ライフサイエンスコーパス: glycine residue

1 moiety of L-Trp and the amide nitrogen of a glycine residue.

2 at the cytoplasmic end by bending at a hinge glycine residue.

3 es with substitutions of Gly(193) with a non-glycine residue.

4 sing mutants that replace a highly conserved glycine residue.

5 n cleavage by caspase 8 caused exposure of a glycine residue.

6 protein in which serine 69 was replaced by a glycine residue.

7 lysis, which is apparently maintained by the glycine residue.

8 to the amino group of a protein's N-terminal glycine residue.

9 sition -1 of the leader instead of the usual glycine residue.

10 strate CexE on a highly conserved N-terminal glycine residue.

11 mino acid substitution at a highly conserved glycine residue.

12 residues with preferred proline or preferred glycine residues.

13 substituted with sterically less-constrained glycine residues.

14 ripeptides, some of which contain additional glycine residues.

15 ere replaced with three (H3G3) or six (H3G6) glycine residues.

16 if sorting signals between the threonine and glycine residues.

17 ded segment that contains two well-conserved glycine residues.

18 filter consists of two absolutely conserved glycine residues.

19 served when W69 was replaced with alanine or glycine residues.

20 G motif is cleaved between the threonine and glycine residues.

21 bility by triggering loops that have several glycine residues.

22 peptides contained methionine and tryptophan-glycine residues.

23 nt protein is gelatin, which consists of 30% glycine residues.

24 ed to a C-terminal coiled-coil trimer by two glycine residues.

25 idual amino acids in bacA were replaced with glycine residues.

26 , 10, 15 or 23 residues or insertion of five glycine residues.

27 Among the most conserved positions are glycine residues.

28 th two PR subunits covalently linked by four glycine residues.

29 of collagen peptides containing multiple aza-glycine residues.

30 ), often at loci normally encoding conserved glycine residues.

31 receded and/or followed by nearby proline or glycine residues.

32 -residue lid domain with one, two, and three glycine residues.

33 uctural flexibility of Tyr409 flanked by two glycine residues.

34 face, and is coordinated by highly conserved glycine residues.

35 the channel involving key, identified, hinge glycine residues.

36 site-specifically modified with C(alpha)D(2) glycine residues.

37 ing signal of BcpA between its threonine and glycine residues.

38 demly dispersed repeats of phenylalanine and glycine residues(1,2).

39 work showed that mutations in conserved NqrB glycine residues 140 and 141 affect ubiquinone reduction

40 ane helices II, IV, and V of subunit B, near glycine residues 140 and 141.

41 da 6-85 variant with alanine substituted for glycine residues 46 and 48 in the third helix (G46A/G48A

42 ure stop mutations [a stop codon in place of glycine residue 542 (G542X) and arginine residue 553 (R5

43 rent conformations: (i) kinked 30 degrees at glycine residue 61 in subunits D(1) and D(3) and (ii) st

44 One switch is mediated by glycine residue 61, which allows a 30 degrees kink to fo

45 Despite the enhanced flexibility of the glycine residues, a total of only six conformers were ob

46 A glycine residue above W583 might act as flexible linker

47 g, mutant polyproteins containing five extra glycine residues added to the folded core of the module

48 d and that each protein is myristylated on a glycine residue adjacent to the initiating methionine.

49 fied by the attachment of a myristate to the glycine residue after the initiator methionine.

50 wo ProD2 residues and between each ProD2 and glycine residues (alphaGly-147 and alphaGly-153) on the

51 he EPO-R-binding peptide (containing the i+3 glycine residue) also forms a highly populated, monomeri

52 dues (amino acids 9 to 76 and 233 to 241) or glycine residues (amino acids 242 to 262) were dispensab

53 the amide bond between the carboxyl-terminal glycine residue and an adjacent aromatic residue in Atg8

54 mine the energetic effects of replacing each glycine residue and to correlate the computed energies w

55 in the occurrence of cysteine, arginine and glycine residues and an overabundance of proline, threon

56 stinguished by the abundance of arginine and glycine residues and consequently termed rg-NLSs.

57 evealed polyalanine stretches interrupted by glycine residues and glycine-alanine couplets within MiS

58 ough modification of adjacent tryptophan and glycine residues and loss of 4 atomic mass units.

59 -dependent hydroxylation of peptide-extended glycine residues and phenethylamines, respectively.

60 rd region contained a functionally important glycine residue, and the fourth region involved a highly

61 CD2831 is cleaved between the threonine and glycine residues, and the carboxyl group of threonine is

62 e (phi,psi) conformational angles of two key glycine residues, and the entropy-driven burial of a str

63 changed through site-specific mutagenesis to glycine residues, and the use of a molecular wire termin

64 replaced both a lysine and an arginine with glycine residues; and a triple mutant, R112G, K115G, F11

65 le the residues involved in coordinating the glycine residue are not.

66 ique tripeptide units, between which 1 to 18 glycine residues are inserted, is characterized by NMR a

67 ity pocket of Sspl is unusual; aspartate and glycine residues are present, which is typical of trypsi

68 Proline and glycine residues are statistically preferred at several

69 Proline and glycine residues are well represented among functionally

70 one aspartic acid separated by zero to five glycine residues, as well as with modification of the N-

71 e particles, while a substitution mutant (10 glycine residues) assembled particles but was unable to

72 Nevertheless, GluRs lack a glycine residue at a homologous structural position as t

73 cereblon through a surface turn containing a glycine residue at a key position, interacting with both

74 inds poorly to H-2K(d), because of the small glycine residue at peptide position p9 that is incapable

75 f the protein contains an aspartic acid or a glycine residue at position 103 and may determine if Srf

76 of glycine for Val-229 and/or insertion of a glycine residue at position 225 resulted in a significan

77 tutions could be alleviated by placing a new glycine residue at position 335, immediately flanking th

78 most over-represented pair is formed by two glycine residues at i and i+4 (GxxxG, 31.6 % above expec

79 imeric structure and the introduction of two glycine residues at positions 38 and 111 on the peripher

80 w that direct packing contacts occur between glycine residues at positions 79 and 83 in the transmemb

81 structure from a range of model candidates: Glycine residues at the 12th, 15th, and 16th positions f

82 ains at the N terminus and repeated arginine-glycine residues at the C terminus.

83 are observed to deform the highly conserved glycine residues at the interface of the cohesin heterod

84 r stereotypical clusters and are enriched in glycine residues at the n+1 position.

85 We mutagenized each of the six glycine residues (at positions 11, 241, 383, 388, 400, a

86 This glycine residue, at the strand/loop junction of beta3/lo

87 the role of point mutations of two conserved glycine residues, at positions 179 and 184 located in tr

88 coupling of peptides to GPI analogues with a glycine residue attached to the phosphoethanolamine moie

89 coupled to GPI derivatives having one or two glycine residues attached to the phosphoethanolamine gro

90 lobins, through the introduction of a single glycine residue between the C-terminus of one alpha-chai

91 increasing the kcat for substrates with a P2 glycine residue but generally decreasing the kcat for su

92 ss-linking and novel muropeptides containing glycine residues but no significant changes in spore res

93 This cysteine residue was altered to a glycine residue by guided site-specific mutagenesis usin

94 f five para-substituted (S)-N-(1-phenylethyl)glycine residues, by NMR spectroscopy.

95 though atomic structures suggest that only a glycine residue can provide the proper torsion angle for

96 Known sequence motifs containing key glycine residues can drive the homo-oligomerization of t

97 helix at one or both of two highly conserved glycine residues (corresponding to G134 and G143 in KirB

98 esidues within the C terminus by alanine and glycine residues (DeltaST) resulted in a receptor capabl

99 Other glycine residues do not influence the alpha-helical cont

100 making substitutions of >=10 proline or >=9 glycine residues dramatically lowered Chi-dependent acti

101 as confined to the "enriched in aromatic and glycine residues" (EAGR) box of MG200, previously descri

102 n of the 14 carbon fatty acid myristate to a glycine residue exposed on a caspase-3-cleaved fragment

103 leaves the protein between the threonine and glycine residues, facilitating the attachment of an exog

104 mutant LT molecule has the substitution of a glycine residue for arginine-192 [LT(R192G)].

105 Substitution of a glycine residue for either Cys(38) or Cys(48) resulted i

106 emonstrate that substitution of the nonpolar glycine residue for either or both of the conserved nega

107 ction of mutants substituting alanine and/or glycine residues for 16 prolines located in or near puta

108 ld with substitutions of PDE6alpha'-specific glycine residues for the corresponding PDE5 alanine resi

109 These two critical glycine residues form part of the structures that regula

110 actose permease has shown that the conserved glycine residue found at the first position in the motif

111 The glycine residue found in the wild-type flavodoxin appear

112 Moreover, replacement of glycine residues found at positions 10 or 15 of the loop

113 dentified Spp2, which contained a motif with glycine residues found in a number of RNA binding protei

114 ns and y' ions (differing by the loss of one glycine residue from the sulfonated diglycine branch) th

115 s support the hypothesis that removal of the glycine residue from the tyrosine corner impairs the fol

116 region provide compelling evidence that the glycine residues function as hinge positions in the refo

117 Two different glycine residues (G(102) and G(112)) are replaced by asp

118 sphosites on LAT, is governed by a preceding glycine residue (G131) but can be accelerated by substit

119 Two conserved glycine residues (G335 and G338) are potent inhibitors o

120 ma-secretase cleavage, we mutated one of the glycine residues, G38, to a helix-stabilizing leucine an

121 by site-directed mutagenesis of a conserved glycine residue (G699) found in a bend joining two helic

122 e residue that directly precedes a conserved glycine residue (Gly-331 in acetate kinase) that binds t

123 esidue in the Fv-4 env-encoded protein for a glycine residue (gly-491 in Moloney MuLV Env) that is ot

124 ible to isomerization due to the presence of glycine residues (Gly) on their C-terminal ends.

125 at are involved in substrate binding and two glycine residues (Gly-477 and Gly-478) allowing for heli

126 mmalian aquaporins reveal two well conserved glycine residues: Gly-57 in transmembrane helix (TM) 2 a

127 here that replacement of a highly conserved glycine residue (Gly121) causes 11-cis-retinal to become

128 in a loop of polypeptide which contains four glycine residues (Gly176, Gly179, Gly180 and Gly184) and

129 The yeast enzyme also contains a conserved glycine residue (Gly80) that is essential for the fat-re

130 which harbor a conserved motif of repetitive glycine residues (GxGxGxG) important for tight transmemb

131 n which residues 51-56 are replaced by three glycine residues (H3G3 Im7*), indicated that the cluster

132 nultimate D-alanine residue (as opposed to a glycine residue) has been examined in peptide substrates

133 Some of the glycine residues have also been replaced with proline, a

134 Glycine residues have been implicated in TM helix intera

135 nucleophile His 166 has been replaced with a glycine residue, have been determined and refined to 1.8

136 Substitution of glycine residues, however, is among the few sorts of alt

137 residues identified a construct containing 8 glycine residues (Ico8) that formed well-defined cages.

138 Val(386) and Thr(387) were substituted with glycine residues (ILK-VT/GG) could neither interact with

139 es are not homologous except that each has a glycine residue immediately preceding the lysine which i

140 cond mutation deleted a conserved stretch of glycine residues immediately downstream of the lipobox.

141 the lumen of water channels, which becomes a glycine residue in aquaglyceroporins.

142 over, since mutations in either gate-binding glycine residue in Axin lead to Axin stabilization in th

143 most of the interactions with antigen, but a glycine residue in CDR-H3 was critical for providing a c

144 Especially, a glycine residue in GCC is replaced by phenylalanine in M

145 residues confirmed that myristoylation of a glycine residue in the 2nd position and acyl modificatio

146 arching for an explanation, a helix-breaking glycine residue in the B chain seemed to be the most aus

147 hat differ only by the insertion of a single glycine residue in the beta1/beta2 loop exhibit dual spe

148 ding to the catalytic histidine and a nearby glycine residue in the catalase-peroxidases.

149 in modeling suggests the substitution of the glycine residue in the degron domain of AUX/IAA16 is esp

150 , while mutation of a symmetrically disposed glycine residue in the first turn had little effect on u

151 re-guided substitutions of an ultraconserved glycine residue in the G3-box motif (DXXG).

152 Alanine substitution for the modified glycine residue in the GP-C signal peptide does not affe

153 ith a one-residue stagger to fit every third glycine residue in the inner core without disturbing the

154 In the recessive sos2-5 allele, a conserved glycine residue in the kinase catalytic domain is change

155 e flexibility afforded by a highly conserved glycine residue in the middle of TM2 is crucial for chan

156 aspartic acid in place of the helix-breaking glycine residue in the receptor-binding region of the B

157 stitution that led to the replacement of one glycine residue in the triple-helical domain, breaking t

158 gate-forming residues, or mutation of either glycine residue in the two Axin segments, completely abo

159 in either of these chains that substitute a glycine residue in the ubiquitous X-Y-Gly repeat with a

160 igned to test the postulate that the smaller glycine residue in the vicinity of the alpha-carbon meth

161 Mutating an essential glycine residue in the Walker A motif abolished ABCG1-de

162 A mutation in a glycine residue in this N-terminal region of POL1 compro

163 ted the critical role of the often conserved glycine residue in this process.

164 that mutation to Cys of two highly conserved glycine residues in a GXXXG motif significantly reduces

165 tic acid in ACR I (Asp 62) and two invariant glycine residues in both ACR I (Gly 64) and ACR IV (Gly

166 a-glycine allows for complete replacement of glycine residues in collagen peptides and truncation to

167 sciuri were composed of one alanine and four glycine residues in contrast to the pentaglycine units i

168 or an understanding of the role of conserved glycine residues in fusion peptides and for the engineer

169 study, we investigated the role of conserved glycine residues in hOAT4 function.

170 The sole glycine residues in linkers 1 and 2 were individually ch

171 data provide experimental evidence that the glycine residues in selectivity filters of HKT proteins

172 The glycine residues in the 2 and 3 positions of dynorphin A

173 the delta and gamma carbons; (iv) the three glycine residues in the beta-turn of the flap are virtua

174 ough modification of adjacent tryptophan and glycine residues in the catalytic domain of the enzyme.

175 ted by changing either conserved cysteine or glycine residues in the EGF motifs.

176 Conserved glycine residues in the FP of paramyxovirus F appear to

177 Unexpectedly, a mutation of glycine residues in the FP of the fusion (F) protein fro

178 Glycine residues in the FPs of other class I vFGPs may a

179 Svc) have mutations affecting the conserved glycine residues in the Gly-Xaa-Yaa collagen repeat.

180 The three glycine residues in the glycine-rich loop of the oncopro

181 Instead, three glycine residues in the H region not only are necessary

182 esponding to the highly conserved serine and glycine residues in the loops.

183 loop suggested an important role of the two glycine residues in the mobility of the loop.

184 y be mediated at least in part by a motif of glycine residues in the second transmembrane domain.

185 Ssp2 also has the aspartate and two glycine residues in the specificity pocket, marking this

186 urface (S3) likely bind to aspartic acid and glycine residues in the substrate located two (P2) and t

187 An analysis of helix packing reveals that glycine residues in the transmembrane region of these pr

188 Mutations of the invariant glycine residues in the triple-helical domain-coding reg

189 ent (TMS) X as well as for membrane-embedded glycine residues in TMS XIII.

190 ne protein structures is based on the use of glycine residues in transmembrane domains.

191 Further, central glycine residues in two membrane-interactive loops may e

192 rain expressing an Asc10 derivative in which glycine residues in two RGD motifs were changed to alani

193 s of (13)Carbonyl CSA tensors of alanine and glycine residues in various peptides are similar, even t

194 e of an aspartic protease in which conserved glycine residues, in two canonical DTG triads, are subst

195 ed, revealing that certain aspartic acid and glycine residues inhibit the intrinsic aggregation prope

196 ased by approximately 4.3 A by inserting 1-3 glycine residues into the chain.

197 ed yields for equimolar couplings in which a glycine residue is at the nascent junction.

198 pe proteins and an E. coli mutant in which a glycine residue is inserted after position 80 to mimic t

199 merase I showed that flexibility around this glycine residue is required for DNA cleavage and relaxat

200 l labeling of proteins containing N-terminal glycine residues is achieved using SrtA(staph) and LPXT

201 of the long loop, its sequence (particularly glycine residues) is highly conserved.

202 genome revealed a remarkable conservation of glycine residues juxtaposed to the canonical LPXTG motif

203 d Plu-MACPF, and conservation of several key glycine residues known to be important for refolding and

204 Since glycine residues lack the beta-carbon common to all othe

205 oss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites th

206 a range of values for these angles that the glycine residues likely occupy in the native enzyme.

207 the mutations followed by other arginine and glycine residues located elsewhere in the transporter bu

208 ccurs in p38alpha kinase due to the critical glycine residue marked by its conformational flexibility

209 This suggests that transmembrane glycine residues mediate helix-helix interactions in pol

210 nown modifiers in that there is no conserved glycine residue near the C terminus which, in ubiquitin

211 Glycine residues occur in many of the turns between adja

212 fatty acid, myristate, to the amino-terminal glycine residue of a subset of eukaryotic proteins that

213 is a missense mutation in a highly conserved glycine residue of the fifth epidermal growth factor (EG

214 in the product-like structure, allowing the glycine residue of the glutathione moiety to hydrogen bo

215 lly and covalently added to the NH2-terminal glycine residue of the nascent polypeptide.

216 rotease, which exposes the C-terminal active glycine residue of the nascent SUMO, the heterodimeric S

217 of an isopeptide bond between the C-terminal glycine residue of ubiquitin and a lysine residue in the

218 ation of a thiocarboxylate at the C-terminal glycine residue of Urm1.

219 istate, via an amide bond, to the N-terminal glycine residues of a variety of cellular proteins.

220 nal changes in membrane-embedded proline and glycine residues of Tet(L) were examined, with a focus o

221 The conserved acidic and glycine residues of the disordered loop L1 and its proxi

222 that amino acid substitutions affecting the glycine residues of the GXXXG motif impaired alpha-facto

223 Alanine substitution of a glycine residue on the dimerization surface that does no

224 substitution for a conserved triple-helical glycine residue on the other.

225 Replacement of a highly conserved glycine residue on transmembrane (TM) helix 3 of bovine

226 abilizes the tetrameric interface, where two glycine residues on the same face of one helix create a

227 cated adjacent to the substitution sensitive glycine residues play a role in blocking the pathway upo

228 equired serine (not threonine), two flanking glycine residues (positions -1 and +1), and either one p

229 for mutations to proline and a mutation of a glycine residue predicted to form a C-terminal beta turn

230 bstitution in AlsK recapitulates a conserved glycine residue present in many ROK proteins, including

231 om missense mutation of one of the conserved glycine residues present in the repeating Gly-X-Y sequen

232 ylsuccinate synthase radical is located on a glycine residue, presumably glycine 828 in Azoarcus sp.

233 electrostatic repulsion between interfacial glycine residues previously shown to be critical for dim

234 Key glycine residues provide the flexibility for the helical

235 ubstituted azurin in which the carbonyl of a glycine residue provides this equivalent ligand.

236 In these structures, conserved glycine residues rarely face the lipid interstices, and

237 d peptide, BS30G, identical to BS30 but with glycine residues replacing proline, was prepared and exa

238 e amino-acid tips of these loops by a single glycine residue result in loss of Tet(O)-mediated tetrac

239 Mutation of highly conserved glycine residues resulted in inefficient F protein expre

240 e two mutants, despite having alterations in glycine residues separated by only 11 residues, have dra

241 ane helix-helix interactions showed that two glycine residues separated by three intervening residues

242 The picture that emerges is one where glycine residues serve as molecular notches for orientin

243 roup on the glutamic acid residue and on the glycine residue shows an intriguing different spatial lo

244 only one of the four conserved intramembrane glycine residues significantly affects the secondary str

245 esulting in the replacement of a valine by a glycine residue, significantly affects the accumulation

246 es (W43, Y45, F52 and T53) are replaced by a glycine residue step-by-step; and (5) most importantly,

247 It contains four symmetrically arranged glycine residues suggesting that flexibility is a key fe

248 ely by the flexibility of a highly conserved glycine residue that connects these components.

249 c.115G>A missense mutation in PPIB alters a glycine residue that has been conserved across vertebrat

250 mutations that disrupted the amino-terminal glycine residue that is important for Gag myristylation

251 Instead, activation depends upon a glycine residue that is predicted to provide sufficient

252 binding segment of Axin there is a conserved glycine residue that lies in the bottom of a narrow "gat

253 as achieved by extending the sCT by a single glycine residue that provides a substrate for endogenous

254 The distal helix contains highly conserved glycine residues that allow the helix to flex and intera

255 s the on-off switching of CheA, possesses 14 glycine residues that are highly conserved in related re

256 Introducing 3 glycine residues that disrupt a rigid IS6-a-interaction

257 Introducing 3 glycine residues that disrupt a rigid IS6-alpha-interact

258 the predicted NAD(+)-binding pocket and four glycine residues that form a cradle directly below the N

259 s is mainly achieved by bending at conserved glycine residues that have been previously reported to a

260 1' and S2' sites of the enzyme both prefer a glycine residue, the S1' site is exclusively selective f

261 s carrying replacements of either of the two glycine residues therefore appears to arise from a commo

262 quences from preferred proline and preferred glycine residues, this simple, efficient strategy will b

263 FPs often contain conserved glycine residues thought to be critical for forming stru

264 Replacement of three highly conserved glycine residues, thought to be required for dimerizatio

265 ALDH1A1 and exploit the presence of a unique glycine residue to achieve their selectivity.

266 s to the main chain nitrogen of the adjacent glycine residue to form an aromatic six-membered ring.

267 a dimer-disrupting alteration of a critical glycine residue to leucine.

268 IIA(Aga/Gam) of the PTS, changes a conserved glycine residue to serine (Gly91Ser).

269 TOPRIM domain changing a strictly conserved glycine residue to serine in either the Y. pestis or E.

270 chain in the Hb tetramer can be linked with glycine residues to form 2 bridges across the central ca

271 ApOmpA), an adhesin that uses key lysine and glycine residues to interact with alpha2,3-sialylated an

272 Upon combinatorial substitution of these glycine residues to proline, functional and structural a

273 h a generic sequence of one serine and eight glycine residues to test the importance of the linker am

274 es repositions to expose previously shielded glycine residues to the pore without significant rotatio

275 Changing these glycine residues to valine affected the sensitivity of t

276 modify proteins carrying a single N-terminal glycine residue under mild conditions in 4-6 h.

277 iched in asparagine, glutamine, tyrosine and glycine residues unifies the majority of yeast prion pro

278 s that trap the macrocycle on the particular glycine residue used to assemble the rotaxane.

279 We propose that a glycine residue was ancestral whether the repressor bind

280 erminal is unacetylated and carries an extra glycine residue, was determined by means of two-dimensio

281 ng a piperidine moiety as a replacement of a glycine residue were tested as potential inhibitors of t

282 Moreover, when glycine residues were engineered at the positions where

283 ariants were synthesized in which individual glycine residues were site-specifically modified with C(

284 GXXXG motif, 41 +/- 9% more than expected if glycine residues were uniformly distributed in those alp

285 all the G5 domain (named after its conserved glycine residues), which is found in a variety of enzyme

286 with phosphoethanolamine, aminoarabinose, or glycine residues, which are key to bacterial pathogenesi

287 rtion of conserved residues, including three glycine residues, which seem to play a role in linking t

288 ctus "R" (= dextro D) chirality in a hydroxy glycine residue whose C-terminus is bonded to an iron at

289 Employing a semicarbazide as an aza-glycine residue with an extra hydrogen-bond donor to tun

290 Substitution of the three glycine residues with alanine or proline or the entire s

291 Replacement of the H-region glycine residues with helix-promoting residues led to a

292 previous work, the effect of replacing these glycine residues with valine has been examined with stop

293 ionally via an amide bond to the penultimate glycine residue within the canonical motif (M)GXXX(S/T/A

294 Replacing a conserved glycine residue within the cytosolic S4-S5 linker of bot

295 ent for Sec insertion and that the conserved glycine residue within this domain was required for SECI

296 molecule contains the structurally relevant glycine residues within the A chain, in the midregion of

297 at confirms the proposed location of hydroxy glycine residues within the polymer.

298 Mutation of the conserved, non-glycine residues within this region caused no significan

299 Mutation of four glycine residues within two proposed ATP binding motifs

300 han residues and one conserved, non-aromatic glycine residue, yeast strains with alterations at these