ライフサイエンスコーパス: glycine transporter

1 av3 channels; and 4) inhibition of the GLYT2 glycine transporter.

2 uences of deleting the two genes that encode glycine transporters.

3 gy proposed for the closely related GABA and glycine transporters.

4 and examined its activity against the cloned glycine transporters.

5 Here we show that administration of a glycine transporter 1 (GlyT1) inhibitor, or molecular Gl

6 In the present study we tested several glycine transporter 1 (GlyT1) inhibitors including NFPS,

7 synthesized a potent selective inhibitor of glycine transporter 1 (GlyT1), and characterized its act

8 Variants of SLC6A9, which encodes glycine transporter 1 (GLYT1), reduced glycine-uptake ac

9 r1 : :GFP(+) amacrine cells colabeled with a glycine transporter 1 antibody.

10 and HMGN3b upregulate the expression of the glycine transporter 1 gene (Glyt1).

11 ine racemase homozygous knockout (SR-/-) and glycine transporter 1 heterozygous mutant (GlyT1-/+).

12 (2) Activation of glycine transporter 1(GlyT1) induced by VEGF led to an i

13 e inner nuclear layer, is immunopositive for glycine transporter 1, and shows the typical morphology

14 The glycine transporter 1, localized to glial cells, regulat

15 ansmission is regulated by the action of the glycine transporters 1 and 2 (GlyT1 and GlyT2)--members

16 d the effects of combining treatments of the glycine transporter-1 (GlyT-1) inhibitor, Org24598, with

17 yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1), represented by analogues

18 rminals were loaded with [3H]glycine via the glycine transporter-1 (GlyT-1), which localized to the c

19 ess disabled-1 (Dab1) but lack expression of glycine transporter-1 (GlyT-1).

20 carboxylic acid hydrochloride (Org 25935), a glycine transporter-1 (GlyT1) inhibitor, and placebo pre

21 ion of glycine reuptake from the synapse via glycine transporter-1 (GlyT1).

22 signaling by treatment with an inhibitor of glycine transporter-1 that elevates levels of extracellu

23 appears to be a misplaced AII cell, by being glycine transporter-1-immunoreactive and by resembling t

24 y was strongly enhanced by inhibition of the glycine-transporter-1 (GlyT1).

25 not of SEC24D, reduced surface levels of the glycine transporter-1a, the betaine/GABA transporter and

26 ffinity allosteric-binding site on the human glycine transporter 2 (GlyT2 or SLC6A5).

27 transgenic mice where neurons expressing the glycine transporter 2 (GlyT2) gene coexpress enhanced gr

28 low frequency, region of MNTB, and elevated glycine transporter 2 (GLYT2) levels.

29 uorescent protein (GFP) under control of the glycine transporter 2 (GLYT2) regulatory sequences to st

30 to the presynaptic terminal by the neuronal glycine transporter 2 (GlyT2) to maintain quantal glycin

31 D67), a marker for GABAergic neurons, or for glycine transporter 2 (GLYT2), a marker for glycinergic

32 utations in SLC6A5, encoding the presynaptic glycine transporter 2 (GlyT2), also cause hyperekplexia.

33 lutamic acid decarboxylase [GAD]67-eGFP, and glycine transporter 2 (GlyT2)-eGFP, respectively).

34 expressed in glycinergic preBotC neurons of glycine transporter 2 (Glyt2, also known as Slc6a5)-Cre

35 These cells express the glycine transporter 2 gene and are the only known ipsila

36 neurons, but no colocalization of sst2a and glycine transporter 2 mRNA in the BotC.

37 ght interneurons were immunoreactive for the glycine transporter 2 or were apposed to gephyrin but di

38 Inhibitors that target the glycine transporter 2, GlyT2, show promise as analgesics

39 ird, SLC6A5, encodes the cognate presynaptic glycine transporter 2.

40 Glutamic acid decarboxylase, glycine transporter-2, and choline acetyltransferase wer

41 Glycine transporter-2-bouton density on lateral motoneur

42 e Botzinger region of the rVRC, they express glycine-transporter-2, and their axons arborize througho

43 uman SLC6A5 gene encoding the neuronal GlyT2 glycine transporter are responsible for the presynaptic

44 ABAergic or glutamatergic targets, including glycine transporters, D-amino acid oxidase, sodium chann

45 urrents dominate, blocking neuronal or glial glycine transporters enhances tonic glycinergic currents

46 yR), notably the GlyRalpha1 subunit, and the glycine transporter (GlyT) isoforms GlyT1 and GlyT2.

47 of glutamate decarboxylase (GAD)-67 mRNA or glycine transporter (GlyT)-2 mRNA detected with in situ

48 ed emergence, we developed a zebrafish glial glycine transporter (glyt1 - / -) mutant model.

49 e mutation in the slc6a9 gene that encodes a glycine transporter (GlyT1) was identified as the cause

50 ding to the serotonin transporter and to the glycine transporters (GlyT1 and GlyT2).

51 Pharmacological studies suggest that the glycine transporter, GlyT1, maintains subsaturating conc

52 f whether the transcription of two different glycine transporters, Glyt1 and Glyt2, is influenced by

53 ted by the Na+/Cl(-) dependent high-affinity glycine transporters, GlyT1 and GlyT2.

54 The glycine transporters GlyT1A, GlyT1B, GlyT1C, and GlyT2 w

55 s of bioactive lipids that inhibit the human glycine transporter GlyT2 (SLC6A5) and provide analgesia

56 B) and the presynaptic Na(+)/Cl(-)-dependent glycine transporter GlyT2 (SLC6A5).

57 tations in the gene encoding the presynaptic glycine transporter GlyT2 are a second major cause of hu

58 ons in the presynaptic Na(+)/Cl(-)-dependent glycine transporter GlyT2 gene (SLC6A5) are rapidly emer

59 The neuronal glycine transporter GlyT2 plays a fundamental role in th

60 sicular glutamate transporter VGluT2 and the glycine transporter GlyT2.

61 sicular glutamate transporter VGluT2 and the glycine transporter GlyT2.

62 enes for glutamatergic neurons, the neuronal glycine transporter (GLYT2) for glycinergic neurons, and

63 enes for glutamatergic neurons, the neuronal glycine transporter (GLYT2) for glycinergic neurons, and

64 which are regulated by Na(+)/Cl(-)-dependent glycine transporters (GlyTs) in neurones and glia.

65 The recent discovery of glycine transporters in both the central nervous system

66 lation via OPN5 and VGAT (the vesicular GABA/glycine transporter) in retinal ganglion cells enhances

67 Dab1 co-localizes with the high-affinity glycine transporter, indicating that these amacrine cell

68 s with hypofunctional NMDA receptors such as glycine transporter inhibitors and mGlu5 receptor PAMs.

69 king either, or both, the glial and neuronal glycine transporters markedly decreased PV+ IN excitabil

70 ll lines recapitulate the characteristics of glycine transporters observed in tissue preparations.

71 All four glycine transporters of the "GLYT family" also belong to

72 However, we found that block of the glial glycine transporter prolongs the glycine transient.

73 Interestingly, GlyT1, the glial glycine transporter, regulates the strength of tonic gly

74 ssays, we reveal that Hem25p-a mitochondrial glycine transporter required for haem biosynthesis-doubl

75 thologue SLC25A38 are the main mitochondrial glycine transporters required for heme synthesis, provid

76 receptor (GlyR) and the cognate presynaptic glycine transporter (SLC6A5/GlyT2) are well-established

77 the serine racemase knockout (SR-/-) and the glycine transporter subtype 1 heterozygote mutant (GlyT1

78 tro, demonstrated that exogenous glycine and glycine transporter type 1 (GLYT1) antagonist selectivel

79 e three amino-terminal isoforms of the human glycine transporter type 1 (GlyT1).

80 ficiently regulated in synaptic areas by the glycine transporter type 1 (GlyT1).

81 Estimates of bitopertin binding to glycine transporter type 1 showed that low to medium lev

82 Blockade of the glycine transporter type 1 to inhibit glycine reuptake a

83 arcinoma (JAR) cells endogenously expressing glycine transporter type 1a (GlyT1a) have been cultured

84 The rat GLYT-1 gene encodes two glycine transporter variants, GLYT-1a and GLYT-1b, that

85 mus (LH) that express the vesicular GABA and glycine transporter (vgat) as a model to further underst

86 ter-1 (GAT-1), GAT-3, and the vesicular GABA/glycine transporter (VGAT) were evaluated in the develop

87 ing transgenic reporter mice [vesicular GABA/glycine transporter (Vgat)-GFP], we then show that >50%

88 GLUT1)] and GABA/glycinergic [vesicular GABA/glycine transporter (VGAT)] vesicular transporters in po