoptosis by targeting R

44 UDP-glucuronate decarboxylase (UGD) catalyzes the formation

45 8036, located within the promoter of the UDP-glucuronate decarboxylase 1 (UXS1) gene, seemed to under

46 r polypeptide identified it as a form of UDP-glucuronate decarboxylase and functionality was establis

47 The UDP-glucuronate decarboxylase was purified as polypeptides o

48 st unique feature of the pathway is a beta-D-glucuronate dehydratase, BcGDH, which we show through st

49 6-hexa)-ol substrate (myo-inositol, MI) to d-glucuronate (DG).

50 er via conjugation of ethanol with activated glucuronate, EtG remains detectable in serum, plasma, an

51 of XynC crystal soaks with the simple sugar glucuronate (GA) and the tetrameric sugar 4-O-methyl-ald

52 E. coli K-12 eda mutants (unable to utilize glucuronate, galacturonate, and gluconate) were construc

53 cetylglucosamine > N-acetylneuraminic acid = glucuronate > mannose > fucose > ribose.

54 to be formed by the 4-epimerization of UDP-D-glucuronate; however, no coding regions for the epimeras

55 e, sorbate, hexanoate, benzoate, glyphosate, glucuronate, ibuprofen, naproxen, and ketoprofen).

56 Our findings reveal a role for UGDH and UDP-glucuronate in NASH pathogenesis and uncover a mechanism

57 Structures determined with glucuronate, in both native and covalently bound interme

58 e metabolism (P=9.0x10(-6)), and pentose and glucuronate interconversions (P=3.0x10(-6)) in pathogene

59 noid and flavonoid biosynthesis, pentose and glucuronate interconversions and starch and sucrose meta

60 n starch and sucrose metabolism, pentose and glucuronate interconversions, and phenylpropanoid biosyn

61 reported using anomeric hydroxy and imidate glucuronate intermediates.

62 D-Glucuronate is a key metabolite in the process of detoxi

63 The loss of fluoride from 3-deoxy-3-fluoro-D-glucuronate is consistent with a stabilized carbanion at

64 ubstrate and product the hydrogen at C2 of D-glucuronate is transferred to the pro-R position at C1 o

65 O-6''-O-malonylglucoside, 19 microM) and UDP-glucuronate (Km, 476 microM).

66 Recovering UDP-glucuronate levels, even after the onset of NASH, improv

67 heparinase III-like, cleaving at hexosamine-glucuronate linkages.

68 Glucuronate, mannose, fucose, and ribose appeared to be

69 H would then catalyze the addition of methyl glucuronate (MeGlcA) to complete the first instance of t

70 s by targeting RIPK1 kinase, and suggest UDP-glucuronate metabolism as a feasible target for more spe

71 triglycan is a linear glycan (xylose-beta1,3-glucuronate)(n), which binds proteins in the extracellul

72 nization, including L-fucose, D-gluconate, D-glucuronate, N-acetyl-D-glucosamine, D-mannose, and D-ri

73 fter abstraction of the proton from either D-glucuronate or D-fructuronate during the isomerization r

74 Polyphenols are present as conjugates of glucuronate or sulfate, with or without methylation of t

75 synthesis is induced by growth on gluconate, glucuronate, or methyl-beta-D-glucuronide; phosphate lim

76 ificant association was with higher level of glucuronate (P(FDR)=0.047).

77 p62/Sqstm1 at Ser349 directs glucose to the glucuronate pathway, and glutamine towards glutathione s

78 (DGN), phosphorylated core M3, and a xylose-glucuronate primer are necessary for matriglycan polymer

79 The glucuronate probe was used to measure the turnover and s

80 , as would be predicted from a defect in UDP-glucuronate production.

81 de followed by base-mediated cleavage of the glucuronate protective groups.

82 Glucuronate represents an integral component of the glyc

83 he role of the free carboxylate group on the glucuronate residue, the enzymatic behavior on chondroit

84 ses primes saturated non-reducing end beta-D-glucuronate residues for hydrolysis by BcGH88.

85 ogen-dependent cells by treatment with a UDP-glucuronate scavenger.

86 se and apiose residues (all produced via UDP-glucuronate) stemmed from UDP-glucose, not glucose 6-pho

87 f arabinose, glucuronic acid, and especially glucuronate strengthen the primary cell wall by strongly

88 Sodium glucuronate substitution did not inhibit cytokine proces

89 metabolized and circulate in the organism as glucuronated, sulphated and methylated metabolites, disp

90 esses RIPK1 by converting UDP-glucose to UDP-glucuronate, the latter directly binds to the kinase dom

91 ant enzyme catalyzed the conversion of UDP-d-glucuronate to a mixture of UDP-d-apiose and UDP-d-xylos

92 hat utilizes a proton transfer from C-2 of D-glucuronate to C-1 that is initiated by the combined act

93 ichia coli, catalyzes the isomerization of d-glucuronate to d-fructuronate and d-galacturonate to d-t

94 catalyzes the reversible isomerization of D-glucuronate to D-fructuronate and of D-galacturonate to

95 latively specific for the isomerization of d-glucuronate to d-fructuronate, confirming this functiona

96 site base abstracts the proton from C2 of D-glucuronate to form a cis-enediol intermediate.

97 the enzymes responsible for conversion of D-glucuronate to L-gulonate, a key step in the ascorbate (

98 fic transfer of a glucuronosyl unit from UDP-glucuronate to the 2''-hydroxyl group of the 3-glucosyl

99 o induce the ExuR regulon, which encodes the glucuronate transporter, ExuT, and the first step in its

100 ucuronate catabolism, gntP does not encode a glucuronate transporter.

101 Galacturonate and glucuronate, two abundant hexuronic acids in pectin and

102 s fumarate and a-ketoglutarate and increased glucuronate, UDP-glucuronate, and non-esterified DHA.

103 ed metabolites (1-methylxantine, nicotinate, glucuronate, uridine, cholesterol, serine, caffeine, and

104 he 4e(-) oxidation of myo-inositol (MI) to D-glucuronate using a substrate activated Fe(II)Fe(III) si

105 s found in an operon for the metabolism of d-glucuronate, whereas Bh0493 is in an operon for the meta

106 rate constant (k(cat) = 1.9 x 10(2) s(-1) on glucuronate), which was more than twofold higher than th

107 ium tumefaciens, we developed an assay for D-glucuronate with a detection limit of 5 microM.

108 A simple and specific assay of D-glucuronate would be useful for studying these processes

109 In mammals, XK is the last enzyme in the glucuronate-xylulose pathway, active in the liver and ki

110 one of the products of MI catabolism via the glucuronate-xylulose pathway, induces an overexpression

111 id is further metabolized to xylitol via the glucuronate-xylulose pathway.