ライフサイエンスコーパス: glucuronosyltransferase

1 me P450 or phase II conjugating enzymes (UDP-glucuronosyltransferase).

2 ficiency of the hepatic enzyme bilirubin-UDP-glucuronosyltransferase.

3 plained by deletion of a uridine diphosphate glucuronosyltransferase.

4 onic acid in the liver via the action of UDP-glucuronosyltransferases.

5 GUX2 and GUX4, have activity as xylan alpha-glucuronosyltransferases.

6 nsferases, glutathione transferases, and UDP-glucuronosyltransferases.

7 osyltransferase, INOSITOL PHOSPHORYLCERAMIDE GLUCURONOSYLTRANSFERASE 1 (IPUT1), which is the first en

8 The human UDP-glucuronosyltransferase 1 (UGT1) locus spans nearly 200

9 A polymorphism in the promoter of the UDP-glucuronosyltransferase 1 (UGT1A1) gene has been shown t

10 Alternative splicing at the human glucuronosyltransferase 1 gene locus (UGT1) produces alt

11 01A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated t

12 (pfu) intravenously) in adult bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient Gunn rats re

13 ance to adenoviral antigens in bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient Gunn rats.

14 gastroduodenostomy tubes into bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient jaundiced Gu

15 In humanized UDP glucuronosyltransferase-1 (hUGT1) mice that express the

16 ransferase (pSV2-CAT) or human bilirubin-UDP-glucuronosyltransferase-1 (pSVK3-hBUGT1) genes were comp

17 ns of bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) completely or partial

18 x promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least

19 esult in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability t

20 UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucu

21 ated the impact of oral iAs treatment on UDP-glucuronosyltransferase 1A1 (UGT1A1) expression and bili

22 aluated the impact of lactational TCS on UDP-glucuronosyltransferase 1A1 (UGT1A1) expression and bili

23 Mutations in the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene are associated

24 To study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and sever

25 UDP-glucuronosyltransferase 1A1 (UGT1A1) is a vital metaboli

26 In mammals, UDP-glucuronosyltransferase 1A1 (UGT1A1) is the sole enzyme

27 UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an important

28 ), CAR, cytochrome P-450 2b10 (Cyp2b10), UDP-glucuronosyltransferase 1a1 (Ugt1a1), sulfotransferase 2

29 lack the enzyme uridine diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1), the absence of whi

30 in turn is detoxified primarily through UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed glucuroni

31 cytochrome P450 [Cyp] 2b10, Cyp2c55, and UDP-glucuronosyltransferase 1a1 [Ugt1a1]).

32 P7A1), CYP27A1, CYP8B1, uridine 5'-diphospho-glucuronosyltransferase 1A1, 1A3, 1A4, 1A6, hydroxystero

33 expressing human uridinediphosphoglucuronate glucuronosyltransferase-1A1 (pSB-hUGT1A1).

34 Uridine diphosphate-glucuronosyltransferase-1A1 deficiency, causing Gilbert'

35 Uridine diphosphate-glucuronosyltransferase-1A1 deficiency, causing Gilbert'

36 uted isozymes encoded at the UGT1 locus, UDP-glucuronosyltransferase 1A10 (UGT1A10) metabolizes a num

37 tutive or ligand-induced CYP1A1; CYP1A2; UDP glucuronosyltransferase 1A2; NAD(P)H dehydrogenase, quin

38 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a major UGT cont

39 The UDP-glucuronosyltransferase 2 family, polypeptide B15 (UGT2B

40 Members of the human UDP-glucuronosyltransferase 2B family are located in a clust

41 tion and stemness by inducing the enzyme UDP-glucuronosyltransferase 2B15 (UGT2B15), which promotes t

42 Uridine diphospho glucuronosyltransferase 2B17 (UGT2B17) glucuronidates an

43 UDP-glucuronosyltransferase 2B17 (UGT2B17) is a key enzyme t

44 EPI is primarily inactivated by UDP-glucuronosyltransferase 2B7 (UGT2B7) in the liver.

45 Whereas UDP-glucuronosyltransferase-2B7 is widely distributed in dif

46 n permethrin resistant mosquitoes included a glucuronosyltransferase (AAEL014279-RA) and the glutathi

47 ly due to interindividual differences in UDP-glucuronosyltransferase activity and/or excretion pathwa

48 increase or a decrease, respectively, in IPC glucuronosyltransferase activity in vitro.

49 This paralleled the hepatic bilirubin-UDP-glucuronosyltransferase activity, which was above 50% of

50 binant adenovirus (Ad), adenovirus human UDP-glucuronosyltransferase (Ad-hBUGT1) carrying the hBUGT1

51 15 (GAME15)] functions both as a cholesterol glucuronosyltransferase and a scaffold protein.

52 Polymorphisms in UDP-glucuronosyltransferases and sulfotransferases may contr

53 , we quantified androgen dependence of UGDH, glucuronosyltransferase, and HA synthase expression.

54 , glutathione S-transferases, esterases, UDP-glucuronosyltransferases, and ABC transporters.

55 eme oxygenase, biliverdin reductase, and UDP-glucuronosyltransferases, and there was concordance with

56 a normal form of uridinediphosphoglucuronate glucuronosyltransferase because of a defect in the promo

57 Glucuronosyltransferase binds these compounds to glucuro

58 human bilirubin-uridine-diphosphoglucuronate-glucuronosyltransferase (BUGT) genes, into BUGT-deficien

59 noviral antigens, we immunized bilirubin-UDP-glucuronosyltransferase (BUGT)-deficient jaundiced Gunn

60 ll as other enzymes (eg, uridine diphosphate-glucuronosyltransferases, cytochrome P450 isozymes, nico

61 as injected intravenously into bilirubin-UDP-glucuronosyltransferase-deficient Gunn rats.

62 fam 03016 that is the hallmark of the beta-d-glucuronosyltransferase domain of exostosins, a class of

63 he enzyme shows sequence similarities to the glucuronosyltransferase domain of exostosins, a class of

64 mes P-450) and phase II (uridine diphosphate glucuronosyltransferases) drug-metabolizing enzymes are

65 Uridine diphosphate glucuronosyltransferase (EC 2.4.1.17) containing microso

66 ng developmental effects of a microsomal UDP-glucuronosyltransferase-encoding gene from pea (Pisum sa

67 he prostate may be to provide precursors for glucuronosyltransferase enzymes, which inactivate and so

68 one transferases, NAD(P)H:quinone reductase, glucuronosyltransferases, epoxide hydrolase) is a major

69 eterogeneity in uridine 5'-diphosphate (UDP) glucuronosyltransferase expression across the human hepa

70 resulted in a reduced level of bilirubin UDP-glucuronosyltransferase expression in the liver.

71 tic inhibition of hepatic conjugation by UDP glucuronosyltransferase family 1 member A1 (UGT1A1), was

72 rved across a 200 kb region spanning the UDP-glucuronosyltransferase family, including UGT1A1, an enz

73 creases 1 (moca1), and identified MOCA1 as a glucuronosyltransferase for glycosyl inositol phosphoryl

74 of the bilirubin uridinediphosphoglucuronate glucuronosyltransferase gene.

75 se (XylT), arabinosyltransferase (AraT), and glucuronosyltransferase (GlcAT).

76 y lacked UDP-glucuronic acid:Galbeta1,3Gal-R glucuronosyltransferase (GlcAT-I) activity, as measured

77 ich is transferred to the AGP glycan by beta-glucuronosyltransferases (GLCATs), is the only acidic su

78 thought to encode UDP-GlcUA:Galbeta1,3Gal-R glucuronosyltransferase (GlcUAT-I), involved in the form

79 tical to the UDP-GlcUA:glycoprotein beta1, 3-glucuronosyltransferase (GlcUAT-P) involved in forming H

80 the position-specific activity of the xylan glucuronosyltransferase GUX1, and so the even pattern of

81 Relocating either galactosyltransferase I or glucuronosyltransferase I had no effect on the other's l

82 d B3GAT3, B4GALT7, and SLC35B2, which encode glucuronosyltransferase I, galactosyltransferase I, and

83 nthetic enzymes: galactosyltransferase I and glucuronosyltransferase I, required for the formation of

84 udy the expression and regulation of beta1,3-Glucuronosyltransferase-I (GlcAT-I), a key enzyme regula

85 While pretreatment with UDP-glucuronosyltransferase inhibitor, nilotinib, reduced gl

86 We recently discovered an Arabidopsis GIPC glucuronosyltransferase, INOSITOL PHOSPHORYLCERAMIDE GLU

87 e hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for ach

88 -103-G) predominantly by uridine diphosphate glucuronosyltransferase isoform 1A1 (UGT1A1).

89 hydrophobic region in the bilirubin-type UDP-glucuronosyltransferase isozyme was first uncovered as a

90 rs6742078 located in the uridine diphosphate-glucuronosyltransferase locus as an instrumental variabl

91 In all 3 treatment phases, a glucuronosyltransferase polymorphism predicted hyperbili

92 Consistent with the UDP-glucuronosyltransferase requirement for regulated phosph

93 related detoxification enzymes, notably UDP-glucuronosyltransferases, suggesting a network of associ

94 attributed to metabolic deactivation by UDP-glucuronosyltransferases that were expressed in RASWT an

95 -HexUA were tested as substrates for various glucuronosyltransferases to better understand enzyme spe

96 The human major bilirubin UDP glucuronosyltransferase (transferase), HUG-Brl, and its

97 e as substrate, we showed that LNCaP had UDP-glucuronosyltransferase (UDPGT) activity.

98 stosterone/4-nitrophenol uridine diphosphate glucuronosyltransferase (UDPGT), and aryl sulfotransfera

99 emical and genetic information on vertebrate glucuronosyltransferases (UGATs), only limited informati

100 The human UDP-glucuronosyltransferase (UGT) 1A (UGT1A) locus is regula

101 s associated with a reduction in hepatic UDP glucuronosyltransferase (UGT) 1A1 activity that can lead

102 ecessive inherited deficiency of hepatic UDP-glucuronosyltransferase (UGT) 1A1 activity.

103 constitutional genetic variation at the UDP-glucuronosyltransferase (UGT) 1A1 locus in breast cancer

104 olized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known that

105 nduce the bilirubin-metabolizing enzyme--UDP-glucuronosyltransferase (UGT) 1A1--to prevent the onset

106 quires the expression of uridine diphosphate glucuronosyltransferase (UGT) 1A1; we investigated its r

107 the rabbit liver dexamethasone-inducible UDP-glucuronosyltransferase (UGT) 2B13 RNA is related in seq

108 Because human prostate-distributed UDP-glucuronosyltransferase (UGT) 2B15 metabolizes 5alpha-di

109 tigate the inhibitory effects of TKIs on UDP-glucuronosyltransferase (UGT) activities, and to quantit

110 dinavir-mediated impairment of bilirubin UDP-glucuronosyltransferase (UGT) activity and would be most

111 these HLM-beads retain uridine 5'-diphospho-glucuronosyltransferase (UGT) activity.

112 en glucuronidation, catalyzed by the two UDP-glucuronosyltransferase (UGT) enzymes UGT2B15 and UGT2B1

113 f the UGT1A gene, encoding half of human UDP-glucuronosyltransferase (UGT) enzymes, undergo alternati

114 The UDP-glucuronosyltransferase (UGT) family of enzymes is impor

115 endoxifen, is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

116 metabolism is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

117 A reduced hepatic bilirubin UPD- glucuronosyltransferase (UGT) is associated with this sy

118 A1) encoding the uridinediphosphoglucuronate glucuronosyltransferase (UGT) isoform bilirubin-UGT1 wer

119 ein-protein interactions between several UDP-glucuronosyltransferase (UGT) isoforms and cytochrome P4

120 The UDP-glucuronosyltransferase (UGT) isozyme system is critical

121 UDP-glucuronosyltransferase (UGT) isozymes catalyze detoxifi

122 UDP-glucuronosyltransferase (UGT) isozymes detoxify metaboli

123 In humans, uridine 5'-diphosphate glucuronosyltransferase (UGT) operates in opposition to

124 Microsomal uridine diphosphate (UDP)-glucuronosyltransferase (UGT) protein expression and UGT

125 (NQO1), glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and phenol sulfotransfera

126 hepatic glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and sulfotransferase (ST)

127 UDP-glucuronosyltransferase (UGT)-mediated glucuronidation o

128 ained at least partly by upregulation of UDP-glucuronosyltransferase (UGT).

129 in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major

130 Human UDP-glucuronosyltransferases (UGT) are the dominant phase II

131 UDP-glucuronosyltransferases (UGT) catalyze the conjugation

132 Particularly, interaction with UDP-glucuronosyltransferases (UGT) enzymes is an important p

133 gamma-glutamylcysteine synthetase (GCS), UDP-glucuronosyltransferases (UGT),epoxide hydrolase, as wel

134 similarity to the rat CGT enzyme and to UDP-glucuronosyltransferases (UGT).

135 iable exons arrayed in tandem, including UDP glucuronosyltransferase (UGT1), plectin, neuronal nitric

136 The human UDP-glucuronosyltransferase UGT1A locus encodes up to 12 uni

137 ioma-associated protein 1 (GLI1) and the UDP glucuronosyltransferase (UGT1A) family of enzymes are el

138 ler-Najjar syndrome model animal lacking UDP-glucuronosyltransferase (UGT1A1), was used as recipient.

139 ncodes hepatic bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1).

140 The UDP-glucuronosyltransferase, UGT1A1, is the critical enzyme

141 uired for hepatic bilirubin elimination, UDP-glucuronosyltransferase, UGT1A1.

142 UDP-glucuronosyltransferase UGT1A7 catalyzes the glucuronida

143 f two androgen-inactivating enzymes, the UDP-glucuronosyltransferases UGT2B15 and UGT2B17, was assess

144 The UDP-glucuronosyltransferase UGT2B7 is an important human UGT

145 Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a

146 ficient in drug conjugation catalyzed by UDP-glucuronosyltransferases (UGTs) and now report on the ro

147 UDP-glucuronosyltransferases (UGTs) are critical to the deto

148 UDP-glucuronosyltransferases (UGTs) are highly expressed in

149 UDP-glucuronosyltransferases (UGTs) are important enzymes th

150 UDP-glucuronosyltransferases (UGTs) are membrane-bound prote

151 Among the 19 functional UDP-glucuronosyltransferases (UGTs) in humans, UGT2B7 is inv

152 ity label [beta-32P]5-azido-UDP-GlcUA to UDP-glucuronosyltransferases (UGTs) in intact, but not in de

153 pid, reversible down-regulation of human UDP-glucuronosyltransferases (UGTs) in LS180 cells following

154 D-glucopyranosides (glucuronides) by the UDP-glucuronosyltransferases (UGTs) is a significant metabol

155 tor-activated receptor alpha (PPARalpha)-UDP-glucuronosyltransferases (UGTs) signalling is an importa

156 n liver microsomes and human recombinant UDP-glucuronosyltransferases (UGTs) was characterized and co

157 hepatic and intestinal uridine-5'-diphospho-glucuronosyltransferases (UGTs), the catalytic site of w

158 The UGT1A cluster encodes a family of UDP-glucuronosyltransferases (UGTs), which facilitate cellul

159 s highly metabolized by uridine-5'-diphospho-glucuronosyltransferases (UGTs), whose catalytic site is

160 ory patterns of the phase II superfamily UDP-glucuronosyltransferases (UGTs).

161 lucuronidated by hepatic uridine diphosphate glucuronosyltransferases (UGTs).

162 carried out by the Super gene family of UDP-glucuronosyltransferases (UGTs).

163 and catalytic activity of human hepatic UDP-glucuronosyltransferases (UGTs).

164 tion of cytoprotective genes such as the UDP-glucuronosyltransferases (UGTs).

165 e to identify the phenol binding site of UDP-glucuronosyltransferases (UGTs).

166 PsUGT1, which encodes a microsomal UDP-glucuronosyltransferase, was cloned from root tips of Pi

167 cyclodeaminase, and the uridine diphosphate glucuronosyltransferases, whereas alleles such as DRB1*0

168 az both induce an unidentified rat liver UDP-glucuronosyltransferase with activity toward benzo(a)pyr