ライフサイエンスコーパス: granular layer

1 own cornification and alter autophagy in the granular layer.

2 epidermis of human skin, particularly in the granular layer.

3 s into the intercellular spaces of the upper granular layer.

4 ructed a large-scale 3D network model of the granular layer.

5 coincident with misshaped nuclei within the granular layer.

6 whereas PTH2R was detected in the spinous to granular layer.

7 the more differentiated keratinocytes of the granular layer.

8 ecular layers, oriented perpendicular to the granular layer.

9 hen granule cell axons are stimulated in the granular layer.

10 r lipid composition and cell adhesion in the granular layer.

11 only scattered cellular staining within the granular layer.

12 SEZ) and early postnatal cerebellar external granular layer.

13 ttern in the junction of stratum corneum and granular layers.

14 onal staining in the molecular, and internal granular layers.

15 elates with the atrophy of the molecular and granular layers.

16 scharges reflected current flow in the supra-granular layers.

17 d sources only within the infra-granular and granular layers.

18 solution of cell-cell junctions in the upper granular layers.

19 the highest similarity in supragranular and granular layers.

20 ised the majority of stimulus information in granular layers.

21 ty correlate with the synaptic distance from granular layers.

22 ng increased tension and TJ stability in the granular layer 2.

23 motor cortex (M1) emphasize its lack of the granular layer 4 (L4) typical of sensory cortices.

24 lateral expansion of the PFC with a distinct granular layer 4 in primates(10,11) remain unknown.

25 a TEs composed of three layers: an outermost granular layer, a middle primary wall composed of a mesh

26 res of BA22/TA were the presence of distinct granular layers, a prominent, jagged layer IIIc, and a d

27 ly in the protoplasmic islet in the internal granular layer after the third postnatal week.

28 in controlling information flow through the granular layer along with cerebellar learning and memory

29 gHrnr(-/-) mice displayed a markedly reduced granular layer and a condensed cornified layer.

30 In addition, a granular layer and a low-density zone typifying the peri

31 je somata and dendrites, neurons in internal granular layer and dentate nucleus, and neuronal element

32 d the most posterior end of GC and overlying granular layer and encompassed an area provisionally ref

33 of granule neuron precursors in the external granular layer and glial precursor cells throughout the

34 cant in the stellate and basket cells of the granular layer and Golgi cells of the molecular layer.

35 al weeks (g.w.), PV appeared in the external granular layer and in a few Purkinje cells at 11 g.w., a

36 ve cells occurred in clusters throughout the granular layer and reached their highest reactivity by P

37 ermis characterized by complete absence of a granular layer and stratum corneum.

38 ranule cells (NeuN-positive) in the internal granular layer and the migrating granule cells did not e

39 e to skin models resulted in the loss of the granular layer and thinning of the epidermis and stratum

40 Conversely, LIMK1 is expressed in the upper granular layers and phosphorylates and inhibits cofilin.

41 ggrin processing, reduced lamellar bodies in granular layers and significantly altered lipid composit

42 ispersed widely before entering the internal granular layer, and a rostral pathway along the cerebell

43 the external granular layer to the internal granular layer, and lack of excitatory inputs triggers t

44 onsisting of three distinct stages: spinous, granular layer, and stratum corneum.

45 ing must take place through a surface porous granular layer, and that layer must be composed of grain

46 e subpial stream is replaced by the external granular layer, and the NTZ organizes into distinct DCN

47 l pattern of lamination and lack an internal granular layer, and those with more complex laminar arch

48 clear visualization of the molecular layer, granular layer, and white matter in chimpanzee and macaq

49 tive koniocellular LGN influence on V1 supra-granular layers, and they indicate comparable capacities

50 with patterns previously derived from supra-granular-layers, and produced stimulation-induced spatia

51 es such as the main olfactory bulb (internal granular layer), anterior olfactory nucleus, and deep la

52 In long-term cultures, the granular layer appeared well preserved and the UBC axons

53 itatory input, consisting of output from the granular layer (approximately 25 ms), exogenous input to

54 PC) synapses made by axon collaterals in the granular layer, are both enriched in areas that control

55 network that hints for the first time at the granular layer as a major determinant of cerebellar bloo

56 that the lack of recurrent excitation in the granular layer as commonly required in traditional reser

57 c-fos expression throughout the ipsilateral granular layer as well as in Purkinje cell nuclei.

58 nule neuron progenitors and thinner external granular layers at P4.

59 A3 and ephrin-A5 is observed in the external granular layer between the posterior and anterior lobes.

60 Within the granular layer, both receptors were expressed in the cyt

61 ume of the molecular layer by 24% and of the granular layer by 22% in comparison with controls.

62 Therefore, granular layer capillaries are controlled by the balance

63 ification of new cell types including a deep granular layer cell that relays sensory information from

64 eterious action is intrinsic to the external granular layer cell.

65 layed barrier formation as embryos, enlarged granular layer cells and corneocytes, and a morphologica

66 of basal cells, stratum spinosum cells, and granular layer cells were all stained uniformly, but not

67 The confinement of SULT2B1b to the granular layer coincides with this being the area with t

68 that the predominant AP-1 heterodimer in the granular layer consists of Fra-2 and JunB while a JunD a

69 l, and, at 13 g.w., the newly formed subpial granular layer contained GABA-immunoreactive cells, as w

70 ortex, affecting primarily the dentate gyrus granular layer (DG) and CA4 of the hippocampus and layer

71 ociated with the epidermal keratinocyte (KC) granular layer differentiation program.

72 human profilaggrin gene is expressed in the granular layer during the late stages of terminal differ

73 human profilaggrin gene is expressed in the granular layer during the late stages of the epidermal d

74 ebellar granule cells remain in the external granular layer (EGL) for 20-48 hr before initiating thei

75 bit the proliferation of cerebellar external granular layer (EGL) neuroblasts by mechanisms that are

76 cursor cells (GCPs), located in the external granular layer (EGL) of the cerebellum, gives rise to me

77 r cytoarchitecture of the transient external granular layer (EGL) of the developing cerebellum, where

78 howed appropriate expression in the external granular layer (EGL) of the postnatal day (PN) 7 cerebel

79 n precursors (GNP) in the postnatal external granular layer (EGL), the internal granular layer formed

80 plasticity provides a dynamic control of the granular layer encoding capacity.

81 the somata of granule cells in the internal granular layer, even though these cells gave large AMPA

82 ype was characterized by a thickening of the granular layer expressing filaggrin and loricrin, but th

83 he normal pattern of suprabasal (spinous and granular layer) expression in transgenic mouse epithelia

84 e circumvented by considering other inherent granular layer features such as inverted input signals o

85 external granular layer (EGL), the internal granular layer formed normally in Smo/Smo mice and tumor

86 Fs) as well as microinjection of NMDA in the granular layer generates beam-like responses with a cent

87 pidermis is fragile, and acantholysis in the granular layer generates localized lesions, compromising

88 rCs and basolateral dendrites of GoCs in the granular layer (GL).

89 Specifically, we targeted granular layers (GL) of rat and turtle cerebella that ar

90 r layer and the mossy fiber terminals in the granular layer glomeruli in late development and during

91 erior frontal cortex affects superficial and granular layer glutamatergic excitation.

92 Surprisingly, after entering the internal granular layer, granule cells re-extend both their somat

93 R, but expression is restricted to the upper granular layers (i.e., no spinous layer expression).

94 contains acellular regions within the inner granular layer (igl) and ectopic, calbindin-immunoreacti

95 xternal germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the develop

96 pment by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) d

97 ressing cells are restricted to the internal granular layer (IGL), but that the BDNF protein is prese

98 population was also detected in the internal granular layer (IGL).

99 Lateral area 29 (29l) has a dense granular layer II-IV and undifferentiated layers V and V

100 evated concentrations of D2 receptors in the granular layer in isocortical regions of the temporal lo

101 enter/surround structures that emerge in the granular layer in response to mossy fiber activity.

102 ration of their progenies in the hippocampus granular layer in vivo.

103 Here we show that a granular layer interneuron, called the unipolar brush ce

104 Unipolar brush cells (UBCs) are excitatory granular layer interneurons in the vestibulocerebellum.

105 e cells, which migrate from the hilus to the granular layer, interneurons traverse this layer in the

106 of structural proteins of the upper spinous/granular layers (involucrin, profilaggrin-filaggrin, lor

107 However, the granular layer is a region with variable metabolic deman

108 ion of KCs from basal epidermal layer to the granular layer is accompanied by marked differences in n

109 he average GCP proliferation in the external granular layer is progressively slower as development pr

110 In sensory cortex, layer 4 (the granular layer) is the target of ascending pathways.

111 patiotemporal dynamics, as the output of the granular layer, is highly regulated by GoCs.

112 ed to originate from the external cerebellar granular layer, it is reasonable to postulate that IGF-I

113 vestigated whether a frontal area that lacks granular layer IV, supplementary eye field, exhibits fea

114 d early spinous layer keratinocytes, whereas granular layer keratinocytes expressed predominantly LNP

115 t low-frequency oscillations observed in the granular layer may provide a reference for repetitive EP

116 aw skin, marked attenuation of the epidermal granular layer, mild acanthosis, and orthokeratotic hype

117 molecular layer and medium-size soma of the granular layer (most likely Golgi cells).

118 Granular layer network modeling indicates that phase dis

119 Leveraging a computational model of the granular layer network, we addressed this question to ex

120 stem-level models and detailed models of the granular layer network.

121 Interneurons or granular layer neurons and some glial cells express NR2C

122 complex set of alterations in the cerebellum granular layer of a mouse model [IB2 (Islet Brain-2) KO]

123 Here, we show, in the granular layer of acute rat cerebellar slices, that capi

124 ere we demonstrate that GFAP(+) cells of the granular layer of cerebellum express GABArho subunits du

125 ilaggrin is expressed in the differentiating granular layer of epidermis and other stratified epithel

126 es (n = 4) immunostained keratohyalin in the granular layer of human epidermis and also showed some r

127 perplasticity disrupt signal transfer in the granular layer of IB2 KO mice, supporting cerebellar inv

128 models, and, moreover, was localized to the granular layer of keratinocytes as seen in psoriasis in

129 skin, whereas weak signal was present in the granular layer of newborn and adult skin.

130 ed multipotent progenitors into the external granular layer of newborn meander tail mice (gene symbol

131 ly isolated and propagated from the external granular layer of newborn wild-type mouse cerebellum, co

132 velopment when reimplanted into the external granular layer of normal mice.

133 into the deep cerebellar tissue or external granular layer of postnatal day 4/5 rats to label dividi

134 each mystacial whisker is represented in the granular layer of primary somatosensory (SI) cortex by a

135 The traditional view of the external granular layer of the cerebellar cortex giving rise to i

136 f the choroid plexus, meninges, and external granular layer of the cerebellum and in columns of cells

137 1 is essential for proper development of the granular layer of the cerebellum and the hair cells of t

138 They project in the granular layer of the cerebellum and the medial reticula

139 llular volume fraction and tortuosity of the granular layer of the cerebellum were determined from me

140 In the granular layer of the cerebellum, two major types of cel

141 s a type of glutamatergic interneuron in the granular layer of the cerebellum.

142 erebrum and MeCP2(lo )neurons highest in the granular layer of the cerebellum.

143 alleja, the olfactory bulb, and the internal granular layer of the cerebellum.

144 of MSCs also were found within the external granular layer of the cerebellum.

145 cells predicted to give rise to the external granular layer of the cerebellum.

146 n also decreased Fos immunoreactivity in the granular layer of the dentate gyrus of the hippocampus b

147 of the CA1-CA3 pyramidal cell layer and the granular layer of the dentate gyrus.

148 l cells of the ventricular zone and external granular layer of the developing cerebellar cortex.

149 ic murine model expressing human KLK5 in the granular layer of the epidermis (Tg-KLK5).

150 ld guide expression of specific genes in the granular layer of the epidermis and could be useful in g

151 expression of SULT2B1b was localized to the granular layer of the epidermis similar to that of filag

152 III of the vagal lobe and in the superficial granular layer of the lateral subnucleus of the commissu

153 matergic interneuron that is enriched in the granular layer of the mammalian vestibulocerebellum and

154 y absent neuronal population in the internal granular layer of the mature meander tail anterior lobe.

155 eizures are generated intracortically in the granular layer of the neocortex.

156 en (PM-Scl), which has been localized to the granular layer of the nucleolus and to distinct nucleocy

157 clude the anterior olfactory nucleus and the granular layer of the olfactory bulb.

158 The superficial granular layer of the rostral AVCN and the medial sheet

159 SRC3 was detected in the suprabasal and granular layer of the skin, similar to cathelicidin expr

160 skin tape strips corresponding to the upper granular layer of the skin.

161 lencephalic area, the glomerular region, the granular layer of the valvula cerebelli, the nucleus dif

162 class of neurons recently identified in the granular layer of the vestibulocerebellum, receive excit

163 gnals were detected in the upper spinous and granular layers of reepithelializing keratinocytes and i

164 oriens of the hippocampus, the molecular and granular layers of the cerebellum, and the molecular lay

165 vglut1 is prominent in granular layers of the cerebellum, habenula, preglomerul

166 cytes is restricted to the upper spinous and granular layers of the epidermis of IBS patients, wherea

167 er of cellular excitation, in the mitral and granular layers of the OB and in the piriform cortex (PC

168 ecrease of these sites occurred in hilar and granular layers of the ventral dentate gyrus.

169 an primates and assessed the effect on supra-granular layers of V1 that project to higher visual cort

170 fragranular layers of V1, and finally in the granular layers of V1.

171 ctive electrical current inflow in the supra-granular layers of V1.

172 are in the more differentiated (spinous and granular) layers of the epidermis, with little expressio

173 of rhythmic neuronal activity in the input (granular) layers of V1, adaptation caused a pronounced i

174 their axon arbors are either confined to the granular layer or proliferate in both the granular and g

175 d from intracellular antigens; and (iii) the granular layer peptidome is skewed toward extracellular

176 etinal rod outer segments and the cerebellar granular layer possessed masked glucuronyl 3-SO4 that be

177 retroviral labeling of cells in the external granular layer produced only granule neurons in the inte

178 types included granule cells of the internal granular layer, Purkinje cells, Golgi cells, and molecul

179 mulus-related activity was first observed in granular layer putative interneurons, whereas target dis

180 ith recurrent models in which neurons in the granular layer receive intracortical inputs from nearby

181 Furthermore, the spatial organization of granular layer responses to mossy fibers shifted from a

182 twork context--whereas neurons in the input (granular) layers showed virtually no correlated variabil

183 ting the response patterns of the cerebellar granular layer.SIGNIFICANCE STATEMENT This article shows

184 separated parallel fibres were activated by granular layer stimulation, the EPSC prolongation produc

185 fect for parallel fibre stimulation than for granular layer stimulation.

186 and infragranular layers of V1, but weak in granular layers, suggesting that it might reflect feedba

187 of binding was significantly greater in the granular layer than in the molecular layer.

188 skin, with higher expressions in spinous and granular layers than in the basal layer.

189 anglionic eminence and via a massive subpial granular layer that may also supply some GABAergic inter

190 y in recently generated cells in the dentate granular layer, the subventricular zone, the olfactory b

191 s and stratum corneum layers, variability in granular layer thickness, and parakeratosis in some regi

192 form that they acquire while traversing the granular layer to finally assume an adult-like pyramidal

193 ature during its migration from the external granular layer to the internal granular layer, and lack

194 iting premature apoptosis in the spinous and granular layers to promote conification, and promoting t

195 ed to increased spike-timing precision among granular layer V1 neurons as well.

196 al pulvinar after LGN lesion activated supra-granular layer V1 neurons.

197 ggrin expression by 24 h, this marker of the granular layer was induced in a smaller subset of HPV ty

198 d highly differentiated keratinocytes of the granular layer were hr-negative.

199 gy is constitutively active in the epidermal granular layer where by electron microscopy we identifie

200 ytes migrate through the epidermis up to the granular layer where, on terminal differentiation, they

201 l they reach the deep strata of the internal granular layer, where they become rounded again and form

202 The granular layer, which mainly consists of granule and Gol

203 network of feedforward excitation within the granular layer, which may amplify vestibular signals and

204 in the parabasal prickle cell layer and the granular layer, while differentiated keratinocytes displ

205 Ectosplenial area 26 has a granular layer with few large pyramidal neurons below.

206 eased numbers of small dense granules in the granular layer with few or no surrounding keratin bundle

207 circuit by stimulating the prefrontal infra-granular-layers with patterns previously derived from su