ライフサイエンスコーパス: glutamine-rich

1 -binding protein and splicing factor proline/glutamine-rich.

2 acid composition: acidic, proline-rich, and glutamine-rich.

3 racting with the splicing factor proline and glutamine-rich.

4 rminal 202 amino acids form a potent glycine/glutamine rich activation domain (GQ domain) that can tr

5 han transiently transfected, whereas the Sp1 glutamine-rich activation domain is more effective on in

6 One activator, however, derived from a glutamine-rich activation domain of Sp1, activated trans

7 ce similarities with each other and with the glutamine-rich activation domain of transcription factor

8 d by a heterologous acidic, proline-rich, or glutamine-rich activation domain.

9 vity, we show that the serine/threonine- and glutamine-rich activation domains A and B of Sp1 are req

10 ophila homolog dTAFII110, interacts with the glutamine-rich activation domains of the human transcrip

11 We observed that, unlike other glutamine-rich activation domains, the GQ domain activat

12 Four ARFs function as activators and contain glutamine-rich activation domains.

13 d Ela activation domains but not acidic- and glutamine-rich activation domains.

14 e GQ domain fundamentally differs from other glutamine-rich activators and may share some properties

15 est a novel mechanism by which the family of glutamine-rich activators promotes cellular gene express

16 ontrast, several studies have suggested that glutamine-rich activators such as human Sp1 are active i

17 el fold creating a cashew-shaped form with a glutamine-rich alpha helix packed against a beta-sheet f

18 st Med15 and its orthologs share an unusual, glutamine-rich amino acid composition.

19 The glutamine rich and WD-repeat domains are separated by a

20 In solution at acid pH, the glutamine-rich and asparagine-rich 18-residue Sup35 pept

21 otein into prions has been attributed to its glutamine-rich and asparagine-rich domain.

22 oteins during macrophage development via the glutamine-rich and PEST domains.

23 EBNA 3C contains glutamine-rich and proline-rich domains and a region in

24 ontains fourteen C2H2-type zinc fingers, and glutamine-rich and proline-rich domains, suggesting that

25 detected when flanking regions including the glutamine-rich and the basic regions that follow the HD

26 polymerase-1 and splicing factor proline and glutamine-rich, and is functional regarding haplotype-sp

27 tifs of the C2H2 type as well as proline and glutamine rich areas.

28 Here we identify SFPQ (splicing factor, poly-glutamine rich) as an RBP that binds and regulates multi

29 Notably, insertion of the glutamine-rich B trans-activation domain of SP1 into a m

30 ive RNA-binding domains, arginine/methionine/glutamine-rich C terminus and 3 potential membrane spann

31 minal region that is linked to two different glutamine-rich C-termini.

32 o fragments, the globular Cks domain and the glutamine-rich COOH terminus.

33 An isocaloric glutamine-rich diet abolishes STING-mediated effector ce

34 al protein VP16, the Drosophila fushi tarazu glutamine-rich domain (ftzQ), and yeast Gal4 were tested

35 orm a dimer through the interaction of their glutamine-rich domain (GRD) to form the stem of the 'dum

36 are characterized by a conserved N-terminal glutamine-rich domain and a conserved C-terminal WD-repe

37 of three RNA recognition motifs (RRMs) and a glutamine-rich domain and binds to uridine-rich RNA sequ

38 zinc finger domain at the C terminus and the glutamine-rich domain at the N terminus of Sp1.

39 wed that RF2a interacts with TBP through the glutamine-rich domain but not the acidic domain.

40 The glutamine-rich domain compensates for otherwise deleteri

41 determined a high-resolution structure of a glutamine-rich domain from human histone deacetylase 4 (

42 We propose that the rodent glutamine-rich domain has (i) fostered accumulation of c

43 e the inherent transcriptional activity of a glutamine-rich domain in yeast S. cerevisiae from its ap

44 polymerase II via the coactivator CBP and a glutamine-rich domain interaction with TFIID via hTAF(II

45 The primary role of the glutamine-rich domain is apparently to mediate tetrameri

46 RM) domain have a minor contribution and the glutamine-rich domain is dispensable.

47 The glutamine-rich domain of HDAC4 (19 glutamines of 68 resi

48 r nutrient signaling, and the histidine- and glutamine-rich domain of TCP20, which is conserved acros

49 The amyloid-forming glutamine-rich domain of Whi3 was required for both mnem

50 de-liganded AR could interact with the SRC-1 glutamine-rich domain that mediates AR NH(2)-terminal bi

51 four domains: a unique N-terminal domain, a glutamine-rich domain, an arginine-glycine (RGG) domain,

52 The long, glutamine-rich domain, which is located between the KD a

53 ls lack a critical co-factor necessary for a glutamine-rich domain.

54 in RE and RS dipeptides, and a proline- and glutamine-rich domain.

55 ncoding (as in mice) a CAG repeat-associated glutamine-rich domain.

56 a transcriptional repressor that contains a glutamine-rich domain.

57 ain at its N terminus, followed by a proline/glutamine-rich domain.

58 it encodes a novel protein with at least two glutamine-rich domains and a highly conserved domain tha

59 Interestingly, we found that glutamine-rich domains are considerably less potent when

60 A truncated CBF that lacked the glutamine-rich domains did not activate transcription fr

61 ne expression, although the proline-rich and glutamine-rich domains each played a role in this functi

62 CREMalpha lacks the glutamine-rich domains found in CREB that are essential

63 sults is supported by our finding that yeast glutamine-rich domains from HAP2 and MCM1 are also trans

64 We also find that the amino-terminal glutamine-rich domains of hGrg and TLE1 are sufficient t

65 ation domain comprises three subdomains, the glutamine-rich domains Q1 and Q2 and the kinase inducibl

66 taQ1 and CREMDeltaQ2), which lack one of the glutamine-rich domains, Q1 and Q2 respectively, and six

67 many native yeast activator proteins contain glutamine-rich domains.

68 c and transient interactions mediated by the glutamine-rich domains.

69 to 675 of EBNA3C flanked by the proline- and glutamine-rich domains.

70 contrast to PU.1, which contains acidic and glutamine-rich domains.

71 tream region of genes and the ability to use glutamine-rich enhancers such as Sp1.

72 Here, we have investigated the activity of a glutamine-rich GAL4-Sp1 domain A (Sp1A) hybrid protein i

73 Glutamine-rich gliadin peptides from ingested cereals, a

74 Proteolytically resistant, proline- and glutamine-rich gluten peptides from wheat, rye, and barl

75 Bioinformatics analysis identified a glutamine-rich, heptad-repeat region; a feature of aggre

76 ortion of the molecule is characterized by 7 glutamine-rich hexapeptide repeats similar to those foun

77 m of the first PAS domain resides a putative glutamine-rich hinge (residues 127 to 136) that connects

78 network of hydrogen bonds within a conserved glutamine-rich layer of poorly understood function.

79 A glutamine-rich low-complexity domain (QLC) in the SNF5 s

80 nes in Arabidopsis thaliana encode ARFs with glutamine-rich middle domains.

81 Although the glutamine-rich middle region (Q) was not sufficient to a

82 g a cluster of glutamic acid residues with a glutamine-rich motif on the conserved VP beta-barrel str

83 We propose that a general role of glutamine-rich motifs be to mediate protein-protein inte

84 lp-1-mediated signaling, and that SEL-8 is a glutamine-rich nuclear protein.

85 th the VP16 activation domain but not with a glutamine-rich or proline-rich activation domain.

86 y GAL4 derivatives containing either acidic, glutamine-rich, or proline-rich activation domains.

87 o are modulated by two alternatively spliced glutamine-rich prion-like domains (PLD1 and 2).

88 recognition motifs of TIA-1 are linked to a glutamine-rich prion-related domain (PRD).

89 s, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can

90 protein MSH6 and splicing factor proline and glutamine-rich protein (SFPQ), as well as the histone ac

91 We hypothesize that this novel glutamine-rich protein participates in a protein complex

92 Here we identify LAG-3, a glutamine-rich protein that forms a ternary complex toge

93 ), which encodes a novel 90 kDa proline- and glutamine-rich protein that interacts with a highly cons

94 DPY-22 is a glutamine-rich protein that is most similar to human TRA

95 rt that ribonucleoprotein condensates of the glutamine-rich protein Whi3 interact with the endoplasmi

96 ed approach and showed that LEUNIG encodes a glutamine-rich protein with seven WD repeats and is simi

97 at the putative MS8 protein was similar to a glutamine-rich protein, of unknown function, from the fu

98 repeats and the relocalization of a nuclear glutamine-rich protein.

99 the level of expression of a suite of other glutamine-rich proteins profoundly affect polyQ toxicity

100 CREMalpha lacks two glutamine-rich Q regions that, in CREB, are thought to b

101 or the length and sequence of the C-terminal glutamine-rich (Q) domain.

102 A recognition motifs (RRMs) and a C-terminal glutamine-rich (Q-rich) domain.

103 well as intermolecular interactions with the glutamine-rich Q1 domain of the TATA-box binding protein

104 sis has revealed specific regions within the glutamine-rich (Q1 to Q4) central region of hTAFII130 th

105 with naturally varying sequences within the glutamine-rich region (QRR) IDR of an RNA-binding protei

106 in-7 interaction domain was localized to its glutamine-rich region and ataxin-7's Crx binding domain

107 A region of MEX-3 containing a glutamine-rich region and potential ubiquitination and p

108 the amino terminus, the homeodomain and the glutamine-rich region at the carboxyl terminus.

109 Thus, the glutamine-rich region contributes to specificity of this

110 ne-rich region of the N terminus and a short glutamine-rich region in the C terminus.

111 t a portion of its intrinsically disordered, glutamine-rich region modulates phase separation by form

112 osphorylation of the ICD and p300 requires a glutamine-rich region of MAM (TAD2) that is essential fo

113 Deletion constructs confirm that the glutamine-rich region of Sp1 is required to enhance vime

114 -Ala261, Tyr121-Gln136, and the proline- and glutamine-rich region Pro64-Leu78, exhibit higher fluctu

115 ic domain between the two zinc-fingers and a glutamine-rich region upstream of the first zinc-finger

116 ptor coactivator/p160-binding region and the glutamine-rich region) were each found to be important f

117 ion has been shown to require the C-terminal glutamine-rich region, this region is dispensable for in

118 ontains three putative activation domains: a glutamine-rich region, which interacts in vitro with TAF

119 complex and contains six BRCT domains and a glutamine-rich region.

120 omeodomain transcription factor containing a glutamine-rich region.

121 (bHLH) and PER-ARNT-SIM (PAS) domains and a glutamine-rich region.

122 ral domain of human TAF(II)130 contains four glutamine-rich regions Q1-Q4 that interact with transcri

123 he central domain of hTAFII130 contains four glutamine-rich regions, designated Q1 to Q4, that are in

124 CREMDelta(C-G) lacks both the KID and the glutamine-rich regions.

125 A 26-amino-acid peptide from the proline-glutamine-rich repetitive N-terminal region was identifi

126 induced by digestion-resistant, proline- and glutamine-rich seed storage proteins, collectively refer

127 Moreover, a truncated variant lacking the glutamine-rich sequence did not form fibrils under the s

128 evisiae Cks protein Cks1 has a COOH-terminal glutamine-rich sequence not present in other homologues.

129 and 3) a 176-residue-long, poorly conserved, glutamine-rich sequence.

130 t species present within the fibrils was the glutamine-rich sequence.

131 to high molecular weight multimers through a glutamine-rich sequence.

132 ng domains and the C-terminal half possesses glutamine-rich sequences characteristic of transcription

133 Glutamine-rich sequences exist in a wide range of protei

134 A subset of glutamine-rich sequences has been shown to form amyloid

135 in motifs that function as binding sites for glutamine-rich sequences.

136 dentify two factors, splicing factor proline/glutamine rich (SFPQ) and non-POU domain-containing octa

137 ee host proteins splicing factor proline and glutamine rich (SFPQ), non-POU domain-containing octamer

138 ional protein, splicing factor, proline- and glutamine-rich (SFPQ) has been implicated in numerous ca

139 coma (FUS) and splicing factor, proline- and glutamine-rich (SFPQ) in human cortical neurons.

140 Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear RNA-b

141 Splicing factor proline- and glutamine-rich (SFPQ) is an RNA binding protein that bro

142 Glutamine-rich Sp1 and proline-rich CTF1, two extensivel

143 ors (i.e., the tumor suppressor p53 protein, glutamine-rich Sp1 and the oncoprotein c-Jun) and compar

144 kworm TBP exhibits characteristics such as a glutamine-rich stretch and three imperfect Pro-Met-Thr-l

145 acid residues 277-543), which consists of a glutamine-rich subdomain and two acidic subdomains.

146 Finally, we demonstrate that the glutamine-rich subdomain of the transcriptional activati

147 e identified three acidic subdomains and one glutamine-rich subdomain.

148 racterized by several conserved motifs and a glutamine-rich tail.

149 d Ssa on [PSI(+)] are modulated by the small glutamine-rich tetratricopeptide cochaperone Sgt2.

150 Small glutamine-rich tetratricopeptide repeat-containing prote

151 le and identify a pivotal role for the small glutamine-rich tetratricopeptide repeat-containing prote

152 Small glutamine-rich tetratricopeptide repeat-containing prote

153 reported Vpu-interacting host factor, small glutamine-rich tetratricopeptide repeat-containing prote

154 and a putative ortholog of a mammalian small glutamine-rich tetratricopeptide repeat-containing prote

155 tail-anchored substrate transfer from small glutamine-rich tetratricopeptide repeat-containing prote

156 ative C. elegans ortholog of the human small glutamine-rich tetratricopeptide-repeat-containing prote

157 Small, glutamine-rich, tetratricopeptide repeat protein 2 (Sgt2

158 Here, we explore how FOXP2 and other glutamine-rich TFs avoid unscheduled assembly.

159 hijacking mechanisms governing solubility of glutamine-rich TFs may offer new strategies for treatmen

160 of Socs3 and Sfpq (splicing factor, proline/glutamine rich) that attenuate optic nerve regeneration.

161 basic region/leucine zipper (bZIP) domain, a glutamine-rich trans-activation domain in CREB called Q2

162 ribe the use of the previously characterized glutamine-rich transactivation domain of Sp1 (B-c) as a

163 affinity binding region colocalizes with the glutamine-rich transactivation domain of the receptor.

164 r assay system, we have established that the glutamine-rich transactivation domain, a portion of the

165 3) Both zinc finger and glutamine-rich transactivation domains of Sp1 are involv

166 mains include multiple N-terminal acidic and glutamine-rich transactivation domains, a PEST domain, s

167 alization of the polyglutamine-containing or glutamine-rich transcription factors TBP, CBP and Sp1 in

168 e tracts alter transcription by sequestering glutamine rich transcriptional regulatory proteins, ther

169 Although each peptide was glutamine-rich, tTGase exhibited a high degree of regios

170 Sti1 also suppresses cytotoxicity of the glutamine-rich yeast prion [RNQ+] while reorganizing spe