ライフサイエンスコーパス: glutamate dehydrogenase

1 s (encoding glutaminase) and Glud1 (encoding glutamate dehydrogenase).

2 lation of insulin secretion by modulation of glutamate dehydrogenase.

3 n products, into glutamate, using urease and glutamate dehydrogenase.

4 ation of L-glutamate catalyzed by beef liver glutamate dehydrogenase.

5 an also be directly converted to alpha-KG by glutamate dehydrogenase.

6 directly converted to alpha-ketoglutarate by glutamate dehydrogenase.

7 log, that acts as an allosteric activator of glutamate dehydrogenase.

8 ions of concurrent NADPH sources, especially glutamate dehydrogenase.

9 ding the key nitrogen metabolism enzyme NADP-glutamate dehydrogenase.

10 in gudB, which encodes an otherwise inactive glutamate dehydrogenase.

11 ism and may be through leucine activation of glutamate dehydrogenase.

12 specificity of ammonium-assimilating enzyme glutamate dehydrogenase.

13 enzyme represents a novel class of microbial glutamate dehydrogenases.

14 ed significant similarity with mitochondrial glutamate dehydrogenases.

15 Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) is commonly upregulated

16 Extended analysis of the glutamate dehydrogenase 1 (Gdh1) revealed that it regula

17 Here we report that a glutaminolytic enzyme, glutamate dehydrogenase 1 (GDH1), upregulated upon detac

18 Examining human gliomas, we find that glutamate dehydrogenase 1 (GLUD1) and GLUD2 are overexpr

19 lease in the CNS by introducing the gene for glutamate dehydrogenase 1 (Glud1) under the control of t

20 aracterized (glutathione S-transferase Pi 1, glutamate dehydrogenase 1) tyrosine phosphorylation site

21 iated protein 1), citrate synthase, and GDH (glutamate dehydrogenase 1), are substrates of PARP-1 in

22 upregulated after EGFR activation in a GDH1 (glutamate dehydrogenase 1)-dependent manner.

23 effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific e

24 on of some key mitochondrial enzymes such as glutamate dehydrogenase 2 (GLUD2), adenylate kinase 2 (A

25 losuccinate lyase and to regulatory sites of glutamate dehydrogenase, 2) the use of affinity cleavage

26 tures of lactate dehydrogenase (145 kDa) and glutamate dehydrogenase (334 kDa), respectively.

27 kDa), 46% for enolase (46 kDa), and 27% for glutamate dehydrogenase (56 kDa), and up to 74% sequence

28 Knockdown of glutamate dehydrogenase, a key TCA pathway component, ab

29 secretion in response to glutamine plus the glutamate dehydrogenase activator 2-amino-2-norbornane c

30 e, alpha-ketoisocaproate, succinate, and the glutamate dehydrogenase activator BCH and blocked by cya

31 by reductions in aspartate transaminase and glutamate dehydrogenase activities, suggesting additiona

32 We conclude that glutamate dehydrogenase activity affects the expression

33 Differently, 3d was the best in enhancing glutamate dehydrogenase activity and deacetylating K68-

34 We measured glutamate dehydrogenase activity in lymphoblasts from ei

35 mice exhibit increased glutamine uptake and glutamate dehydrogenase activity.

36 for the biomarkers of hepatocellular injury glutamate dehydrogenase, alanine aminotransferase, aspar

37 unit-subunit interactions for homo-hexameric glutamate dehydrogenase, allowing DeltaDeltaG of reversi

38 A-metabolizing enzymes glutamine synthetase, glutamate dehydrogenase, alpha-ketoglutarate dehydrogena

39 Irradiation of the complex of glutamate dehydrogenase and AMPS-Succ-BP at lambda >300

40 As a result of overexpressing the mutant glutamate dehydrogenase and Bacillus subtilis threonine

41 tridge assay determines the presence of both glutamate dehydrogenase and Clostridium difficile toxins

42 CFEs were suitable sources of peptidases, glutamate dehydrogenase and cystathionine gamma-lyase.

43 nd catalase as the primary autoantigens, and glutamate dehydrogenase and epoxide hydrolase-2 as addit

44 led by the nitrogen regulatory (Ntr) system, glutamate dehydrogenase and histidase.

45 interesting similarities to the structure of glutamate dehydrogenase and leucine dehydrogenase and al

46 conjunction with above average abundances of glutamate dehydrogenase and proline utilization protein

47 tion of key mitochondrial proteins including glutamate dehydrogenase and pyruvate dehydrogenase.

48 impaired glutamine flux to the TCA cycle via glutamate dehydrogenase and reduction in acetyl-CoA pool

49 difficile infection (diarrhoea with positive glutamate dehydrogenase and toxin A or B enzyme immunoas

50 allel by a real-time PCR assay (PCR), a dual glutamate dehydrogenase and toxin A/B enzyme immunoassay

51 ing algorithm (specimens initially tested by glutamate dehydrogenase and toxin EIA; if discordant res

52 gene tcdB, and a 3-step algorithm detecting glutamate dehydrogenase and toxins A and B by enzyme imm

53 n measurements on a small protein complex (l-glutamate dehydrogenase) and a range of VLPs with masses

54 an enzyme immunoassay for toxins A and B or glutamate dehydrogenase, and a PCR for toxin B genes wer

55 rase, branched chain ketoacid dehydrogenase, glutamate dehydrogenase, and glutamic acid decarboxylase

56 For 51 CDI patients, PCR, glutamate dehydrogenase, and toxigenic culture results c

57 rase chain reaction (PCR) for toxin B genes, glutamate dehydrogenase, and toxigenic culture, from pos

58 life function in cases such as G to F-actin, glutamate dehydrogenase, and tubulin and flagella format

59 tridium difficile: an enzyme immunoassay for glutamate dehydrogenase antigen (Ag-EIA) and then, for a

60 ce of the rapid C. diff Quik Chek Complete's glutamate dehydrogenase antigen (GDH) and toxin A/B (CDT

61 stal structures of glutathione reductase and glutamate dehydrogenase are now available; another drug

62 Finally, using glutamate dehydrogenase as a case study, we observe incr

63 The Vidas C. difficile glutamate dehydrogenase assay had performance comparable

64 ct effect is the stimulation of succinate or glutamate dehydrogenase by decreasing matrix Mg2+.

65 Glutamate dehydrogenase catalyses the oxidative deaminat

66 d nucleotide absorbance time courses for the glutamate dehydrogenase catalyzed oxidative deamination

67 intermediate complexes of the bovine liver l-glutamate dehydrogenase-catalyzed reaction.

68 e glutamate dehydrogenase gene by sequencing glutamate dehydrogenase complementary DNA prepared from

69 on glutamine synthesis, we hypothesize that glutamate dehydrogenase complements mitochondrial ammoni

70 Glutamate dehydrogenase covalently attached on tip of VA

71 reaction catalyzed by Clostridium symbiosum glutamate dehydrogenase (csGDH) producing the real-time

72 Here, we used mice with beta-cell-selective glutamate dehydrogenase deletion (betaGlud1(-/-)), lacki

73 , TSC1/2-/- cells become highly dependent on glutamate dehydrogenase-dependent glutamine metabolism v

74 and tandem mass spectrometry to investigate glutamate dehydrogenase dodecamers and serum amyloid P d

75 odelling study using sequences of a range of glutamate dehydrogenases drawn from species which span a

76 fixation genes and represses a gene encoding glutamate dehydrogenase during nitrogen fixation.

77 homolog of the ryanodine receptor type-2 and glutamate dehydrogenase (EC 1.4.1.3), were further inves

78 sympathoadrenal activity and reduced hepatic glutamate dehydrogenase enzymatic activity.

79 o examples: the TATA-box binding protein and glutamate dehydrogenase families.

80 balanced by a NAC-independent activation of glutamate dehydrogenase formation during nitrogen-limite

81 s also showed a loss of a weak repression of glutamate dehydrogenase formation.

82 The sHSP also prevented bovine glutamate dehydrogenase from aggregating at 56 degrees C

83 Glutamate dehydrogenase from beef liver (bl GDH) and the

84 The recent structure determination of glutamate dehydrogenase from the hyperthermophile Pyroco

85 stal structure of the extremely thermostable glutamate dehydrogenase from Thermococcus litoralis has

86 direct structure comparison on the hexameric glutamate dehydrogenases from the hyperthermophiles Pyro

87 mitochondria by either PDG (from 5-(15)N) or glutamate dehydrogenase (from 2-(15)N) enjoys the same p

88 o-sector ATPase, syntaxin binding protein 1, glutamate dehydrogenase, gamma-actin, and elongation fac

89 ondrial GTP (mtGTP)-insensitive mutations in glutamate dehydrogenase (GDH(H454Y)) result in fasting a

90 uses NAD to ADP-ribosylate and downregulate glutamate dehydrogenase (GDH) activity.

91 assay, which tests for the presence of both glutamate dehydrogenase (GDH) and C. difficile toxins A

92 lating enzymes glutamine synthetase (GS) and glutamate dehydrogenase (GDH) and the ammonium-evolving

93 D(+)-dependent activity of the mitochondrial glutamate dehydrogenase (GDH) and thereby enables anaple

94 neously detecting both Clostridium difficile glutamate dehydrogenase (GDH) and toxin A/B antigens aga

95 dies, targeting two C. difficile biomarkers, glutamate dehydrogenase (GDH) and toxin B (TcdB), are co

96 ed for toxigenic Clostridium difficile using glutamate dehydrogenase (GDH) and toxin immunoassays com

97 an enzyme immunoassay (EIA) for detection of glutamate dehydrogenase (GDH) and toxins A and B arbitra

98 mino acid polymorphisms in the NAD-dependent glutamate dehydrogenase (Gdh) and trehalase (Treh) genes

99 ls were screened for C. difficile-associated glutamate dehydrogenase (GDH) antigen and, if positive,

100 p algorithm which includes a C. Diff Chek-60 glutamate dehydrogenase (GDH) antigen assay followed by

101 Diff Chek-60 glutamate dehydrogenase (GDH) antigen assay followed by

102 algorithm which includes the C. Diff Chek-60 glutamate dehydrogenase (GDH) antigen assay followed by

103 n this study we identify a novel activity of glutamate dehydrogenase (GDH) as a histone H3-specific p

104 s from symptomatic patients were tested by a glutamate dehydrogenase (GDH) assay, a toxin A and B enz

105 pecimens that were positive for C. difficile glutamate dehydrogenase (GDH) by Wampole C Diff Quik Che

106 Glutamate dehydrogenase (GDH) catalyzes the oxidative de

107 tor method; toxin enzyme immunoassays (EIA), glutamate dehydrogenase (GDH) detection, and PCR were pe

108 s a specific class of 120-kDa NAD+-dependent glutamate dehydrogenase (GDH) enzymes found in fungi and

109 The glutamate dehydrogenase (GDH) enzymes of 19 Streptococcu

110 gnostic algorithm, an enzyme immunoassay for glutamate dehydrogenase (GDH) followed by the cytotoxin

111 Two linked mutations affecting glutamate dehydrogenase (GDH) formation (gdh-1 and rev-2

112 ment of the Giardia genome that contains the glutamate dehydrogenase (GDH) gene and a portion of a se

113 The structure of human glutamate dehydrogenase (GDH) has been determined in the

114 Glutamate dehydrogenase (GDH) has been shown to play a r

115 Glutamate dehydrogenase (GDH) has been shown to play a r

116 Identification of regulatory mutations of glutamate dehydrogenase (GDH) in a form of congenital hy

117 nthetase (GS)/glutamate synthase (GOGAT) and glutamate dehydrogenase (GDH) in response to varying amm

118 Mammalian glutamate dehydrogenase (GDH) is a homohexameric enzyme

119 Glutamate dehydrogenase (GDH) is a key enzyme interlinki

120 is of beta-cells is partly turned on because glutamate dehydrogenase (GDH) is activated by a decrease

121 Glutamate dehydrogenase (GDH) is allosterically activate

122 The mitochondrial enzyme glutamate dehydrogenase (GDH) is central for hepatic amm

123 Glutamate dehydrogenase (GDH) is found in all organisms

124 Glutamate dehydrogenase (GDH) is found in all organisms

125 Glutamate dehydrogenase (GDH) is regulated by both posit

126 Glutamate dehydrogenase (GDH) is ubiquitous to all organ

127 In pancreatic beta-cells, glutamate dehydrogenase (GDH) modulates insulin secretio

128 ) operon and to repress transcription of the glutamate dehydrogenase (gdh) operon in K. aerogenes.

129 erate glutamate and the second occurring via glutamate dehydrogenase (GDH) or transaminases.

130 The glutamate dehydrogenase (GDH) pathway is important durin

131 Glutamate dehydrogenase (GDH) plays an important role in

132 ng, and two- and three-step algorithms using glutamate dehydrogenase (GDH) screening followed by eith

133 The role of NADH-dependent glutamate dehydrogenase (GDH) was investigated by studyi

134 gluD was highly conserved and glutamate dehydrogenase (GDH) was readily expressed in v

135 Tag cells and in vivo, whereas activation of glutamate dehydrogenase (GDH) was required to stimulate

136 cyl-coenzyme A dehydrogenase short chain and glutamate dehydrogenase (GDH) were decreased by 68% and

137 he GTP and ADP binding sites of bovine liver glutamate dehydrogenase (GDH) were identified using phot

138 oach is illustrated for three model systems: glutamate dehydrogenase (GDH), a 334 kDa hexameric prote

139 We illustrate this here using glutamate dehydrogenase (GDH), a 336-kDa metabolic enzym

140 noassays (EIAs), an EIA for the detection of glutamate dehydrogenase (GDH), and culture of C. diffici

141 shunt, such as glutamine synthetase (glnA1), glutamate dehydrogenase (gdh), glutamate synthase (gltD/

142 We have previously shown that glutamate dehydrogenase (GDH), mitochondrial DNA (mtDNA)

143 ong them, GDH2, which encodes one subunit of glutamate dehydrogenase (GDH), was chosen for further st

144 on that encodes a catabolic NAD(+)-dependent glutamate dehydrogenase (GDH), which converts l-glutamat

145 From 2-step testing, all glutamate dehydrogenase (GDH)-positive specimens, regard

146 gnaling functions via its metabolism through glutamate dehydrogenase (GDH).

147 le, with a large increase in the activity of glutamate dehydrogenase (GDH).

148 synthetase, glutamate synthase (GOGAT), and glutamate dehydrogenase (GDH).

149 e derived from nonglycolytic sources; and 3) glutamate dehydrogenase (GDH).

150 decarboxylation and allosteric activation of glutamate dehydrogenase (GDH).

151 S/GOGAT cycle) or the action of biosynthetic glutamate dehydrogenase (GDH).

152 trogen metabolism, such as the gene encoding glutamate dehydrogenase (GDH).

153 nsulin secretion fine-tuned by mitochondrial glutamate dehydrogenase (GDH).

154 -CoA was formed from glutamine downstream of glutamate dehydrogenase (GDH).

155 promotes glutamine anaplerosis by activating glutamate dehydrogenase (GDH).

156 a strategy of treating nobody, lateral-flow glutamate dehydrogenase (GDH)/odPCR generated 831 true-p

157 nia through reductive amination catalyzed by glutamate dehydrogenase (GDH); secondary reactions enabl

158 ST, GLT-1 and EAAT-1), glutamate metabolism (glutamate dehydrogenase [GDH] and glutamine synthetase [

159 evels of biomarkers of mitochondrial damage (glutamate dehydrogenase [GDH] and mitochondrial DNA [mtD

160 The protein complex also contains glutamate dehydrogenase (GDH1), 4-nitrophenylphosphatase

161 Notably, expression of glutamate dehydrogenase GDH2, a hominoid-specific enzyme

162 addition to its known regulation by NCR, NAD-glutamate dehydrogenase (GDH2) gene expression is down-r

163 The gene encoding an NAD(P)H-dependent glutamate dehydrogenase (gdhA) in Bacteroides thetaiotao

164 ation in the structural gene for NADP-linked glutamate dehydrogenase, gdhA, which disrupts metabolism

165 tinamide adenine dinucleotide (NAD)-specific glutamate dehydrogenases (GDHs), YwlG overexpression can

166 We identified mutations in the glutamate dehydrogenase gene by sequencing glutamate deh

167 nemia syndrome is caused by mutations in the glutamate dehydrogenase gene that impair the control of

168 The expression of the am (glutamate dehydrogenase) gene is dependent upon two upst

169 ona fide C. difficile promoters for rRNA and glutamate dehydrogenase genes.

170 Urease (Urs) and glutamate dehydrogenase (GLDH) are covalently attached t

171 43) were assayed for microRNA-122 (miR-122), glutamate dehydrogenase (GLDH), total cytokeratin 18 (K1

172 K18; markers of necrosis and apoptosis), and glutamate dehydrogenase (GLDH; marker of mitochondrial d

173 K18], high mobility group box-1 [HMGB1], and glutamate dehydrogenase [GLDH]).

174 c effects of palmitate, whereas knockdown of glutamate dehydrogenase (Glud1) had no effect on palmita

175 Whereas most cells use glutamate dehydrogenase (GLUD1) to convert glutamine-der

176 Comparisons of the structures of glutamate dehydrogenase (GluDH) and leucine dehydrogenas

177 ive, as revealed by the activity profiles of glutamate dehydrogenase, glutamate synthase, and glutami

178 tains two genes with the potential to encode glutamate dehydrogenase (GlutDH) enzymes.

179 al reactions: glutamate synthase (GltAB) and glutamate dehydrogenase (GudB), which make and break glu

180 ory pathway, we determined that biosynthetic glutamate dehydrogenase has an inverse isotope effect in

181 Studies of new serum biomarkers such as glutamate dehydrogenase, high mobility group box protein

182 e following: (i) GDH2 encoding NAD-dependent glutamate dehydrogenase; (ii) AAT1 and AAT2 encoding mit

183 the gene (gdh) that encodes the biosynthetic glutamate dehydrogenase in Salmonella.

184 d by a loss of interaction between SCHAD and glutamate dehydrogenase in the pancreatic beta-cells.

185 een tea polyphenols are potent inhibitors of glutamate dehydrogenase in vitro and can efficaciously b

186 etion stimulates succinate dehydrogenase (or glutamate dehydrogenase) in state 4 without decreasing m

187 ia, and NADH) and L-leucine (an activator of glutamate dehydrogenase) in the standard assay mixture,

188 dependent valine dehydrogenases, the evolved glutamate dehydrogenase increased the conversion yield o

189 eticulum and in leakage of the mitochondrial glutamate dehydrogenase into the plasma, reflecting mito

190 Glutamate dehydrogenase is covalently attached to the ti

191 Glutamate dehydrogenase is found in all organisms and ca

192 Bovine liver glutamate dehydrogenase is known to be allosterically ac

193 nt of BCAT activity in tissue homogenates by glutamate dehydrogenase is observed.

194 e of Bacillus subtilis, encoding a catabolic glutamate dehydrogenase, is transcribed by SigL (sigma(5

195 ere found not to be detectable substrates of glutamate dehydrogenase, L-leucine dehydrogenase, L-phen

196 demonstrated that BCH-induced activation of glutamate dehydrogenase leads to the conversion of gluta

197 nd development as well as a 50% reduction in glutamate dehydrogenase levels.

198 Glutamate dehydrogenase mRNA and activity remained uncha

199 The NAD(+)-dependent glutamate dehydrogenase (NAD-GDH) from Pseudomonas aerug

200 stinct cDNA clones encoding NAD(H)-dependent glutamate dehydrogenase (NAD[H]-GDH) in Arabidopsis thal

201 onium-inducible, chloroplastic NADP-specific glutamate dehydrogenase (NADP-GDH) isozymes composed of

202 DIFF CHEK, a new screening test that detects glutamate dehydrogenase of C. difficile.

203 of lack of the glutamate-synthesizing enzyme glutamate dehydrogenase on glucose-limited growth is alt

204 lebsiella aerogenes, the gdhA gene codes for glutamate dehydrogenase, one of the enzymes responsible

205 latory system (Ntr), which in turn represses glutamate dehydrogenase, one pathway of glutamate produc

206 increasing alpha-ketoglutarate production by glutamate dehydrogenase or mitochondrial aspartate amino

207 ydrogenase ( PLDH) and Plasmodium falciparum glutamate dehydrogenase ( PfGDH), respectively, through

208 the malaria biomarker Plasmodium falciparum glutamate dehydrogenase (PfGDH) in serum samples.

209 cellular metabolic signal transduction, with glutamate dehydrogenase playing a key role in the amplif

210 fficile infection and indeterminate results (glutamate dehydrogenase positive, toxin A and B negative

211 the assay mixture, the interference from the glutamate dehydrogenase reaction is minimized.

212 creatic islets suggest that flux through the glutamate dehydrogenase reaction is quiescent during glu

213 Therefore, we propose that glutamate dehydrogenase regulation of insulin secretion

214 utophagy, Rim15 phosphorylates NAD-dependent glutamate dehydrogenase, resulting in increased levels o

215 The glutamate dehydrogenase RocG of Bacillus subtilis is a b

216 ted by an algorithm that utilized an initial glutamate dehydrogenase screening test.

217 hesis of the other glutamate-forming enzyme, glutamate dehydrogenase, severalfold, but this is still

218 Due to the presence of glutamate dehydrogenase substrates (alpha-ketoglutarate,

219 t has fewer than 3 loose stools per day; the glutamate dehydrogenase test for CDI is sensitive and th

220 ls, as did the activities of glutaminase and glutamate dehydrogenase, the enzymes needed to convert g

221 ulin release is associated with flux through glutamate dehydrogenase, the flux is in the direction of

222 The metabolic activity of glutamate dehydrogenase thus has important and previousl

223 The sensitivity of glutamate dehydrogenase to inhibition by guanosine 5'-tr

224 both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and

225 ate, the data suggest that P. mirabilis uses glutamate dehydrogenase to monitor carbon-nitrogen balan

226 Single molecular or multistep assays (glutamate dehydrogenase, toxin A/B, +/- molecular) are r

227 argets for C difficile detection: bacterium (glutamate dehydrogenase), toxins, or toxin genes.

228 ive glutamate biosensor is prepared based on glutamate dehydrogenase/vertically aligned carbon nanotu

229 Weak inhibition of aminotransferases and glutamate dehydrogenase was found with some of the alpha

230 In addition, high activity of glutamate dehydrogenase was incompatible with activity o

231 Glutamate dehydrogenase was more resistant (K(i)(app) =

232 the Roc pathway indicated that rocG-encoded glutamate dehydrogenase was required for such repression

233 ocitrate dehydrogenase-2, malic enzymes, and glutamate dehydrogenase) was assessed.

234 nthetase) was repressed in vivo, while gdhA (glutamate dehydrogenase) was upregulated in vivo.

235 illus subtilis rocG gene, encoding catabolic glutamate dehydrogenase, was found to be subject to dire

236 ments of the genes encoding beta-giardin and glutamate dehydrogenase were sequenced and their alignme

237 s positioned within the crystal structure of glutamate dehydrogenase, where it should also mark the A

238 sterically activate glutamate deamination by glutamate dehydrogenase, which can supply alpha-ketoglut

239 mmonemia was caused by excessive activity of glutamate dehydrogenase, which oxidizes glutamate to alp

240 late the activity of a large NAD(+)-specific glutamate dehydrogenase with an unusually low affinity f

241 ia is transferred to alpha-ketoglutarate via glutamate dehydrogenase, yielding glutamate and the oxid