ライフサイエンスコーパス: glutamate residue

1 ive to modifications in either metal-binding glutamate residue.

2 ase using this mechanism, is an aspartate or glutamate residue.

3 ortant for the initial addition of the first glutamate residue.

4 caps the chain with a single alpha-linked l-glutamate residue.

5 ated version of the SH3 domain lacking a key glutamate residue.

6 -quinone cross-linked to the side chain of a glutamate residue.

7 obe the functional importance of a conserved glutamate residue.

8 was confirmed by mutagenesis of a conserved glutamate residue.

9 ion, where most myosins have an aspartate or glutamate residue.

10 nism requiring an active site zinc ion and a glutamate residue.

11 interactions with the conserved active site glutamate residue.

12 han that of removal of a single gamma-linked glutamate residue.

13 these roles frequently include aspartate and glutamate residues.

14 lular side and new conformations for two key glutamate residues.

15 r is composed of six conserved histidine and glutamate residues.

16 y a selectivity filter (SF) composed of four glutamate residues.

17 tern of predominantly lysine, histidine, and glutamate residues.

18 terminal sequence mutation to add additional glutamate residues.

19 unbiased mass spectrometry, we identify that glutamate residue 141 (E141) of variant histone H2AX is

20 agenesis of a critical Lys(882) residue to a glutamate residue abolished all evidence of kinase activ

21 A glutamate residue adjacent to the box2 region in IFNLR1

22 lecular interaction between partially buried glutamate residues adjacent to the active site of Escher

23 ctures show that binding site tryptophan and glutamate residues adopt different rotamers to conform t

24 es of the putative zipper were replaced with glutamate residues also failed to form stable rings.

25 C-tail clusters require Tha4's transmembrane glutamate residue and its amphipathic helix, both of whi

26 n, were mutated to alanine; in addition, the glutamate residue and one aspartate residue were mutated

27 The glutamate residue and the aromatic pteridine ring intera

28 om a neutral histidine residue to a negative glutamate residue and the disruption of the "dilysine tr

29 nts to a position that engages the catalytic glutamate residue and would block cognate protein substr

30 The mutants include the conversion of all 20 glutamate residues and 24 of the 25 aspartate residues i

31 cluster ligated by three histidine and four glutamate residues and activates dioxygen to perform its

32 Analysis of six conserved aspartate or glutamate residues and an additional 18 disease-causing

33 tions such as those caused by methylation of glutamate residues and by ligand-induced conformational

34 te-directed mutagenesis of nine aspartate or glutamate residues and four histidine residues to leucin

35 Cleavage occurs between cysteine and glutamate residues and results in a pyroglutamate produc

36 ormation: a gamma-glutamyl ligase adds 1-3 l-glutamate residues and the ATP-grasp-type ligase describ

37 Mouse CCP5 removes multiple glutamate residues and the branch point glutamate from t

38 quinone, which leads to the deprotonation of glutamate residues and the construction of gamma-carboxy

39 lpolyglutamate synthetase (FPGS), which adds glutamate residues, and gamma-glutamyl hydrolase (GGH),

40 ids 24-48) that is enriched in aspartate and glutamate residues, and we previously speculated that th

41 wn, it is unknown whether single or multiple glutamate residues are added following each folate bindi

42 Glutamate residues are commonly found surrounding the me

43 ach active site, the catalytic histidine and glutamate residues are contributed by one monomer, and t

44 s, and two cytoplasmic amino-terminal domain glutamate residues are essential for this inhibitory act

45 the clan of GH-A enzymes, the two catalytic glutamate residues are located on strand 4 (the acid/bas

46 tallographic data suggested that neighboring glutamate residues associated with two of these tyrosine

47 We recently reported the importance of a glutamate residue at position 257 in the binding and tra

48 the E257D mutant protein also showed that a glutamate residue at position 257 of this permease is sp

49 the torsinA gene resulting in the loss of a glutamate residue at position 302 or 303 (torsinA DeltaE

50 Furthermore, potentiation required the glutamate residue at position 493.

51 l ATP sensitivity, while the mutation of the glutamate residue at position 51 to glycine (E51G) did n

52 electrostatic repulsions between the peptide glutamate residue at position 7 and 152D of the MHC mole

53 oduction of a bulkier and negatively charged glutamate residue at position 787 could destabilize the

54 sine deaminase (ADA) contains an active site glutamate residue at position-217 that is highly conserv

55 fm-AAs) through the coupling reaction with a glutamate residue at the C-terminus and a glycine at the

56 eolytic cleavage site to acquire the optimal glutamate residue at the N-terminus.

57 ts of the substrate specificity, including a glutamate residue at the rim of the channel entrance tha

58 tion E262 shows that the naturally occurring glutamate residue at this position provides the optimal

59 The interaction involves glutamate residues at distal NT and is disrupted by acid

60 domain elements and containing "activating" glutamate residues at loop and autophosphorylation sites

61 Glutamate residues at positions 9 and 13 and a basic ami

62 nels have a ring of eight negatively charged glutamate residues at the entrance to the intracellular

63 apore H3 domain modified by two gamma-linked glutamate residues at the epsilon-amino group of the COO

64 pends not only on the presence of a specific glutamate residue but also the presence of Cl(-) ions.

65 DRONC autoprocesses itself following a glutamate residue, but processes a second caspase, drICE

66 f variants with all possible combinations of glutamate residues changed to glutamine and arginine cha

67 son with prokaryotic CLC shows that a gating glutamate residue changes conformation and suggests a ba

68 ling a metal-binding site consisting of four glutamate residues close to the symmetry axis.

69 A mutation in a glutamate residue conserved across CLC exchangers is lik

70 Moreover, the introduction of two catalytic glutamate residues conserved across glycosidases into sK

71 nation of mutations that included a specific glutamate residue, conserved in all known Tim9 and Tim10

72 P(1) study identified that the corresponding glutamate residue, conserved in all S1P receptors, ion p

73 Specifically, we demonstrate that glutamate residues contribute to the induction of non-ph

74 idue on TM2, and replacing lysine 319 with a glutamate residue converts PAC to a cation-selective cha

75 Mutant analysis showed that the glutamate residue corresponding to Asp(85) in bacteriorh

76 This glutamate residue corresponds to one of the residues cau

77 .5 MOPS buffer, suggesting that the original glutamate residue could be substituted with other ioniza

78 st evidence that the conserved aspartate and glutamate residues could be involved in the catalysis or

79 the oligomerization domain) was mutated to a glutamate residue, CPS formed an (alphabeta)2 dimer in t

80 ded phytochrome superfamily has identified a glutamate residue critical for bilin binding.

81 (AdoHcy) at 2.8 A resolution and identify a glutamate residue critical for its monomethylation behav

82 harged segments containing only aspartate or glutamate residues ("D/E repeats") are found in many euk

83 regions containing consecutive aspartate or glutamate residues ("D/E repeats").

84 ion is achieved using a novel Fc mutation, a glutamate residue deletion at position 294 (Del) that en

85 ciated with the deletion of one of a pair of glutamate residues (DeltaE302/303) near the C terminus o

86 However, the replacement of Thr(318) with a glutamate residue demonstrated that the simple addition

87 Loss of this single glutamate residue disrupts favorable electrostatic inter

88 However, the mutation of Tyr992 to a glutamate residue does not alter the receptor internaliz

89 Replacement of serines 152 and 153 with glutamate residues down-regulates the activity of NET1 a

90 V13'T in M2 together with neutralization of glutamate residues (E-1'A) and the adjacent insertion of

91 ribution due to a ring of negatively charged glutamate residues (E-2') at the narrow intracellular en

92 is facilitated by the deprotonation of a key glutamate residue (E115) located at the bottom of the bi

93 In this mutant, the protonation state of a glutamate residue (E120) in the pH sensor is sensitive t

94 The role of two glutamate residues (E164 and E144) in the active site of

95 d at the bottom of this cleft is a conserved glutamate residue (E173) that is in position to play an

96 Site-directed mutagenesis of these two glutamate residues (E181A and E182A) along with another

97 Moreover, in RNase H, the glutamate residue E188 has been shown to be essential fo

98 Two glutamate residues, E199 and E408, align with the conser

99 an aspartate residue (Asp 52) rather than a glutamate residue (E317) as in SeCobT.

100 nsport involves protonation of the conserved glutamate residue E373.

101 K+-binding site comprising four co-ordinated glutamate residues (E423 and E426 from each monomer) at

102 Three aspartate residues and a glutamate residue: E424, D498, D500 and D502, thought to

103 4938, D4945, D4953) with asparagine and four glutamate residues (E4942, E4948, E4952, E4955) with glu

104 Previous simulations suggested that a glutamate residue (E623) mediates the PCET reaction betw

105 ucrose synthase 3 (RSuS3), the two conserved glutamate residues (E678 and E686) in this motif and a p

106 Replacement of two unique glutamate residues, E9 and E13, from the cytoplasmic ami

107 Four glutamate residues (EEEE locus) are essential for ion se

108 a channels contain a cluster of four charged glutamate residues (EEEE locus), which seem essential fo

109 mental evidence that protonation of Glu37, a glutamate residue embedded in a hydrophobic pocket of Hd

110 The gamma-carboxylation of glutamate residues enables Ca(2+)-mediated membrane asse

111 interacts with two neighboring aspartate and glutamate residues essential for NorA-mediated antibioti

112 In the Ca(2+)-binding site, two essential glutamate residues exhibit different conformations compa

113 ration, which appears to prime the catalytic glutamate residue for ATP hydrolysis.

114 The predicted catalytic glutamate residue for transglycosylase activity of bacte

115 for deacetylated cell wall, and usage of two glutamate residues for catalysis.

116 on the top face of the Kelch domain and the glutamate residues form multiple hydrogen bonds with hig

117 The invariant catalytic glutamate residue found in lysozyme and various bacteria

118 Mutation of an invariant glutamate residue found within the catalytic domain of g

119 es; in particular, the conserved active site glutamate residues found in retaining glycosidases are p

120 S metal ion in a manner similar to that of a glutamate residue from collagen.

121 Removal of a glutamate residue from the binding site resulted in the

122 tive mutation in most cases is deletion of a glutamate residue from the carboxy terminal of torsinA,

123 The enzyme also removed multiple glutamate residues from side chains and C termini of pac

124 aGH) catalyze the hydrolysis of gamma-linked glutamate residues from the polyglutamyl of folates and

125 site-directed mutagenesis to include the two glutamate residues functioning in acid/base catalysis in

126 residues in Sso7d (D16 and D35) and a single glutamate residue (G54) showed significantly perturbed p

127 ng S2 cells, DIAP1 is cleaved by DRONC after glutamate residue Glu-205, located between the first and

128 a mechanism according to which the invariant glutamate residue (Glu-243) acts as a general base catal

129 rystal structure of T7 helicase shows that a glutamate residue (Glu-343), located at the subunit inte

130 docking studies have implicated a conserved glutamate residue (Glu-348) as a general base in the syn

131 Mutational analysis identified a titratable glutamate residue (Glu-536) in the linker between TM3 an

132 transient coordination to a highly conserved glutamate residue (Glu-67) during the catalytic cycle.

133 Mutagenesis of either of two conserved glutamate residues (Glu(66) and Glu(70)) within the Nudt

134 of betaS fibril structures indicate that key glutamate residues (Glu-31 and Glu-61) in these domains

135 vitro binding assays, we have identified two glutamate residues (Glu-849 and Glu-902) in beta(2)-adap

136 the role of the highly conserved C-terminal glutamate residue, Glu-590, on catalysis and malonyl-CoA

137 port the effects of mutations of active site glutamate residues, Glu(78) and Glu(122), on reactant bi

138 tions of two symmetry-related, lumen-exposed glutamate residues, Glu-122 and Glu-226.

139 ow protonation of a single membrane embedded glutamate residue (Glu14) within the homodimer of EmrE m

140 A conserved glutamate residue (Glu156) is the most likely target for

141 e and that this caused the relocation of two glutamate residues (Glu181 and Glu182) into the proximit

142 diated by a single, evolutionarily conserved glutamate residue (Glu373) at a position where synapsin

143 As an alternative explanation, a specific glutamate residue (Glu59 in this flavodoxin), which is h

144 residues (His78, His161 and His225) and one glutamate residue (Glu77).

145 equence in Rad30, in which the aspartate and glutamate residues have each been changed to alanine.

146 is of a selection of conserved aspartate and glutamate residues, identified aspartate 145 as being es

147 he central subunit NuoM contains a conserved glutamate residue in a position that is taken by a lysin

148 Replacement of the external glutamate residue in domain II by cysteine reduces sodiu

149 ified that catalyze the epimerization of the glutamate residue in L-Ala-D/L-Glu.

150 dentified the amino-terminal neighbor of the glutamate residue in motif III as a determinant of pore

151 tributed to an additional negatively charged glutamate residue in PaNhaP.

152 In addition, we show the importance of this glutamate residue in sigma(54).DNA conformation sensing,

153 rginine 'toggles' between interacting with a glutamate residue in the 'lid' subdomain and the catalyt

154 esidue at the end of the beta10 strand and a glutamate residue in the beta1-beta2 linker.

155 hysiological experiments further show that a glutamate residue in the extracellular vestibule of the

156 A conserved glutamate residue in the inhibitory helix motif was prev

157 ant role in histone substrate binding, and a glutamate residue in the protein core as playing an esse

158 We have now identified a highly conserved glutamate residue in the transmembrane region of E. coli

159 enzyme for collagen and the importance of a glutamate residue in the unique catalytic triad (Ser(278

160 cid with only one methyl group less than the glutamate residue in the wild-type enzyme, resulted in c

161 beta-solenoid conformation with a protonated glutamate residue in their fibrillar core.

162 Mutations of this glutamate residue in Torpedo ray ClC channels alter gati

163 SMR family transporters contain a conserved glutamate residue in transmembrane 1 (Glu14 in EmrE) tha

164 vidence of a H-bond between the ligand and a glutamate residue in transmembrane helix 3, which is con

165 The glutamate residue in turn might be further polarized thr

166 affects channel selectivity, suggesting that glutamate residues in both TM1 and TM3 face the lumen of

167 Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), an

168 Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and G

169 GGCX), the enzyme responsible for converting glutamate residues in certain proteins to gamma-carboxyg

170 The enzyme has the expected two glutamate residues in close proximity to one another in

171 region consisting of numerous aspartate and glutamate residues in close proximity.

172 e show that a pair of invariant arginine and glutamate residues in each receptor alpha-subunit electr

173 brane helices (TMHs) and show that conserved glutamate residues in GldL TMH2 are essential for glidin

174 ally mimicked for NCX3-B by mutating several glutamate residues in its cytoplasmic loop.

175 eriments show that aspargine, glutamine, and glutamate residues in MSP are perturbed by photooxidatio

176 We find that two consecutive glutamate residues in NOD2 are required for interaction

177 , 5 histidine, and 4 of the 28 aspartate and glutamate residues in the 202 residue VanX protein.

178 f methylation and demethylation of conserved glutamate residues in the Bacillus subtilis chemotaxis r

179 ent Cxs shows the presence of well conserved glutamate residues in the C terminus of TM-1; only Cx26

180 Exchanges of catalytically important glutamate residues in the Nudix motif impaired or abolis

181 rected mutagenesis of conserved arginine and glutamate residues in the parasite-specific third cGMP s

182 ein and produces F420with predominantly 5-7l-glutamate residues in the poly-gamma-glutamate tail.

183 Four glutamate residues in the prototypic gamma-class carboni

184 By comparison, mutagenesis of aspartate and glutamate residues in the putative linker regions showed

185 functionally replaces one of the active site glutamate residues in the reactions catalyzed by crotona

186 catalyzed methylation (and demethylation) of glutamate residues in the signaling domains of methyl-ac

187 his study, we assessed the role of conserved glutamate residues in the Walker B domain of the two ATP

188 yotic Na(+)-channels is the presence of four glutamate residues in their selectivity filter.

189 e side-chain resonances of the aspartate and glutamate residues in uniformly (13)C-labeled alpha-lyti

190 s have confirmed that this unusual "bridging glutamate" residue in CntA is essential in catalysis and

191 likely filled by the analogous aspartate (or glutamate) residue in protein disulfide isomerase, DsbA,

192 backbone of rabbit CYP4B1; (ii) this I-helix glutamate residue influences substrate orientation in th

193 with this possibility, merely introducing a glutamate residue into the active site of a PTPS protein

194 n outside the cyclodextrin cavity, while the glutamate residue is anchored in the interior of the alp

195 d region includes a GIXE motif, in which the glutamate residue is completely conserved among the perm

196 ur interpretation is that this region of the glutamate residue is crucial in relaying the activating

197 al modification - polyglutamylation, where a glutamate residue is enzymatically linked to the gamma-c

198 A glutamate residue is identified as the key contact with

199 activity, respectively, indicating that this glutamate residue is important but not critical to catal

200 A conserved essential glutamate residue is involved in this interaction.

201 of an E809A mutant showed that the conserved glutamate residue is not relevant for the PatZ catalytic

202 However, a glutamate residue is not the only residue capable of fun

203 rom Escherichia coli indicate an unspecified glutamate residue is phosphorylated.

204 We show that a single anionic glutamate residue is responsible for maintaining the dis

205 de that the steric hindrance provided by the glutamate residue is responsible for the heme orientatio

206 This post-translational modification of glutamate residues is catalyzed by the membrane-embedded

207 The water molecule, which bridges two glutamate residues, is reminiscent of the enolase active

208 nt protein shows that the negatively charged glutamate residue lies on the surface of the N-terminal

209 However, mutation at two consecutive glutamate residues located within the hinge between the

210 Glutamine substitutions in two conserved glutamate residues, located within predicted transmembra

211 her suggest a mechanism by which a conserved glutamate residue mediates proton symport.

212 erefore, the protonation of aspartate and/or glutamate residues must provide an additional driving fo

213 ene, which changes the charge at a conserved glutamate residue near the outer mouth of the pore, has

214 ing and selectivity, a set of four conserved glutamate residues near the external mouth of the pore.

215 These roles include polarization by a glutamate residue of a water molecule for the attack on

216 We found that a glutamate residue of GIRK2 (E315), located on a hydropho

217 mutagenesis, we demonstrated that the first glutamate residue of the conserved DEIDFEFL motif (E97)

218 The glutamate residue of the HXE motif is catalytically requ

219 7 transgenes were mutagenized to replace the glutamate residue of the HXE motif, and transgenic plant

220 plex uses surface-attached FV and y-carboxyl-glutamate residues of FX and FII to attach to EC surface

221 the posttranslational modification of select glutamate residues of its vitamin K-dependent substrates

222 the mannitol permease and the corresponding glutamate residues of other PTS permeases play important

223 out the spatial arrangement of two conserved glutamate residues of rat liver enoyl-CoA hydratase to w

224 In vertebrates, the modification of glutamate residues of target proteins is facilitated by

225 e of Glu181, the second of the two invariant glutamate residues of the double E loop that coordinate

226 lpha-helix-turn-beta-strand motifs, with the glutamate residues of the EEEE motif located in the turn

227 strate the catalytic role of two interacting glutamate residues of TSP1, located in a cleft between t

228 Furthermore, we show that a glutamate residue on E3 is involved in catalyzing ubiqui

229 from its catalytic histidine to aspartate or glutamate residues on 43-kDa membrane proteins.

230 A ring of glutamate residues on its extracellular side forms the s

231 Along with neutralization of glutamate residues on the B loop, these changes cause a

232 in ligation with the burial of three charged glutamate residues on the same helix.

233 The high density of aspartate and glutamate residues on the surface follow a helical patte

234 , we measured acid dissociation constants of glutamate residues on troponin C and of histidine on ske

235 These results indicate that both glutamate residues play crucial roles in the hydration c

236 e product catalyzes the addition of multiple glutamate residues (polyglutamation) to methotrexate upo

237 2 form extensive hydrogen-bond networks with glutamate residues predominantly in the unstructured, ac

238 3 into the FtsY active site orients a single glutamate residue provided by Ffh (E277), triggering GTP

239 A close approach of two key glutamate residues provides an elegant mechanism for the

240 Substitution of arginine 282 with a glutamate residue (R282E-PepT1) gave a protein at the pl

241 ltetrahydropterin synthase (PTPS) in which a glutamate residue replaces or accompanies the catalytic

242 Single-site mutations of aspartate and glutamate residues reveal their role in interactions wit

243 eaction in the absence of a highly conserved glutamate residue seen in Gcn5-related N-acetyltransfera

244 mutant in which histidine was replaced by a glutamate residue showed preferential heterodimer format

245 S of an altered conformation, in which a key glutamate residue swings out toward one of the heme prop

246 The active site contains a glutamate residue that contacts the substrate, but, beca

247 The E166A mutant lacks a critical glutamate residue that has a key role in the deacylation

248 n of a previously unidentified intracellular glutamate residue that is critical for drug resistance.

249 Each subunit contains a buried glutamate residue that is essential for function, and th

250 ime identified and characterized a catalytic glutamate residue that is involved in the energy transdu

251 E623, a glutamate residue that is near these tyrosines only in t

252 is known only inferentially by two conserved glutamate residues that act as way-stations for H(+) in

253 MH1 and MH2 contain glutamine and glutamate residues that are subject to deamidation, meth

254 ficance of strategically placed arginine and glutamate residues that form interacting pairs in respon

255 tituting each of the four negatively charged glutamate residues that form the ion selectivity filter

256 e occurrence of carboxylate shifts involving glutamate residues that ligate the catalytic iron atoms.

257 res are characterised by conserved aspartate/glutamate residues that provide ligands for metal bindin

258 nsity of acidic residues, including specific glutamate residues that serve as receptor adaptation sit

259 Ca channels rely on four glutamate residues (the EEEE locus), whose carboxyl side

260 pore-lining mutants, we find that a ring of glutamate residues, the "E-locus," serves as the channel

261 E144A, we studied the effect of shifting the glutamate residue to all sites within helix V and three

262 We show that the enzyme adds a glutamate residue to both F(420)-0 and F(420)-1 in two d

263 In contrast, modification of either of the glutamate residues to alanine caused a dramatic decrease

264 he processive addition of approximately four glutamate residues to DDAH 4PteGlu 1.

265 atalyses the GTP-dependent addition of two L-glutamate residues to F(420)-0 to form F(420)-2.

266 ynthesis pathway by successive additions ofl-glutamate residues to F420-0, producing a poly-gamma-glu

267 nstrate that full-length FbiB adds multiplel-glutamate residues to F420-0in vitroto produce F420-5 af

268 ation of VK hydroquinone to convert specific glutamate residues to gamma-carboxyglutamate residues in

269 -translational conversion of certain protein glutamate residues to gamma-carboxyglutamate.

270 ational modification, gamma-carboxylation of glutamate residues to Gla.

271 with the known ability of negatively charged glutamate residues to substitute functionally, in some c

272 the heterogeneous addition of glycine and/or glutamate residues to the disordered C-terminal tails (C

273 FB, an enzyme that catalyzes the addition of glutamate residues to the folate molecule to form folylp

274 red", electrostatic networks of arginine and glutamate residues to the surfaces of the coiled-coil bu

275 ical disorder caused by deletion of a single glutamate residue (torsinA DeltaE) in the C-terminal reg

276 Our results show that the catalytic glutamate residue transitions from an active to an inact

277 licated in substrate binding were changed to glutamate residues using PCR based site-directed mutagen

278 not completely abolished when the invariant glutamate residue was altered.

279 It was found that protonation of a single glutamate residue was enough to modify the conformation

280 t and for both mu and delta receptors when a glutamate residue was incorporated into the extracellula

281 Glutamate residues were also introduced mutagenically as

282 residue (F680) that resides between the two glutamate residues were changed by site-directed mutagen

283 1p and Phr2p was conducted and two conserved glutamate residues were shown to be essential for activi

284 Hence, aspartate and glutamate residues were systematically substituted with

285 31 novel lipophilic TS inhibitors, lacking a glutamate residue, were synthesized; 26 of them had in c

286 s the charge-charge repulsion from the three glutamate residues when carbamate passes through the tun

287 -CRD interface, is coordinated by a triad of glutamate residues which are, to some extent, neutralise

288 ring aspartate substitutions for each of the glutamate residues which normally undergo gamma-carboxyl

289 een the positively charged drug and a buried glutamate residue, which is the key to cation selectivit

290 number and location of the active lysine and glutamate residues, which can participate independently

291 SASP-C of Bacillus megaterium two conserved glutamate residues, which form part of the germination p

292 The presence of one glutamate residue with its chain directed toward the int

293 ring penetrates into the CD cavity while the glutamate residue with the aminobenzoic part of FA is ex

294 inability of K(+) to fit between a plane of glutamate residues with the preferred solvation geometry

295 We further identify a glutamate residue within a conserved region adjacent to

296 in EmrE is defined by two negatively charged glutamate residues within a hydrophobic pocket formed fr

297 The ion selectivity locus comprises four glutamate residues within the channel's pore.

298 involves reversible methylation of specific glutamate residues within the cytoplasmic domains of met

299 modified by carboxyl methylation of specific glutamate residues within their cytoplasmic domains.

300 First, a conserved glutamate residue, within HMCES' active site, catalyses