ライフサイエンスコーパス: glycerol 3-phosphate

1 1,1-difluorodeoxy analogues of (2R)-acyl-sn-glycerol 3-phosphate.

2 gulon mediate utilization of glycerol and sn-glycerol 3-phosphate.

3 ith NaCl plus an alpha subunit ligand, alpha-glycerol 3-phosphate.

4 d GuH(+)) and of an allosteric ligand, alpha-glycerol 3-phosphate.

5 tro by PRK2 in the presence of 1,2-diolyl-sn-glycerol 3-phosphate.

6 ted by the K(m) values for palmitoyl-CoA and glycerol 3-phosphate.

7 attached via ester bonds to enantiomeric sn-glycerol 3-phosphate.

8 e bisphosphatase-1, including AMP, P(i), and glycerol 3-phosphate.

9 droxyacetone phosphate (DHAP), glycerol, and glycerol-3-phosphate.

10 ysophospholipid species, including 1-acyl-sn-glycerol-3-phosphate.

11 and has profound effects on the Km(app) for glycerol-3-phosphate.

12 two molecules of CTP and then titrated with glycerol-3-phosphate.

13 fic activity coupled with an elevated Km for glycerol-3-phosphate.

14 duction by contributing to the production of glycerol-3-phosphate.

15 conversion of dihydroxyacetone phosphate to glycerol-3-phosphate.

16 Glycerol-3-phosphate 1-acyltransferase is a soluble chlo

17 c for the acyltransferase reaction involving glycerol 3-phosphate, 1-acylglycerol 3-phosphate, and di

18 thout significantly increasing the K(m) of L-glycerol-3-phosphate (10.0-14.5 mm).

19 ions, including [2,5-(13)C]glucose, [2-(13)C]glycerol 3-phosphate, [2-(13)C]phosphoenolpyruvate (PEP)

20 , urea, and TMAO on the mechanism of binding glycerol 3-phosphate, a substrate analogue, to yeast tri

21 tudied as a function of the concentration of glycerol 3-phosphate, a substrate surrogate.

22 ity of a mutant, gat1Deltagat2Delta, lacking glycerol-3-phosphate activity.

23 RAM2 encodes a glycerol-3-phosphate acyl transferase (GPAT) and is invo

24 RAM1 regulates the expression of RAM2, a glycerol-3-phosphate acyl transferase that promotes cuti

25 ON1 (RAM1), which was reported to regulate a glycerol-3-phosphate acyl transferase that promotes cuti

26 irst reaction of the pathway in the plastid, glycerol-3-phosphate acyl-acyl carrier protein acyltrans

27 ely used for the net synthesis of PC through glycerol 3-phosphate acylation.

28 o the sn-1 and sn-2 positions of DAG through glycerol-3-phosphate acylation.

29 provide most of the acyl chains for de novo glycerol-3-phosphate acylation.

30 Glycerol 3-phosphate acyltransferase (GPAT) catalyzes th

31 enzymes: glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate acyltransferase and lysophosphatidi

32 oelii glycerol 3-phosphate dehydrogenase and glycerol 3-phosphate acyltransferase are expressed only

33 SF binds constitutively to the mitochondrial glycerol 3-phosphate acyltransferase promoter during fas

34 mutation in the soluble chloroplastic enzyme glycerol-3-phosphate acyltransferase (ACT1) completely r

35 -relevant key nodes, including mitochondrial glycerol-3-phosphate acyltransferase (GPAM), were expose

36 ansferases essential for cutin biosynthesis, glycerol-3-phosphate acyltransferase (GPAT) 4 and GPAT8.

37 Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) catalyzes th

38 Glycerol-3-phosphate acyltransferase (GPAT) catalyzes th

39 t that LpxL shares distant homology with the glycerol-3-phosphate acyltransferase (GPAT) family, incl

40 Arabidopsis (Arabidopsis thaliana) has eight glycerol-3-phosphate acyltransferase (GPAT) genes that a

41 tion, enzymatic activity of liver microsomal glycerol-3-phosphate acyltransferase (GPAT) increased 4-

42 Four glycerol-3-phosphate acyltransferase (GPAT) isoforms, ea

43 The topography of mitochondrial glycerol-3-phosphate acyltransferase (GPAT) was determin

44 G biosynthesis, including those that encoded glycerol-3-phosphate acyltransferase (GPAT), acyl-CoA:di

45 Gene expression of sn-glycerol-3-phosphate acyltransferase (GPAT), diacylglyce

46 Two genes encoding glycerol-3-phosphate acyltransferase (GPAT), the first c

47 In addition, the activity of sn-glycerol-3-phosphate acyltransferase (GPAT), which like

48 t study, we show that AGPAT6 is a microsomal glycerol-3-phosphate acyltransferase (GPAT).

49 d storage triacylglycerols is catalyzed by a glycerol-3-phosphate acyltransferase (GPAT).

50 The expression of glycerol-3-phosphate acyltransferase (GPAT3) was examine

51 Microsomal and mitochondrial isoforms of glycerol-3-phosphate acyltransferase (GPAT; E.C. 2.3.1.1

52 ave previously shown rat liver mitochondrial glycerol-3-phosphate acyltransferase (mtGAT), which cata

53 The sn-glycerol-3-phosphate acyltransferase (plsB) catalyzes th

54 in homology modeling of both the AGPATs with glycerol-3-phosphate acyltransferase 1 (GPAT1) revealed

55 ulating oleoyl-CoA utilization by microsomal glycerol-3-phosphate acyltransferase 3.2-fold and protec

56 Glycerol-3-phosphate acyltransferase 4 (GPAT4), which ca

57 in the model plant Arabidopsis thaliana: the glycerol-3-phosphate acyltransferase 6 (GPAT6) and a mem

58 t a dual functionality of pathogen-inducible GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 6 (GPAT6) in contro

59 opersicum 'Micro-Tom'; the wild type and the GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE [GPAT6] and CUTIN S

60 loss of both dihydroxyacetone phosphate and glycerol-3-phosphate acyltransferase activities in yeast

61 AT resulted in a complete loss of Leishmania glycerol-3-phosphate acyltransferase activity and a majo

62 shmania major promastigotes express a single glycerol-3-phosphate acyltransferase activity important

63 istent with this, inhibition of ER-localized glycerol-3-phosphate acyltransferase activity protected

64 Furthermore, mitochondrial glycerol-3-phosphate acyltransferase activity was reduce

65 on of LPT1 had a minimal effect on 1-acyl-sn-glycerol-3-phosphate acyltransferase activity, but overe

66 iana GPAT5, encoding a protein with acyl-CoA:glycerol-3-phosphate acyltransferase activity.

67 alyses revealed that LmGAT is a low-affinity glycerol-3-phosphate acyltransferase and exhibits higher

68 In this study, we targeted the glycerol-3-phosphate acyltransferase GPAM along with cho

69 Second-site mutations in the ACT1-encoded glycerol-3-phosphate acyltransferase or GLY1-encoded gly

70 cooperative activation of the mitochondrial glycerol-3-phosphate acyltransferase promoter by USF and

71 xotrophs, and this lipid export requires the glycerol-3-phosphate acyltransferase RAM2, a direct targ

72 hesis is primarily mediated by the 1-acyl-sn-glycerol-3-phosphate acyltransferase reaction.

73 s based on competition between Ole1p and the glycerol-3-phosphate acyltransferase Sct1p/Gat2p for the

74 e PlsB26 protein had a significantly reduced glycerol-3-phosphate acyltransferase specific activity c

75 act1, which encodes the chloroplast acyl-ACP:glycerol-3-phosphate acyltransferase, and one in lpat1,

76 ose-6-phosphate dehydrogenase, malic enzyme, glycerol-3-phosphate acyltransferase, and stearoyl-CoA d

77 mice; however, the activities of microsomal glycerol-3-phosphate acyltransferase, diacylglycerol acy

78 The glycerol-3-phosphate acyltransferase, mitochondrial hapl

79 nzymes involved in both TAG synthesis, Gpam (glycerol-3-phosphate acyltransferase, mitochondrial), Dg

80 s impair insulin signaling, we overexpressed glycerol-3-phosphate acyltransferase-1 (GPAT1) in primar

81 osis by upregulating target genes, including glycerol-3-phosphate acyltransferase-1 (Gpat1), which ca

82 vitro studies suggest that the mitochondrial glycerol-3-phosphate acyltransferase-1 (mtGPAT1) isoform

83 Overexpressing glycerol-3-phosphate acyltransferase-1 or -4 inhibited i

84 Glycerol-3-phosphate acyltransferase-4 (GPAT4) null pups

85 l-3-phosphate dehydrogenase, and plsB, an sn-glycerol-3-phosphate acyltransferase.

86 c pathway, including fatty acid synthase and glycerol-3-phosphate acyltransferase.

87 acid synthase, acetyl-CoA carboxylase 1, and glycerol-3-phosphate acyltransferase.

88 c enzymes, including fatty acid synthase and glycerol-3-phosphate acyltransferase.

89 e homozygous mutant deficient of the plastid glycerol-3-phosphate acyltransferase; both mutations blo

90 nnotated as lysophosphatidic acid (1-acyl-sn-glycerol-3-phosphate) acyltransferase (AGPAT).

91 In the plastidic glycerol-3-phosphate acyltransferase1 mutant, which is d

92 (lacs2), permeable cuticle1 (pec1), cyp77a6, glycerol-3-phosphate acyltransferase6 (gpat6), and defec

93 cy in a mutant thereafter named gpat6-a (for glycerol-3-phosphate acyltransferase6).

94 vo pathway for TAG synthesis is catalyzed by glycerol-3-phosphate acyltransferases (GPATs).

95 y the transfer of fatty acids to glycerol by glycerol-3-phosphate acyltransferases, which facilitate

96 o from [1,2-(13)C(2)]glucose; by lowering of glycerol 3-phosphate an allosteric inhibitor of phosphof

97 Lysophosphatidic acid (LPA; 1-acyl-sn-glycerol-3-phosphate), an abundant constituent of serum,

98 FBP1) in association with a decrease in cell glycerol 3-phosphate, an inhibitor of PFK1, rather than

99 production depends on the concentrations of glycerol 3-phosphate and calcium and correlates positive

100 depend upon tissue source, concentrations of glycerol 3-phosphate and calcium, and the presence of di

101 respectively, by 1.0 M phosphite dianion, d-glycerol 3-phosphate and d-erythritol 4-phosphate.

102 Both glycerol 3-phosphate and fatty acyl-CoA increased the GP

103 and by overexpression of mGPDH, which lowers glycerol 3-phosphate and G6P and also mimics the G6pc re

104 Replacement of Pi with sn-glycerol-3-phosphate and 2-aminoethylphosphonate yielded

105 recombinant EDI3 protein cleaves GPC to form glycerol-3-phosphate and choline.

106 of fructose-1,6-bisphosphate, production of glycerol-3-phosphate and competition that rods exert on

107 GDPDs metabolize glycerophosphodiesters into glycerol-3-phosphate and corresponding alcohols, but whe

108 Herein we describe the sn-glycerol-3-phosphate and dihydroxyacetone phosphate tran

109 roxyacetonephosphate at the sn-1 position by glycerol-3-phosphate and dihydroxyacetonephosphate acylt

110 a virulence, initiates with the acylation of glycerol-3-phosphate and dihydroxyacetonephosphate at th

111 ut significant, sequence similarity with the glycerol-3-phosphate and fucose permeases from Escherich

112 e monophosphate, pyruvate, lactate, alanine, glycerol-3 phosphate, and isocitrate were significantly

113 s of epidermal cell glycerol, its metabolite glycerol-3-phosphate, and ATP were found in AQP3 deficie

114 imulate insulin secretion, glucose flux into glycerol-3-phosphate, and esterification of long chain C

115 are enantiomeric polymers: WTA is made of sn-glycerol-3-phosphate, and LTA is made of sn-glycerol-1-p

116 anisms for catalyzing the dehydrogenation of glycerol-3-phosphate are envisioned, based on the confor

117 ride synthesis in mammalian tissues requires glycerol 3-phosphate as the source of triglyceride glyce

118 if 2 to alanines resulted in a Km defect for glycerol 3-phosphate binding leading to the conclusion t

119 nclusion that this motif corresponded to the glycerol 3-phosphate binding site.

120 ting the potential role of these residues in glycerol 3-phosphate binding.

121 bsaturating amounts of a substrate analogue, glycerol 3-phosphate, both NMR peaks were present, with

122 Consistent with the specificity of LmGAT for glycerol-3-phosphate but not dihydroxyacetonephosphate,

123 sfer of the acyl group from acylphosphate to glycerol 3-phosphate by an integral membrane protein, Pl

124 The oxidation of sn-glycerol 3-phosphate by mitochondrial sn-glycerol 3-phos

125 ic acid that begins with the acylation of sn-glycerol-3-phosphate by PlsY using an acyl-phosphate (ac

126 CTP:glycerol-3-phosphate cytidylyltransferase (GCT) catalyze

127 The bacterial enzyme, glycerol-3-phosphate cytidylyltransferase (GCT), is a mo

128 otein family and was previously annotated as glycerol-3-phosphate cytidylyltransferase (GCT).

129 rial lipopolysaccharide (LPS), mitochondrial glycerol 3-phosphate dehydrogenase (GPD2) regulates gluc

130 hain cation of R269 lies at the surface of l-glycerol 3-phosphate dehydrogenase (GPDH) and forms an i

131 ate decarboxylase (ScOMPDC), and human liver glycerol 3-phosphate dehydrogenase (hlGPDH) for catalysi

132 sn-glycerol 3-phosphate by mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) is a major pa

133 truncated substrate glycolaldehyde (GLY) by glycerol 3-phosphate dehydrogenase (NAD (+), GPDH) satur

134 ncluding pyruvate dehydrogenase kinase 4 and glycerol 3-phosphate dehydrogenase 1, was acutely induce

135 s that apicoplast-targeted Plasmodium yoelii glycerol 3-phosphate dehydrogenase and glycerol 3-phosph

136 Gpd1p is a cytosolic NAD(+)-dependent glycerol 3-phosphate dehydrogenase that also localizes t

137 rogenase, glucose 6-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase, and glucose oxidase.

138 three-step reaction utilizing three enzymes: glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate

139 plasmic reticulum Ca2+-ATPase, mitochondrial glycerol 3-phosphate dehydrogenase, PGC1alpha, CoxII, an

140 uncoupling protein (Ucp1) and mitochondrial glycerol-3-phosphate dehydrogenase (Gdm) result in mice

141 Sn-glycerol-3-phosphate dehydrogenase (GlpD) is an essentia

142 stabilize the integral membrane flavoenzyme, glycerol-3-phosphate dehydrogenase (GlpD), and the solub

143 osphoserine phosphatase (PSP) motif fused to glycerol-3-phosphate dehydrogenase (GPD) domains.

144 ion and activity (P<0.02), a 61% increase in glycerol-3-phosphate dehydrogenase (GPDH) activity (P<0.

145 Here we evaluate the effects of glycerol-3-phosphate dehydrogenase (Gpdh) and cytosolic

146 An extensive investigation of two proteins, glycerol-3-phosphate dehydrogenase (GPDH) and superoxide

147 nd hence their glycolytic enzymes, including glycerol-3-phosphate dehydrogenase (GPDH), are considere

148 n extensive investigation of three proteins, glycerol-3-phosphate dehydrogenase (GPDH), superoxide di

149 ehyde-3-phosphate dehydrogenase (GAPDH), and glycerol-3-phosphate dehydrogenase (GPDH).

150 The R269A mutation of glycerol-3-phosphate dehydrogenase (hlGPDH) results in a

151 , both the malate/oxaloacetate shuttle and a glycerol-3-phosphate dehydrogenase 1(Gpd1p)-dependent sh

152 co-imported with the PTS2-containing enzyme Glycerol-3-phosphate dehydrogenase 1, Gpd1.

153 ion (A280V) in a conserved amino acid of the glycerol-3-phosphate dehydrogenase 1-like (GPD1-L) gene.

154 Here, we identify the enzyme glycerol-3-phosphate dehydrogenase 1-like (GPD1L) as a n

155 production of the mature miRNA, derepresses glycerol-3-phosphate dehydrogenase 1-like enzyme (GPD1L)

156 Recently, a novel mutation in the glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L)

157 azepam also blocked the mutant A280V GPD1-L (glycerol-3-phosphate dehydrogenase 1-like) effect on red

158 luted and identified by mass spectrometry as glycerol-3-phosphate dehydrogenase 2 (Gpd2).

159 nthase activity (P<0.001), a 48% increase in glycerol-3-phosphate dehydrogenase activity (P<0.01) and

160 ve effects by inducing maximal mitochondrial glycerol-3-phosphate dehydrogenase activity in rat liver

161 d by 12 +/- 0.4 % in TG SOL and single fibre glycerol-3-phosphate dehydrogenase activity was decrease

162 dulated formation of a complex between alpha-glycerol-3-phosphate dehydrogenase and l-lactate dehydro

163 The activation of pure glycerol-3-phosphate dehydrogenase by either L-ascorbic

164 ol kinase encoded by glpK and suggest that a glycerol-3-phosphate dehydrogenase encoded by the upstre

165 Glycerol-3-phosphate dehydrogenase from pig brain mitoch

166 xpress the gene for the conserved aerobic sn-glycerol-3-phosphate dehydrogenase GlpD.

167 The glycerol-producing PTS2 protein glycerol-3-phosphate dehydrogenase Gpd1p shows a tripart

168 robic conditions, increasing the activity of glycerol-3-phosphate dehydrogenase induces complex dynam

169 letion within the glpD gene encoding aerobic glycerol-3-phosphate dehydrogenase might account for the

170 ally linked to the gpdC gene of the putative glycerol-3-phosphate dehydrogenase operon (gpdABC), base

171 is shifted towards the pentose phosphate and glycerol-3-phosphate dehydrogenase pathways.

172 -3-phosphate acyltransferase or GLY1-encoded glycerol-3-phosphate dehydrogenase restored 18:1 levels

173 n upstream gene, gpdA, encoding a homolog of glycerol-3-phosphate dehydrogenase subunit A, were upreg

174 equire GPD1, which encodes an NADH-dependent glycerol-3-phosphate dehydrogenase that is important for

175 Homogeneous pig brain mitochondrial glycerol-3-phosphate dehydrogenase was activated by eith

176 rom NADL to glycolaldehyde (GA) catalyzed by glycerol-3-phosphate dehydrogenase were determined over

177 and the glycerol-3-phosphate shuttle (Gut2, glycerol-3-phosphate dehydrogenase) are novel longevity

178 sure and a glycerol synthesis gene, gpd1(+) (glycerol-3-phosphate dehydrogenase), and is independent

179 They encode glycerol-3-phosphate dehydrogenase, an ABC transporter,

180 rug tolerance loci, glpABC, the anaerobic sn-glycerol-3-phosphate dehydrogenase, and plsB, an sn-glyc

181 mology, the closest structural neighbors are glycerol-3-phosphate dehydrogenase, N-(1-d-carboxylethyl

182 e glycerol facilitator, glycerol kinase, and glycerol-3-phosphate dehydrogenase, respectively, all of

183 s a physiological activator of mitochondrial glycerol-3-phosphate dehydrogenase, that the enzyme is p

184 GPD1-L has >80% amino acid homology with glycerol-3-phosphate dehydrogenase, which is involved in

185 ng the activity of its ancillary subunit-the glycerol-3-phosphate dehydrogenase-like protein.

186 e (MAs(III)), which is a potent inhibitor of glycerol-3-phosphate dehydrogenase.

187 e and suppression of GLUT2, glucokinase, and glycerol-3-phosphate dehydrogenase.

188 acetone phosphate transport system and an sn-glycerol-3-phosphate dehydrogenase.

189 nergy metabolism (triosephosphate isomerase, glycerol-3-phosphate-dehydrogenase, alpha enolase and L-

190 Saccharomyces cerevisiae has two homologous glycerol-3-phosphate dehydrogenases, Gpd1 and Gpd2, that

191 nal, the lysine catabolite pipecolic acid, a glycerol-3-phosphate-dependent factor and the dicarboxyl

192 Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) displays an intriguing cell biolog

193 Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) displays an intriguing cell biolog

194 utation causes an intracellular depletion of glycerol-3-phosphate due to constitutive synthesis of Gl

195 going cardiac catheterization and identified glycerol-3-phosphate (G-3-P) as the most significant cor

196 Renal vein glycerol-3-phosphate (G-3-P) had the strongest correlati

197 Modeling a ternary complex glycerol 3-phosphate (G3P) and NAD(+) with LmGPDH identi

198 ajor facilitator superfamily, moves external glycerol 3-phosphate (G3P) into the cytoplasm in exchang

199 te transporter (GlpT) mediates the import of glycerol 3-phosphate (G3P) using the gradient of inorgan

200 osephosphate isomerase (TIM) in complex with glycerol 3-phosphate (G3P).

201 Gram-positive bacterial pathogens carry out glycerol-3-phosphate (G3P) acylation, which is the first

202 loss-of-function mutation in the plastidial glycerol-3-phosphate (G3P) acyltransferase (act1) have e

203 pressors demonstrated that a balance between glycerol-3-phosphate (G3P) and 18:1 levels is critical f

204 onical GPD enzymes catalyze the synthesis of glycerol-3-phosphate (G3P) by reduction of dihydroxyacet

205 null mutations in transketolase A (tktA) and glycerol-3-phosphate (G3P) dehydrogenase (glpD) increase

206 glpD encodes the glycerol-3-phosphate (G3P) dehydrogenase, which is invol

207 e (DHAP) and its subsequent conversion to sn-glycerol-3-phosphate (G3P) for synthesis of phospholipid

208 lely by glycerol kinase (encoded by glpK) to glycerol-3-phosphate (G3P) in Haloferax volcanii.

209 Glycerol-3-phosphate (G3P) is a well-known mobile regula

210 Glycerol-3-phosphate (G3P) is an important component of

211 Glycerol-3-phosphate (G3P) is an important metabolite th

212 The metabolism of glycerol-3-phosphate (G3P) is important for environmenta

213 of the major facilitator superfamily is the glycerol-3-phosphate (G3P) transporter (GlpT) from the E

214 The glycerol-3-phosphate (G3P) transporter (GlpT) of the E.

215 secondary active transporter family, the sn-glycerol-3-phosphate (G3P) transporter (GlpT) of the inn

216 The glycerol-3-phosphate (G3P) transporter, GlpT, from Esche

217 GlpQ hydrolyzes deacylated phospholipids to glycerol-3-phosphate (G3P) while GlpT transports G3P int

218 the signaling molecules azelaic acid (AzA), glycerol-3-phosphate (G3P), and salicylic acid (SA).

219 esponse to extracellular phosphates, such as glycerol-3-phosphate (G3P), glucose-6-phosphate (G6P), a

220 lity to produce lactate by generating excess glycerol-3-phosphate (G3P), the production of which also

221 covery that the Escherichia coli periplasmic glycerol-3-phosphate (G3P)-binding protein UgpB can serv

222 ne and storage glycerolipids is acylation of glycerol-3-phosphate (G3P).

223 from cytidine diphosphate-diacylglycerol and glycerol 3-phosphate, generating the precursor phosphati

224 The glpE gene, a member of the sn-glycerol 3-phosphate (glp) regulon of E. coli, encodes t

225 When the alpha-site ligand (ASL) alpha-D,L-glycerol 3-phosphate (GP) binds and closes the alpha-sit

226 y glycerophosphate dehydrogenase (GPD) to sn-glycerol 3-phosphate (GP), which is then converted by gl

227 ipid biosynthesis that controls acylation of glycerol 3-phosphate (GPAT) at the sn-1 position.

228 cally hydrolyze glycerophosphodiesters to sn-glycerol 3-phosphate (Gro3P) and their corresponding alc

229 FA cycle is regulated by the availability of glycerol-3-phosphate (Gro3P) and fatty acyl-CoA.

230 lpha-site, indole is cleaved from 3-indole-D-glycerol 3'-phosphate (IGP) and is channeled to the beta

231 mimic the binding of substrates, 3-indole-d-glycerol 3'-phosphate (IGP) or d-glyceraldehyde 3-phosph

232 red for triacylglycerol (TAG) synthesis from glycerol 3-phosphate in most mammalian tissues.

233 ntrations of glucose intermediates including glycerol-3-phosphate increased when simulating IR due to

234 as not inhibited by either orthophosphate or glycerol 3-phosphate, indicating that either a glycerol

235 nthesis of GlpD and subsequent channeling of glycerol-3-phosphate into metabolic pathways.

236 of this superfamily, GlpT, which transports glycerol-3-phosphate into the cytoplasm and inorganic ph

237 e initial step of acylation of the precursor glycerol 3-phosphate is not essential for the synthesis

238 ose phosphate acquisition pathway whereby sn-glycerol-3-phosphate is directly transported and incorpo

239 This depletion of glycerol-3-phosphate is predicted to limit phospholipid

240 Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) is an important phospholipid media

241 identified, including glycerophosphocholine, glycerol-3-phosphate, L-carnitine, L-aspartate, glutathi

242 , protein synthesis, and ATP levels, whereas glycerol 3-phosphate levels were increased in the mutant

243 ve sufficient acyltransferase activities and glycerol-3-phosphate levels to support rates of TAG synt

244 red for triacylglycerol (TAG) synthesis from glycerol 3-phosphate, lipin 1 has been the focus of most

245 lacked appreciable acylating activity toward glycerol 3-phosphate, lysophosphatidic acid, lysophospha

246 No differences in glucose, lactate, alanine, glycerol 3-phosphate, malate, myo-inositol, or stearic a

247 mutants affected in pathways involved in sn-glycerol-3-phosphate metabolism have led to the identifi

248 Similarly, glycerol 3-phosphate, necessary for the penultimate step

249 Most interestingly B. mori glycerol-3-phosphate O-acyltransferase (BmGPAT) was foun

250 transferase activities were detected against glycerol 3-phosphate or a variety of lysophospholipids,

251 ombinant ALCAT1 were detected against either glycerol-3-phosphate or a variety of other lysophospholi

252 from oxidation of ATP by glycerol kinase and glycerol 3-phosphate oxidase entrapped in the second lay

253 s able to produce hydrogen peroxide by using glycerol-3-phosphate oxidase, and addition of glycerol t

254 based on the activity of glycerol kinase and glycerol-3-phosphate oxidase.

255 ed examination of H(2)O(2) production during glycerol 3-phosphate oxidation by skeletal muscle, brown

256 hosphatidate phosphatase (PAP) enzyme in the glycerol 3-phosphate pathway for triglyceride storage an

257 Therefore, we investigated the role of the glycerol 3-phosphate pathway in dietary lipid absorption

258 which phosphatidic acid synthesized via the glycerol-3-phosphate pathway inhibits mTORC2 activity by

259 data support roles for intermediates in the glycerol-3-phosphate pathway of triacylglycerol synthesi

260 alyze the formation of diacylglycerol in the glycerol-3-phosphate pathway, implicating them in the re

261 zation of a putative organic Pi transporter, Glycerol-3-phosphate permease (G3Pp) family, comprising

262 aracterization indicate that Rv1692 is a D,L-glycerol 3-phosphate phosphatase.

263 f the functional thermodynamic cycle for the glycerol-3-phosphate:phosphate antiporter GlpT by using

264 molecule, may largely determine the rate of glycerol 3-phosphate production.

265 tly increased the dihydroxyacetone phosphate/glycerol 3-phosphate ratio in INS-1(832/13) cells, indic

266 inferred from the dihydroxyacetone phosphate:glycerol-3-phosphate ratio), mitochondrial membrane pote

267 tions in different conserved portions of the glycerol 3-phosphate repressor which are not part of the

268 Aat1 [aspartate amino transferase]) and the glycerol-3-phosphate shuttle (Gut2, glycerol-3-phosphate

269 function: the standing triglyceride pool and glycerol-3-phosphate shuttle-assisted flight.

270 cluding the malate-aspartate shuttle and the glycerol-3-phosphate shuttle.

271 he intermediates of the malate-aspartate and glycerol 3-phosphate shuttles.

272 ed in substrate binding and catalysis at the glycerol-3-phosphate site.

273 ubfamilies, LONG-CHAIN ACYL-COA SYNTHETASE2, GLYCEROL-3-PHOSPHATE SN-2-ACYLTRANSFERASE4, and the ATP-

274 Glycerol-3-phosphate (sn-glycerol-3-P, G3P) acyltransfer

275 aturating amounts of a substrate analogue DL-glycerol 3-phosphate so that the populations of the open

276 ty is of parasite origin and is specific for glycerol 3-phosphate substrate.

277 Both the gly1 mutation, which reduces glycerol-3-phosphate supply to the prokaryotic pathway,

278 (3) Glyceroneogenesis contributes more to glycerol-3-phosphate synthesis during epinephrine infusi

279 nvolved in binding of the phosphate group of glycerol 3-phosphate to the enzyme.

280 redox enzyme that catalyzes the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate.

281 were rapidly esterified with glucose-derived glycerol-3-phosphate to form lysophosphatidic acid, mono

282 Binding of either CTP or glycerol-3-phosphate to GCT was biphasic, with two bindi

283 thesis, it was demonstrated that addition of glycerol-3-phosphate to the growth medium ameliorated th

284 recognition to the crystal structure of the glycerol 3-phosphate transporter (GlpT) from Escherichia

285 Glycerol 3-phosphate transporter (GlpT) mediates the imp

286 Using the x-ray structure of the glycerol 3-phosphate transporter (GlpT), we devised a mo

287 omology model that used the Escherichia coli glycerol 3-phosphate transporter as a template has been

288 ure similar to that of the distantly related glycerol 3-phosphate transporter GlpT.

289 Hence, the data support the glycerol 3-phosphate transporter-based homology model of

290 omic structures of the related transporters, glycerol-3-phosphate transporter (GlpT) and lactose perm

291 In the sn-glycerol-3-phosphate transporter (GlpT) from Escherichia

292 ophosphodiester phosphodiesterase (GlpQ) and glycerol-3-phosphate transporter (GlpT), respectively.

293 In addition, the glycerol-3-phosphate transporter is monomeric and stable

294 ry transporter structures (lactose permease, glycerol-3-phosphate transporter) as well as to a low re

295 whose putative product shows homology to the glycerol-3-phosphate transporter.

296 , biophysical, and structural studies of the glycerol-3-phosphate transporter.

297 cotransporter from the unrelated lactose and glycerol 3-phosphate transporters.

298 e second step in triglyceride formation from glycerol-3-phosphate, was studied in 3T3-L1 adipocytes a

299 Glycerol 3-phosphate, which is produced in vivo by a gly

300 glycerolipid biosynthesis, the acylation of glycerol 3-phosphate with saturated long-chain acyl-CoAs