ライフサイエンスコーパス: gonad

1 diting via Oviductal Nucleic Acids Delivery (GONAD).

2 ise from a common precursor, the bipotential gonad.

3 mitotic cells in the Caenorhabditis elegans gonad.

4 the new oviduct electroporation technique i-GONAD.

5 line stem cell progenitors in the C. elegans gonad.

6 l self-fertilization in a mixed ovary/testis gonad.

7 channel diameter and dynamics throughout the gonad.

8 ed germ cell abnormalities in the C. elegans gonad.

9 patterning within the Caenorhabditis elegans gonad.

10 nd enabled their subsequent removal from the gonad.

11 t to specify male cell identity in the mouse gonad.

12 ergo a long-range migration to the embryonic gonad.

13 can be faithfully replicated outside of the gonad.

14 l (DTC), the germline stem cell niche in the gonad.

15 (OTDSD), testicular tissue is present in the gonad.

16 opeptides released from somatic cells of the gonad.

17 s in the myoepithelial sheath of the somatic gonad.

18 and germ cells in the Caenorhabditis elegans gonad.

19 and maintenance to form the functional adult gonad.

20 7.5-day, 14.5-day and 18.5-day old embryonic gonads.

21 n various organs including skin, kidneys and gonads.

22 of key events during the development of the gonads.

23 fects of sex chromosomes, and male or female gonads.

24 ons and maintains genome integrity in animal gonads.

25 ic analyses of reproductive tissues or whole gonads.

26 , heart, lungs, diaphragm, gut, kidneys, and gonads.

27 ion in the post-temperature sensitive period gonads.

28 suppress transposable elements in the animal gonads.

29 ncoding VEGF receptor 2, in murine embryonic gonads.

30 steroidogenic cells in both male and female gonads.

31 ter than females instead of developing their gonads.

32 most of the somatic cells in both XX and XY gonads.

33 pecific Sox9 expression in developing murine gonads.

34 tivation of WNT/beta-catenin signaling in XX gonads.

35 e testis-promoting gene Sox9 in embryonic XX gonads.

36 about Vtg levels, at least in marine mussel gonads.

37 F-acids) (38.2%) was detected in TAG of male gonads.

38 iencephalon, midbrain tegmentum, retina, and gonads.

39 responses remains unclear in the undeveloped gonads.

40 pteropods but also the functioning of their gonads.

41 sex determination (SD) period and in mature gonads.

42 ASH protein ZYG-12 was mislocalized in ooc-5 gonads.

43 ly reduced Tspo levels in adrenal cortex and gonads.

44 eins silence transposon expression in animal gonads.

45 tropins that drive steroid production in the gonads.

46 work in the brain with little effects in the gonads.

47 ynthesized in the brain, adrenal glands, and gonads.

48 pts in cultured murine embryonic kidneys and gonads.

49 ely expressed in the germ cells of mammalian gonads.

50 gicarpus Tfap2 mutants lacked germ cells and gonads.

51 eight gain in the presence of male or female gonads.

52 XX mice display masculinization of the fetal gonads.

53 ccurs within the hypothalamus, pituitary, or gonads.

54 matic-cell interface in both male and female gonads.

55 Of >7,000 transcripts found in the gonads, 243 (testes) and 3,600 (ovaries) occurred pairin

56 rred in the brain ( approximately 50%), male gonads (42%), and kidney (39%).

57 FA group in TAG of muscle (51.8%) and female gonads (47.8%) whereas high proportion of furan fatty ac

58 or component of both male (67.6%) and female gonad (58.6%) lipids.

59 with female-biased expression in developing gonads after the critical period during which sex is det

60 3 years and 9 months induced feminized male gonads, although the intersex condition was relatively m

61 ulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in

62 ing the autumn and winter through effects on gonad and egg development, variation in copepod timing m

63 as an endocrine organ to synchronize somatic gonad and germline development during dauer diapause and

64 for bmm function in the somatic cells of the gonad and in neurons in the regulation of male-female di

65 for bmm function in the somatic cells of the gonad and in neurons in the regulation of whole-body tri

66 resent in both the somatic cells of the male gonad and in neurons, revealing a previously unrecognize

67 -3 integrin was selectively activated in the gonad and recruited laminin, which directed moderate col

68 ) that acts inter se and between the somatic gonad and the germline.

69 muscle, fat, liver, brain, gill, kidney and gonad and the tissue FA measured by gas-liquid chromatog

70 als from the somatic cells of the developing gonads and a suite of intrinsic receptors, signal transd

71 Morphological changes of gonads and accessory glands attributed to androgen effec

72 ation hormone receptor (FSHR) is confined to gonads and at low levels to some extragonadal tissues li

73 saicism is a mutation that is limited to the gonads and can be transmitted to offspring.

74 ntification of vitellogenin in marine mussel gonads and compared the results with those obtained with

75 d on the presence of individuals with mature gonads and conducted statistical analysis of the expecte

76 ssue of eels but maternally transferred into gonads and eggs.

77 oteins involved in the normal development of gonads and external genitalia.

78 o-calcium complex, and the second one in the gonads and intestinal tract, as a protein complex.

79 d that it is suspected to complex uranium in gonads and intestinal tract.

80 ic day 11.5 (E11.5) postembryonic day 5 (P5) gonads and performed lineage tracing to analyze primordi

81 The gonads and peripheral organs are targets of EDCs, and re

82 They act on gonads and promote their development and functions inclu

83 one in humans, produced by the adrenals, the gonads and the brain.

84 thway represses transposable elements in the gonads and thereby plays a vital role in protecting the

85 onic development stage at E34 in the XY(DSD) gonad, and high activation of the female specific genes,

86 tosis regulates germ cell homeostasis in the gonad, and propose a role for intercellular pressure in

87 in the brain, followed by liver, muscle, and gonads, and can be attributed to direct exposure to WWTP

88 by transcription factors SRY and SOX9 in XY gonads, and ovarian differentiation involves R-spondin1

89 multiple GU tissues, including the kidneys, gonads, and reproductive ductal systems: the intermediat

90 udo-pregnant females, the females used for i-GONAD are not sacrificed and can be used for other exper

91 ertility, but their functions outside of the gonad are not well understood.

92 Paracentrotus lividus gonads are gastronomic delicacies widely appreciated in

93 How sexually dimorphic gonads are generated is a fundamental question at the in

94 Their essential roles include leading gonad arm outgrowth, serving as the germline niche, conn

95 Our results implicate the somatic gonad as an endocrine organ to synchronize somatic gonad

96 ished stem cell model system, the C. elegans gonad, as well as on two other model systems widely used

97 xpressed in somatic cells of male and female gonads, as well as in accessory reproductive tissues.

98 of human fetal testes explants called FEtal Gonad Assay (FEGA) with tissue obtained at 10 and 12 ges

99 ae of Auanema, despite the immaturity of the gonad at the time of the microinjection.

100 As Amhr2-Cre is expressed in gonads at 12.5 dpc, these findings suggest preimplantati

101 reased Kdr transcripts in cultured embryonic gonads at multiple developmental stages.

102 on1 as a novel molecular player in the brain-gonad axis and underscores the significance of inter-org

103 Sex determination of the gonads begins with fate specification of gonadal support

104 Here, we show that the decision of somatic gonad blast cells (SGBs) and germline stem cells (GSCs)

105 re two major somatic cell types in mammalian gonads, but the mechanisms that control their differenti

106 element (TE) activity is repressed in animal gonads by PIWI-interacting RNAs (piRNAs) produced by piR

107 Subsequently, we developed improved GONAD (i-GONAD) by delivering CRISPR ribonucleoproteins (RNPs; Ca

108 i-GONAD can also generate knock-in models containing up to

109 Thus GONAD can bypass many complex steps in transgenic techno

110 For these populations, high-quality gonads can be harvested during fall, despite being safe

111 mbranous protrusions of the adjacent somatic gonad cell pair (Sh1).

112 that DAF-16/FOXO activity in certain somatic gonad cells is required for germline progenitor maintena

113 nalysis suggests that daf-18 acts in somatic gonad cells to produce a "pro-quiescence" signal (or sig

114 During embryonic gonad coalescence, primordial germ cells (PGCs) follow a

115 Cell lineages of the early human gonad commit to one of the two mutually antagonistic org

116 vived and 40%, 5.3% and 2.4% of the examined gonads contained fluorescent labeled donor PGCs.

117 ces of software we benchmarked on C. elegans gonad datasets.

118 cyst-derived embryonic stem cells (ESCs) and gonad-derived embryonic germ cells (EGCs) represent two

119 Consequently, Rspo1 Sox8 Sox9 triple mutant gonads developed as atrophied ovaries.

120 l), cytoskeleton organization (k1C18, mtpn), gonad development (nell2, tcp4), lipid metabolism (ldah,

121 s regulatory functions in chondrogenesis and gonad development among species, we performed chromatin

122 Transplanted wild-type cells rescued gonad development but not germ cell induction in Tfap2 m

123 hich is critically involved in regulation of gonad development of vertebrates.

124 ms that control their differentiation during gonad development remain elusive.

125 phosphorylated proteins regardless of sex or gonad development stage.

126 line metabolic rates, but had lower grazing, gonad development, and calcification rates than those in

127 reveals another aspect of sexually dimorphic gonad development, establishes a precise timeline and st

128 During gonad development, expression of Cyp26b1 is maintained b

129 during four distinct stages of development: gonad development, gonad differentiation, development of

130 rgans but has been given little attention in gonad development.

131 among female mussels at different stages of gonad development.

132 anism of somatic cell differentiation during gonad development.

133 . elegans VAP homolog VPR-1 is essential for gonad development.

134 bility is incompatible with a normal pace of gonad development.

135 cell wrapping, which is critical for normal gonad development.

136 and is enriched in genes involved in female gonad development.

137 ered fundamental regulators of embryonic and gonad development.

138 Analysis of gonads development and mating experiments indicate that

139 d becomes pre-granulosa cell-specific as the gonads differentiate.

140 ct stages of development: gonad development, gonad differentiation, development of secondary sex char

141 mportance of the nervous system for flatworm gonad differentiation.

142 Further analysis revealed that SC-SF-1(-/-) gonads displayed lower MDM2 levels resulting in elevated

143 p to 66 um for cells, Caenorhabditis elegans gonads, Drosophila melanogaster larval brain, mouse reti

144 via estrogen receptor alpha within the left gonad epithelium.

145 ChIP-Seq databases in conjunction with mouse gonad explant transfection assays, we identified TCF/LEF

146 pled with a comprehensive description of the gonad, external sex characters and timing of the reprodu

147 the strongest yellow colouration and highest gonad firmness, protein, lipid, polyunsaturated fatty ac

148 e, which is converted to testosterone in the gonads, followed by further activation to 5alpha-dihydro

149 In C. elegans, sexual dimorphism in gonad form and function largely originates in different

150 mechanism for the evolutionary plasticity of gonad form seen in nematodes [11-15].

151 Mid and Lola work in parallel in gonad formation and surprisingly Mid overexpression in a

152 s in sexual development, but its function in gonad formation is still unclear.

153 In a screen for mutants affecting gonad formation we identified a SGP cell autonomous role

154 hIP-seq) using developing limb buds and male gonads from embryos of two vertebrates, mouse and chicke

155 gonad phenotypes of female perch: developed gonads from reference lakes, developed/irradiated from m

156 onal composition and antioxidant activity of gonads from the sea urchin, Stomopneustes variolaris, in

157 n limb bud genes compared with those in male gonad genes.

158 nt cultures of human fetal organs (adrenals, gonads, genital skin) from the major period of sexual di

159 We recently developed a method named GONAD (genome editing via oviductal nucleic acids delive

160 uscle, with relatively low expression in the gonads, gizzard and subcutaneous fat tissues of chickens

161 In addition, whereas gonad growth was associated with an increase in DNA meth

162 nt, the following rating: intestinal tract > gonads >> test, was obtained.

163 Our work uncovers a male gonad-gut axis coupling diet and sperm production, revea

164 n early embryos before colonization into the gonads, had slower timing of colonization, and had a dif

165 itions cannot be accurately evaluated unless gonads have fully matured under the new conditions.

166 ver, its effects on the corresponding female gonads have not been evaluated.

167 an tissues and organs, including the kidney, gonads, heart and nervous system.

168 ions and adverse effects on reproduction and gonad histology at higher levels.

169 Subsequently, we developed improved GONAD (i-GONAD) by delivering CRISPR ribonucleoproteins

170 onji genes are transcribed mostly within the gonad in adult oysters whereas they display a ubiquitous

171 Coalescence of the embryonic gonad in Drosophila melanogaster requires directed migra

172 xpressed in the body wall muscle and somatic gonad in which UNC-87 is also expressed.

173 e and is more restricted to gills and female gonads in adult zebrafish.

174 Initially, gonads in all dsx mutants (both XX and XY) initiate the

175 e in the normal postnatal development of the gonads in both sexes.

176 covered pairing-induced processes within the gonads including stem cell-associated and neural functio

177 Spawning occurred between spring-summer, yet gonad index peaked only in one population during winter.

178 niches are usually not observed in the same gonad, indicating that cells make a 'group decision' abo

179 Sry expression through formation of the male gonad indirectly negatively impacts the potential for lo

180 to olfactory bub glomeruli in unmanipulated (gonad-intact) adult mice from both sexes, and found that

181 processes in several tissues, including the gonad, intestine and appendages.

182 GONAD involves injection of CRISPR components (Cas9 mRNA

183 -response regulation between neurons and the gonad involving serotonin.

184 The formation of the Drosophila embryonic gonad, involving the fusion of clusters of somatic gonad

185 from their place of origin to the embryonic gonad is an essential reproductive feature in many anima

186 and mammals, the sexual fate of the somatic gonad is remarkably plastic and is controlled by a combi

187 Sex-specific development of the gonads is a key aspect of sexual dimorphism that is regu

188 The formation of male gonads is determined by the expression of Sry.

189 As SOX9 biological role in mammalian gonads is to determine Sertoli cells, we correlated this

190 Helicase (GRTH/DDX25), expressed in the male gonad, is essential for the completion of spermatogenesi

191 tion mutation, Cys342Tyr substitution in the gonad leads to loss of function, as demonstrated by sex

192 slocated from skeletal tissues to muscle and gonads, leaving both elements in constant proportion in

193 T_F_OV) and XY(DMY-) female medaka (TA_F_OV) gonad libraries.

194 y originates at the beginning of the somatic gonad lineage three generations earlier, and onset of HL

195 The highest TTX levels in gonads, livers, intestines and skins of female fish were

196 Changes in the levels of TTX in the gonads, livers, intestines, skins and muscles as a funct

197 ) had reduced reproductive investment (lower gonad mass).

198 in slow developing marine species with long gonad maturation times, as the effects of altered condit

199 n our experiments (e.g., during diapause and gonad maturation), and for contaminant transfer to eggs

200 A methylation status of their oocytes during gonad maturation.

201 Therefore, the wider applications of i-GONAD may promote gene function studies using novel muri

202 de of the PGE2-cAMP-PKA pathway in the aorta-gonad-mesonephros (AGM) abolished enhancement in hematop

203 poietic stem cells (HSCs) arise in the aorta-gonad-mesonephros (AGM) and mature as they transit throu

204 y putative direct Notch targets in the aorta-gonad-mesonephros (AGM) embryonic tissue by chromatin pr

205 SC development, but which cells in the aorta-gonad-mesonephros (AGM) microenvironment produce these f

206 hematopoietic stem cells (HSCs) in the aorta-gonad-mesonephros (AGM) of the developing mouse embryo.

207 aft irradiated adult mice arise in the aorta-gonad-mesonephros (AGM) on embryonic day 11.5 (E11.5).

208 first arise during development in the aorta-gonad-mesonephros (AGM) region of the embryo from a popu

209 helium fates concurrently occur in the aorta-gonad-mesonephros (AGM) region prior to haematopoietic s

210 etic stem cells (HSCs) emerge from the aorta-gonad-mesonephros (AGM) region, but the molecular regula

211 essels such as the dorsal aorta of the aorta-gonad-mesonephros (AGM) region, suggesting that signals

212 the ventral domain of the aorta in the aorta-gonad-mesonephros (AGM) region.

213 tly the different stages of EHT in the aorta-gonad-mesonephros (AGM) region.

214 s (HSCs) first emerge in the embryonic aorta-gonad-mesonephros (AGM) region.

215 ls harvested from embryonic day 9 (E9) aorta-gonad-mesonephros (AGM) regions of GATA2 null embryos sh

216 Rare endothelial cells in the aorta-gonad-mesonephros (AGM) transition into hematopoietic st

217 merge, similar to hematopoiesis in the aorta-gonad-mesonephros (AGM).

218 distinct subset of macrophages in the aorta-gonad-mesonephros (AGM).

219 orming assay and in embryonic day 10.5 aorta-gonad-mesonephros explants.

220 pool undergoes dramatic growth in the aorta-gonad-mesonephros region and by E11.5 reaches the size t

221 SCs as they are first generated in the aorta-gonad-mesonephros region, but at later developmental sta

222 s pivotal for in vivo HSC emergence in aorta-gonads-mesonephros region.

223 d hematopoietic stem cells (HSCs) from aorta/gonad/mesonephros (AGM) regions of midgestation mouse em

224 step-by-step protocol for establishing the i-GONAD method.

225 that in mice germline stem cells compete for gonad niches, and in mice and humans, blood-forming stem

226 dual can have both male-type and female-type gonad niches; however, male and female niches are usuall

227 and Sm-Sox19 are expressed differentially in gonads, no sex differences in their expression were obse

228 tip cell niche maintains GSCs in the distal gonad of both sexes and does so via two key stem cell re

229 The myoepithelial sheath in the somatic gonad of the nematode Caenorhabditis elegans has nonstri

230 In the gonad of the nematode worm Caenorhabditis elegans, ring

231 cyp19a1a were significantly increased in the gonad of the ZZ dmrt1 mutant.

232 cribed preferentially or specifically in the gonads of both genders, we uncovered pairing-induced pro

233 The gonads of female fish were toxic in all seasons (>2mug/g

234 ession vectors and incorporate them into the gonads of host embryos.

235 toxic in all seasons (>2mug/g), whereas the gonads of male fish were only toxic in the spring and au

236 , we subjected small RNAs and mRNAs from the gonads of piRNA and siRNA defective mutants to high-thro

237 In gonads of teneral and 15-day old insects, Spiroplasma de

238 pete less successful competitors both in the gonads of the genotype partner from which they arise and

239 ype partner from which they arise and in the gonads of the natural parabiotic partners.

240 The gonads of the remaining fish stayed undifferentiated unt

241 i-GONAD offers other advantages: it does not require vasec

242 erm cells (PGCs) is determined in developing gonads on the basis of cues from somatic cells.

243 Female gonads, or oocytes isolated from MIHR mutants, failed to

244 sterol in mitochondria of adrenal glands and gonads/ovaries.

245 a de novo assembly was applied to different gonad phenotypes of female perch: developed gonads from

246 chanisms underpinning the development of the gonad phenotypes of wild perch and how fish may respond

247 that are wrapped individually by two somatic gonad precursor cells (SGPs).

248 ell lineages from the Anopheles gambiae male gonads: premeiotic, meiotic (primary and secondary sperm

249 endomesoderm upon feeding, migrate into the gonad primordia, and mature into germ cells.

250 The gonad primordium contains two PGCs that are wrapped indi

251 les to three regulatory cells of the somatic gonad primordium in young larvae.

252 erm cells (PGCs) in the C. elegans embryonic gonad primordium.

253 a laminin-based basement membrane around the gonad primordium.

254 e between normoxia and constant hypoxia, and gonad production correlated negatively with continuous t

255 owth, calcification, spine regeneration, and gonad production under constant, 3-hour variable, and 6-

256 aracterized, for the first time, in terms of gonad quality (market-related traits such as colour, tex

257 ular dynamics and physical forces within the gonad remains poorly understood.

258 ome complex from protein purified out of the gonads revealed that it is suspected to complex uranium

259 matography-mass spectrometry (GC/MS) in male gonad samples, including less common 12,15-epoxy-13,14-d

260 In XY gonads, sex-determining region Y (SRY) triggers fibrobla

261 migratory distal tip cells and the proximal gonad sheath, where it becomes enriched in response to t

262 Mutant gonads showed a loss of cell polarity in the surface epi

263 al, characterized by obvious feminization of gonads, significant down-regulation of testicular marker

264 In mammalian embryonic gonads, SOX9 is required for the determination of Sertol

265 piwil2 is a gonad-specific and maternally deposited gene in Nile til

266 SFiNX consists of Nxf2-Nxt1, a gonad-specific variant of the heterodimeric messenger RN

267 important components of the male and female gonad stem cell niches (hubs and terminal filaments/cap

268 Estimated Se concentrations in yellow perch gonads suggest that in two of our study lakes one-third

269 vealed a lasting thermal effect on zebrafish gonads, suggesting new avenues for detection of function

270 gram of development, but later half of these gonads switch to form female stem cell niche structures.

271 Here, we report a key role for the male gonad, testosterone, and androgen receptor (AR) in CNS r

272 ns showed higher concentrations in liver and gonad than in muscle tissues.

273 eam regions of genes more frequently in male gonads than in limb buds.

274 tile fish that possessed minimally-developed gonads that lacked any gametes.

275 ression of Dmrt1 was induced in ZW embryonic gonads that were masculinized by aromatase inhibitor tre

276 In the Caenorhabditis elegans gonad, the broad outlines of germline stem cell (GSC) re

277 and function of the anchor cell (AC) of the gonad, the critical organizer of uterine and vulval deve

278 Although its primary location is the gonad, the FSHR has also been reported in extragonadal t

279 present in select somatic cells outside the gonads, the role of a non-gonadal somatic piRNA pathway

280 ations and is specified within the embryonic gonad, thus making it an excellent model for studying ni

281 (FA) composition was analyzed in muscle and gonad tissues of marketed common carp (Cyprinus carpio).

282 TEN acts non-autonomously within the somatic gonad to maintain developmental quiescence of both SGBs

283 nes must remain active in the differentiated gonads to avoid genetic sex reprogramming, as described

284 in mammals, and subsequently migrate towards gonads to mature into functional gametes.

285 sion of Sry in pre-Sertoli cells directs the gonad toward a male-specific fate.

286 n until the sex determination stage in fetal gonads using Prdm14 H2BVenus knock-in rats.

287 Total phenol content of the gonad was 9.90+/-0.01 mg GAE/g and the IC50 of the extra

288 Using GONAD, we demonstrated that target genes can be disrupte

289 Using GONAD, we show that NAs (e.g., eGFP mRNA or Cas9 mRNA/sg

290 A small reduction in gonad weight was detected at the vents, but no differenc

291 ing revealed that fish with undifferentiated gonads were all males, who grew larger than the genetic

292 responses that were modulated in irradiated gonads were found to be involved in biological processes

293 The gonads were rich in essential amino acids (ca. 32.1% of

294 defects in the body wall muscle and somatic gonad, whereas clik-1 depletion alone caused no detectab

295 ring-dependent differentiation of the female gonads which finally leads to egg synthesis.

296 xtrinsically controlled by the adjacent male gonad, which activates JAK-STAT signaling in enterocytes

297 es more frequently in limb buds than in male gonads, while SOX9 bound to the proximal upstream region

298 ing small interfering RNA (piRNA) pathway in gonads, while the small interfering RNA (siRNA) pathway

299 that vitellogenin is only detected in female gonads with expression levels that are rather variable a

300 being found at trace levels in seawater and gonads, with low risk for consumers.