ライフサイエンスコーパス: granule exocytosis

1 is the precise role of Munc18-2 during lytic granule exocytosis.

2 an important role for myosin 1e in cortical granule exocytosis.

3 g, independent of fertilization and cortical granule exocytosis.

4 nodeficiency characterized by impaired lytic granule exocytosis.

5 tion of myosin 1e antibody inhibits cortical granule exocytosis.

6 cell-receptor (TCR)-mediated cytotoxicity or granule exocytosis.

7 linking of the T cell receptor that leads to granule exocytosis.

8 ositive for the proteins essential for lytic granule exocytosis.

9 imulated SNARE complex formation and insulin granule exocytosis.

10 rbol-12-myristate-13-acetate-evoked cortical granule exocytosis.

11 gher levels of CD107a, a marker of lysosomal granule exocytosis.

12 annot account for the profound inhibition of granule exocytosis.

13 n known for many years to be key signals for granule exocytosis.

14 oes not mediate the role of ERK in CTL lytic granule exocytosis.

15 er jasplakinolide or latrunculin A abolished granule exocytosis.

16 r mitochondrial ATP production and secretory granule exocytosis.

17 ing roles for Munc18c and/or Syn4 in insulin granule exocytosis.

18 ion of Mac-1 (CD11b/CD18) and with azurophil granule exocytosis.

19 s via a high-affinity interaction to promote granule exocytosis.

20 ed to identify genes required for dense core granule exocytosis.

21 on and has been assumed to involve low level granule exocytosis.

22 ged proteins that secretion does not involve granule exocytosis.

23 ty and gamma-interferon secretion as well as granule exocytosis.

24 s of PC12 cell processes at or near sites of granule exocytosis.

25 extracellular Ca2+, is required for perforin/granule exocytosis.

26 hypothesize that rab3 functions in cortical granule exocytosis.

27 induces FasL/Fas-mediated cytolysis but not granule exocytosis.

28 sec, or roughly at the same time as cortical granule exocytosis.

29 alcium dependence of sea urchin egg cortical granule exocytosis.

30 es beta-cell electrical activity and insulin granule exocytosis.

31 VAMP8 overexpression inhibits insulin granule exocytosis.

32 granules reorientation but crucial for lytic granule exocytosis.

33 of these proteins in platelets and assessed granule exocytosis.

34 ge-dependent Ca2+ channels to elicit insulin granule exocytosis.

35 a critical orchestrator of goblet cell mucin granule exocytosis.

36 s virulence factors, such as LLO, facilitate granule exocytosis.

37 rmone and transmitter release during insulin granule exocytosis.

38 ectly associated with primary (or secondary) granule exocytosis.

39 Munc13-4, syntaxin-11, and Munc18-2 in lytic granule exocytosis.

40 e effect of the LAT deletion on each step of granule exocytosis.

41 2+) sensor at rate-limiting priming steps in granule exocytosis.

42 VAMP8 is an essential SNARE in airway mucin granule exocytosis.

43 VAMP8 as one of the SNAREs regulating mucin granule exocytosis.

44 ition improved ERK phosphorylation and lytic granule exocytosis.

45 cal Ca(2+) nanodomains around TPCs stimulate granule exocytosis.

46 ) mobilization and substantial inhibition of granule exocytosis.

47 ) embryos despite fertilization and cortical granule exocytosis.

48 2+)-sensitive regulatory pathway for zymogen granule exocytosis.

49 d directly lysed YAC-1 thymoma cells through granule exocytosis.

50 bers is required for the regulation of lytic granule exocytosis.

51 y active mutant calcineurin A enhanced lytic granule exocytosis.

52 r a critical step between NKIS formation and granule exocytosis.

53 ing proteins are also essential for cortical granule exocytosis.

54 teps of membrane fusion in calcium-dependent granule exocytosis.

55 y pathways for resting secretion and reserve granule exocytosis, a high capacity, low sensitivity pat

56 -CSF induced the highest sustained azurophil granule exocytosis, almost exclusively in PMNs with acti

57 F. alocis with Toll-like receptor 2 induced granule exocytosis along with a transient ERK1/2 and sus

58 family GTPase Cdc42 is required for insulin granule exocytosis, although the regulatory proteins inv

59 nding of sperm to the egg initiates cortical granule exocytosis, an event that contributes to a susta

60 ase antibodies were able to trigger cortical granule exocytosis and activation of GalTase-expressing

61 FcgammaRIIIA-induced granule exocytosis and both spontaneous and Ab-dependent

62 sion of genes related to cell-cell adhesion, granule exocytosis and cell-mediated cytotoxicity.

63 Among these, cortical granule exocytosis and compensatory endocytosis provide

64 ease-mediated reactions that follow cortical granule exocytosis and contribute to the block to polysp

65 effector-cell responses, including secretory granule exocytosis and cytokine production.

66 nt egg activation events, including cortical granule exocytosis and cytoplasmic segregation.

67 , representing a critical step in lymphocyte granule exocytosis and cytotoxicity.

68 Dynamin triple deletion impairs insulin granule exocytosis and decreases intracellular Ca(2+) re

69 Interestingly, alpha-granule exocytosis and deposition of the alpha-granule c

70 rotein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broa

71 Alterations in insulin granule exocytosis and endocytosis are paramount to panc

72 C indicates that cell-mediated immunity with granule exocytosis and Fas pathways have been conserved

73 pases) has been proposed to mediate both the granule exocytosis and Fas-Fas ligand pathways of rapid

74 ) CTL clone that kills via both the perforin/granule exocytosis and FasL/Fas mechanisms, and a clone

75 elets demonstrated a partial defect in dense granule exocytosis and impaired aggregation.

76 y and characterize a role for syntaxin 11 in granule exocytosis and in the generation of cell-mediate

77 its putative role in facilitating secretory granule exocytosis and its consequent extracellular acti

78 or bacteria, bacterial killing, TNF-induced granule exocytosis and phox assembly, and endothelial tr

79 LOX-1 induction was dependent on granule exocytosis and promoted up-regulation of reactiv

80 natural killer (NK) cells use Ca2+-dependent granule exocytosis and release of cytotoxic proteins, Fa

81 Based on primary granule exocytosis and scatter profiles, CF airway neutr

82 luation of patients with defects in platelet granule exocytosis and the generation of mice lacking sp

83 coordinated functions: to regulate cortical granule exocytosis and to mediate chromosome separation.

84 killing of parasitized cells is dependent on granule exocytosis and, specifically, granzyme B.

85 and Rac1 are pivotal regulators of adhesion, granule exocytosis, and cellular cytotoxicity.

86 sphorylation, integrin activation, secondary granule exocytosis, and cytokine secretion.

87 From the calcium dependence of cortical granule exocytosis, and from the exposure time and conce

88 dependent functions, including phagocytosis, granule exocytosis, and migration.

89 IP(4) limits NKR-induced IFNgamma secretion, granule exocytosis, and target-cell killing, in part by

90 Cytotoxicity, lytic granule exocytosis, and the phosphorylation of Pyk2 are

91 as the site at which lipids regulate insulin granule exocytosis; and 3) deletion of the N-terminal mi

92 The substrates of PKCs involved in lytic granule exocytosis are currently unknown, but subcellula

93 cytotoxic granules and comparable levels of granule exocytosis are induced by PMA and calcium ionoph

94 membrane in a manner reminiscent of cortical granule exocytosis as described in other species.

95 HUVEC cytolysis was dependent on granule exocytosis, as demonstrated by the paralyzing ef

96 As ATP is also required for insulin granule exocytosis, both reduced exocytosis and less bet

97 ivation of calcineurin is required for lytic granule exocytosis but suggest that it is not the sole C

98 of activated human NK cells not only induces granule exocytosis, but also subsequently results in the

99 onstrate that PKCdelta is required for lytic granule exocytosis, but is dispensable for activation, c

100 ressive drugs, JNK is not required for lytic granule exocytosis, but we were not able to exclude a ro

101 osylation diminished the effects of GLP-1 on granule exocytosis by approximately 40% in betaTC3 cells

102 Only granule exocytosis by CTLs was markedly impaired in the

103 Granule exocytosis by cytotoxic lymphocytes is the key m

104 ncerning the regulation of TCR-induced lytic granule exocytosis by revealing novel intracellular loca

105 xpressed at the earliest stage that cortical granule exocytosis can be detected in oocytes.

106 Interestingly, cortical granule exocytosis can be elicited in immature Xenopus o

107 deleterious STX11 variants impairs cytotoxic granule exocytosis, causing familial hemophagocytic lymp

108 a(2+)-dependent events that include cortical granule exocytosis, cell cycle resumption with concomita

109 owed by insemination does not block cortical granule exocytosis, cell cycle resumption, as assessed b

110 egg activation, including abnormal cortical granule exocytosis (CGE), cytoplasmic segregation, cleav

111 The data demonstrate that neutrophil granule exocytosis contributes to phagocytosis-induced r

112 urmised that the involvement of ERK in lytic granule exocytosis could be mediated through cross-talk

113 of Ca2+ release and also inhibited cortical granule exocytosis, cytoplasmic alkalinization, MAP kina

114 The granule exocytosis cytotoxicity pathway is the major mol

115 resence of cathepsin inhibitors requires the granule exocytosis cytotoxicity pathway, as it is normal

116 in the cytotoxic T lymphocyte (CTL)-mediated granule exocytosis death pathway and of granzyme entry i

117 cesses that are expected to be important for granule exocytosis-dependent killing.

118 Granule exocytosis-dependent target cell killing is a co

119 Granule exocytosis did not appear to play a role in Moon

120 HP2, had no effect on Ca2+ release, cortical granule exocytosis, DNA synthesis, or cleavage.

121 ls by both the Fas ligand (FasL)/Fas and the granule exocytosis effector pathways.

122 ced by CTL via the FasL/Fas, but not via the granule exocytosis, effector pathway was specifically bl

123 xerts dual roles in glucose-mediated insulin granule exocytosis, facilitating refilling of releasable

124 mice with genetic deficiencies affecting the granule exocytosis-, Fas-, or tumor necrosis factor rece

125 rab3 functions in the regulation of cortical granule exocytosis following vesicle docking.

126 ling has been solely attributed to cytotoxic granule exocytosis from activated CD8(+) T cells.

127 nc18c is required for SNARE-mediated insulin granule exocytosis from islet beta cells and GLUT4 vesic

128 alpha Granule exocytosis from VAMP-7(-/-) platelets was dimini

129 ing of which SNARE isoforms mediate platelet granule exocytosis has occurred following evaluation of

130 ome events of egg activation, e.g., cortical granule exocytosis, however, appear more sensitive to in

131 and recruitment of maternal mRNAs; cortical granule exocytosis, however, did not occur normally.

132 The site(s) of dense granule exocytosis, however, has been unknown.

133 Following cortical granule exocytosis, however, rab3 reassociates with a di

134 rylated on the activation loop and regulates granule exocytosis in a kinase-dependent manner.

135 s show the capacity of MARCKS-ED to regulate granule exocytosis in a PKC-dependent manner, consistent

136 s well as by interfering with the process of granule exocytosis in CD8(+) T cells.

137 ignaling pathway(s) that selectively induces granule exocytosis in CTL has not been defined to date.

138 ion in helper T cells, plays a role in lytic granule exocytosis in cytotoxic T lymphocytes (CTLs).

139 ibe characteristics of fusion during zymogen granule exocytosis in exocrine pancreatic acinar cells.

140 evidence of histamine secretion by classical granule exocytosis in human mast cells in vivo.

141 miR-7 genomic circuit that regulates insulin granule exocytosis in pancreatic beta cells and support

142 ed calcium signaling and, therefore, insulin granule exocytosis in pancreatic beta cells.

143 second/granule mobilization phase of insulin granule exocytosis in pancreatic islet beta cells, altho

144 with syntaxin enhanced Ca2+-triggered dense granule exocytosis in permeabilized cells.

145 Premature granule exocytosis in Rho-deficient neutrophils activate

146 at small central synapses, as well as single granule exocytosis in secretory cells, have been detecte

147 ntial activity in cell division and cortical granule exocytosis, in developmentally programmed cell d

148 contrast, the caspase inhibitors blocked CTL granule exocytosis-induced target apoptotic nuclear dama

149 H deficiency induces exacerbated azurophilic granule exocytosis, inflammation, and decreased survival

150 ) T cells to kill pathogen-infected cells is granule exocytosis, involving the release of perforin an

151 Control of mast cell granule exocytosis is a major therapeutic goal for aller

152 Hence, cytotoxic granule exocytosis is a sequential, multivesicle fusion

153 s of the rab3 protein, we find that cortical granule exocytosis is inhibited in eggs injected with ef

154 In pancreatic beta cells, insulin granule exocytosis is regulated by SNARE (soluble N-ethy

155 Mucin granule exocytosis is regulated by specific protein comp

156 les are heterogeneous and demonstrating that granule exocytosis is required for platelet spreading.

157 Lytic granule exocytosis is the major effector function used b

158 Lytic granule exocytosis is the major pathway used by CD8+ CTL

159 tients with CHS and how LYST regulates lytic granule exocytosis is very limited.

160 In cells specialized for secretory granule exocytosis, lysosomal hydrolases may enter the r

161 ement for specific PKC localization in lytic granule exocytosis may have important implications for t

162 channels; and (iii) Ca(2+)-dependent insulin granule exocytosis, measured as increases in membrane ca

163 -and-run exocytosis (as determined by single-granule exocytosis measurements) in which the fusion por

164 ve lost the ability to kill via the perforin/granule exocytosis mechanism of killing, although they e

165 se for its inability to trigger the perforin/granule exocytosis mechanism of killing.

166 The perforin/granule exocytosis mechanism uses preformed cytolytic gr

167 h receptor pathways mediated by caspases and granule exocytosis mediated by direct GrB activity or Gr

168 kines and exhibit a potent Ag-specific lytic granule exocytosis-mediated cytolytic effector function

169 Granule exocytosis-mediated cytotoxicity by CD8(+) CTL p

170 l known to be critical for the regulation of granule exocytosis-mediated cytotoxicity in CD8+ T cells

171 tions, we show that PKCdelta is required for granule exocytosis-mediated lytic function in mouse CD8+

172 n interaction with target cells sensitive to granule exocytosis-mediated spontaneous cytotoxicity, an

173 n, showing neither lytic activity, nor lytic granule exocytosis, nor IFN-gamma production.

174 attachment protein receptor (SNARE)-mediated granule exocytosis occur in islet beta cells, adipocytes

175 Cytolytic granule exocytosis occurs at peptide concentrations insu

176 mage, but show that target cell lysis by CTL granule exocytosis occurs by a caspase-independent pathw

177 We find that whereas cortical granule exocytosis occurs over a narrow threshold range

178 Lymphocyte-mediated cytotoxicity via granule exocytosis operates by the perforin-mediated tra

179 PMA together with Ionomycin did not induce granule exocytosis or cytotoxicity by YT cells.

180 which effector mechanisms of CD8(+) T cells, granule exocytosis or Fas ligand expression, play a role

181 lular Ca2+, resume meiosis, undergo cortical granule exocytosis, or ZP2 cleavage to ZP2f.

182 These CD4+ T-cell lines lysed targets by the granule exocytosis pathway and reduced the viability of

183 Biochemical inhibition of the granule exocytosis pathway in CD4(+) and CD8(+) T cells

184 suggest involvement of the perforin/granzyme granule exocytosis pathway in immune regulation of gamma

185 Our data implicate the granule exocytosis pathway in TB-IRIS pathophysiology.

186 me C can support CTL-mediated killing by the granule exocytosis pathway in the absence of functional

187 However, target lysis via the granule exocytosis pathway is completely resistant to ca

188 d natural killer cells comes from either the granule exocytosis pathway or the Fas pathway.

189 Although the granule exocytosis pathway plays a major role in NK cell

190 TL activity was blocked by inhibitors of the granule exocytosis pathway such as ethylene-glyco-tetra-

191 Cytotoxic lymphocytes use the granule exocytosis pathway to kill pathogen-infected cel

192 though activated murine NK cells can use the granule exocytosis pathway to kill target cells immediat

193 hus, when caspase activation is blocked, the granule exocytosis pathway triggers several parameters o

194 The granule exocytosis pathway utilizes perforin to traffic

195 as ligand interaction and CD8(+) CTL via the granule exocytosis pathway.

196 cells exhibited notable abnormalities in the granule exocytosis pathway.

197 ng of target cells by the perforin-dependent granule exocytosis pathway.

198 phocytes (CTLs) can kill target cells by the granule/exocytosis pathway or the Fas-mediated apoptosis

199 when induced by the FasL/Fas, but not by the granule exocytosis, pathway.

200 Our findings imply that secretory granule exocytosis pathways in other cell types may also

201 he native J-domain of csp inhibited cortical granule exocytosis, point mutations that interfere with

202 it ligand/stem cell factor-induced secretory granule exocytosis, proliferation, and phosphorylation o

203 ocrine cells, that upon stimulated secretory granule exocytosis, raft-associated Tac-CPE25 was rapidl

204 ion," resulting in calcium release, cortical granule exocytosis, recruitment of maternal mRNAs, and c

205 and then examined the effect on the cortical granule exocytosis, recruitment of maternal mRNAs, and c

206 Whereas granule exocytosis targets any antigen-bearing cell, fas

207 lar phase of synthesis, packaging and apical granule exocytosis that is followed by an extracellular

208 ificantly inhibited cytotoxicity-mediated by granule exocytosis, that is, cytotoxicity of alloantigen

209 raacetic acid, which inhibit cytotoxicity by granule exocytosis, the CD4(+) cytotoxic T lymphocytes (

210 on events such as sperm-egg fusion, cortical granule exocytosis, the elevation of phosphatidylinosito

211 E proteins have been implicated in cytotoxic granule exocytosis, the role of vesicular SNARE proteins

212 lso appears to have an essential function in granule exocytosis through actions mediated by its E pep

213 racellular granzyme (Gr) B content and lytic granule exocytosis through surface CD107a expression.

214 y, use distinct members of the TNF family or granule exocytosis to mediate target cell death.

215 4 bound Ca(2+) and restored Ca(2+)-dependent granule exocytosis to permeable cells (platelets, mast,

216 ng the transcriptional profile while leaving granule exocytosis unabated.

217 We investigated the role of Ca(2+) influx in granule exocytosis using TALL-104 human leukemic cytotox

218 internalized TrkA receptors promote insulin granule exocytosis via F-actin reorganization.

219 Insulin granule exocytosis was accelerated twofold, but the secr

220 ted in the trans-Golgi network and secretory granule exocytosis was more responsive to secretagogue.

221 that bypasses TCR/CD3-dependent signalling, granule exocytosis was not significantly altered, sugges

222 ression of full-length Xenopus csp, cortical granule exocytosis was reduced by approximately 80%.

223 IP(3)-induced cortical granule exocytosis was significantly decreased in these

224 locis-induced secretory vesicle and specific granule exocytosis were p38 MAPK dependent.

225 I and cortical actin filaments in chromaffin granule exocytosis were studied by confocal fluorescence

226 tural killer cells, that are released during granule exocytosis when a specific virus-infected or tra

227 myosin 1e augments the kinetics of cortical granule exocytosis, whereas tail-derived fragments of my

228 quent egg activation steps, such as cortical granule exocytosis, which modifies the vitelline membran

229 e fact that Arg1 activation requires primary granule exocytosis, which occurs in CF, but not HC, airw

230 and suggest a mechanism whereby VAMP-7 links granule exocytosis with actin reorganization.

231 r involving, at least in part, inhibition of granule exocytosis without affecting effector/target cel