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1 of the TA chain to either peptidoglycan or a glycolipid.
2 vivo by incorporating an NKT cell-activating glycolipid.
3 ily members that are specific for C1P versus glycolipid.
4 mechanism for recognizing this mycobacterial glycolipid.
5 ect the thermal hysteresis properties of the glycolipid.
6 he carbohydrate portion of glycoproteins and glycolipids.
7 ide (NO) upon challenge with corynebacterial glycolipids.
8 ssential enzyme involved in assembling these glycolipids.
9 membrane lipids are replaced with amino- or glycolipids.
10 of total non-starch lipids, or non-polar and glycolipids.
11 of globotrioasylceramide (GL-3) and related glycolipids.
12 key component of specific proteoglycans and glycolipids.
13 loid cells and sense mycobacterial cell wall glycolipids.
14 lated glycan structures on glycoproteins and glycolipids.
15 arbohydrate-carbohydrate interaction between glycolipids.
16 iling the temporal accumulation of different glycolipids.
17 characterized its binding to CD1d-presented glycolipids.
18 nd relative quantification of intact neutral glycolipids.
19 nd phospholipids at the interface along with glycolipids.
20 teraction of the M. leprae-specific phenolic glycolipid 1 (PGL-1) with myelinating glia and their sub
22 T cell function by endogenous brain-derived glycolipids, a family of molecules traditionally deempha
24 iency in which the ganglioside GM2 and other glycolipids accumulate intracellularly within lysosomes.
28 r mechanism dominates in the face of cognate glycolipid activation during chronic inflammation, as mi
29 oreover, the cHA(mg) vaccine combined with a glycolipid adjuvant designed for class switch further en
30 augmented and or prolonged presentation of a glycolipid Ag leads to increased activation of NK cells
31 y, treating DR4tg mice with a TH2-polarizing glycolipid agonist of iNKT cells reduced SEB-inflicted m
33 lation characterized by their recognition of glycolipid Ags and rapid cytokine production upon activa
37 T lymphocytes that recognize and respond to glycolipid Ags such as alpha-galactosylceramide (alpha-G
38 tion of Siglec-7 can be exploited to deliver glycolipid Ags to their target cell and increase the eff
39 iNKT cells to respond even in the absence of glycolipid Ags, for example, during viral infections.
41 table for studying protein interactions with glycolipids, an important class of cellular receptors.
42 nt of sample needed, N-glycan, O-glycan, and glycolipid analyses are performed on the same enriched f
45 unoblotting, flow cytometry, and LC-MS-based glycolipid and glycan profiling, we found that CRISPR/Ca
46 eered sialic acids were detected in both the glycolipid and glycoprotein fractions of MLV producer ce
47 terial cord factor, is an abundant cell wall glycolipid and major virulence factor of Mycobacterium t
48 or imbalances in NSs and dramatic changes in glycolipids and glycoproteins, including a subset of int
51 Like proteins, such as CD1D and MR1, present glycolipids and microbial riboflavin precursor derivativ
53 al lipids, consisting of 72.8% punicic acid, glycolipids and phospholipids rich in essential fatty ac
54 ted, together with enhanced turnover of both glycolipids and phospholipids, supporting the drastic ne
55 are found on both N- and O-glycoproteins and glycolipids and play an important role in development, i
59 e of several enzymes that controls levels of glycolipids and whose activity is linked to several huma
60 eins involved in the modification of surface glycolipids and, surprisingly, the auxiliary proteins of
61 AP domain are able to bind sterol and acidic glycolipid, and are involved in sterol transport and bet
62 LEC18 modulates host immunity via binding to glycolipids, and are also involved in glycolipid transpo
67 s might increase antigen capture and enhance glycolipid antigen presentation in addition to the class
68 sed expression of CD1c, which is involved in glycolipid antigen presentation, and of the immune compl
71 ed Streptococcus pneumonia, known to express glycolipid antigens activating NKT cells, increased the
72 cells are innate-like T cells that recognize glycolipid antigens and play critical roles in regulatio
74 the sharply reduced levels of CD1d-presented glycolipid antigens in ConA-treated GF mice compared wit
75 ubpopulation of T lymphocytes that recognize glycolipid antigens in the context of CD1d-mediated anti
76 are a subset of T lymphocytes that recognize glycolipid antigens presented by the CD1d molecule (CD1d
78 c enzymes and lipases that process lipid and glycolipid antigens, as well as a set of lipid transfer
79 turing and presenting a variety of different glycolipid antigens, including multiple forms of alpha-g
82 hydrate polymers, glycoproteins and membrane glycolipids are among candidates for this role, it is he
84 suggest that these microbial alpha-mannosyl glycolipids are capable of being recognized by both the
88 ng simple mono- and disaccharides that mimic glycolipids are known to self-assemble into glycodendrim
90 Due to their charge and ability to coalesce, glycolipids are therefore the likely primary EF sensor d
91 -to-analyze structures (e.g., proteoglycans, glycolipids), are functionally important in a biological
93 y approach that utilizes essential microbial glycolipids as chemical fingerprints for identification
95 aride molecules represent a unique family of glycolipids based on a highly conserved lipid moiety kno
96 n the synthesis and biological properties of glycolipids based on glucose and trehalose scaffolds whi
98 responsible for synthesis of this conserved glycolipid belong to a new family of glycosyltransferase
102 only increased the ionization efficiency of glycolipids but also facilitated structural characteriza
103 probes, we studied the mobilities of labeled glycolipids by time-lapse microscopy and fluorescence re
104 n the thymus, precursor cells recognize self-glycolipids by virtue of their semi-invariant TCR, which
105 us homologous series of l-ascarylose-derived glycolipids called ascarosides, which include several hi
107 all arabinan, demonstrating that non-natural glycolipids can serve as biosynthetic intermediates and
109 typal CDC requires interaction with the sLeX glycolipid cellular receptor as an essential step before
110 he enzymes that build the conserved terminal glycolipid characterizing other capsules using this meth
111 to which the relative abundances of protein-glycolipid complexes observed by ESI-MS reflect the rela
113 e the backbone of a novel thermal hysteresis glycolipid containing a linear glycan sequence of altern
114 for iNKT cells has led to the development of glycolipid containing nanoparticles which efficiently ac
115 The potentially antigenic alpha-mannosyl glycolipids contributed to the protection of mice agains
116 raits of Pi starvation, such as phospholipid/glycolipid conversion, and the accumulation of starch an
118 nd O-glycans from pig lung glycoproteins and glycolipid-derived glycans were fluorescently tagged and
119 urther, activation of iNKT cells via cognate glycolipid during IL-18-mediated inflammation overrides
121 fatides and gangliosides are raft-associated glycolipids essential for maintaining myelinated nerve i
122 antigen, including binding analyses with the glycolipid extract of the prostate cancer cell line PC3,
124 e bartolosides, unprecedented cyanobacterial glycolipids featuring aliphatic chains with chlorine sub
127 represent an attractive method to solubilize glycolipids for protein interaction studies in aqueous s
130 is of a complex beta-1,2-mannosyloxymannitol glycolipid from Malassezia pachydermatis 44-2, which was
133 in A and lipids, PDs), to screen mixtures of glycolipids (GLs) against water-soluble proteins to dete
134 ith the use of nanodiscs (NDs) to solubilize glycolipids (GLs) has recently emerged as a promising an
135 -1 (GCase) catalyzes the cleavage of a major glycolipid glucosylceramide into glucose and ceramide.
138 njugates (glycosaminoglycans, glycoproteins, glycolipids, glycosylphosphatidylinositol-anchored prote
141 seven different lipids species including the glycolipid GM3 in the outer leaflet and the anionic lipi
142 ed form of GIFT4 was constructed by fusing a glycolipid (GPI)-anchoring sequence and incorporated int
147 eral blood samples, along with anti-phenolic glycolipid I serology and skin tests from the same indiv
150 n IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-mediated food al
151 a small number of phospholipids, to display glycolipids in a lipid environment for protein-glycolipi
152 resent evidence that hopanoids interact with glycolipids in bacterial outer membranes to form a highl
153 was <6% measured across four representative glycolipids in five different ratios and triplicate expe
158 ng the distribution of numerous phospho- and glycolipids in mouse cerebellum and kidney slices, and i
161 -glycans of glycoproteins, as well as intact glycolipids in parallel, using the same enriched membran
162 induce antibodies that cross-react with self-glycolipids in peripheral nerves, causing neuropathy.
165 sses of biomolecules, including phospho- and glycolipids in tissue sections at high lateral resolutio
167 nd chemical modifications (including various glycolipids) in the PDB, and both PDB and PDBx/mmCIF for
173 ycolipids in a lipid environment for protein-glycolipid interaction studies in aqueous solution.
174 of low, moderate, and high affinity protein-glycolipid interactions serve to demonstrate the reliabi
178 carbon (PGC) column, while the N-glycans and glycolipids isolated from the same cell membrane fractio
179 s of F. thermalis constitutively overproduce glycolipid isomers associated with high temperature to l
180 ral killer T (NKT) -cells activated with the glycolipid ligand alpha-galactosylceramide (alpha-GalCer
183 dated, but the basis for enhanced binding to glycolipid ligands, in which hydrophobic substituents ar
184 he cerebellum, and secondary accumulation of glycolipids like GM2 and GM3 gangliosides and unesterifi
185 vaccine incorporating an NKT cell-activating glycolipid linked to an MHC class I-restricted peptide f
186 glycerides affected transfer action by human glycolipid lipid transfer protein (GLTP), which is glyco
187 -TOF mass spectrometry of bacterial membrane glycolipids (lipid A) has the potential to identify micr
188 d by concentrating the tuberculosis-specific glycolipid, lipoarabinomannan (LAM), a promising urinary
190 mannan, and lipoarabinomannan, which are key glycolipids/lipoglycans of the mycobacterial cell envelo
191 two cellular membranes, with the specialized glycolipid lipopolysaccharide (LPS) exclusively found on
192 olipids in the inner leaflet and the complex glycolipid lipopolysaccharide (LPS) in the outer leaflet
196 1 was originally proposed to translocate the glycolipid Man5GlcNAc2-PP-dolichol (needed to synthesize
198 These results demonstrate that bacterial glycolipid mass spectra represent chemical barcodes that
199 s (e.g., dot products) do not work well with glycolipid mass spectra such as those produced by lipid
209 can induce aggregation with glycoproteins or glycolipids on the cell surface and thereby regulate cel
211 lycans that are carried as glycoproteins and glycolipids on the outer leaflets of their plasma membra
212 stal structures of 19 different binary (CD1d-glycolipid) or ternary (CD1d-glycolipid-TCR) complexes a
218 veal in vivo functions for specific phenolic glycolipids (PGLs) in the mycobacteria that cause tuberc
219 n clinical laboratories, a reliable MS-based glycolipid phenotyping method that identifies colistin r
220 y components of the cell wall, including the glycolipids phosphatidylinositol mannoside, lipomannan,
222 ) are high-molecular-weight, surface-exposed glycolipids present in a broad range of nontuberculous m
224 e and innate lymphocytes, and they recognize glycolipids presented by an MHC class I-like CD1d molecu
226 cells are innate lymphocytes that respond to glycolipids presented by the MHC class Ib molecule CD1d
228 e thymus and periphery due to defective self glycolipid processing and presentation by DP thymocytes
229 common basic structure with trehalose-based glycolipids produced by Mycobacterium tuberculosis TPP p
232 n glycans (sugars) existing predominantly as glycolipids, proteoglycans, or glycoproteins formed by t
234 HIV infection, and tracked the mycobacterial glycolipid-reactive T-cell repertoire by using CD1b tetr
235 It has been shown that CD1d expression and glycolipid-reactive, CD1d-restricted NKT cells exacerbat
238 n mimics inhibited IAV binding to underlying glycolipid receptors, and this density correlated to the
241 e glycoproteins following N-glycan and lipid/glycolipid removal by PNGase F digestion and Folch extra
243 link clinical and mechanistic evidence that glycolipid-responsive, polycytotoxic T cells contribute
244 obacteria, nocardia, and rhodococci) share a glycolipid-rich cell wall dominated by mycolic acids (te
245 sistant membranes, which contain cholesterol-glycolipid-rich membrane regions known as lipid rafts, s
247 hese data indicate that, in addition to self-glycolipids, self-lysophospholipids are also recognized
248 k areas between the (12)C- and (13)C-labeled glycolipids served as surrogate measure of their relativ
249 ipid lipid transfer protein (GLTP), which is glycolipid-specific and has few cationic residues near i
250 Invariant natural killer T (iNKT) cells (glycolipid-specific, CD1d-restricted innate lymphocytes)
251 l protein-deficient mice suggests that these glycolipids stabilize membrane proteins including neurof
252 ase activity and protein levels, and reduced glycolipid storage in both iPSC-derived macrophages and
254 asurements of enzyme catalyzed hydrolysis of glycolipid substrates and the detection of low, moderate
255 d glucocerebrosidase activity and stored the glycolipid substrates glucosylceramide and glucosylsphin
256 eptive neurons in vitro and identify the Mtb glycolipid sulfolipid-1 (SL-1) as the nociceptive molecu
257 e in co-ordination with cell division, while glycolipid synthesis takes place throughout the membrane
258 Another iminosugar activity, inhibition of glycolipid synthesis, resulted in a drug for Gaucher dis
260 fic embryonic antigen-4 (SSEA-4) is one such glycolipid target expressed in many cancers, including b
261 nt binary (CD1d-glycolipid) or ternary (CD1d-glycolipid-TCR) complexes at resolutions between 1.67 an
263 nt Gram-negative pathogens share a conserved glycolipid terminus containing 3-deoxy-beta-d- manno-oct
264 Glycosylphosphatidylinositol (GPI) is a glycolipid that anchors >150 various proteins to the cel
265 vironment and process it to form cholesterol glycolipids that are incorporated onto their membranes.
266 alactan layer or incorporated into trehalose glycolipids that associate with the MM non-covalently.
269 arides, glycoproteins, and proteoglycans, to glycolipids that make up a complex glycan code that impa
270 acid terminates glycans of glycoproteins and glycolipids that play numerous biological roles in healt
271 re we show that ascaroside pheromones, small glycolipids that signal population density, suppress exp
272 n done to identify the structures of natural glycolipids that stimulate NKT cells and to determine ho
273 bolism intermediates instead of cell surface glycolipids, thus maintaining levels of ATP and antioxid
274 found to play a key role in the binding of a glycolipid to the carbohydrate recognition domain of the
275 ical MHC molecule able to present lipids and glycolipids to a specialized subset of T cells known as
276 ydrophilic lipooligosaccharides and phenolic glycolipids to hydrophobic phthiocerol dimycocerosates,
277 hesis, assembly, and export of these complex glycolipids to the cell surface are the object of the pr
278 d nearly ubiquitous two-layer, alpha-helical glycolipid transfer protein (GLTP)-fold now further adva
280 ing to glycolipids, and are also involved in glycolipid transportation and protein aggregation in the
283 usly shown that transient acetylation of the glycolipid trehalose monohydroxycorynomycolate (hTMCM) e
284 w route to access original glycopeptide- and glycolipid-type analogues possessing a C-C bond at the C
285 Phosphatidyl-inositol mannosides (PIM) are glycolipids unique to mycobacteria and other related bac
286 g chronic inflammation, as might result from glycolipid vaccination or infection during chronic autoi
287 so review studies designed to understand how glycolipid variants, both natural and synthetic, can alt
288 amers to isolate clones recognizing the same glycolipid, we identified a previously unknown pattern o
292 ly, we found the intestinal bacteria contain glycolipids which can be presented by CD1d and recognize
295 large family of glycans of glycoproteins and glycolipids whose branching and peripheral substitutions
297 atides and complex gangliosides are membrane glycolipids with important roles in maintaining nervous
298 produced in aquaponics have higher levels of glycolipids with n-3 fatty acids (DGDG 36:3; SQDG 36:3;
299 hts into the presentation and recognition of glycolipids with polar moieties in an otherwise apolar m
300 the underlying organization and dynamics of glycolipids within the cell envelope remain poorly under