ライフサイエンスコーパス: glycolytic

1 found to be important for both HCMV-mediated glycolytic activation and high titer infection.

2 inases, relying on their activity to support glycolytic activation and productive infection.IMPORTANC

3 Further, we find that AMPK-mediated glycolytic activation is important for infection, as ove

4 y-specific inflammation was defined as total glycolytic activity (TGA) on [18]F-fluorodeoxyglucose (F

5 d GLUT4 levels in conjunction with decreased glycolytic activity and glycogen storage in skeletal mus

6 transfer to mitochondria, thereby supporting glycolytic activity and promoting oxidative phosphorylat

7 First, tumor glycolytic activity as reflected by the maximum SUV (SUV

8 Glycolytic activity downstream of fibroblast growth fact

9 help to refine the targeting of endothelial glycolytic activity in disease.

10 Mechanistically, Apelin signaling enhances glycolytic activity in ECs at least in part by increasin

11 Disease-associated glycolytic activity in wall-residing T-cell populations

12 shift in cone mitochondrial positioning and glycolytic activity increases.

13 G-PET/CT) can be influenced by the increased glycolytic activity of inflammatory lesions.

14 that neonatal CD8(+) T cells exhibit higher glycolytic activity than adult CD8(+) T cells postinfect

15 The manipulation of glial glycolytic activity through this pathway enabled us to a

16 To support ongoing glycolytic activity, the DeltahemB SCV induced over a 10

17 At baseline, total glycolytic activity, total lesion volume, and maximum st

18 roduction via metformin-mediated increase in glycolytic activity.

19 ssed mitochondrial respiration and increased glycolytic activity.

20 on and also shifts cell metabolism to higher glycolytic activity.

21 reserve capacity and compensatory increased glycolytic activity.

22 d DCF induced changes in cell morphology and glycolytic activity.

23 7 with ATP5B was accompanied by reduction of glycolytic activity.

24 st way of separating cells based on elevated glycolytic activity; a biomarker associated with cancer

25 in regulating mTORC1 activity and downstream glycolytic alterations during HCC development, highlight

26 s in steady-state metabolite concentrations (glycolytic, anaplerotic, Krebs cycle intermediates).

27 we show severely diminished availability of glycolytic and citric acid cycle (CAC) pathways metaboli

28 , represses mTOR, which induces a reversible glycolytic and epigenetically H4K16Ac-negative, diapause

29 of mixed muscle fibre types (i.e. both fast glycolytic and fast oxidative fibres), which differ mark

30 Endothelial cells (ECs) are highly glycolytic and generate the majority of their energy via

31 , such as Akt and c-Myc, control most of the glycolytic and glutaminolysis genes.

32 cogen, and lipids, whereas the expression of glycolytic and lipogenic genes was reduced.

33 By measuring both glycolytic and mitochondrial activity we observed that t

34 Glycolytic and mitochondrial ATP production were increas

35 f alternative fuel sources to supplement the glycolytic and mitochondrial pathways such as glycogen,

36 Surprisingly, the expression of both glycolytic and mitochondrial programs strongly correlate

37 at OXPHOS(high) BAP1 mutant UM cells utilize glycolytic and nucleotide biosynthesis pathways, whereas

38 Lactate stands at the crossroads of glycolytic and oxidative energy metabolism.

39 owever, mCAT macrophages exhibited increased glycolytic and oxidative metabolism, coupled with increa

40 fatty acid (FA) uptake and oxidation in both glycolytic and oxidative muscle fibers without altering

41 (P)H-quinone oxidoreductase 1 (NQO1) in both glycolytic and oxidative muscles but reduced exercise-me

42 phenotype to increased activity of both the glycolytic and oxidative pathways and glucose flux throu

43 eq, ChIP-seq, and metabolomics revealed that glycolytic and pentose phosphate pathway genes are induc

44 ers acute IL-15 stimulation-induced raise in glycolytic and respiration rates, and causes a dramatic

45 circuits and suppressed the T(eff) cell-like glycolytic and respiratory programs, which contributed t

46 Endothelial cells are reported to be glycolytic and to minimally rely on mitochondria for ATP

47 translation rate, decreases lactate and key glycolytic and tricarboxylic acid (TCA) cycle enzyme lev

48 Glycolytic and tricarboxylic acid cycle metabolites reve

49 ar cuff of post-capillary venules are highly glycolytic as manifested by strong expression of lactate

50 tochondrial toxins with an adaptive shift to glycolytic ATP generation that allows for DDR signaling.

51 intracellular NADH:NAD(+) ratio, upregulated glycolytic ATP production and restored cellular prolifer

52 es inhibit respiration even when there is no glycolytic ATP production, and vice versa.

53 y GA-binding protein alpha as a regulator of glycolytic beige adipocyte differentiation through a myo

54 suggested that CHRNA2 signaling may activate glycolytic beige fat, a subpopulation of beige adipocyte

55 T cells is the shunting of glucose away from glycolytic breakdown and mitochondrial processing toward

56 Metabolic pathways related to the glycolytic by-product methylglyoxal (MGO) are rewired in

57 a prostate cancer model lactate released by glycolytic cancer-associated fibroblasts (CAFs) acts on

58 is difference associated with their distinct glycolytic capacities.

59 AKR1B10(High) tumour cells have reduced glycolytic capacity and dependency on glucose as fuel so

60 In addition, SIRT3 inhibits glycolytic capacity in anchorage-independent cells there

61 Metabolic experiments showed decreased spare glycolytic capacity in HD neurons, while maximal and spa

62 ddition, psychological distress enhanced the glycolytic capacity in PINK1-KO-PBMCs but not in WT-PBMC

63 In contrast, anaerobic glycolytic capacity is surprisingly high, and sufficient

64 king Itch exhibited increased proliferation, glycolytic capacity, and mTORC1 activation.

65 characterized by increased basal glycolysis, glycolytic capacity, maximal mitochondrial respiration,

66 cient Th17 cells had elevated glycolysis and glycolytic capacity.

67 t these mitochondria dense cells have a high glycolytic capacity.

68 R) activity and restriction in CD4(+) T cell glycolytic capacity.

69 function, and loss of these forms in highly glycolytic cells resulted in p53 accumulation.

70 on source for trehalose production, while in glycolytic cells using trehalose for carbon, aspartate i

71 XL induces a significant cell killing in the glycolytic cells without affecting the cells with active

72 MCT-4) specialized in secreting lactate from glycolytic cells.

73 re metabolically active and self-renew under glycolytic conditions.

74 lycolytic metabolites, suggesting a role for glycolytic deficits as part of the metabolic disturbance

75 Despite the high glycolytic demand of skeletal cells, we discovered that

76 in TNBC that comes into play in response to glycolytic disruption.

77 Our results show that when pre-neurons are glycolytic early in differentiation mitophagy is unimpai

78 Glycolytic efflux doubled with 25 mm [U-(13)C(6)]glucose

79 Depletion of the host glycolytic enzyme aldolase A resulted in decreased inclu

80 isoform (tM2-PK), which is an isoform of PK-glycolytic enzyme and appears on the surface of cancerou

81 vate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme and transcriptional coactivator and is

82 f the bacterial symbionts lack the essential glycolytic enzyme enolase, which may be overcome by the

83 d with impaired glucose metabolism and lower glycolytic enzyme expression, rendering knockout-enginee

84 oss of Th17 cells, whereas deficiency of the glycolytic enzyme glucose phosphate isomerase (Gpi1) sel

85 mechanism for the nuclear moonlighting of a glycolytic enzyme in plant response to environmental cha

86 Pyruvate kinase (PYK) is an essential glycolytic enzyme in the phosphoenolpyruvate-pyruvate-ox

87 vate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme involved in ATP generation and critica

88 this question using, as a model system, the glycolytic enzyme pyruvate kinase M2 (PKM2).

89 In addition, loss of the glycolytic enzyme pyruvate kinase M2 impairs trabeculati

90 The glycolytic enzyme Pyruvate Kinase Muscle 2 (PKM2) has de

91 ed NK cells have increased expression of the glycolytic enzyme pyruvate kinase muscle isozyme M2 and

92 e muscle isoenzyme 2) is an isoenzyme of the glycolytic enzyme pyruvate kinase.

93 e show that the pyruvate kinase M2 (PKM2), a glycolytic enzyme required for cancer cell proliferation

94 homolog 5 (Sirt5)-mediated inhibition of the glycolytic enzyme triosephosphate isomerase (TPI) throug

95 egulating the expression of a key regulatory glycolytic enzyme, 6-phosphofructo-2-kinase/fructose-2,6

96 te dehydrogenase (GAPDH), a rate-controlling glycolytic enzyme, during the WE.

97 ression of FOXC1 downregulated that of a key glycolytic enzyme, fructose-1,6-bisphosphatase 1 (FBP1).

98 amined the relationship of TG2 to a terminal glycolytic enzyme, pyruvate kinase M2 (PKM2), and found

99 tabolically reprogrammed RA T cells includes glycolytic enzymes (glucose-6-phosphate dehydrogenase, p

100 ediated by biochemical interactions with the glycolytic enzymes Aldolase and Phosphoglycerate mutase.

101 t enriched cSABPs, which corresponded to the glycolytic enzymes alpha-enolase (ENO1) and pyruvate kin

102 ms leading to inclusion localization of host glycolytic enzymes and how it could benefit the bacteria

103 wider protein-protein interactions of plant glycolytic enzymes and reveal a moonlighting role for sp

104 Our in vitro results show that glycolytic enzymes and TG2 are upregulated in fibroblast

105 RNA-Seq revealed up-regulation of glycolytic enzymes and transcription factors regulating

106 Glycolytic enzymes are known to form transient multi-enz

107 sion of the glucose transporter Glut1 and of glycolytic enzymes as well as mitochondrial oxygen consu

108 Two of these targets were the glycolytic enzymes fructose bisphosphate aldolase (FBPA)

109 and reveal a moonlighting role for specific glycolytic enzymes in mediating the co-localization of m

110 ometastases, in contrast to higher levels of glycolytic enzymes in primary tumour cells, which we cor

111 sis showed that expression of C. trachomatis glycolytic enzymes inversely correlated with host enzyme

112 We searched for glycolytic enzymes whose expression is essential for the

113 nal upregulation of glucose transporters and glycolytic enzymes(3-5), it is not known whether there i

114 In this study, we show that two host glycolytic enzymes, aldolase A and pyruvate kinase, as w

115 Argonaute 1-4, glycolytic enzymes, and cytoskeletal proteins were not d

116 interactomes shared RNA regulation proteins, glycolytic enzymes, and cytoskeleton/motor proteins, but

117 tor 1 (HIF-1) up-regulates the expression of glycolytic enzymes, and the HIF-1alpha inhibitor (FIH) i

118 is known about the biochemical regulation of glycolytic enzymes, less is understood about how they ar

119 relates to its ability to target and inhibit glycolytic enzymes, providing an example of a natural an

120 reaction, and both potently inhibit two key glycolytic enzymes, triosephosphate isomerase and phosph

121 d glycolysis and increased expression of key glycolytic enzymes.

122 actor, linking PRMT6 with hypoxia in driving glycolytic events.

123 ated glucose uptake partly relies on PAK2 in glycolytic extensor digitorum longus muscle By contrast

124 cose uptake was slightly reduced in isolated glycolytic extensor digitorum longus muscle lacking PAK2

125 In vitro, GCBCs had a very low glycolytic extracellular acidification rate but consumed

126 itochondrial orientation observed in mature, glycolytic fibres.

127 pectroscopic imaging showed heterogeneity in glycolytic flux across the tumor and an early decrease i

128 ns to test how changes in glucose supply and glycolytic flux affect mTOR activation.

129 cipal transcriptional regulator for adapting glycolytic flux and downstream pathways like de novo lip

130 ose 1,6-bisphosphate, which senses the upper-glycolytic flux and ensures that glycerol uptake defers

131 rsion rates in aggressive tumors to enhanced glycolytic flux and lactate dehydrogenase A (LDHA) activ

132 t ethanologenic organism with extremely high glycolytic flux and low biomass yield.

133 ial of glucose 6-phosphate (G6P) to regulate glycolytic flux and mTOR activation.

134 e 2 (PKM2) has described roles in regulating glycolytic flux and signal transduction, particularly ge

135 ic imaging for quantitative mapping of tumor glycolytic flux and to assess response to chemotherapy.

136 Inhibition of glycolytic flux at the level of PGI caused G6P accumulat

137 of La(-) represent the response to increased glycolytic flux elicited by increasing work rate, and de

138 vide evidence that over-expressed BNA2 skews glycolytic flux from LDs towards the SA-BNA pathways, ef

139 resolution of 10 minutes, was used to image glycolytic flux in a murine tumor model after bolus inje

140 enzymes and transcription factors regulating glycolytic flux in lung macrophages from cadmium-exposed

141 allosteric activation of hLPYK will control glycolytic flux in the diabetic liver to reduce hepatic

142 ative and spatially resolved measurements of glycolytic flux in tumors that can be used to assess tre

143 novel role for TRIM32 in the maintenance of glycolytic flux mediated by biochemical interactions wit

144 C]pyruvate transmembrane influx in vivo, not glycolytic flux or LDHA activity, driving a reinterpreta

145 This increase in glycolytic flux promotes Yap/Tead signaling, which activ

146 e sensitive marker of the early decreases in glycolytic flux that occur following cell death than PET

147 ced metabolism and developed a dependence on glycolytic flux to lactate.

148 cient mice can be corrected by enhancing the glycolytic flux via pharmacological Akt or AMPK activati

149 sed cytoplasmic (iso)citrate levels, reduced glycolytic flux, and functional mitochondrial activity.

150 roscopy) do not allow quantitative images of glycolytic flux.

151 h defects, synthetic lethality and decreased glycolytic flux.

152 Results showed higher rates of glycolytic function in activated CD4(+) T cells from lat

153 dmium exposure promoted increased macrophage glycolytic function with enhanced extracellular acidific

154 lpha reversed attenuated proinflammatory and glycolytic gene expression in KLF6-deficient macrophages

155 deficiency attenuates broad inflammatory and glycolytic gene expression in macrophages.

156 or 1-alpha and c-Myc, which together promote glycolytic gene expression.

157 cs in zebrafish, we show that disrupting the glycolytic gene phosphoglycerate kinase-1 (pgk1) impairs

158 ication rate and increased expression of key glycolytic genes (GLUT1, HK2, TPI, and MCT4); activation

159 es (Ucp3 and Cpt1) and downregulation of key glycolytic genes (Pdk1, Pdk4, Ppara), also denote distur

160 lternative splicing of pre-mRNAs of critical glycolytic genes such as GLUT1 and PKM2.

161 an elevated expression of hypoxia-associated glycolytic genes, and an increased level of lactate in c

162 uals display increased expression of two key glycolytic genes, suggestive of a glucose shortage durin

163 metabolism while concomitantly up-regulating glycolytic genes, whereas HIF-2alpha primarily up-regula

164 expression of PER2, which regulates multiple glycolytic genes.

165 as a coactivator of HIF-1alpha to upregulate glycolytic genes.

166 and ATP are impaired and both oxidative and glycolytic glucose metabolism are reduced.

167 Here we report a mechanism by which glycolytic glyceraldehyde-3-phosphate dehydrogenase of A

168 during the switch between gluconeogenic and glycolytic growth conditions.

169 e gene promoters but not the inflammatory or glycolytic HIF2alpha or HIF1alpha target genes.

170 atory capacity and an inability to perform a glycolytic immunometabolic switch.

171 nerated via glycolytic inhibition or by both glycolytic inhibition and azide-induced ATP depletion.

172 on whether cellular stress was generated via glycolytic inhibition or by both glycolytic inhibition a

173 and was exacerbated by 2-deoxyglucose (2-DG) glycolytic inhibition, despite preventing IL-1beta synth

174 escribed antidiabetic drug metformin and the glycolytic inhibitor 2-deoxyglucose (2-DG) have been use

175 metabolism and response to treatment with a glycolytic inhibitor in an orthotopic mouse model of gli

176 py were repeated after administration of the glycolytic inhibitor WP1122, a prodrug of 2-deoxy-d-gluc

177 which rendered them more susceptible toward glycolytic inhibitors.

178 iding a rationale to target these cells with glycolytic inhibitors.

179 iency confers a therapeutic vulnerability to glycolytic inhibitors.

180 regulated RBPs that functions as a switch of glycolytic intensity.

181 ncoded by thin (tn), shows reduced levels of glycolytic intermediates and amino acids.

182 in Atp7b (-/-) mice, including increases in glycolytic intermediates and components of the tricarbox

183 We hypothesized that the accumulated glycolytic intermediates are channeled into cardioprotec

184 es of aerobic glycolysis, which provides the glycolytic intermediates needed for the increased biosyn

185 m oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways.

186 The relative abundance of (13)C-glycolytic intermediates was reduced, suggesting attenua

187 remodeling and/or aging, pentoses/pentitols, glycolytic intermediates, and lipid metabolism.

188 VPA treatment increased levels of glycolytic intermediates, increased expression of glycol

189 ession in mutants is accompanied by elevated glycolytic intermediates, reduced TCA cycle intermediate

190 e correlates with a reduction in the size of glycolytic larval muscle and brain tissue.

191 teinemia (HHcy) induced T cell intracellular glycolytic-lipogenic reprogramming and IFN-gamma secreti

192 leukemia cells were characterized by a more glycolytic metabolic phenotype, exemplified by a more pr

193 We demonstrate that the loss of glycolytic metabolism and mTOR activity within the exhau

194 Overall, PKM2-regulated glycolytic metabolism and redox status, not transcriptio

195 n a wing disc-associated tumor model reduces glycolytic metabolism and restricts growth.

196 ned the effect of progesterone treatments on glycolytic metabolism and senescence as possible mechani

197 Human eosinophils engage a largely glycolytic metabolism but also employ mitochondrial meta

198 ependent of its apoptotic function, enforces glycolytic metabolism by inhibiting the transport of pyr

199 pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates t

200 genes, such as LDHA, consequently reprogram glycolytic metabolism for CRC proliferation.

201 tabolism, detected as a relative increase of glycolytic metabolism in live-cell metabolic assays in e

202 ic conditions, emphasising the importance of glycolytic metabolism in osteoclast biology.

203 Non-beta cells compensate by increasing glycolytic metabolism to maintain ATP levels; however, b

204 l prostatic epithelium employs comparatively glycolytic metabolism to sustain physiological citrate s

205 er 400 genes, with evidence for induction of glycolytic metabolism without a depression of oxidative

206 iciency displayed enhanced mitochondrial and glycolytic metabolism, and memory CD8 T cells had enhanc

207 -driven adaption of pathways associated with glycolytic metabolism, collagen biosynthesis and remodel

208 isolated from obese adults display defective glycolytic metabolism, mTORC1 signaling, and SLC7A5 aa t

209 on and a concomitant increased CD4(+) T cell glycolytic metabolism.

210 and Raptor to inactive mTORC1-mediated hyper-glycolytic metabolism.

211 ochondrial respiration and causes a shift to glycolytic metabolism.

212 ction of genes involved in proliferation and glycolytic metabolism.

213 n and oxidative metabolism and a reliance on glycolytic metabolism.

214 1 to facilitate increased glucose uptake and glycolytic metabolism; however, the role of other glucos

215 ounterbalancing homeostatic function for the glycolytic metabolite lactate.

216 rate metabolism during delirium, we assessed glycolytic metabolite levels in CSF in humans during inf

217 Pyruvate is a glycolytic metabolite used for energy production and mac

218 t glutaminolysis, leading to accumulation of glycolytic metabolites and depletion of glutamate.

219 l tumors show dramatically reduced levels of glycolytic metabolites by metabolomics, and significantl

220 The recovering heart appears to direct glycolytic metabolites into pentose-phosphate pathway an

221 h enhanced extracellular acidification rate, glycolytic metabolites, and lactate excretion.

222 be rescued with addition of pyruvate or late glycolytic metabolites, but not earlier glycolytic metab

223 late glycolytic metabolites, but not earlier glycolytic metabolites, suggesting a role for glycolytic

224 ulated glucose uptake partly rely on PAK2 in glycolytic mouse muscle, whereas PAK1 is dispensable for

225 proteins at the sarcolemma differ in highly glycolytic muscle compared to wild-type and that these c

226 of controls but an increase in lean mass and glycolytic muscle fibers and reduced fat mass.

227 s, suggesting a novel ecological context for glycolytic muscle fibres in small birds.

228 rate of protein synthesis in Acsl1(M) (-/-) glycolytic muscle was 2.1-fold greater 30 min after exer

229 result in increased intestinal expression of glycolytic or angiogenic HIF2alpha target genes.

230 found little evidence that suramin disrupts glycolytic or glycosomal pathways, we noted increased mi

231 ALS-causing mutations in FUS did not affect glycolytic or mitochondrial energy metabolism of human M

232 l metabolic oscillations of mitochondrial or glycolytic origin has been poorly explored.

233 cated a comparatively increased role for non-glycolytic oxidative phosphorylation.

234 s demonstrated a metabolic dependency on the glycolytic pathway for IL-10 production, shifting from t

235 an autosomal-recessive enzyme defect of the glycolytic pathway that causes congenital nonspherocytic

236 1, ENO2, GAPDH, TPI1, LDHA, and LDHB) in the glycolytic pathway with concomitant reduction in metabol

237 ephosphate isomerase (TIM), an enzyme of the glycolytic pathway, has emerged as a useful drug target

238 ed in induction of IL-1beta and genes in the glycolytic pathway.

239 denine dinucleotide as the final step in the glycolytic pathway.

240 roviding an alternative ferredoxin-dependent glycolytic pathway.

241 d alters metabolic reprogramming by shifting glycolytic pathways and inhibiting reactive oxygen speci

242 f HIF1A or drug inhibition of HIF-associated glycolytic pathways selectively impairs brain tumor grow

243 duces microglia to metabolically tune from a glycolytic phenotype (M1) to an oxidative phenotype (M2)

244 Transcriptome analysis reveals that the glycolytic phenotype is associated with mesenchymal-like

245 ome c deficiency promoted the acquisition of glycolytic phenotypes and mitochondrial dysfunction, whe

246 ncrease in inflammatory response, apoptosis, glycolytic process and decrease in myocardial structural

247 uctural components, intensified fibrosis and glycolytic processes as well as decreased proteins relat

248 lectron chain functions, gluconeogenesis and glycolytic processes while transcripts associated with c

249 Oral supplementation of the glycolytic product pyruvate strongly protected from neur

250 Instead, the interim glycolytic products (pyruvate and NADH) are held in cyto

251 This equilibrium supplies the glycolytic products to the mitochondrial matrix for OXPH

252 Our studies indicate that glycolytic protein PFK-1.1 can dynamically form condensa

253 mine the dynamic subcellular localization of glycolytic protein phosphofructokinase-1/PFK-1.1 in Caen

254 that enhances the translation efficiency of glycolytic proteins in cells responding to oxygen depriv

255 The glycolytic rate in neurons is low in order to allow gluc

256 wer cytokine secretion was coupled to higher glycolytic rate of monocytes in patients with a higher g

257 g glucose, which may point towards increased glycolytic rate.

258 (MCTs), resulting in a negative feedback on glycolytic rate.

259 levels of various cytokines and showed lower glycolytic rates compared with monocytes isolated from m

260 Maintenance of high glycolytic rates depends on the lactate dehydrogenase-ca

261 hanical cues enables the persistence of high glycolytic rates in cancer cells despite constant altera

262 -cell lung cancer cells, which maintain high glycolytic rates regardless of changing environmental me

263 romotes the growth of leukemia cells via the glycolytic regulator PFKFB3.

264 -2,6-bisphosphatase (PFKFB3) is an essential glycolytic regulator that is consistently overexpressed

265 h TLR4 activation leads to mitochondrial and glycolytic reprogramming are unknown.

266 We recently showed that IL-1-induced glycolytic reprogramming contributes to allergic airway

267 This glycolytic reprogramming depends on Akt kinases, indepen

268 In summary, the requirement of glycolytic reprogramming for proinflammatory cytokine pr

269 how that NOD1 and NOD2 agonists induce early glycolytic reprogramming of human monocyte-derived macro

270 e posttranscriptional level through distinct glycolytic reprogramming of human myeloid immune cells.

271 phosphorylation is critical for LPS-induced glycolytic reprogramming, production of the central immu

272 ery requires a CD31 receptor-induced, robust glycolytic response sustaining junction re-annealing.

273 analysis showed that ZIKV infection evokes a glycolytic response, as evidenced by elevated extracellu

274 This glycolytic response, paired with enhanced axon-glia meta

275 T cell effector function, migration and glycolytic responses were amplified in LXA(4)-deficient

276 Apart from its glycolytic role and independent of the Nogo66 pathway, e

277 iated mitochondrial DNA depletion promotes a glycolytic shift in differentiated RPE cells and enhance

278 The glycolytic shift in SCs is largely driven by the metabol

279 stance in GBM is associated with mesenchymal/glycolytic shifts involving YKL-40 and ZEB1.

280 nges in the structures and activities of key glycolytic signaling pathway proteins, including GAPDH a

281 nd self-organization of cells exhibiting the glycolytic state, serving as a carbon source that fuels

282 1alpha and reprogrammed cell metabolism to a glycolytic state.

283 ells into groups exhibiting gluconeogenic or glycolytic states.

284 context-dependent requirement for individual glycolytic steps has not been fully explored.

285 We propose that this pathway represents a "glycolytic stress response" in which the initiation of a

286 lly suppressed if the uptake flux of another glycolytic substrate exceeds a threshold, which is set t

287 ensures that glycerol uptake defers to other glycolytic substrates but not to gluconeogenic ones.

288 ic acid (TCA) cycle during the metabolism of glycolytic substrates but, due to carbon recycling to th

289 uconeogenic substrates than during growth on glycolytic substrates.

290 These results indicate that glycolytic suppression and ATP production are necessary

291 Recent studies indicate that a glycolytic switch plays a role in induced pluripotent st

292 Innate immune signaling promotes a glycolytic switch that is required for transdifferentiat

293 Ectopic expression of N-Myc induced a glycolytic switch that was concomitant with enhanced sen

294 Generated MDSCs displayed a glycolytic switch, which rendered them more susceptible

295 We show that synapses can switch from glycolytic to oxidative metabolism, but to do so, they r

296 lecular potentiometers to adjust and control glycolytic to respiratory power output.

297 For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal mu

298 d slow-twitch type 1 fibres, together with a glycolytic-to-oxidative metabolic switch.

299 rotect injured axons by virtue of a dramatic glycolytic upregulation that arises in SCs as an inheren

300 ypes, MEFs have the capacity to uncouple the glycolytic utilization of glucose from mitochondrial res