ライフサイエンスコーパス: glycolytic pathway

1 used Adh(A) to recycle NADH generated in the glycolytic pathway.

2 o be a mechanism for compartmentation of the glycolytic pathway.

3 ATP generation in the terminal stage of the glycolytic pathway.

4 oglycerate mutase (PGAM)-B, an enzyme of the glycolytic pathway.

5 loning and shown to encode an enolase in the glycolytic pathway.

6 resence of pharmacological inhibition of the glycolytic pathway.

7 lent metals play a role in regulation of the glycolytic pathway.

8 th a multilocus response to selection in the glycolytic pathway.

9 A clone coded for aldolase, an enzyme of the glycolytic pathway.

10 protein, which plays a critical role in the glycolytic pathway.

11 ng competitive inhibitor of an enzyme in the glycolytic pathway.

12 component of the gluconeogenic branch of the glycolytic pathway.

13 ctions with YPK and in the regulation of the glycolytic pathway.

14 sphofructokinase, an important enzyme in the glycolytic pathway.

15 ated for by appropriate up-regulation of the glycolytic pathway.

16 portant role in cells that require an active glycolytic pathway.

17 analogue that can inhibit key enzymes in the glycolytic pathway.

18 the glycogen/trehalose shunt to balance the glycolytic pathway.

19 ing systems such as the mitochondria and the glycolytic pathway.

20 inase 2 (HK2), a rate-limiting enzyme of the glycolytic pathway.

21 pendent processes is by interfering with the glycolytic pathway.

22 enesis and suppressed the biomass-supporting glycolytic pathway.

23 th associated increased glucose flux through glycolytic pathway.

24 the muscle and enhanced the activity of the glycolytic pathway.

25 crease the levels of enzymes involved in the glycolytic pathway.

26 K2), one of the rate-limiting enzymes of the glycolytic pathway.

27 ed the glutaminolytic pathway instead of the glycolytic pathway.

28 an enzyme normally designed to terminate the glycolytic pathway.

29 on that diverts serine biosynthesis from the glycolytic pathway.

30 in glucose uptake and metabolism through the glycolytic pathway.

31 the canonical Embden-Meyerhoff-Parnass (EMP) glycolytic pathway.

32 APDH) is a ubiquitous enzyme involved in the glycolytic pathway.

33 (NAD(+)) pool for continuous fueling of the glycolytic pathway.

34 ed in induction of IL-1beta and genes in the glycolytic pathway.

35 splays enzymatic activities intrinsic to the glycolytic pathway.

36 denine dinucleotide as the final step in the glycolytic pathway.

37 or several glycolytic enzymes throughout the glycolytic pathway.

38 roviding an alternative ferredoxin-dependent glycolytic pathway.

39 sphate (G6P), which is the first step in the glycolytic pathway.

40 le and enhanced pyruvate shunting toward the glycolytic pathway.

41 -dependent genes clustering in signaling and glycolytic pathways.

42 e between the utilization of respiratory and glycolytic pathways.

43 gy conversion away from oxidative and toward glycolytic pathways.

44 catalytic activity of two key enzymes in the glycolytic pathway, 6-phosphofructokinase and pyruvate k

45 hat the members of this lineage use in their glycolytic pathway a GAPDH species with properties and a

46 rains whose growth depended on two nonnative glycolytic pathways: a complete glycolysis from the rela

47 ium lactate, which bypasses the block in the glycolytic pathway, abolished the anticonvulsant activit

48 under double nutrient deficiency, and higher glycolytic pathway activities were observed in both root

49 Loss of BT3172 reduces glycolytic pathway activity in vitro and in vivo.

50 Glycolytic pathways also increased following the adminis

51 of carbon flux through the gluconeogenic and glycolytic pathways, also stimulated glucose-6-phosphata

52 important transcriptional activators of the glycolytic pathway and contribute to the Warburg effect

53 ypoxia, including increased flux through the glycolytic pathway and decreased flux through the tricar

54 trates HIF1-alpha-dependent induction of the glycolytic pathway and HIF1-alpha-independent maintenanc

55 However,Mtbalso maintains a functional glycolytic pathway and its role in the cellular metaboli

56 xisomes that uniquely contain enzymes of the glycolytic pathway and other parts of intermediary metab

57 ch have come to compartmentalize most of the glycolytic pathway and play a role in developmental sign

58 with mammalian flagella, including an entire glycolytic pathway and proteasome, but also document a v

59 Malignant cancer cells use the glycolytic pathway and require MCTs to efflux lactate th

60 nfluences metabolism via upregulation of the glycolytic pathway and suppression of mitochondrial resp

61 an enhanced flux of glucose through both the glycolytic pathway and the hexose monophosphate shunt.

62 changes in the level of intermediates in the glycolytic pathway and the ratios of ATP/ADP and NAD(P)H

63 e-grown cells that are unique to the unusual glycolytic pathway and three in peptide-grown cells that

64 kably heterogeneous, although changes in the glycolytic pathways and an increase in the generation of

65 Given DHA's incorporation into glycolytic pathways and induction of mitochondrial stres

66 d alters metabolic reprogramming by shifting glycolytic pathways and inhibiting reactive oxygen speci

67 We introduce modifications in glycolytic pathways and the Calvin Benson cycle to incre

68 as supported by silencing other genes in the glycolytic pathway, and confirmed by observation of a si

69 DENV activates the glycolytic pathway, and inhibition of glycolysis signifi

70 1) We are still missing key enzymes from the glycolytic pathway, and the conjecture is that this is d

71 port chain, in which adjacent enzymes in the glycolytic pathway are assembled to permit efficient flu

72 surprising discovery that components of the glycolytic pathway are enriched on the apoptotic cell su

73 doroff (ED) and Embden-Meyerhof-Parnas (EMP) glycolytic pathways are largely conserved across glycoly

74 ycerol, which interfaces with the glycosomal glycolytic pathway, are also toxic during PEX14 RNAi.

75 nase (PFKP), two key enzymes involved in the glycolytic pathway, are hyperactivated in head and neck

76 this review, we will discuss the role of the glycolytic pathway as a source of signaling molecules in

77 rrelation plots between metabolites from the glycolytic pathway, as well as with the observed ATP/ADP

78 PGM plays a central role in the glycolytic pathway at the branch point leading to glycog

79 hysical basis for plasma membrane-associated glycolytic pathway been established.

80 cells maintain largely normal fluxes through glycolytic pathways, but the entire output of these path

81 colysis, catalyses the committed step of the glycolytic pathway by converting fructose-6-phosphate to

82 This discovery reveals that the glycolytic pathway can bypass the formation of 3-phospho

83 These signals emanating from the glycolytic pathway can profoundly impact cell function,

84 The glycolytic pathway, comprising aldehyde dehydrogenase (A

85 ic isoenzymes by any alternative, functional glycolytic pathway configuration.

86 further show that prokaryotes use different glycolytic pathways depending on their energy supply.

87 hese included putative genes involved in the glycolytic pathway, DNA, RNA, and protein metabolism, an

88 tion of oxygen tension, Hb conformation, and glycolytic pathway dominance.

89 Pharmacologically inhibiting the glycolytic pathway dramatically reduced DENV RNA synthes

90 e (YPK) is regulated by intermediates of the glycolytic pathway [e.g., phosphoenolpyruvate (PEP), fru

91 ate shuttle and/or the distal portion of the glycolytic pathway, either of which can lead to producti

92 s a protein that is highly homologous to the glycolytic pathway enzyme, Pgm.

93 fructose-1,6-bisphosphate aldolases (FBPA), glycolytic pathway enzymes, exhibit no amino acid sequen

94 ression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions

95 the increased dependence of cancer cells on glycolytic pathway for ATP generation provides a biochem

96 en microenvironment and actively utilize the glycolytic pathway for ATP generation.

97 linal variation is common for enzymes in the glycolytic pathway for Drosophila melanogaster and is ge

98 Most of these species rely on the glycolytic pathway for energy production, with the one e

99 their increased reliance on the inefficient glycolytic pathway for energy production.

100 r-Doudoroff pathway rather than the standard glycolytic pathway for glucose catabolism, and anaplerot

101 iated enolase deSUMOylation, which fortifies glycolytic pathway for growth and contributes to V. dahl

102 s demonstrated a metabolic dependency on the glycolytic pathway for IL-10 production, shifting from t

103 Targeting the glycolytic pathway for the treatment of hematological ma

104 is asaccharolytic because it lacks an active glycolytic pathway for the use of sugars as a carbon sou

105 e 2-epimerase (NanE) belongs to a convergent glycolytic pathway for utilization of the three amino su

106 Accordingly, in organisms that possess both glycolytic pathways (for example, Escherichia coli), its

107 r cells frequently exhibit uncoupling of the glycolytic pathway from the TCA cycle (i.e., the "Warbur

108 Molecular analyses show elevated glycolytic pathway gene transcripts and active enzymes.

109 inhibited HIF-1alpha, showed upregulation of glycolytic pathway genes, glucose transporter 1-4 (Glut1

110 rgeting down-regulated expression of several glycolytic pathway genes, with a corresponding decrease

111 includes three successive enzymes along the glycolytic pathway: glyceraldehyde-3-phosphate dehydroge

112 ephosphate isomerase (TIM), an enzyme of the glycolytic pathway, has emerged as a useful drug target

113 The genes encoding three enzymes of the glycolytic pathway have been identified and sequenced co

114 ing allostery or key regulatory nodes in the glycolytic pathway impacted the size of the outer segmen

115 se results indicate that perturbation of the glycolytic pathway in adipose tissue has multiple effect

116 l oxidative phosphorylation, the role of the glycolytic pathway in axon morphogenesis and maintenance

117 st localization of the upstream steps of the glycolytic pathway in Chlamydomonas.

118 is based on an orthogonal, NMN(+)-dependent glycolytic pathway in Escherichia coli which can be coup

119 ext by 'predicting' the intermediates in the glycolytic pathway in Escherichia coli.

120 s gives clear insight into this exchange for glycolytic pathway in human red blood cell, including th

121 The importance of the glycolytic pathway in invasion and plaque formation was

122 on and functional levels and a switch to the glycolytic pathway in mphis, while IL-4-treated mphis ut

123 Flux through the glycolytic pathway in myeloid cells is inextricably link

124 demonstrate the cell autonomous role of the glycolytic pathway in outer segment maintenance and prov

125 ely suppressed LPS-induced activation of the glycolytic pathway in the hippocampus, as evidenced by i

126 Up-regulation of the anaerobic glycolytic pathway in the muscle of fast-growing fish wa

127 specifically produced by a compartmentalized glycolytic pathway in the principal piece of the flagell

128 abundant components and extensive study, the glycolytic pathway in the yeast Saccharomyces cerevisiae

129 erences in flux through the lower end of the glycolytic pathway in this stage.

130 ct between the histidine decarboxylation and glycolytic pathways in acid stress survival.

131 several species--controls the gluconeogenic/glycolytic pathways in liver in response to fasting sign

132 y and decreased allosteric regulation by the glycolytic pathway intermediate fructose 1,6-bisphosphat

133 spontaneous formation of methylglyoxal from glycolytic pathway intermediates.

134 The glycolytic pathway is a potential therapeutic target to

135 We report that the glycolytic pathway is actively regulated during the diff

136 Regulation of the glycolytic pathway is considered to be primarily achieve

137 functional evidence that the ATP-generating glycolytic pathway is directly coupled to the ATP-hydrol

138 These data indicate that the glycolytic pathway is operative in distal axons and cont

139 esults imply that metabolic flux through the glycolytic pathway is reduced in diabetes.

140 ence of NGF, while in the absence of NGF the glycolytic pathway is required for axon maintenance.

141 and that, in the absence of NGF, the axonal glycolytic pathway is required for axon maintenance.SIGN

142 The data reveal that the glycolytic pathway is required for normal sensory axon e

143 eoxy-d-glucose, indicating that a functional glycolytic pathway is required for this protective effec

144 r, previous studies indicated that an active glycolytic pathway is required to achieve normal sperm f

145 the Entner-Doudoroff and the DeLey-Doudoroff glycolytic pathways is described.

146 rotein abundance for carbon assimilatory and glycolytic pathways leading to fatty acid synthesis in r

147 replenished through the very ATP-inefficient glycolytic pathway; macrocyclic polyamines appear to be

148 he energy currency phosphocreatine, elevated glycolytic pathway metabolites, increased TCA cycle meta

149 s identity as a key regulatory enzyme in the glycolytic pathway, namely phosphofructokinase-M (PFK-M)

150 creased and 20 decreased) clustered into the glycolytic pathway, nucleotide sugars, intermediates of

151 Enzymes in the glycolytic pathway of mammalian sperm are modified exten

152 e activity for reconstitution of the defunct glycolytic pathway of the bacterial auxotroph.

153 somerase (GPI), the first two enzymes of the glycolytic pathway of the diplomonads Giardia intestinal

154 The glycolytic pathway of these organisms resides within the

155 -1-phosphate, which then feed into the novel glycolytic pathway of this organism.

156 studies demonstrate that HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint f

157 ting increase in abundance of enzymes in the glycolytic pathway (pentose phosphate and pyruvate metab

158 Thus, telomerase activity controls the glycolytic pathway, potentially altering the energy stat

159 n in these bacteria limits conversion of the glycolytic pathway product phosphoenolpyruvate to the tr

160 cluding Smurf1, Smurf2, YAP1, and CEBPZ, and glycolytic pathway proteins, including PFKFB3.

161 t the method can detect intermediates of the glycolytic pathway, quantify their rate of formation, an

162 rosstalk between histone acetylation and the glycolytic pathway resulting in a vulnerability of breas

163 ome phosphofructokinase (PFK) that block the glycolytic pathway resulting in very fast parasite kill

164 ive genes encode for critical enzymes in the glycolytic pathway, revealing how CD44 could be a gateke

165 f HIF1A or drug inhibition of HIF-associated glycolytic pathways selectively impairs brain tumor grow

166 al biochemical networks, including microbial glycolytic pathways, signal transduction pathways and re

167 TP and higher utilization of glucose via the glycolytic pathway than ECV304 cells.

168 at Il22ra2(-/-) macrophages rely more on the glycolytic pathway than wild-type (WT) controls.

169 an autosomal-recessive enzyme defect of the glycolytic pathway that causes congenital nonspherocytic

170 lation of PGAM1 and may provide an alternate glycolytic pathway that decouples adenosine triphosphate

171 The Entner-Doudoroff (ED) pathway is a glycolytic pathway that parallels textbook glycolysis bu

172 tabolic processes within the cells, both the glycolytic pathway that produces ATP and the cellular pr

173 tionalization in this organism of an unusual glycolytic pathway that was previously thought not to co

174 ncapable of performing the first step of the glycolytic pathway, the phosphorylation of glucose.

175 larly diverse, including several alternative glycolytic pathways, the most common of which is the Ent

176 e expression of hexokinase-ll (HK-II) in the glycolytic pathway through elevated c-MYC.

177 ts demonstrate that Rho GTPases regulate the glycolytic pathway through Pak and suggest a link betwee

178 ve traditionally been thought to rely on the glycolytic pathway to generate ATP, recent studies sugge

179 dvance our understanding of how to block the glycolytic pathway to inhibit tumor progression by using

180 se experiments suggest that DENV induces the glycolytic pathway to support efficient viral replicatio

181 responsible for localizing components of the glycolytic pathway to the fibrous sheath and that this l

182 hibiting PFKFB3, a key regulator in the host glycolytic pathway, we successfully modulated HIF1alpha-

183 To assess enzyme-specific control in the glycolytic pathway, we used P-element excision-derived m

184 sole enzyme linking hexosamine systems with glycolytic pathways, we propose that it provides a sourc

185 th a highly efficient pyrophosphate-mediated glycolytic pathway, which under oxygen limitation partic

186 CD4A is a transcriptional coregulator of the glycolytic pathway whose dysfunction accounts for the di

187 This enzyme equips the glycolytic pathway with a special steering function for

188 1, ENO2, GAPDH, TPI1, LDHA, and LDHB) in the glycolytic pathway with concomitant reduction in metabol

189 phoenolpyruvate utilization and connects the glycolytic pathway with the TCA cycle, restored CFA to r