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1 a systemic supply of FKRP protein acting as glycosyltransferase.
2 ransferase domain and a predicted C-terminal glycosyltransferase.
3 by cellulose synthase, a processive family-2 glycosyltransferase.
4 rimer installed onto protein targets by an N-glycosyltransferase.
5 separately from related Golgi-resident GT32 glycosyltransferases.
6 nto LacNAc and then elaborated by a panel of glycosyltransferases.
7 diverse range of substrates required for the glycosyltransferases.
8 the nucleotide-sugar substrates required by glycosyltransferases.
9 hat CgT represents a new member of GT-A-type glycosyltransferases.
10 s then extended to up to 11 HMOs by 4 robust glycosyltransferases.
11 by virtue of the inherent specificity of the glycosyltransferases.
12 amine (UDP-GlcNAc), a substrate for cellular glycosyltransferases.
13 inds the sugar nucleotide UDP-glucose, as do glycosyltransferases.
14 d serine-rich repeat adhesins by a series of glycosyltransferases.
15 process regulated by the availability of key glycosyltransferases.
16 ntrasted with common properties of canonical glycosyltransferases.
17 to the cell membrane and is hence exposed to glycosyltransferases.
18 encode seed-specific uridine 5'-diphosphate-glycosyltransferases.
19 the substrate specificities glycosidases and glycosyltransferases.
20 Golgi apparatus by glycoside hydrolases and glycosyltransferases.
21 ites that serve as monosaccharide donors for glycosyltransferases.
22 daptable to high-throughput screens of other glycosyltransferases.
23 dentified a unique hybrid protein dGT1 (dual glycosyltransferase 1) that contains two distinct domain
25 genes involved in zinc finger CCCH protein, glycosyltransferase, 1-aminocyclopropane-1-carboxylate o
26 yzed by the integral membrane lipid-to-lipid glycosyltransferase 4-amino-4-deoxy-L-arabinose transfer
27 ns proximal to the substrate binding site of glycosyltransferase 8 domain containing 1 (GLT8D1) are a
30 ped FKRP might circulate as an extracellular glycosyltransferase, able to exert a "glycan remodelling
31 ure of a previously disordered region in the glycosyltransferase active site and discuss its implicat
34 oreover, so far unknown chitin hydrolase and glycosyltransferase activities were detected using GlcNA
37 inactive point mutants indicated that OGT-1 glycosyltransferase activity is dispensable for GABA neu
39 tein-protein interaction and crucial for the glycosyltransferase activity of CgT in vitro and in vivo
40 l number of enzyme activities comprising the glycosyltransferase activity of class A PBP1b and the D,
43 eriophora excreted-secreted products contain glycosyltransferase activity, these results demonstrate
48 njugates that takes advantage of recombinant glycosyltransferases and a corresponding sugar nucleotid
51 g mechanisms that concentrate Golgi-resident glycosyltransferases and glycosidases in distinct Golgi
52 nzymatic labeling (or SEEL) uses recombinant glycosyltransferases and nucleotide-sugar analogues to a
53 y as a general approach for the screening of glycosyltransferases and other group-transfer enzymes.
54 neer glycans using different permutations of glycosyltransferases and to investigate biosynthetic pat
55 he bifunctional class A PBPs, which are both glycosyltransferases and transpeptidases, and monofuncti
56 among saponin biosynthesis genes, especially glycosyltransferases, and may be the driving force of th
57 ulfurylases, carbohydrate-sulfotransferases, glycosyltransferases, and one family 16 glycoside hydrol
58 ughput screening assay (FP-tag) for beta-Kdo glycosyltransferases, and use it to identify a class of
59 ent signaling pathways regulated by O-GlcNAc glycosyltransferase are thus fundamental for T cell biol
60 g target for control of the pathogen, as the glycosyltransferases are absent from mammalian hosts.
61 n to examples where genetic mutations within glycosyltransferases are associated with neurodegenerati
65 neer glycans using different permutations of glycosyltransferases as well as to investigate biosynthe
68 s that nucleotide sugar donors for GT-A fold glycosyltransferases bind in similar positions and confo
69 in the center of the plant secondary product glycosyltransferase box (A389V) reduced the enzymatic ac
70 ditional ectopic expression of an engineered glycosyltransferase, "bump-and-hole" (BH)-GalNAc-T2, boo
71 c peptides of proteins, which modifies Tn by glycosyltransferase C1GalT1 with isotopically labeled UD
72 e associated with a gene encoding a putative glycosyltransferase called MUCILAGE-RELATED70 (MUCI70).
73 n on cells, where the products of individual glycosyltransferases can be selectively characterized or
75 aryotic protein N-glycosylation, a series of glycosyltransferases catalyse the biosynthesis of a doli
76 m uses a catch and release approach in which glycosyltransferase-catalysed reactions are performed in
77 differs, with the enzyme WbbY possessing two glycosyltransferase catalytic sites solely responsible f
79 otide sugars throughout the cell for various glycosyltransferase-catalyzed glycosylation reactions.
81 ed alpha repeat of the PGANT9A and PGANT9B O-glycosyltransferases confers distinct preferences for a
82 ly required for induction of Fut7 and Gcnt1, glycosyltransferases critical for selectin ligand biosyn
83 lyses reveal specific gene expansions in the glycosyltransferase, cytochrome P450, shikimate hydroxyc
86 llographic model for inhibition of the PBP1b glycosyltransferase domain by the potent substrate analo
89 proteolytic fragment containing the putative glycosyltransferase domain was tested in isolation for a
90 mer in which each blade contains a GT-B-type glycosyltransferase domain with a typical Rossmann fold.
91 The csaA gene product contains a predicted glycosyltransferase domain with structural homology to G
93 we propose the linkage specificities of the glycosyltransferase domains are conserved in KpsC homolo
96 rases (ppGalNAc-Ts) on catalytic activity of glycosyltransferases during O-GalNAc glycan biosynthesis
97 we consider potential mechanisms connecting glycosyltransferase dysfunction to neurodegeneration.
98 tpM is the first member of a novel family of glycosyltransferase effectors employed to subvert hosts.
99 ations support the hypothesis that GT-A fold glycosyltransferases employ coevolving donor, acceptor,
100 n vivo glycoengineering technologies and the glycosyltransferase-enabled in vitro engineering method,
101 g penultimate sugar assembled by a different glycosyltransferase enables testing of the conformationa
102 of Xoc flagellin was altered by deletion of glycosyltransferase-encoding rbfC, but this had little e
103 or is regulated in part by the repertoire of glycosyltransferase enzymes (which make the glycan ligan
104 beta-Kdo counterparts were not identified as glycosyltransferase enzymes by bioinformatics tools and
107 tead of the canonical DxD motif of GT-A type glycosyltransferases, essential for enzyme activity and
108 Interestingly, KS biosynthesis specific glycosyltransferases expression was differentially regul
110 epresented among the 98 currently recognized glycosyltransferase families in the Carbohydrate-Active
111 ential evolution of gene families, including glycosyltransferase family 25, whose activities are excl
112 gene, At3g57630, in clade E of the inverting Glycosyltransferase family GT47 as a candidate for the t
113 e of the adaptation by trypanosomes of beta3-glycosyltransferase family members to catalyze beta1-2 g
114 hat TbGT15, another member of the same beta3-glycosyltransferase family, encodes an equally divergent
116 cularly redundant yet disease-relevant human glycosyltransferase family, the polypeptide N-acetylgala
119 IBP was first catalyzed by P450, and then by glycosyltransferase, followed by further storage or meta
120 ype O-glycan, and Tn-antigen; identified the glycosyltransferases for assembling novel nuclear O-Fuc-
121 ngs to a large family of membrane-associated glycosyltransferases for which the understanding of the
122 how that due to the asymmetric effect of the glycosyltransferase Fringe, different outcomes are gener
123 found that Toxoplasma utilizes a cytoplasmic glycosyltransferase from an ancient clade of CAZy family
124 tidine monophosphate-Kdo-dependent alpha-Kdo glycosyltransferase from LPS assembly is well characteri
125 lass B PBPs work together with transmembrane glycosyltransferases (FtsW and RodA) from the shape, elo
126 structural information exists that shows how glycosyltransferases functionally assemble with each oth
129 crystallographic experiments showed that the glycosyltransferase Gat1 is specific for Skp1 in Toxopla
130 ene, a lipB (kpsS)-like gene, and a putative glycosyltransferase gene designated csaA (capsule synthe
131 s induce upregulated expression of the Gcnt1 glycosyltransferase gene in T cells mediating graft-vers
135 I (TbGnTI) among a set of putative T. brucei glycosyltransferase genes belonging to the beta3-glycosy
136 ion of a genomic island strongly enriched in glycosyltransferase genes involved in exopolysaccharide
137 d glycan array is self-renewable and reports glycosyltransferase genes required (or blocking) for int
140 an biosynthesis in mycobacteria involves two glycosyltransferases, GlfT1 and GlfT2, which have been t
141 ormation of this polymer is catalyzed by the glycosyltransferase GlfT2, a processive carbohydrate pol
142 tribution of processing machineries, such as glycosyltransferases, glycosidases, and nucleotide sugar
144 discovered that the gene Mgat3 encoding the glycosyltransferase GnT-III is elevated in epithelial ov
145 ified by five sugars via the action of three glycosyltransferases, Gnt1, PgtA, and AgtA, which are re
148 rstood, largely because of the resistance of glycosyltransferase (GT) enzymes to structural character
150 of LtpM uncovered a remote similarity to the glycosyltransferase (GT) toxin PaTox from the bacterium
151 nts) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a
152 e EpsHIJK proteins suggest EpsH and EpsJ are glycosyltransferases (GT) with a GT-A fold; EpsI is a GT
153 ylases, they constitute a distinct family of glycosyltransferases (GT108) that have likely been acqui
156 lyzed the mechanism by which the cytosolic O-glycosyltransferase GtfA/B of Streptococcus gordonii mod
157 O-antigen can be modified by the activity of glycosyltransferase (gtr) operons acquired by horizontal
159 zymes such as glycoside hydrolases (GHs) and glycosyltransferases (GTs) are of growing importance as
162 al MUCILAGE-RELATED (MUCI) genes that encode glycosyltransferases (GTs) involved in the production of
163 c analysis identified six main proteins: two glycosyltransferases (GTs) TaGT43-4 and TaGT47-13; two p
164 identified the roles of three virus-encoded glycosyltransferases (GTs) that have four distinct GT ac
168 Here, we examine a putative ecdysteroid glycosyltransferase, Hba_07292 (Hb-ugt-1), which was pre
169 is predicted to possess a typical GT-A-type glycosyltransferase, however, the activity remains unkno
170 l wall synthesis is achieved by a balance of glycosyltransferase, hydrolase and transglycosylase acti
172 ced intermediates that can be diversified by glycosyltransferases in a branch-selective manner to giv
173 Predictions for the function of two UDP-glycosyltransferases in flavonoid metabolism were confir
175 sugars, which serve as donor substrates for glycosyltransferases in the lumen of Golgi vesicles and
177 nor and acceptor recognition among GT-B fold glycosyltransferases in the synthesis of diverse glycan
179 rcially available and recombinantly produced glycosyltransferases including key N-acetylglucosaminylt
180 creased abundance of transcripts for several glycosyltransferases indicated the enzymes that may be i
181 udy, we show that using moenomycin and other glycosyltransferase inhibitors as templates, we were abl
182 mechanistic insights into the regulation of glycosyltransferase interactions, the transitions betwee
183 pid II, that is polymerized by peptidoglycan glycosyltransferases into glycan strands that are subseq
184 ations affecting exostosin-like 3 (EXTL3), a glycosyltransferase involved in heparan sulfate (HS) bio
185 nt with the predicted functions of the WbkD (glycosyltransferase involved in the biosynthesis of the
187 R XYLEM9-LIKE [IRX9L]) encodes a family GT43 glycosyltransferase involved in xylan backbone biosynthe
188 inyltransferases (B3GNTs) are Golgi-resident glycosyltransferases involved in the biosynthesis of pol
189 fold of ppGalNAc-Ts in enzymatic activity of glycosyltransferases involved in the O-glycan biosynthes
190 role in the process; thus understanding the glycosyltransferases involved is key to identifying new
191 role in the process, thus understanding the glycosyltransferases involved is key to identifying new
192 irst evidence that isolated dysfunction of a glycosyltransferase is sufficient to cause a neurodegene
196 ining member of a new class of cytoplasmic O-glycosyltransferases, is required and sufficient for fla
198 and dependent on the expression of both like-glycosyltransferase (LARGE) and partially functional FKR
199 HepII) are controlled by phase-variable LOS glycosyltransferase (lgt) genes; we sought to define how
201 this binding requires Mg(2+) Mutation of the glycosyltransferase-like metal ion binding motif in H3 g
202 synthesis, while UPEX1 encodes a family GT31 glycosyltransferase likely involved in galactosylation o
203 dentified colonization genes, epaX encodes a glycosyltransferase located in a variable region of the
204 Thus, bryophytes and algae likely lack the glycosyltransferase machinery required to synthesize api
205 y studies have suggested the significance of glycosyltransferase-mediated macromolecule glycosylation
206 issue of Cell, Liu et al. present FucoID, a glycosyltransferase-mediated tagging platform, to bioche
207 ontaining multiple cellulose synthase (CESA) glycosyltransferases mediates cellulose microfibril form
208 removal, or forced expression of Dll4 or the glycosyltransferase Mfng, blocks coronary plexus remodel
214 reactive antigen that was lost in a putative glycosyltransferase mutant, suggesting that this antigen
215 Moreover, we provide evidence that three glycosyltransferases (MXAN_3027/ExoK, MXAN_3262/ExoO and
216 ion by the Actinobacillus pleuropneumoniae N-glycosyltransferase (NGT) at every possible position alo
218 -ALG3, ALG9, ALG12, ALG6, ALG8 and ALG10-are glycosyltransferases of the C-superfamily (GT-Cs), which
219 O-GlcNAc and leptin, whereas inhibition of O-glycosyltransferase (OGT) decreased O-GlcNAc and leptin.
221 T-IV, and GnT-V in cells revealed that these glycosyltransferases, particularly GnT-IV, play importan
222 previously shown that loss of a conserved O-glycosyltransferase (PGANT4) in Drosophila results in ab
223 ers to the pathway in which Protein N- and O-glycosyltransferases (PGTases) sequentially add monosacc
224 that perform these reactions, polyisoprenyl-glycosyltransferases (PI-GTs) include dolichol phosphate
226 t, mice double heterozygous for Jag1 and the glycosyltransferase, Poglut1 (Rumi), start showing a sig
227 rase (Und-P GT), a flippase, and a polytopic glycosyltransferase (PolM GT) dedicated to attaching sug
228 ate-dependent dioxygenases and UDP-dependent glycosyltransferases potentially involved in diterpenoid
235 h the physiological function of blood stream glycosyltransferases remains unclear, they are likely re
237 transferase 1 gene (Pofut1), which encodes a glycosyltransferase required for NotchR-mediated cell-ce
239 ighlight the discovery of the monofunctional glycosyltransferases RodA and FtsW and describe how thes
240 gy to measure the group-transfer activity of glycosyltransferases sensitively using simple fluorescen
243 This Synopsis considers recent advances in glycosyltransferase structural biology and site-directed
248 ugar and its linkage, here we identified the glycosyltransferase that completes the glycan and found
249 thin a GBS-specific gene encoding a putative glycosyltransferase that confers resistance to HMOs, sug
251 mannosyltransferase A (PimA) is an essential glycosyltransferase that initiates the biosynthetic path
252 demonstrated that lymphostatin is a putative glycosyltransferase that is important in intestinal colo
256 l, deeply conserved family of plant-specific glycosyltransferases that add arabinose sugars to divers
257 mediators in vivo by engineering solubilized glycosyltransferases that attach galactose or sialic aci
258 (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccha
259 by mixing-and-matching cell-free synthesized glycosyltransferases that can elaborate a glucose primer
260 s the Salmonella enterica SseK effectors are glycosyltransferases that modify host protein substrates
261 esized by membrane-integrated and processive glycosyltransferases that polymerize UDP-activated gluco
262 Quantitative PCR gene expression studies of glycosyltransferases that regulate display of sLe(X) rev
263 nserved glycolipid belong to a new family of glycosyltransferases that shares little homology with ot
264 ellulose synthase-like (CSL) families encode glycosyltransferases that synthesize the beta-1,4-linked
265 e a highly conserved family of transmembrane glycosyltransferases that work in concert with class B p
266 (also referred to as Gpi3) of the fungal UDP-glycosyltransferase, the first step in GPI biosynthesis,
268 omains that are diversely decorated by Golgi glycosyltransferases to become extended rodlike structur
269 that at each arm can be uniquely extended by glycosyltransferases to give access to highly complex as
270 rate biosynthetic pathway and use engineered glycosyltransferases to incorporate chemically tagged su
272 In the early 1980s, while using purified glycosyltransferases to probe glycan structures on surfa
273 the precursor, which is extended by cellular glycosyltransferases to produce 4-N(3)-Bn-alpha-O-glycan
274 ic strategy, using a limited number of human glycosyltransferases, to access a collection of 60 asymm
276 N-terminal DUF1792 is a novel GT-D-type glycosyltransferase, transferring Glc residues to Glc-Gl
277 s study, we determine that CgT is a distinct glycosyltransferase, transferring GlcNAc residues to Glc
278 cluding a phage protein and a phase-variable glycosyltransferase ubiquitous among the diverse set of
279 espite the importance of uridine diphosphate glycosyltransferase (UGT) enzymes in drug and chemical m
280 iptomic data, identifying four UDP-dependent glycosyltransferase (UGT) genes as wound-induced and 12-
283 dae, for example, are known to produce a UDP-glycosyltransferase (UGT) that negatively regulates ecdy
284 ed to involve a family 1 UDP-sugar dependent glycosyltransferase (UGT) to facilitate acetophenone acc
285 ncatula In addition, two uridine diphosphate glycosyltransferases, UGT73F18 and UGT73F19, which gluco
286 lated metabolites generated by UDP-dependent glycosyltransferases (UGTs) play critical roles in plant
289 ecaprenyl-phosphate (Und-P) sugar-activating glycosyltransferase (Und-P GT), a flippase, and a polyto
290 into the lumen of the Golgi apparatus where glycosyltransferases use them for the modification of pr
291 sm for modulating substrate preferences of O-glycosyltransferases via alternative splicing within spe
292 uding cytochrome P450 monooxygenases and UDP-glycosyltransferases, was shared between both treatments
294 In contrast, O2c polymerization requires glycosyltransferases WbmV and WbmW, which interact with
296 ring the substrate promiscuity of endogenous glycosyltransferases, we developed a single-step fluores
297 teen hypothetical proteins and uncategorized glycosyltransferases were also required for maximum comp
298 ntibiotic moenomycin that inhibits bacterial glycosyltransferases, which are essential for peptidogly
300 arge clostridial toxins, which are retaining glycosyltransferases with a DXD motif involved in bindin